ORS SUPPORTERS. LEVEL 3 Open at press time

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2 ORS SUPPORTERS OUR THANKS to the following supporters for contributions. LEVEL 1 Zimmer Biomet* LEVEL 2 DePuy Synthes* Smith&Nephew* LEVEL 3 Open at press time LEVEL 4 Bioventus* Exactech Inc* Histogenics* Medtronic Restorative Therapy Groups Orthofix* Shriners Hospital for Children LEVEL 5 Micro Photonics, Inc. Novartis* Upwelling Foundation Vericel Corporation* Virginia Tech Wiley-Blackwell Thank you to our 2017 New Investigator Recognition Awards (NIRA) Supporters Brown University Duke University Medical Center Hospital for Special Surgery Hospital of the University of Pennsylvania International Chinese Musculoskeletal Research Society (ICMRS) University of California, San Francisco University of Minnesota Medical Center University of Pittsburgh Medical Center University of Rochester Medical Center Washington University in St. Louis * Support received for Annual Meeting educational activities 4 2

3 TABLE OF CONTENTS Annual Meeting Corporate Supporters...2 Meeting Information and Schedules...5 Future ORS Annual Meetings...13 GENERAL INFORMATION Meeting Objectives/CME/FDA/Disclaimer/Safety Tips/Guest Badge Information...14 Saturday, March Sunday, March Monday, March Tuesday, March Wednesday, March Poster Sessions Overview...69 Exhibitor Listing and Floor Plan

4 GENERAL INFORMATION WELCOME TO THE ORS 2017 ANNUAL MEETING Sunday Wednesday, March 19 22, 2017 San Diego Convention Center, San Diego, California Dear Fellow ORS Members, Colleagues, and Guests, On behalf of the Orthopaedic Research Society s Board of Directors, we would like to welcome you to the ORS 2017 Annual Meeting our 63rd Annual Meeting. The ORS Annual Meeting serves as the home to all of us that share a passion for musculoskeletal research. Indeed, many of the groundbreaking innovations that have been introduced in the field of orthopaedics were first presented at the ORS Annual meeting. To date, we have presented over 66,000 scientific abstracts at the Annual Meeting since 1954! As we make tremendous strides toward our 5-year strategic plan ORS2020 the activities of the ORS have expanded much beyond the Annual Meeting, and now include formation of scientific Sections, multiple satellite meetings, and a wealth of inter-society collaborations, professional development activities, publications, and other strategic initiatives. The Annual Meeting continues to serve as our primary venue for presentation of new findings in the field, interacting with our colleagues, and recognizing and celebrating the many successes and scientific breakthroughs by ORS members. We congratulate those of you who will be presenting your work at this meeting, which provides so many opportunities for us to network, to learn, to inspire, and to be inspired. We also thank our many dedicated volunteers and members for giving the ORS an incredibly successful year. Our membership is at its highest, and we are truly in an extraordinary time of progress in our field. The success of the society and of the Annual Meeting would not be possible without your support! We hope that you find many opportunities to learn, to communicate, and to collaborate at this year s meeting. Enjoy your time in San Diego! Farshid Guilak, PhD President, Orthopaedic Research Society Washington University in St. Louis 4

5 SCHEDULE INNOVATION CENTRAL (POSTER AND EXHIBIT HALL) Sails Pavilion, SDCC Innovation Theater, Charging Stations, Seating, Refreshment Breaks and Lunch* Sunday, March 19 Monday, March 20 Tuesday, March 21 Wednesday, March 22 No exhibits or posters 10:00 AM 5:30 PM* 9:00 AM 11:30 AM & 2:00 PM 5:00 PM 10:00 AM 4:00 PM* GENERAL INFORMATION SPEAKER READY ROOM Room 11A, SDCC Sunday, March 19 Monday, March 20 Tuesday, March 21 Wednesday, March 22 7:00 AM 6:00 PM 6:00 AM 6:00 PM 7:00 AM 6:00 PM 6:30 PM 5:00 PM CHECK-IN AND REGISTRATION City-side Corridor, SDCC Sunday, March 19 Monday, March 20 Tuesday, March 21 Wednesday, March 22 7:00 AM 6:00 PM 7:00 AM 6:00 PM 7:00 AM 6:00 PM 7:00 AM 6:00 PM * Complimentary lunch provided in the exhibit hall SUPPORT ORTHOPAEDIC RESEARCH! ORS Silent Auction During the Annual Meeting, we will host an online silent auction with great opportunities to bid on some wonderful items via the mobile app. Silent auction items will be displayed in the ORS booth in Innovation Central (exhibit/poster hall) and will be open for the duration of the meeting. Final bids will close on Wednesday, March 22 at the close of the poster session! If you are the winning bidder you will be notified via the online app. Don t forget to pick up your prize at the conclusion of the auction on Wednesday at the ORS booth. 100% of the funds raised through our auction go toward research grants including the ORS/ OREF Post-Doctoral Fellowship ($50,000), the ORS/OREF Resident Research Grant ($5,000), travel grants, and other meritorious awards for excellence! To make your bid log in to: or text ors2017 to (855) 735-BIDR (2437) to join the auction. 5

6 GENERAL INFORMATION ORS BOARD OF DIRECTORS Farshid Guilak, PhD President Rick Sumner, PhD 1st Vice President Gloria Matthews, DVM, PhD 2nd Vice President Mathias P.G. Bostrom, MD Past President Kristy Weber, MD Secretary Jennifer Westendorf, PhD Treasurer Susanna G. Chubinskaya, PhD Annual Meeting Committee Chair Elizabeth Loboa, PhD Member-at-Large Elise Morgan, PhD Member-at-Large Alessandra Carriero, PhD Member-at-Large Anton Bowden, PhD Communications Council Chair Hubert Kim, PhD, MD Membership Committee Chair Robert L. Sah, MD, ScD Editorial Advisory Board Chair Jeremy Rawlinson, PhD Professional Development & Mentoring Council Chair Ken Kozloff, PhD Strategic Initiatives Committee Chair* *non-voting ORS STAFF Brenda Frederick Amber Blake Mary Jo Heflin Natalie Hinman Jola Lewsza Bailey McMurray Alyson Scolaro Matt Zuleg Executive Director Communications Manager Education Manager Meetings Coordinator Professional Development Program Manager Member Relations Coordinator Administrative Coordinator Education Coordinator ANNUAL MEETING COMMITTEE Susanna G. Chubinskaya, PhD, Chair Susan V. Bukata, MD Natalie H. Kelly Ken Kozloff, PhD Alayna Loiselle, PhD Xin Lucas Lu, PhD Michael Ominsky, PhD Robin M. Queen, PhD Marjolein C.H. van der Meulen, PhD J. Mark Wilkinson, PhD, FRCS PROGRAM COMMITTEE J. Mark Wilkinson, PhD, FRCS, Chair Marjolein C.H. van der Meulen, PhD, Poster Chair Paul Beaule, MD Johnny Huard, PhD Stavros Thomopoulos, PhD Peter van der Kraan, PhD TOPIC CHAIRS TISSUE-BASED TOPICS Biomaterials: Daniel Kelly, PhD Bone: Glen Niebur, PhD and Amarjit Virdi, PhD Cartilage and Synovium: Laurie Goodrich, DVM, PhD and Karen Lyons, PhD Diagnostic Imaging: Xiaojuan Li, PhD Infection: Weiping Ren, MD, PhD Meniscus: Lutz Dürselen, PhD Muscle: Christopher Mendias, PhD, ATC Osteoarthritis and Other Forms of Arthropathy: Karen King, PhD and Stephen B. Trippel, MD Tendon and Ligament: Hani Awad, PhD and Braden Fleming, PhD Trauma and Fractures: Michael Gardner, MD and Zijun Zhang, MD, PhD Tumors: Michelle Ghert, MD ANATOMIC TOPICS Foot and Ankle: Samuel B Adams, MD Hand and Wrist: Roger Cornwall, MD Hip and Knee Arthroplasty: John DesJardins, PhD and Moussa Hamadouche, MD, PhD Knee: Lisa Larkin, PhD Hip: Andrew E. Anderson, PhD Shoulder and Elbow: Brian Feeley, MD Spine: Stephen Ferguson, PhD, Rita Kandel, MD and Fackson Mwale, PhD 6

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9 JOIN US AUGUST 6 9, 2017 SUN VALLEY, IDAHO 47TH INTERNATIONAL Musculoskeletal Biology Workshop in Sun Valley Modern Methodologies and Novel Therapies PROGRAM HIGHLIGHTS Major Methodologies: The Essentials of Finite Element and Analysis for Basic and Clinical Studies Problems in Endocrinology: Rare Bone Diseases Fibrous Dysplasia New Progress in Imaging Musculoskeletal Tissues Using Genetically Engineered Animal Models to Solve Problems in Musculoskeletal Disease: State of the Art and Application Problems in Orthopaedics: Degenerative Disk Disease Career Development Workshop for Young Investigators Awards available to offset travel expenses for young and under-represented minority investigators Next Generation Therapies

10 GRANT WRITING WORKSHOP TOOLS FOR SUCCESS GENERAL INFORMATION APRIL 28 29, 2017 Baltimore, Maryland Chair: Kurt Spindler, MD; Co-Chair: Stavros Thomopoulos, PhD Grant writing is an important and essential skill in order to achieve a successful career in academia and as an investigator. Writing your first grant is often a milestone in your career, and receiving your first grant is an achievement to be celebrated. As part of our commitment to those in the field of musculoskeletal research, the ORS, OREF, and AAOS have partnered for more than 20 years to provide our research community of residents, surgeons, basic scientists, and engineers with the opportunity to learn the necessary skills to reach that milestone and write a successful grant application. Investigators selected to take part in this unique program will: Learn Grant Writing Strategy & Skills, Networking for Collaboration Participate in Interactive Mock Study Section and Specific Aims Lab Meet Face-to-Face with NIH Section Review Officer and Program Director and Receive Real Time Feedback Learn Tips for Writing Successful New and Revised Grant Applications Obtain Essential and Practical Information for Early Career Development To learn more, please visit ORS GUEST NATION CHINA The ORS is pleased to welcome representatives from China, this year s Guest Nation. The Guest Nation Program honors our colleagues in China, recognizes their contributions to the field of musculoskeletal research, and celebrates our collaborations with the Chinese Orthopaedic Research Society (CORS) and the Chinese Orthopaedic Association (COA). The ICORS st International Combined Meeting of the Orthopaedic Research Societies was held September in Xi an, Shanxi Province (PR China). The ICORS conference provided a platform for clinicians, scientists, and industries from around the world to discuss current issues and innovations in the field of orthopaedics and related disciplines. Stop by and visit representatives from the CORS and the COA at their table located in Innovation Central (exhibit/poster hall). DON T FORGET TO DOWNLOAD THE ORS 2017 ANNUAL MEETING MOBILE APP! m.core-apps.com/ors_

11 ORS SECTIONS The purpose of ORS Research Sections is to promote the common interest of ORS members in specified areas of research related to orthopaedics and the musculoskeletal system. Sections offer members opportunities to increase communication and interaction among individuals of similar interest within the framework. They also provide an opportunity for those individuals to participate actively in the ORS. NEW! ORS International Section of Fracture Repair Join the fracture repair community! The ORS International Section of Fracture Repair was formed by the leadership of the International Society for Fracture Repair and ORS. The section will serve as the primary global research community within the larger parent organization ORS as the organization dedicated to the advancement and interchange of the science of fracture repair and its application to the improvement of patient care. It will be the home of experts in the field of fracture repair and will thereby serve an important role within the ORS in areas of scientific program developments, identification of research priorities, and the dissemination of research in the field. Visit the section website, ors.org/ors-isfr, for more information. ORS Meniscus Research Section Join the meniscus research community today! The ORS Meniscus Research Section launched November 2015 by Meniscus RIG organizers and ORS. Currently, the section represents over members from around the world including biologists, clinicians, engineers, orthopaedic surgeons, veterinarians, and more. The section s goal is to support professionals specializing in meniscus research and sciences and to provide a forum for education and research on many initiatives. Visit the ORS Meniscus Section website, for more information. GENERAL INFORMATION QUESTIONS? membership@ors.org or stop by the ORS Member Center in Innovation Central! * Not an ORS member? Interested in joining ORS? Ask us how to join today or visit for more information. 11

12 ORS SECTIONS GENERAL INFORMATION NEW! ORS Orthopaedic Implants Research Section Join the orthopaedic implants research community today! The ORS Orthopaedic Implants Research Section launched August 2016 by the section organizers and ORS. The section currently has over 60 members. The section serves as a unified voice in developing implant related programming. The ORS is the most important research platform to bring together experts from various disciplines to foster the multidisciplinary interaction which is required to improve the quality of the implants, ensure that new implants are adequately tested at the pre-clinical stage, that implants are introduced carefully to the orthopaedic market and that the clinical outcome is appropriately registered. Visit the ORS Orthopaedic Implants Section website, for more information. NEW! ORS Preclinical Models Research Section Join the preclinical models research community today! The ORS Preclinical Models Research Section launched July 2016 by the section organizers and the ORS. Currently the section has over 50 members. The Section is a natural evolution of discussions held over a number of years between veterinarians and non-veterinarians within the ORS, all of whom use preclinical models in their research and who struggle with the issues that this work raises. The section will leverage the expertise of veterinarians within the ORS, including those in both academia and industry, as well as those in specialty training in laboratory animal medicine, surgery, and medicine. Visit the ORS Preclinical Models Section website, for more information. ORS Spine Research Section Join the spine research community today! The section launched at the ORS 2015 Annual Meeting in Las Vegas, Nevada by the Spine RIG organizers and ORS. The Spine Section currently has over 240 members from all around the world in various sub specialties of spine. The Spine Section s mission is to advance spine research and related sciences as to improve patient care through basic, translational, and clinical research. The Spine Section is also committed to providing leadership by representing researchers in the ORS! Visit the ORS Spine Section website, for more information. NEW! ORS Tendon Research Section Join the tendon research community today! The section launched August 2016 formed by the section organizers and the ORS. Currently the section has 40 members. The section will promote and provide an interactive forum for education, collaboration, professional development, and strengthen scientific exchange in the ORS membership and tendon research community. This section will provide an open forum for wide ranging discussions on topics of interest among investigators from a wide diversity of backgrounds in the field, including basic researchers (engineers, biologists), biomaterial scientists and clinicians. Visit the ORS Tendon Section website, for more information. QUESTIONS? membership@ors.org or stop by the ORS Member Center in Innovation Central! * Not an ORS member? Interested in joining ORS? Ask us how to join today or visit for more information. 12

13 FUTURE ORS ANNUAL MEETINGS ORS 2018 Annual Meeting GENERAL INFORMATION Saturday, March 10 Tuesday, March 13, 2018 New Orleans, Louisiana ORS 2019 Annual Meeting Saturday, February 2 Tuesday, February 5, 2019 Austin, Texas 13

14 IMPORTANT DETAILS GENERAL INFORMATION CONTINUING MEDICAL EDUCATION This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians. The American Academy of Orthopaedic Surgeons designates this live activity for a maximum of 35.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Following the meeting a CME claim form will be available on the ORS Annual Meeting website. There is a $50 fee to claim CME from the ORS 2017 Annual Meeting. SAFETY TIPS DO: Travel with only the credit card and ID cards you will use. Check that the lock works and that the door closes securely in your hotel room. Put the chain or deadbolt on the door after entering the room. Walk with another person. Single targets are the most likely victims of crime. DON T: Wear your badges or carry conference bags outside. Walk in dark, isolated areas, such as closed plazas. NOTE TO PARENTS: Children 16 years of age and under are not permitted to enter the exhibit and poster hall area or the session rooms at any time. No supervision is offered. MEETING OBJECTIVES To present the best available research from all disciplines of musculoskeletal research. To promote the exchange of ideas and encourage collaborations in orthopaedic research. To encourage promising and emerging areas in musculoskeletal research including basic science education, and research strategies by use of forums, workshops, special sessions and special interest meetings. FDA All drugs and medical devices used in the United States are administered in accordance with Food and Drug Administration (FDA) regulations. These regulations vary depending on the risks associated with the drug or medical device, the similarity of the drug or medical device to products already on the market, and the quality and scope of clinical data available. Some drugs or medical devices demonstrated at this 2017 Annual Meeting of the Orthopaedic Research Society may have not been cleared by the FDA or have been cleared by the FDA for specific purposes only. The FDA stated that it is the responsibility of the physician to determine the FDA clearance status of each drug or medical device he or she wishes to use in clinical practice. Orthopaedic Research Society policy provides that off label uses of a drug or medical device may be described in the Orthopaedic Research Society s CME activities so long as the off label use of the drug or medical device is also specifically disclosed (i.e., it must be disclosed that the FDA has not cleared the drug or device for the described purpose). Any drug or medical device is being used off label if the described use is not set forth on the product s approved label. DISCLAIMER The materials presented at the 2017 Annual Meeting of the Orthopaedic Research Society have been made available by the Orthopaedic Research Society for educational purposes only. The material is not intended to represent the only, nor necessarily best, method or procedure appropriate for the medical situations discussed, but rather is intended to present an approach, view, statement or opinion of the faculty, which may be helpful to others who face similar situations. The Orthopaedic Research Society disclaims any and all liability for injury or other damages resulting to any individual attending the meeting and for all claims, which may arise out of the use of the techniques demonstrated therein by such individuals, whether these claims shall be asserted by physician or any other person. No reproduction of any kind, including audiotapes and videotape, may be used in any portion of the ORS Annual Meeting. The ORS reserves all of its rights to such material, and commercial reproduction is specifically prohibited. IMAGE CONSENT POLICY By attending the ORS 2017 Annual Meeting you give your consent, unless you notify us otherwise, to use your image captured during the conference through video, photographs, or digital imagery, to be used by the ORS in promotional materials, publications, and web site and waive any and all rights to these images. FILMING/RECORDING POLICY The photography or recording of any kind (cell phone, camera, video recorder, etc.) of a scientific presentation, educational program, workshop, posters, or meetings of the ORS is strictly forbidden without prior approval in writing by the ORS. This policy will be strictly enforced. 14

15 COMMITTEE MEMBERS Advocacy Committee Chelsea Bahney, PhD, Chair Jarrett Cain, DPM, MSc, FACFAS Joyce Keyak, PhD Megan Killian, PhD Yi-Xian Qin, PhD Irving Shapiro, PhD ORS Ambassadors Rebecca Chung, ME, Northeast Yutaka Inaba, MD, PhD, Japan Thomas Kean, PhD, West South Central/Texas Megan Killian, PhD, Mid-Atlantic/ Pennsylvania Catherine Kuo, PhD, Northeast Muhammad Farooq Rai, PhD, Midwest Roshni Rainbow, PhD, Toronto, Canada Dmitriy Sheyn, PhD, Pacific/California Annual Meeting Committee Susanna G. Chubinskaya, PhD, Chair Susan V. Bukata, MD Natalie H. Kelly Ken Kozloff, PhD Alayna Loiselle, PhD Xin Lucas Lu, PhD Michael S. Ominsky, PhD Robin M. Queen, PhD Marjolein C.H. van der Meulen, PhD J. Mark Wilkinson, PhD, FRCS Associate Member Forum Alessandra Carriero, PhD, Chair Lauren Barber, BA Alexander Christ, MD Josa Hanzlik, MS Natalie H. Kelly Karl Lewis, PhD Nikolaos Paschos, PhD Jennifer Racine Chavaunne Thorpe, PhD Rebacca Wachs, PhD Awards & Recognition Committee Alayna Loiselle, PhD, Chair Don Anderson, PhD Hannah J. Lundberg, PhD, (Ex-officio) Marjolein C.H. van der Meulen, PhD Rebecca Wachs, PhD Liyun Wang, PhD Basic Science Education Committee Martin Stoddart, PhD, Chair Alexis Dang, MD Louis Gerstenfeld, PhD Muhammad Farooq Rai, PhD Gulshan Sharma, PhD Amarjit Virdi, PhD Dimitrios Zeugolis, PhD Ex-Officio members: Warren O. Haggard, PhD Robin M. Queen, PhD Vicki Rosen, PhD Frederick Werner, MME Clinical Research Committee Kurt P. Spindler, MD, Chair Roy K. Aaron, MD Joel J. Gagnier ND, MSc, PhD Michelle Ghert, MD, FRCSC Mandi Lopez, DVM, MS, PhD George F. Muschler, MD Jennifer Racine Jessica Rivera, MD David Wasserstein, MD, MSc, MPH(c) FRCSC Michael J. Yaszemski, MD, PhD Chunfeng Zhao, MD Publications Advisory Board Robert L. Sah, MD, ScD, Chair Qian Chen, PhD James Iatridis, PhD Kenneth Mann, PhD Martha Murray, MD Doug Robertson, MD, PhD Edward Schwarz, PhD Linda Sandell, PhD, Editor-in-Chief (non-voting) Mia Ricci, Publisher (Ex-officio) Finance Committee Jennifer Westendorf, PhD, Chair Mathias P.G. Bostrom, MD, Past President Farshid Guilak, PhD, President Elise Morgan, PhD, 1st year Member-at-Large Kristy Weber, MD, Secretary Ex-Officio members: Rick Sumner, PhD, 1st VP Susanna G. Chubinskaya, PhD, ORS Annual Meeting Chair Industry Engagement Committee Michael S. Ominsky, PhD, Chair Alexander Christ, MD Judd Day, PhD Sally LiArno, PhD Michael Lehmicke, MS Chris Roche, MS, MBA International Committee John Antoniou, MD, Co-Chair Theodore Miclau, MD, Co-Chair Mauro Alini, PhD Mats Brittberg, MD, PhD Zigang Ge, PhD Edward Guo, PhD David Little, MBBS, FRACS, PhD Niamh Nowlan, PhD Michiaki Takagi, MD, PhD Nico Verdonschot, PhD Media Relations & Communications Committee Vaida Glatt, PhD, Chair Erin Hsu, PhD Serkan Inceoglu, PhD Nikolaos Paschos Kartik Varadarajan, PhD Vincent Wang, PhD Membership Committee Hubert Kim, MD, PhD, Chair Lauren Barber Larry Bonassar, PhD Chris Hernandez, PhD Audrey McAlinden, PhD Chavaunne Thorpe, PhD Strategic Initiatives Committee Ken Kozloff, PhD, Chair Jaimo Ahn, MD George Dodge, PhD Kurt Hankenson, DVM, PhD Elizabeth Loboa, PhD Deepak Vashishth, PhD New Investigator Mentoring Committee X. Lucas Lu, PhD, Chair Tamara Alliston, PhD, Grant Writing Course Co-Chair Roger Cornwall, MD Hicham Drissi, PhD Karl Lewis, PhD Devina Purmessur, PhD Mitch Schaffler, PhD, Grant Writing Course Co-Chair Kurt Spindler, MD, Grant Writing Workshop Co-Chair Starvros Thomopoulos, PhD Grant Writing Workshop Co-Chair Karen Troy, PhD Chunfeng Zhao, MD Nominating Committee Mathias P.G. Bostrom, MD Magali Cucchiarini, PhD Richard Debski, PhD Henning Madry, MD Cecilia Pascual-Garrido, MD Edward Schwarz, PhD Johanna Temenoff, PhD Andre van Wijnen, PhD Joseph Wallace, PhD Program Committee J. Mark Wilkinson, PhD, FRCS, Chair Marjolein C.H. van der Meulen, PhD, Poster Chair Paul Beaule, MD Johnny Huard, PhD Stavros Thomopoulos, PhD Peter van der Kraan, PhD Women s Leadership Forum Susan V. Bukata, MD, Co-Chair Robin M. Queen, PhD, Co- Chair Magali Cucchiarini, PhD Mary Goldring, PhD, Senior Member Josa Hanzlik, MS Deana Mercer, MD Nancy Pleshko PhD Sophie Verrier, PhD Jennifer Woodell-May, PhD GENERAL INFORMATION 15

16 THANK YOU TO THE ADJUNCT REVIEWERS GENERAL INFORMATION Joseph Abboud, MD Eduardo Abreu, MD Yousef Abu-Amer, PhD Cheryl Ackert-Bicknell, PhD Douglas J. Adams, PhD Samuel B. Adams, MD Naga Suresh Adapala, PhD Adetola Adesida, PhD Animesh Agarwal, MD Jaimo Ahn, MD, PhD Toshihiro Akisue, MD Mazen Al-Hajjar, PhD Mauro Alini, PhD Catherine Ambrose, PhD Andrew E. Anderson, PhD Donald D. Anderson, PhD Siddhesh R. Angle, PhD Valentin Antoci, MD, PhD Mohammad Arabmotlagh, MD Jacobus J. Arts, PhD Michel Assad, PhD Janie Astephen Wilson, PhD Kivanc Atesok, MD Peter Augat, PhD Hani Awad, PhD Umur Aydogan, MD Won Bae, PhD Todd Baldini, MSc Jennifer Bara, PhD George Barnes, PhD Thomas W. Bauer, MD, PhD Josh Baxter, PhD Mary Bayers-Thering, MS, MBA Paul Beaule, MD Rebecca Bell, PhD Scott Berkenblit, MD, PhD Nicky Bertollo, PhD Michael Bey, PhD Bahar Bilgen, PhD Fabrizio Billi, PhD Jeff Bischoff, PhD Joel Boerckel, PhD Lawrence Bonassar, PhD Anton E. Bowden, PhD Elizabeth A. Bradley, MD Gavin Braithwaite, PhD Todd Bredbenner, PhD Claire Brockett, PhD Thomas Buchanan, PhD Conor Buckley, PhD William Bugbee, MD J. Chloe Bulinski, PhD Sjoerd Bulstra, MD David Burr, PhD Michael Bushelow, MS Donita Bylski-Austrow, PhD Jarrett Cain, DPM, MSc, FACFAS Cathy Carlson, DVM, PhD Alessandra Carriero, PhD Sarah Cartmell, PhD Jeffrey Cartmell, PhD Nadeen Chahine, PhD Pen-Hsiu (Grace) Chao, PhD Christopher Chen, PhD Qian Chen, PhD Yupeng Chen, PhD Wing Hoi Cheung, PhD Kazuhiro Chiba, MD Andy Chien, PhD Blaine A. Christiansen, PhD Rhima Coleman, PhD Timothy E. Cooney, MS Roger Cornwall, MD David Corr, PhD J.J. Trey Crisco, PhD Michael Cross, MD Magali Cucchiarini, PhD Quanjun Cui, MD Yifei Dai, PhD Timothy Damron, MD Marina D Angelo, PhD Michael Hast, PhD Richard L. Debski, PhD Dominik R. Haudenschild, PhD Jeroen DeGroot, PhD Tammy Haut Donahue, PhD Mohammad Mehdi Dehghan, Scott Hazelwood, PhD DVM, PhD Corinne Henak, PhD James E. Dennis, PhD Heath Henninger, PhD Agnes d Entremont, PhD Noreen Hickok, PhD C. Alex DePaula, PhD Howard J. Hillstrom, PhD John DesJardins, PhD David A. Hoey, PhD Mehul Dharia, MSME Jason Horton, PhD Andy Domenighetti, PhD Ali Hosseini, PhD Yufeng Dong, PhD Judith Hoyland, PhD Andrew Dooris, PhD Adam Hsieh, PhD Matt Dressler, PhD Erin Hsu, PhD Lutz Dürselen, PhD Alice Huang, PhD Jonathan Dyke, PhD Charles Huang, PhD Edward Ebramzadeh, PhD Johnny Huard, PhD Brent Edwards, PhD Shawn Hunter, PhD John Elias, PhD James C. Iatridis, PhD Arin Ellingson, PhD Anita Ignatius, DVM Martin Englund, MD, PhD Svenja Illien-Junger, PhD Hiroyuki Enomoto, MD, PhD Gun-Il Im, MD Motomi Enomoto-Iwamoto, DDS, PhD Carl W. Imhauser, PhD Isaac E. Erickson, PhD Serkan Inceoglu, PhD Alejandro A. Espinoza Orias, PhD Andreia Ionescu, PhD Bradley Estes, PhD Hiromu Ito, MD, PhD Paul J. Fanning, PhD Hiroshi Ito, MD Sara Farquhar Voorhees, PT, PhD Norimasa Iwasaki, MD, PhD Brian Feeley, MD Alicia R. Jackson, PhD Stephen Ferguson, PhD David Jamison, PhD Russell J. Fernandes, PhD Dennis Janssen, PhD Elisabeth Ferreira, PhD Jessica Jennings, PhD Krzysztof Ficek, PhD James Johnston, PhD Aaron Fields, PhD Jennifer Jonason, PhD David Findlay, PhD Lynne Jones, PhD Matthew Fisher, PhD Bong-Jae Jun, PhD Clare Fitzpatrick, PhD Natalia Juncosa-Melvin, PhD Braden Fleming, PhD Melissa Kacena, PhD Casper Foldager, MD, PhD Takashi Kaito, MD, PhD Kharma Foucher, MD, PhD Niraj Kalore, MD Douglas Fredericks, BS Robin Kamal, MD Darin Friess, MD Helen Kambic, PhD Simon Frostick, MD Satoshi Kamijo, MD Stefan Gabriel, PhD Rita Kandel, MD Joel Gagnier, ND, MSc, PhD Mehran Kasra, PhD Laura Gamer, PhD Makoto Kawasaki, MD, PhD Xueqin Gao, MD, PhD Daniel Kelly, PhD Bo Gao, PhD Oran Kennedy, PhD Michael Gardner, MD Oliver Kessler, MD William Garrett, MD, PhD Kristine Kieswetter, PhD Alison Gartland, PhD Megan Killian, PhD Zulma Gazit, PhD Do-Gyoon Kim, PhD Albert Gee, MD Hyun-Min Kim, MD Damian Genetos, PhD Karen King, PhD Jessica Geotz, PhD Thorsten Kirsch, PhD Michelle, Ghert, MD Melissa Kluczynski, MS Vaida Glatt, PhD Matthew Koff, PhD Mary Goldring, PhD David Komatsu, PhD Said T. Gomaa, PhD Andreas Kontaxis, PhD Enrique Gomez-Barrena, MD Sebastian Kopf, MD, PhD Laurie Goodrich, DVM, PhD Kenneth M. Kozloff, PhD Sibylle Grad, PhD Laurel Kuxhaus, PhD Alexander Greene, BS Young-Min Kwon, MD, PhD Helen Gruber, PhD Masayuki Kyomoto, PhD Weiyong Gu, PhD Benjamin Lakin, PhD Zbigniew Gugala, MD, PhD Mario Lamontagne, PhD X Edward Guo, PhD Joseph Lane, MD Ashim Gupta, PhD Lisa Larkin, PhD Sean Haddock, MS Daniel Latt, MD, PhD Warren Haggard, PhD Thomas Laumonier, PhD Lisbet A. Haglund, PhD Michel Laurent, PhD Moussa Hamadouche, MD, PhD Christine Le Maitre, PhD David Hamilton, PhD William R. Ledoux, PhD Matthew Hamilton, PhD Chang Lee, PhD Hyuk-Soo Han, MD, PhD Francis Lee, MD, PhD Hirotaka Haro, MD, PhD Oscar Lee, MD, PhD Michael Harris, PhD Reginald Lee, MS Joshua D. Harris, MD Wayne Lee, PhD David Hart, PhD Michael Lehmicke, MS Edward Harvey, MD Clifford Les, DVM, PhD Philipp Leucht, MD Megan Oest, PhD Victor Y. Leung, PhD Rema Oliver, PhD Marc Levenston, PhD Ebru Oral, PhD Cara Lewis, PT, PhD Patrick Orth, MD Bingyun Li, PhD Donna Pacicca, MD Guoan Li, PhD Jukka Pajarinen, MD, PhD Jiliang Li, MD, PhD Saba Pasha, PhD Wan-Ju Li, PhD Shantanu Patil, MD Xiaojuan Li, PhD Girish Pattappa, PhD Xinning Li, MD Ming Pei, MD Zhen Li, PhD Anthony Petrella, PhD Sally LiArno, PhD Ferris M. Pfeiffer, PhD Jiann-Jong Liau, PhD Robert Pilliar, PhD Chia-Ying Lin, PhD Dominique Pioletti, PhD Fang (Amanda) Lin, DSc, MMed, BEng Anna Plaas, PhD Jian-Hao Lin, MD Nancy Pleshko, PhD Alan Litsky, MD, ScD Robert A. Poggie, PhD Dianne Little, DVM, PhD Ryan Porter, PhD Chuanju Liu, PhD Hollis Potter, MD X. Sherry Liu, PhD Christopher Price, PhD Xiangyi (Cheryl) Liu, PhD Ling Qin, PhD Xuhui (Philip) Liu, PhD Yi-Xian Qin, PhD Alayna Loiselle, PhD Qing-Qing Qiu, PhD Gabriela Loots, PhD Michael J. Rainbow, PhD Mandi J. Lopez, DVM, PhD Chamith S. Rajapakse, PhD Timothy Lowe, MS Jeremy Rawlinson, PhD Hongbin Lu, PhD Gwendolen Reilly, DPhil Hannah J. Lundberg, PhD Weiping Ren, PhD Zong-Ping Luo, PhD Katherine Reuther, PhD Karen Lyons, PhD Stephen Richardson, PhD Henning Madry, MD Ryan Riddle, PhD Tristan Maerz, PhD Claude Rieker, PhD Suzanne A. Maher, PhD Makarand Risbud, PhD Anne-Marie Malfait, MD, PhD Duane Robinson, DVM, PhD Sachin Mamidwar, MBBS, MS Christopher P. Roche, MS, MBA Takeo Mammoto, MD, PhD Bernd Rolauffs, MD Kenneth Mann, PhD Marie E. Roy, PhD Bryan S. Margulies, PhD Paul J. Rullkoetter, PhD Mathew T. Mathew, PhD James T. Ryaby, PhD Tomoyuki Matsumoto, MD, PhD Jonathan Rylander, PhD Robert Mauck, PhD Simo Saarakkala, PhD Meghan McGee-Lawrence, PhD Vani Sabesan, MD Terence McIff, PhD Robert L. Sah, MD, ScD Todd McKinley, MD Hideyuki Sakoda, PhD Amy McNulty, PhD Hee-Jeong Im Sampen, PhD John Medley, PhD Erik Sampson, PhD Christopher Mendias, PhD, ATC Sophia Sangiorgio, PhD Arthur Michalek, PhD Hirotaka Sano, MD Michael J. Mienaltowski, PhD Masato Sato, MD, PhD Anna Miller, MD Tannin Schmidt, PhD Shuichi Mizuno, PhD Maria Serrat, PhD Meghan M. Moran, PhD Sameer B. Shah, PhD Elise Morgan, PhD Arun Shanbhag, PhD, MBA Michael M. Morlock, PhD Blanka Sharma, PhD Mark Morrison, PhD Gulshan B. Sharma, PhD Isaac Moss, MD Jason Shearn, PhD Foteini Mourkioti, PhD Julia C. Shelton, PhD Franklin Moutos, PhD Jie Shen, PhD Annegret Muendermann, PhD Hua Shen, PhD Muturi Muriuki, PhD Shuiliang Shi, PhD Ciara Murphy, PhD Stefanie Shiels, PhD Fackson Mwale, PhD Tolou Shokuhfar, PhD Yusuke Nakagawa, MD Matthew Silva, PhD Naoki Nakayama, PhD Anita Singh, PhD Aniruddh Nayak, MS Robert A. Siston, PhD Ara Nazarian, PhD Lachlan Smith, PhD Fred Nelson, MD Margaret Smith, PhD Valentina Ngai, PhD, PEng Andrew Speirs, PhD Shane J. Nho, MD Amber Stern, PhD Jennifer Nichols, PhD Matthew Stewart, DVM, PhD Glen Niebur, PhD Martin Stoddart, PhD Athanasia Nikolaou, PhD Aaron Stoker, PhD James T. Ninomiya, MD Hongli Sun, PhD Kohei Nishitani, MD, PhD Sharath Sundararaj, PhD Philip C. Noble, PhD Viswanathan Swaminathan, PhD David Nuckley, PhD Michiaki Takagi, MD, PhD Syam Nukavarapu, PhD Mitsuhiko Takahashi, MD, PhD Jeffry Nyman, PhD Tsuneari Takahashi, MD, PhD Grace O Connell, PhD Yuya Takakubo, MD, PhD J. Patrick O Connor, PhD Yasunobu Tamaki, MD, PhD Tingting Tang, PhD Simon Tang, PhD Kenneth Taylor, MD Matthew Teeter, PhD Stavros Thomopoulos, PhD Harukazu Tohyama, MD Steven Tommasini, PhD Jeffrey Toth, PhD Francesco Travascio, PhD Stephen Trippel, MD Karen L. Troy, PhD Tsung-Yuan Tsai, PhD Riichiro Tsukamoto, MD Wakenda Tyler, MD, MPH Keita Uetsuki, PhD Douglas Van Citters, PhD Peter van der Kraan, PhD Marjolein CH van der Meulen, PhD Andre Van Wijnen, PhD Kartik M. Varadarajan, PhD Deepak Vashishth, PhD Andrea Vernengo, PhD Sophie Verrier, PhD Amarjit Virdi, PhD Nam Vo, PhD J. Turner Vosseller, MD Edward Vresilovic, MD, PhD Stephen Waldman, PhD Erik Waldorff, PhD Joseph Wallace, PhD Qun (Leo) Wan, PhD Hali Wang, PhD Jaw-Lin Wang, PhD Jennifer Wayne, PhD Julien Wegrzyn, MD, PhD Lei Wei, PhD Jeffrey Weiss, PhD Frederick W. Werner, MME Britt Wildemann, PhD J. Mark Wilkinson, PhD, FRCS Thomas Willett, PhD John L. Williams, PhD Sophie Williams, PhD Bettina Willie, PhD Ryan Willing, PhD Edward Wojtys, MD Jennifer Woodell-May, PhD Yang Xia, PhD Chao Xie, MD Ei Yamamoto, PhD Raghunatha Yammani, PhD Shang-You Yang, PhD Wei Yao, MD Hai Yao, PhD Tomohiro Yasuda, MD, PhD Albert Yee, MD Clare Yellowley, PhD Yener N. Yeni, PhD Kelvin Yeung, PhD Gokce Yildirim, MS Hiroki Yokota, PhD Toshitaka Yoshii, MD, PhD Yuichi Yoshii, MD Aliaa Youssef, PhD Hongchuan Yu, PhD Kiminori Yukata, PhD Tunku Zaman, MD, PhD Stephan Zeiter, DVM, PhD Ronald Zernicke, PhD, DSc Dimitrios Zeugolis, PhD Nianli Zhang, PhD Zijun Zhang, MD Chunfeng Zhao, MD Zhong Zheng, PhD Yilu Zhou, MS Michael Zuscik, PhD 16

17 WELCOME TO ICORS MEMBER SOCIETIES/ORGANIZATIONS! GENERAL INFORMATION The International Combined Orthopaedic Research Societies (ICORS) serves as a forum, which gathers together a global community of musculoskeletal researchers; basic, translational, and clinical. Australia/New Zealand Orthopaedic Research Society British Orthopaedic Research Society Canadian Orthopaedic Research Society Chinese Orthopaedic Research Society European Orthopaedic Research Society Japanese Orthopaedic Association Korean Orthopaedic Research Society Orthopaedic Research Society Taiwanese Orthopaedic Research Society Scientific Associate Members: AO Foundation International Chinese Musculoskeletal Research Society Candidate Members: Asia Pacific Orthopaedic Research Society Turkish Orthopedic Research Council A special congratulations to the Chinese Orthopaedic Research Society on the success of the 2016 International Combined Meeting of the Orthopaedic Research Societies held September 2016 in Xi an, China! Future ICORS Meeting: ICORS 2019, June 19 22, 2019 in the beautiful city of Montreal, Quebec, Canada, hosted by the Canadian Orthopaedic Association and the Canadian Orthopaedic Research Society 17

18 ORS WELCOMES OUR NEW MEMBERS GENERAL INFORMATION Matthew Adams Shoshi Akiyama Ryan Akman Zoe Album Jose Alcerro, MD Patrick Allison, PhD Omar Al-Mohrej Oscar Alvarez, PhD Britta Anderson, PhD Jennifer Anderson Dennis Anderson, PhD Takashi Ando Parham Aram, PhD Marzieh Ardestani Amit Aurora Darryl Auston, MD, PhD Ravi Balasubramanian, PhD Kian Banks Lauren Barber Lena Bartell Adam Bartsch, PhD Nathaniel Bates, PhD Michael-John Beltejar Nicholas Bernthal Katherine Best Samrath Bhimani Alexander Bina Marianne Black Carina Blaker Hans Boesebeck, PhD Melanie Boeyer, MS Nicholas Bolz Edward Bonnevie, PhD Ryan Borem John Boyle Bryan Brockman Shannon Brown Athena Brunt Stephanie Bryant Evan Buettmann Arina Buizer Eileen Cadel, MS Bradley Campbell Emily Camilleri, PhD Valentina Campanelli, PhD Bradley C. Campbell Samuel Carlson Chad Carroll, PhD Katherine Carruthers, MD Ryan Castile Carlos Castro Anthony Catanzano, MD Danilo Catelli Raymond Catton Jiun Chiu Chang Danny Chang Ryan Chapman, MS Abhijit Chaudhari, PhD Bing Chen Chiu-Fang Chen Haizi Cheng Tegan Cheng, PhD Chantal Chenu, PhD Lillia Cherkasskiy, PhD Ka-Yee Cheuk Andy Chien Hanna Cho Jang-Hwan Choi Philip Chuang Danielle Chun Eric Cohen, MD Aimee Colbath, VMD, MS, DACVS 18 Stephanie Cone Guang-Ting Cong Brianne Connizzo, PhD Stephen Cook, PhD Ralph Cook Benjamin Cooper Eithne Comerford Michele Corrigan Thomas Coughlin, PhD Jared Crasto, MD Shari Cui, MD Amber Cussen Debbie Dang Elvis Danso Elizabeth Delve Lee Deokcheol Alix Deymier, PhD Anna Di Laura, MS Tamim Diab Matthew Dietz Yuanjing Ding, MD Benjamin Dourthe Rebecca Drake Erxia Du, PhD Chelsey Dunham Devendra Dusane, PhD Felix Dyrna A. Anas Easa, MD Jennifer Edwards Mark Ehrensberger Claire Eliasberg Alarbi Emmakah Masataka Enomoto, DVM Brandon Erickson, MD Aidin Eslam Pour Shongshan Fan Bailey Fearing Elizabeth Feeney Meng Feng, PhD Hazel Fermor, PhD Tera Filion-Potts, PhD Nicole Fischer, MS Mary Foltz Jacob Forstat Mark Forwood, PhD Brent Foster Samuel Franklin, DVM, PhD Daniela Frauchiger Masataka Fujii, MD, PhD Takeshi Fujii Taku M. Fujita Katsunori Fukutake, MD, PhD Grahmm Funk Dana Gaddy, PhD Jiri Gallo Jenna Galloway, PhD Sarah Galvis Laura Gamer, PhD Lee Gammon Anup Gandhi, PhD Chunzheng Gao Arlene Garcia Oliver Gardner, PhD Christina Garman Michael Gaspar, MD Joseph Geissler Ivor Geoghegan Mohammad Sadegh Ghiasi Michael Gibbons Devin Gibson Juliane Glaeser, PhD Matthew J. Gluck Charles Godbout Jörg Goldhahn, PhD Stephen Goldman Riccardo Gottardi, PhD Fiorella Grandi Benjamin Gray Alexander Greene Ryan Greene, DO, MS Dawn Groves, PhD Thomas Michael Grupp, PhD Carl Gustafson Gabriel Haller, PhD Hiroki Hamano Natalia Harasymowicz Michael Harris, PhD Della Harrison, DAOM Henning Haschke Bryan Heard Lauren Heckelman Asadullah Helal Ryan Helber Su-Jin Heo Chelsea Heveran Kevin Ki-wai Ho Tom Hodgkinson Lindsay Holdcroft Judith Hollander Justin Hollenbeck Sophie Hollenberg Henry Huang Victor Huayamave, PhD David Hudson, PhD Julianne Huegel Jessica L. Hughes, MD Carrie Hui Mingalone Donald Hume Ben Hung, PhD Ruby Huynh Sharon Hyzy Tsuyoshi Ichinose Enaam Idrees Matthew Igbinigie Tsuyoshi Iida Laurianne Imbert Rebecca Irwin Hidenobu Ishibashi Masahiro Ishikawa Sravisht Iyer, MD Morgan T. Izkowski Ehsan Jabbarzadeh Timothy Jacobsen Amirhossein Jahandar Aaron James Eemeli Jämsen Tina Jeon, PhD Youngjae Jeong Vivek Jeyakumar Marit Johnson, MSPT, COMT Spine Clifford Jones, MD, FACS Hugh Jones Paul Jutte Assaf Kadar, MD Aysha N. Khan, MD Erica Kahn Jarred Kaiser Robin Kamal, MD Satoshi Kamijo Tomonoshin Kanazawa, MD, PhD Courtney Karner Jonathan Karnes Mehran Kasra, PhD Karina Katchko Kenji Kato Toshiyuki Kawai Christopher Kegelman Robert Kent Ashutosh Khandha Saeed Khayatzadeh Mehdi Khoshgoftar Yoichi Kitano Christopher Kleck, MD Kelsey Kleinhans Noelle Klocke, MS Yong-Gon Koh Nischal Koirala Yogesh Kolwadkar, MD Tadashi Komatsubara Matthew Kossol Alexander Kot Olga Krupkova, MSc Aaron Krych, MD Yohei Kumabe Gentaro Kumagai Nikhil Kurapati Edward Kwee Louis Kwong, MD Vinicius Ladeira Craveiro Benjamin Lakin, PhD Katherine Lakstins Gernot Lang, MD Jeffrey Lange Tanner Langston David Largaespada, PhD Annalise Larson Kelly Lauter Roszko, MD, PhD Kent Leach, PhD Devin Leahy, PhD Aron Lechtig Wayne Lee Katie Lee Kwang Il Lee Ming-Song Lee Nick Leegwater Elizabeth Leimer Garrett Leonard, MD Kathleen Lewicki Jing-Sheng Li Haixiang Liang, MD Andrea Liebowitz Stephen Linderman, MS Xiangyi (Cheryl) Lindsay Loundagin Richard Lovering Laura Y. Lu Viviane Luangphakdy Paula Ludewig Mengxi Lv Xiaoyuan Ma Lauren MacCormick, MD Robert Maciel Tristan Maerz, PhD Vasu Mahalingam Melvin Makhni Anna-Lena Makowski Valerie Malfroy Camine Neil Malhotra, MD Jon Mandell Alan Marionneaux Audrey Martin Roxana Martinez Campuzano Maleeha Mashiatulla Elysia Masters Takashi Matsumura Takashi Matsushita Tokio Matsuzaki Andrea Matuska Rahel May Ciaran Mc Donald, MSc Matthew Meaghe Chad Mears Sean Meehan Irene Mencía Castaño Melodie Metzger, PhD Ingrid Meulenbelt Jill Middendorf Rebecca J. Mills Geetha Mohan Hossein Mokhtarzadeh Stephanie N. Moore-Lotridge Stacyann Morgan Yugo Morita Grace Mosley Aliyeh Mousavi Joseph Mummert Mark Murphy, MD, PhD Cameron Murphy Conor Murphy, MD Casey Myers Akira Nabeshima Kanto Nagai Narihito Nagoshi Masaya Nakamura, MD, PhD Takuya Nakanishi Daisuke Nakashima Puay Yong Neo Michael Newton Thu Nguyen Anne Nichols Reza Nickmanesh Wanting Niu Katja Nuss, VMD Christopher O Conor Tetsuro Ohba Takashi Ohsawa, MD, PhD Toshiki Okubo Yaichiro Okuzu Jeffrey J. Olson Patrick O. Omoumi Takao Omura Keat Ong Renee Ormsby Hongwei Ouyang Deepanwita Pal, PhD Ji Hun Park Jong Woo Park Sucharitha Parthasarathy Jay Patel Savan Patel Sonja Pavlesen, MD Monica Pechanec Valentina Pedoia Hunter Pelham George Pellegrino Giorgio Perino, MD Vijay Permeswaran Mitchell Peterson Charlotte Phillips, PhD Colton Phippen Heidi-Lynn Ploeg Beth Pollot Christopher Proctor, MD Kari Puma, MS David Putzer Marinko Rade, PhD Anastasia Rakow Aimee Raleigh Raul Ramos Swithin Razu Jacob Reeves Ines Reichert, MD, PhD, FRCS Nicolas Reina Yinshi Ren Alan Reynolds Stephen Richardson Ryan Riddle Bently Robinson Alexander Robling, PhD Kevin Rocco Francisco Rodriguez Fontan, MD David Rojas, MD Samuel Rosas, MD Derrick Ross Julie Rosser, DVM, DACVS, DESCVS Joshua Roth Dmitry Royhman Marissa Ruehle Maria Runa, MSc Ryan Russell Bryan Rynearson, MD Pradeep Kumar Sacitharan Fayez, Safadi, PhD Yoshinobu Saitoh Sameh Saleh Cris Salinas, MD Jason Samona Uma Sankar, PhD Michael Schallmo Lennart Scheys Nathan Schilaty, DC, PhD Andrew Schneider, MD Prism Schneider, MD, PhD Jordy Schol Peter Sculco, MD Dylan Shearer Shoji Seki Arvinth Sethuraman Johnathan Sevick Shivam Shah Mohsen Sharifi Renani Blanka Sharma, PhD Lizzy Shaw Vickie Shim Jie Shen Yue Shen Claire G. Shortt Lara Silverman Irene Simfia Hadley Sis Jordan Skelly, ME Mike Slomczykowski Marie Smith Justin Smith, MD Corey Smith Andrew Smith Lucas Smolders, DVM, PhD Darryl Sneag, MD Yongnam Song Yu Song Takashi Sono Jeffrey Spang, MD Grazyna Sroga, PhD James St. Clair, MD, PhD R. Grant Steen David Steinberg, MD Andre Steinert, MD Michael Stokes Sharath Sundararaj, PhD Leigh Sundem Gaurav Swarnkar, PhD Suzanne Tabbaa, PhD Kenji Takahashi, MD Takumi Takahashi Tsuneari Takahashi Yu Tan Yu Tanabe Ke Tao Victor Taylor II, PhD Kevin Tetsworth, MD, FRACS Bo Tian, PhD Michelle Titunick Andrew Tomaschke Olivia Torre Meng Sam Tran Estevan Trujillo Jeremy Truntzer Wei-Ju Tseng John Tuttle, MD Sardar Uddin Mustafa Unal Vidyadhar Upasani, MD Samuel Van de Velde, MD, MPH Martijn Van Griensven, MD, PhD Thomas Vanasse Bhavya B. Vendra Stefaan Verbruggen, PhD Andrea Vernengo, PhD Christopher Vertullo, MBB, FRACS, FAOrthA Brian Walczak, DO David Walker Kyle Walker Ke Wang Yuchen Wang Xiao Wang Lijun Wang Jesse Wang Sebastian Wangler Laura Watkins Matthew Webb, MD Thomas J. Webster, PhD Kenneth Weekes Joseph Weiner Eric Wherley Daniel Whitney Kaitie Whitney Robert Whittaker Hans-Joachim Wilke Rolanda Willacy Brittany Wilson Travis Wilson Joseph Withrow Jason Wong Shane Woods Jingheng Wu Yongren Wu, PhD Alex Wu Yuanqiao Wu Grace Xiong Xiao Xu Junichi Yamada Kazuki Yamada, MD Akira Yamakawa Go Yamako Yohei Yanagisawa Maria Yanez Xi Yin Aki Yoshida Catherine Yuh Suraya Zainul Abidin Gustavo Zanotto Beata Krystyna Zatorska Ben Zhang Jiajun Zhang, PhD Songning Zhang, PhD Yaxia Zhang, MD, PhD Yunpeng Zhao Mingxin Zheng Shouan Zhu Sophia Ziemian Jared Zitnay Lee Zuckerman, MD

19 SATURDAY MEETING HIGHLIGHTS 8:00 AM 5:00 PM ORS Basic Science Course Offered as part of AAOS Specialty Day Room 2 8:00 AM 5:00 PM ORS/OREF Grant Writing Course Hilton Bayfront Aqua Salon EF SATURDAY 19

20 SATURDAY MEETING DETAILS SATURDAY 8:00 AM 5:00 PM ORS Basic Science Course Room 2 Organizers: Marjolein C.H. van der Meulen, PhD, Cornell University Richard L. Lieber, PhD, Rehabilitation Institute of Chicago Theodore Miclau, MD, Orthopaedic Trauma Institute Martin Stoddart, PhD, AO Research Institute Davos The ORS Basic Science Course will provide attendees with the tools to explain the functions and limitations of the science behind the decisions, treatments and procedures that are performed in practice every day. The course content has been derived from the Orthopaedic Basic Science: Foundations of Clinical Practice textbook developed in partnership with the AAOS and ORS. Course attendees will receive a copy of the textbook as part of the registration fee. The knowledge of the concepts learned in this course is evaluated through the Orthopaedic In-Training Examination and the American Board of Orthopaedic Surgery Part 1 and Recertification Examinations. Understanding the science behind clinical decisions is important as we strive to improve patient care. The course will benefit anyone currently in the field or entering the field of orthopaedics including orthopaedic residents and fellows, practicing orthopaedic surgeons and musculoskeletal researchers. 8:00 AM 5:00 PM ORS/OREF Grant Writing Course Hilton Bayfront Aqua Salon EF This popular introductory course is the first in a sequence of opportunities offered by ORS and OREF for new investigators to learn the art of grant writing. This course is ideal for investigators who are in the process of writing their first grant proposal. Experts will offer strategies for writing a compelling Aims page, developing a strong approach to test an exciting hypothesis, using preliminary data and supporting documents to present a cohesive final grant proposal. A mock study section provides a first-hand look at what is involved in NIH peer review. Lunch and a post-course networking reception are included in the registration fee. $175 /PERSON (pre-registration required) Registering for the ORS Basic Science Course To register for the ORS Basic Science Course visit AAOS registration located in the San Diego Convention Center, Hall D Lobby, or Hall A Lobby Friday, March 17, 7:00 AM 6:00 PM or Saturday, March 18 beginning at 6:30 AM. 20

21 SUNDAY MEETING HIGHLIGHTS 7:00 AM 6:00 PM Registration Open City-Side Corridor 7:00 AM 11:30 AM ORS Clinical Research Forum Room 2 7:15 AM 8:50 AM ORS International Section of Fracture Repair Business Meeting Room 7AB 8:00 AM 11:30AM ORS Meniscus Section Meeting Room 8 8:00 AM 10:45 AM ORS Tendon Section Meeting Room 3 8:00 AM 11:30 AM ORS Spine Section Meeting Room 5AB 8:00 AM 11:30 AM ORS Orthopaedic Implants Section Meeting Room 4 9:00 AM 11:30 AM ORS International Section of Fracture Repair Meeting Room 7AB 9:00 AM 11:30 AM ORS Preclinical Models Section Meeting Room 1B 12:00 PM 1:00 PM SESSIONS: Fracture Repair Room 6A Tendon Repair and Regeneration Room 6B Foot and Ankle Room 7AB SPOTLIGHT SESSIONS: Cartilage Repair Room 6CF Joint Replacement Registries Room 5AB 1:15 PM 2:15 PM SESSIONS: Cartilage Repair and Stem Cells Room 6CF Diagnostic Imaging Room 7AB SPOTLIGHT SESSION: Meniscal Cell Biology Room 6B NIRA PRESENTATIONS: Bone Room 6A Joint Arthroplasty and Spine Room 5AB 2:45 PM 4:15 PM PROFESSIONAL ADVANCEMENT SESSION: Launching and Navigating a Successful Career as a Clinician-Scientist Room 7AB WORKSHOPS: Research Gaps in Care of Hip Fracture Room 6A Osteoarthritis: From Bench to Bedside and Back Room 6CF Additive Manufacturing in Orthopaedics Current State of the Art, Future Trends, and Regulatory Oversights (Part I: Scientific Workshop) Room 6B Instability in Total Knee Arthroplasty: Where are We Now and Where Do We Need to Go? Room 5AB 4:30 PM 5:30 PM HANDS-ON WORKSHOP Additive Manufacturing in Orthopaedics 3D Printing in Orthopaedics Presented by Materialise (Part II: Technology Based Workshop) Room 2 4:30 PM 5:45 PM ORS Excellence in Orthopaedics Awards Session Room 6CF SATURDAY SUNDAY 21

22 SUNDAY PROGRAM DETAIL SUNDAY 7:00 AM 11:30 AM ORS Clinical Research Forum: Navigating the Pathway from Research Discoveries to Clinical Practice Room 2 Organized by the ORS Clinical Research Committee Kurt Spindler, MD, Chair The 2017 ORS Clinical Research Forum will bring together key clinical research leaders to focus on two areas of research. The first session, on Biomedical Research, will include talks on barriers to translation to clinical practice, the commercialization process, funding sources, and conflicts of interest in clinical research. The second session, on Clinical Research Training in Orthopaedics, and will include talks on key principles in orthopaedic research, measurements in clinical research, mitigation bias in clinical studies, and knowledge translation. Presentations in the second session will be based on the ORS Clinical Research Training in Orthopaedics web-based curriculum to launch in the fall of This is an interactive conference with sufficient time for questions and discussion. Session I: Biomedical Research Moderator: Michael J. Yaszemski, MD, PhD, Mayo Clinic Barriers to Translation to Clinical Practice Anthony Ratcliffe, PhD, Synthasome, Inc. Commercialization Process Scott Bruder, MD, PhD, Bruder Consulting International, LCC Funding Sources Lloyd Hey, MD, Hey Clinic for Scoliosis and Spine Surgery Conflicts of Interest in Clinical Research Michael J. Yaszemski, MD, PhD, Mayo Medical Center Panel Discussion Session II: Clinical Research Training in Orthopaedics Moderator: David Wasserstein, MD, MSc, MPH(c), FRCSC, Sunnybrook Health Sciences Centre Key Principles in Orthopaedic Research Kurt Spindler, MD, Cleveland Clinic Measurements in Clinical Research Man Hung, PhD, MEd, Mstat, University of Utah Mitigating Bias in Clinical Studies Stephen Lyman, PhD, Hospital for Special Surgery Knowledge Translation David Wasserstein, MD, MSc, MPH(c), FRCSC, Sunnybrook Health Sciences Centre Panel Discussion 22

23 SUNDAY PROGRAM DETAIL 7:15 AM 11:30 AM ORS International Section of Fracture Repair Meeting Room 7AB, 7:15 AM 8:50 AM Room 7AB, 9:00 AM 11:30 AM Organizers: Peter Augat, MD, Institute of Biomechanics Murnau; Chelsea Bahney, PhD, Orthopaedic Trauma Institute; Mathias P.G. Bostrom, MD, Hospital for Special Surgery; Chantal Chenu, PhD, Royal Veterinary College; David Hak, MD, MBA, Denver Health; Jörg Goldhahn, MD, PhD, ETH Zurich; Allen Goodship, MD, Institute of Orthopaedics & Musculoskeletal Science; Amy Hoang-Kim, MSc, St. Michael s Hospital; Alan Johnstone, MD, Aberdeen Royal Infirmary; Ralph Marcucio, PhD, University of California, San Francisco; Cyril Mauffrey, MD, Denver Health Medical Center; Takahiro Niikura, MD, Kobe University; Emil Schemitsch, MD, St. Michael s Hospital; Yoshinobu Watanabe, MD, Teikyo University Objectives: The ORS ISFR will serve as the primary global research community dedicated to the advancement and interchange of the science of fracture repair and its application to the improvement of patient care. It will be the home of experts in the field of fracture repair and will thereby serve an important role within the ORS in areas of scientific program developments, identification of research priorities, and the dissemination of research in the field. We invite you to join us for the first official ORS ISFR meeting. Organizers from the Bone Regeneration RIG that has taken place at the ORS Annual Meeting have helped to develop the programming for this important section meeting. Participants will help set the course for the future of our field, and will have the opportunity to network with recognized experts. Programming will include a session for junior investigators as well as a presentation from senior investigators, Unmet Clinical Needs and Future Research Directions in Fracture Healing. 8:00 AM 11:30 AM ORS Meniscus Section Meeting Room 8 Organizers: Adetola Adesida, PhD, University of Alberta; Tammy Haut Donahue, PhD, Colorado State University; Lutz Dürselen, PhD, Ulm University; Martin Englund, MD, PhD, Lund University; Trent Guess, PhD, University of Missouri; Matthew Koff, PhD, Hospital for Special Surgery; Marc Levenston, PhD, Stanford University; Suzanne Maher, PhD, Hospital for Special Surgery; Amy McNulty, PhD, Duke University; Vicki Rosen, PhD, Harvard School of Medicine Objectives: After the inaugural meeting of the Meniscus Section in March 2016, the 2017 meeting will provide a forum for clinicians, engineers, scientists, and corporate representatives who are interested in the field of meniscus research. The meeting will feature scientific presentations related to Embryonic Development of the Meniscus and Harnessing this for Tissue Engineering the Meniscus. The section will also provide networking opportunities for attendees and have Meniscus Poster Teasers. Anyone interested in meniscus research is encouraged to attend. 8:00 AM 10:45 AM ORS Tendon Section Meeting Room 3 Organizers: Peter C. Amadio, MD, Mayo Clinic; Paul Ackermann, MD, PhD, Karolinska Hospital; Nelly Andarawis-Puri, PhD, Cornell University; Kathe Derwin, PhD, Cleveland Clinic; Evan Flatow, MD, Mt. Sinai School of Medicine; Catherine K. Kuo, PhD, University of Rochester; Ronen Schweitzer, PhD, Shriners Hospital; Lou Soslowsky, PhD, University of Pennsylvania; Stavros Thomopoulos, PhD, Columbia University Objectives: The first annual section meeting will feature speakers, Scott Rodeo, MD, Hospital for Special Surgery, and Hani Awad, PhD, University of Rochester Medical Center presenting on Current Strategies to Advance Treatment Options (e.g. stem cell therapies, biologics, tissue engineering, etc.). The meeting will also include opportunities for attendees to network and engage in discussion. SATURDAY SUNDAY 23

24 SUNDAY PROGRAM DETAIL SUNDAY 8:00 AM 11:30 AM ORS Spine Section Meeting Room 5AB Organizers: Judith Hoyland, PhD, University of Manchester; James C. Iatridis, PhD, Icahn School of Medicine at Mount Sinai; Christine Le Maitre, PhD, Sheffield Hallam University; Jeff Lotz, PhD, University of California, San Francisco; Devina Purmessur, PhD, The Ohio State University; Makarand Risbud, PhD, Thomas Jefferson University; Daisuke Sakai, MD, PhD, Tokai University School of Medicine; Nam Vo, PhD, University of Pittsburgh Objectives: This year s section meeting topics include IVD Tissue Engineering, and Clinical Opportunities for Technological Solutions to Address IVD Degeneration and Spine Pain. 8:00 AM 11:30 AM ORS Orthopaedic Implants Section Meeting Room 4 Organizers: Dennis Janssen, PhD, Radboud University Medical Center; Kenneth Mann, PhD, SUNY Upstate Medical University; Heidi-Lynn Ploeg, PhD, University of Wisconsin Madison; Chris Roche, MSE, MBA, Exactech, Inc.; Harry van Lenthe, PhD, KU Leuven; Nico Verdonschot, PhD, Radboud University Medical Center; Peter Walker, PhD, New York University-Hospital for Joint Diseases; Janie Wilson, PhD, Dalhousie University; Markus Wimmer, PhD, Rush University Medical Center Objectives: We are excited to announce the first meeting of the Orthopaedic Implants Section. Of many possible themes, we have chosen to focus on total knee replacement (TKR) this year. Presentations of esteemed invited speakers will last for 20 minutes followed by an extensive discussion. Topics will focus on historical aspects and retrieval analyses of TKR in order to identify lessons learned from historical (failed) and existing designs. Furthermore, a retrospective view will be taken of the innovation process and whether innovation has stagnated in recent years. Additionally, a future perspective will be presented in terms of design, materials, surgical tools and evaluation methods to improve the quality of TKR. It will also be discussed how CE and FDA regulations affect clinical introduction and whether the testing requirements and efforts are reasonably balanced against the risk to introduce unsafe devices on the market. The meeting will end with a general assembly. We look forward to your contributions to the open discussion, so that together we can shape the future of the Orthopaedic Implants Section to meet your needs in orthopaedic research. 24

25 SUNDAY PROGRAM DETAIL 9:00 AM 11:30 AM ORS Preclinical Models Section Meeting Room 1B Organizers: Matthew Allen, Vet MB, PhD, University of Cambridge; Laurie Goodrich, DVM, PhD, Colorado State University; Kurt Hankenson, DVM, PhD, Michigan State University; Dianne Little, PhD, DVM, Purdue University; Stephan Zeiter, DVM, PhD, DipECLAM, AO Research Institute Objectives: The first annual section meeting will begin with a business and planning meeting, then be followed by an exciting series of presentations on refining and standardizing models of load induced bone formation moderated by Russell Main, PhD, Purdue University and Bettina Willie, PhD, McGill University. Leading groups will present their best practices for their individual loading models, as well as current challenges and issues with each loading paradigm. Presentations will be followed by a panel discussion with the aim of guiding the group to reach consensus on a variety of issues, including application and translatability, loading methodologies, post-loading analyses, overall experimental design and reporting and animal welfare and care and use committee considerations. 2:45 PM 4:15 PM Launching and Navigating a Successful Career as a Clinician-Scientist Room 7AB Organized by the ORS New Investigator Mentoring Committee Organizers: Roger Cornwall, MD, Cincinnati Children s Hospital; Benjamin Alman, MD, Duke University Clinician-scientists are uniquely poised to identify important unsolved clinical problems, work through the scientific approaches to address those problems while maintaining clinical relevance, and then translate scientific breakthroughs into therapies with game-changing public health potential. Granting agencies encourage applications from them. Hospital and university departments love to showcase them. So why wouldn t everyone want to become a clinician-scientist? Why do we need so many efforts to increase the number of clinician-scientists in the world of orthopaedic research? Why is it so hard? This session will discuss the challenges, benefits, opportunities, and logistics of planning, launching, and sustaining a career as a clinician-scientist. Many people have an interest in science but do not know where to start if they didn t chose the MD-PhD route early in medical school. Many clinicians have ideas or questions and do not know that they can be explored scientifically, or how to go about it. In this session, experienced clinician-scientists will address these problems in brief talks and answer questions of budding clinicianscientists in open discussions. The purpose is to give those curious about, or struggling in, a clinician-scientist career an overview of the strategies, hurdles, and keys to a successful career, while celebrating the unique joy that such a career can bring. Why a Clinician-Scientist Career? Roger Cornwall, MD, Cincinnati Children s Hospital Motivations for Basic Science Research Pathways into the Lab What You Need Before Making the Leap Nuts and Bolts Jonathan Schoenecker, MD, PhD, Vanderbilt Negotiating a Clinician-Scientist Job Managing Time/Expectations Getting Funding Started Building Sustained Success Francis Lee, MD, PhD, Yale University Networks/Collaboration Sustained Funding Career Progression The Next Generation Brian Snyder, MD, PhD, Boston Children s Hospital Teaching Residents to Love Science Supporting Resident Science at Many Levels Clinician-Scientist: Not a Dying Breed The Big Picture Regis J. O Keefe, MD, PhD, Washington University The Role of Clinician-Scientists in the Orthopedic Research World The Future of the Clinician-Scientist Model The Rewards of a Clinician-Scientist Career SUNDAY 25

26 SUNDAY PROGRAM DETAIL SUNDAY 2:45 PM 4:15 PM WORKSHOP Research Gaps in Care of Hip Fracture Room 6A Organized by The Hip Society and ORS Organizers: Harry Rubash, MD, Massachusetts General Hospital and Kevin Bozic, MD, MBA, University of Texas at Austin Hip fracture is a common event with the 3rd highest cost in American medicine today. It carries the highest mortality rate of any common orthopaedic diagnosis and also has the highest 30-day readmission. There have been few improvements in care over the past 30 years and this situation makes hip fracture an important orthopaedic condition to study so that we can improve upon patient outcomes. Research Gaps in Basic and Translational Research William Macaulay, MD, New York City Medical Center Research Gaps in Clinical and Health Services Research Stephen Kates, MD, Virginia Commonwealth University 2:45 PM 4:15 PM WORKSHOP Osteoarthritis: From Bench to Bedside and Back Room 6CF Organized by the ORS Women s Leadership Forum Organizers: Robin Queen, PhD, FACSM, Virginia Tech and Susan V. Bukata, MD, University of California Los Angeles Osteoarthritis (OA) is a chronic, debilitating condition affecting many adults worldwide. It affects 1 in 5 adults in the United States and the risk of developing OA by age 85 approaches 50%. In 2009, $185.5 billion was spent in the US for medical care related to OA, representing more than 1% of the entire gross domestic product (GDP) for that year. Despite widespread prevalence of the disease and tremendous costs to the healthcare system, very little remains understood about the etiology and progression of osteoarthritis. Further, no definitive therapeutic options have been established for OA, and care remains focused on symptom relief with eventual progression for many patients to total joint replacement. Pain and disability resulting from arthritis remains a dominant complaint of most adults over age 65 and a limiting factor for activity and quality of life for many of these patients. Research is seeking to better understand the biology, biomechanics, and clinical interactions that combine to create the disease of osteoarthritis. This workshop will review the current state of the art in biology, biomechanics, and clinical medicine in the care of osteoarthritis and discuss the emerging research goals and frontiers for this prevalent and costly disease. The Biology of Aging Cartilage and Development of OA: What Do We Know About the Process? Anna Spagnoli, MD, Rush University Current Clinical Treatments for OA: Pills, Injections, And Metal. Does Anything Make a Difference? Constance Chu, MD, Stanford University How Do We Know it Works: Measuring Functional Outcomes in Response to OA Interventions? Stephen Messier, PhD, Wake Forest University 26

27 SUNDAY PROGRAM DETAIL 2:45 PM 4:15 PM Additive Manufacturing in Orthopaedics Current State of the Art, Future Trends, and Regulatory Oversight (Part I: Scientific Workshop) Room 6B Organizers: Michael Lehmicke, MSc, DePuy Synthes, and Judd Day, PhD, Exponent Additive Manufacturing (AM), including 3D printing and other additive techniques, covers the range from a rapid prototyping method and a research tool to a valid manufacturing technique for orthopaedic implants and instrumentation. This is an area of increasing interest among ORS members. AM allows research groups to develop ideas and implement both experimental and clinical research programs more easily than in the past. The technology can be easy to use but there are many parameters and considerations that go into getting reproducible results. This workshop will provide an overview of how additive manufacturing techniques may be applied to create orthopedic implants and instrumentation from a variety of materials for different applications. Workshop attendees will gain an understanding of how additive manufacturing may apply to their own research as well as future translational applications. Application of 3D Printing to Total Joint Design & Evaluation Peter Walker, PhD, New York University From Allografts to 3D Printed Scaffolds: Advances in Bone Tissue Engineering Hani Awad, PhD, University of Rochester FDA Resources and Guidance for Additive Manufacturing James Coburn, MS, US - Food and Drug Administration CME is not available for this workshop. 2:45 PM 4:15 PM WORKSHOP Instability in Total Knee Arthroplasty: Where Are We Now and Where Do We Need to Go? Room 5AB Organized by The Knee Society and ORS Organizers: Timothy Wright, PhD, Hospital for Special Surgery and Guoan Li, PhD, Massachusetts General Hospital Instability is among the major causes of dissatisfaction and failure in total knee arthroplasty (TKA) and can be related to patient actors, surgical technique, and implant design. The problem of recreating adequate joint stability with TKA is confounded by the complex static constraints provided by the ligaments and joint capsule and by the active contribution of muscle forces. The workshop will serve to establish where we are in understanding instability and where we need to go to prevent and treat instability by addressing the following questions: What is the scope of the clinical problem and what current treatments exist? What is the multiplanar target for a stable knee and how can computational modeling be used to improve TKA function? What postoperative outcome measures link joint stability and function to patient satisfaction? What is the Scope of the Clinical Problem of Instability in TKA and What Current Treatments Exist? Douglas Dennis, MD, Colorado Joint Replacement What is the Multiplanar Target for a Stable Knee and How Can Computational Modeling be Used to Improve TKA Function? Paul Rullkoetter, PhD, University of Denver What Postoperative Outcome Measures Link Joint Stability and Function to Patient Satisfaction? Scott Banks, PhD, University of Florida SUNDAY 27

28 SUNDAY PROGRAM DETAIL SUNDAY 4:30 PM 5:30 PM HANDS-ON WORKSHOP Additive Manufacturing in Orthopaedics 3D Printing in Orthopaedics Presented by Materialise (Part II: Technology Based Workshop) Room 2 Presented by Materialise 3D printing is transforming orthopaedic healthcare and improving patient treatment in a variety of ways, as researchers and clinicians are continually striving to improve the standard of care. During the hands-on workshop, attendees will learn how to convert medical image data into a highly accurate 3D model of a patient s anatomy. Attendees will be instructed on how to: 1) Segment medical image data 2) Design a custom implant 3) Prepare a part for 3D printing * Attendees need to register for the workshop in order to receive a trial version of the Mimics Innovation Suite software that needs to be downloaded. ** Attendees are welcome to attend and follow along without downloading the software. CME is not available for this workshop. SOLD OUT 4:30 PM 5:45 PM ORS Excellence in Orthopaedics Awards Session featuring Kappa Delta, Orthopaedic Research & Education Foundation, and CORR ORS Richard A Brand for Outstanding Orthopaedic Research Room 6CF PAPER PRESENTATIONS Kappa Delta Young Investigator Award Robin M. Queen, PhD, FACSM, Virginia Tech Using Lower Extremity Biomechanics in Patients with Ankle Osteoarthritis and Ankle Arthroplasty to Direct Clinical Care Kappa Delta Ann Doner Vaughn Award Matthew Dobbs, MD, Washington University in St. Louis Advancing Precision Medicine for Clubfoot Treatment through Basic Research Kappa Delta Elizabeth Winston Lanier Award Scott W. Wolfe, MD, Hospital for Special Surgery/ Weill Medical College of Cornell University Kinematics of the Normal and Injured Wrist: The Importance of the Midcarpal Joint OREF Clinical Research Award Henrik Malchau, MD, PhD, Sahlgrenska University Hospital Arthroplasty Implant Registries Over the Past Five Decades: Development, Current and Future Impact CORR ORS Richard A. Brand Award for Outstanding Research Joseph H. Schwab, MD, Massachusetts General Hospital Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone 28

29 SUNDAY, MARCH 19, 2017 SESSIONS 12:00 PM 1:00 PM TIME SESSION 1 Fracture Repair SPOTLIGHT SESSION 2 Cartilage Repair SESSION 3 Tendon Repair and Regeneration SPOTLIGHT SESSION 4 Joint Replacement Registries SESSION 5 Foot and Ankle ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Chelsea Bahney, PhD and David Little, PhD Hani Awad, PhD and Lawrence J. Bonassar, PhD Lisa Larkin, PhD and Russell Main, PhD Kenneth Mann, PhD and Sophie Williams, PhD Louis E DeFrate, PhD and Daniel Latt, MD, PhD 12:00 PM Paper No. 1 A Wireless Strain Sensor Platform to Longitudinally Quantify Mechanical Boundary Conditions During Bone Healing in Small Animals Brett S. Klosterhoff, Andrew J. DeRouin, Kevin M. Hetzendorfer, Melissa Tsang, Laxminarayanan Krishnan, Young-Hui Chang, Mark G. Allen, Keat Ghee Ong, Robert E. Guldberg, Nick J. Willett Paper No. 10 Characterization of Rat Adipose-Derived Stem Cells and Their Use in Regeneration of Achilles Tendon Jolanta B. Norelli, David P. Plaza, Hudson Liang, Daniel A. Grande Paper No. 19 Rotational Motion of Mid-foot Joints During Stance Phase of Normal Walking: A Bi-planar Fluoroscopic Study Cong-Bo Phan, Kyoung Min Lee, Seungbum Koo 12:10 PM Paper No. 2 Altering Spacer Material Affects Bone Regeneration in the Masquelet Technique Victoria Ip, Zachary Toth, Daniel Kim, Katherine Gnanarajah, Emily Evans, Tracy Watson, Daemeon Nicolaou, Sara McBride-Gagyi SPOTLIGHT SPEAKER Jos Malda, PhD 3D Printing for Cartilage Repair Paper No. 11 Small Molecules Improving Tendon Healing by Harnessing Endogenous Stem/ Progenitor Cells Solaiman Tarafder, Esther Chen, Charles K. Levin, Daniel Kim, Chang H. Lee SPOTLIGHT SPEAKER Philip Noble, PhD Joint Replacement Registries, Signal Detection and Clinical Outcomes Paper No. 20 Effects of Ankle Arthroplasty Versus Fusion on Hindfoot Kinematics During Simulated Gait Daniel R. Sturnick, Josh R. Baxter, Constantine A. Demetracopoulos, Robin M. Queen, Scott J. Ellis, Jonathan T. Deland 12:20 PM Paper No. 3 Validation of the Radiographic Union Score for Tibial Fractures (RUST) Using Medical Imaging and Biomechanics Testing in an In-Vivo Rat Model Sandra L. Fiset, Aaron Nauth, Emil H. Schemitsch Paper No. 12 Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) as a Potential Topical Treatment for Tendinopathy Vishal Deshmukh, Timothy Seo, Maureen Ibanez, Luis Dellamary, Josh Stewart, John Hood, Yusuf Yazici Paper No. 21 Can Ankle Syndesmosis With a Tricortical Screw or Suture Button Restore Physiologic Tibiofibular Kinematics? Thomas Pfeiffer, Conor Murphy, Jason Zlotnicki, Patrick Haggerty, Volker Musahl, Richard Debski, MaCalus Hogan SUNDAY 12:30 PM Paper No. 4 Progranulin Growth Factor Promotes Diabetic Bone Healing Yuanjing Ding, Jianlu Wei, Aubryanna Hettinghouse, Yuqi Guo, Qingyun Tian, John Buza, Thomas Einhorn, Chuanju Liu Paper No. 7 Biodegradable Anchors Enable Fixation and Integration of 3D Woven Polycaprolactone Scaffolds in a Porcine Focal Cartilage Defect Model James M. Friedman, Mackenzie L. Sennett, Marcelo B. Bonadio, Kerry O. Orji, Alex L. Neuwirth, Niobra M. Keah, James L. Carey, Franklin T. Moutos, Bradley T. Estes, Farshid Guilak, Henning Madry, Robert L. Mauck, George R. Dodge Paper No. 13 MicroRNA29a Improves Tendon Injury -a Randomized Controlled Trial In An Equine Tendinopathy Model Ashlee E. Watts, Josh Platt, Susan M. Kitson, Raquel Rech, Jay Griffin, Roy Pool, Tom Hughes, Iain B. McInnes, Derek S. Gilchrist, Neal L. Millar Paper No. 16 Tradeoffs Between Avoiding Complications and Restricting Access to Total Joint Arthroplasty: The Implications of BMI Cutoffs Nicholas J. Giori, Shalini Gupta, Thomas Bowe, Derek F. Amanatullah, Alex HS. Harris Paper No. 22 The Effect of Malalignment on a Mobile Bearing Total Ankle Replacement Alexandra Smyth, John Fisher, Silvia Suñer, Claire Brockett 12:40 PM Paper No. 5 Serum Proteomic Assessment of the Progression of Fracture Healing Amira I. Hussein, Christian Mancini, Margaret E. Cooke, Kyle E. Lybrand, Heather E. Matheny, Brenna L. Hogue, Paul Tornetta III, Louis C. Gerstenfeld Paper No. 8 Guiding Collagenous Matrix Organization by Varying Interstrand Spacing: Implications for Meniscus Tissue Engineering Paul B. Warren, Pedro Huebner, Daniel A. Chester, Jeffrey T. Spang, Ashley C. Brown, Rohan A. Shirwaiker, Matthew B. Fisher Paper No. 14 Systemic Apoptotic Inhibition Modulates Cell Microenvironment of Fatigue Damage Tendons Meagan Robles-Harris, Evan Flatow, Nelly Andarawis-Puri Paper No. 17 Early Identification and Longitudinal Changes of Patient Satisfaction Two-Years After Total Knee Arthroplasty Kathryn L. Young, Elise Laende, Joanna Mills-Flemming, Michael J. Dunbar, Janie Wilson Paper No. 23 Imbalance of Neuropeptide Signaling in the Synovium of Charcot Neuroarthropathy Zijun Zhang, Yi Guo, Talal Zahoor, Apisan Chinanuvathana, Lew Schon 12:50 PM Paper No. 6 Negative Effects Of Age-related Chronic Inflammation On Skeletal Stem Cells Anna M. Josephson, Vivian Bradaschia Correa, Shane S. Neibart, Philipp Leucht Paper No. 9 Constrained Tissue Culture Reduces Collagen Solubility and Promotes Collagen Maturation to Improve Engineered Cartilage Functional Properties Robert J. Nims, Alexander D. Cigan, Krista M. Durney, Brian K. Jones, Wing-Sum A. Law, Clark T. Hung, Gerard A. Ateshian Paper No. 15 Tendon Strain Stiffening Is Reduced During Healing And High Magnitude Long Duration Dynamic Loading Benjamin R. Freedman, Ashley B. Rodriguez, Cody H. Hillin, Stephanie A. Weiss, Joseph J. Sarver, Louis J. Soslowsky Paper No. 18 Is Outpatient Total Knee Arthroplasty Safe and Effective? Lacey Giambelluca Lavie, Miles Parsons, Gabriel Lensing, Vinod Dasa, Claudia Leonardi Paper No. 24 Synovial Fluid Cytokines, Matrix Metalloproteinases, and Cartilage Breakdown Products Correlate with Time from Intra-Articular Ankle Fracture Samuel Adams, Rachel Reilly, Janet Huebner, Virginia Kraus, Dana L. Nettles 29

30 SUNDAY, MARCH 19, 2017 SESSIONS 1:15 PM 2:15 PM TIME NIRA PRESENTATIONS 6 Bone NIRA PRESENTATIONS 9 Joint Arthroplasty and Spine ROOM Room 6A Room 5AB Moderators Marjolein C.H. van der Meulen, PhD and Amarjit Virdi, PhD Paul Beaule, MD and James C. Iatridis, PhD 1:15 PM Paper No. 25 Subchondral Bone Plate Sclerosis During Late Osteoarthritis is Mediated by Loading-induced Decrease in Sclerostin Amount Xiaoyuan Ma Paper No. 43 NF-κB Decoy Oligodeoxynucleotide Mitigates Polyethylene Wear Particle- Induced Bone Loss but has no Effects on Exogenous Macrophage Infiltration in a Murine Continuous Femoral Particle Infusion Model Tzu-hua Lin, Akira Nabeshima, Jukka Pajarinen, Luis Cordova, Florence Loi, Emmanuel Gibon, Laura Lu, Karthik Nathan, Zhenyu Yao, Stuart B. Goodman 1:22 PM Paper No. 26 Non Viral mir-133a Inhibition Using Collagen-nanohydroxyapatite Scaffolds Rapidly Enhances Stem Cell Osteogenesis and In Vivo Bone Repair Irene Mencía Castaño, Caroline M. Curtin, Rosanne M Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O Brien Paper No. 44 Mutant CCL2 Protein Mitigated Wear Particle-Induced Systemic Macrophage Trafficking In The Murine Continuous Polyethylene Infusion Model Akira Nabeshima, Jukka Pajarinen, Tzu-hua Lin, Xinyi Jiang, Emmanuel Gibon, Luis A. Cordova, Laura Lu, Karthik Nathan, Fan Yang, Zhenyu Yao, Stuart B. Goodman 1:29 PM Paper No. 27 Novel Bone-growth Factors from the Blood: Cxcl16 and Others Benchmarked to Bmp2 Ling He, Yufeng Shen, Juan Zhong, Qimei Gong, Jinxuan Zheng, Francis Lee, Scott Rodeo, Lusai Xiang, Paulo G. Coelho, Junqi Ling, Jeremy J. Mao Paper No. 45 How Well Does Kinematically Aligned Total Knee Arthroplasty Limit Imbalances Between the Medial and Lateral Contact Forces? Joshua D. Roth, Stephen M. Howell, Maury L. Hull SUNDAY 1:36 PM Paper No. 28 Translating the Fundamental Role of Osteogenic-Angiogenic Coupling in Bone Formation: Highly Efficient Combinatorial Gene-Activated Scaffolds Accelerate Bone Regeneration in Critical-sized Defects Rosanne M. Raftery, Irene Mencía Castaño, Gang Chen, Brian Quinn, Brenton Kavanagh, Caroline Curtin, Sally-Ann Cryan, Fergal J. O Brien Paper No. 46 Elucidating the Mechanism Of Anti-IsdB-mediated S.aureus Sepsis and Death Following Surgical Site Infection in a MRSA Implant-associated Osteomyelitis Model Masahiro Ishikawa, Kohei Nishitani, Karen L. de Mesy Bentley, Noriaki Yokogawa, Benjamin L. Smith, Hiromu Ito, Stephen L. Kates, John L. Daiss, Edward M. Schwarz 1:43 PM Paper No. 29 Notch Signaling Regulates Mesenchymal-Osteoblast Differentiation Daniel W. Youngstrom, Kurt D. Hankenson Paper No. 47 Q-space Imaging is a Novel Technique to Evaluate Intervertebral Disc Degeneration Daisuke Nakashima, Nobuyuki Fujita, Junichi Hata, Takeo Nagura, Kanehiro Fujiyoshi, Hideyuki Okano, Masahiro Jinzaki, Morio Matsumoto, Masaya Nakamura 1:50 PM Paper No. 30 Exploring the Link between Fetal Movements and Hip Dysplasia in Singleton and Twin Pregnancies Stefaan W. Verbruggen, Bernhard Kainz, Joseph V. Hajnal, Mary A. Rutherford, Andrew TM Phillips, Niamh C. Nowlan Paper No. 48 Hypoxia Differentially Regulates The Metabolism Of Human Nucleus Pulposus Cells Under Basal And Il-1β-stimulated Conditions Through Hif-2α Yu Song, Cao Yang 1:57 PM Paper No. 31 Potential of Bone Morphogenetic Protein-6 as a Pharmacological Agent for Increasing Bone Formation in Patients with Type 1 Diabetes Jesse F. Wang, Tsung-Lin Tsai, Ming-Song Lee, Ellen Leiferman, Darrin Trask, Wan-Ju Li Paper No. 49 High Mobility Group Box-1 Promotes Pro-inflammatory Signaling in Human Nucleus Pulposus Cells via Toll-Like Receptor 4 Bhranti S. Shah 2:04 PM Paper No. 32 Novel Role Of TGFβ In Osteocytes: Regulation Of Perilacunar Remodeling And Bone Quality Neha S. Dole, Courtney A. Mazur, Claire Acevedo, Tristan W. Fowler, Justin Lopez, David A. Monteiro, Jonathan J. Woo, Khalid S. Mohammad, Tamara Alliston Paper No. 50 Engineered Endplates Enhance the In Vivo Performance of a Replacement Disc-Like Angle Ply Structure (DAPS) Sarah E. Gullbrand, John T. Martin, Beth G. Ashinsky, Dong Hwa Kim, Lachlan J. Smith, Dawn Elliott, Harvey Smith, Robert Mauck 2:11 PM Paper No. 33 Detecting Chronic Post-traumatic Osteomyelitis in Mouse Tibia Via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe Li Xiao, Tinghui Li, Mengmeng Ding, Jiezuan Yang, David B. Weiss, Li Jin, Harry C. Dorn, Xudong Li Paper No. 51 Human Ipsc-derived Notochordal Cells Survive and Retain Their Phenotype in Degenerated Porcine IVD Dmitriy Sheyn, Shiran Ben-David, Sandra De Mel, Virginia Chan, Joseph Giaconi, Dan Gazit, Zulma Gazit 30

31 SUNDAY, MARCH 19, 2017 SESSIONS 1:15 PM 2:15 PM TIME SESSION 7 Cartilage Repair and Stem Cells SPOTLIGHT SESSION 8 Meniscal Cell Biology SESSION 10 Diagnostic Imaging ROOM Room 6CF Room 6B Room 7AB Moderators Amiee Colbath, DVM and Laurie Goodrich, DVM, PhD Magali Cucchiarini, PhD and Amy McNulty, PhD Jonathan Dyke, PhD and Yang Xia, PhD 1:15 PM Paper No. 34 A Novel Cell Source For Cartilage Repair Rebekah Decker, Minwook Kim, Matthew Fisher, Breanna N Seiber, James Friedman, Mackenzie Sennett, Elizabeth Henning, Eiki Koyama, Robert Mauck, Maurizio Pacifici Paper No. 52 T1rho as a Predictor for Cartilage Morphological Lesion Progression 2 Years After ACL Reconstruction Matthew Tanaka, Valentina Pedoia, Luca Facchetti, Alan Li, Jan Neumann, Kevin Gao, Sharmila Majumdar, C. Benjamin Ma, Xiaojuan Li 1:25 PM 1:35 PM Paper No. 35 Intercellular Communication in Chondrocyte/MSC Co-Cultures is Mediated by Extracellular Vesicles Minwook Kim, Jason A. Burdick, Robert L. Mauck Paper No. 36 The Mechano and Osmosensitive Ion Channel TRPV4 Serves as a Functional Regulator of ipsc Chondrogenesis Vincent P. Willard, Holly A. Leddy, Chia-Lung Wu, Wolfgang B. Liedtke, Farshid Guilak SPOTLIGHT SPEAKER Darryl D Lima, MD, PhD Meniscal Cell Identity and Function: Implications for Tissue Regeneration Paper No. 53 The Location of Uptake By Positron Emission Tomography-computed Tomography on Cam Deformity in Femoroacetabular Impingement Patients Takayuki Oishi, Naomi Kobayashi, Yutaka Inaba, Hyonmin Choe, Taro Tezuka, So Kubota, Daigo Kobayashi, Takashi Sakai, Tomoyuki Saito Paper No. 54 Dynamic MRI Of The Actively Moving Wrist: Feasibility As A Supplement To Conventional MRI Abhijit J. Chaudhari, Brent Foster, Igor Immerman, Christopher O. Bayne, Robert M. Szabo, Robert D. Boutin SUNDAY 1:45 PM Paper No. 37 Are Multiple Intra-articular Injections of Synovium-Derived Mesenchymal Stem Cells With HA more effective than Single Injection for Articular Cartilage Defects? Maya Kubo, Masato Takao, Shinya Miki, Hirotaka Kawano Paper No. 40 Avascular Meniscus Healing by Stem Cell Recruitment: Effect of Dose and Release Rate of CTGF and TGFβ3 Solaiman Tarafder, Joseph Gulko, Abrar A. Nadroo, Daniel H. Kim, Andy Sim, Shawn F. Gutman, Chang H. Lee Paper No. 55 Chondral Injury Associated With ACL Injury: Monitoring Disease Progression Caroline Figgie, Matthew Koff, Parina H. Shah, Hollis G. Potter, Scott A. Rodeo, Kimberly K. Amrami, Aaron J. Krych, Valentina Pedoia, Keiko Amano, Xiaojuan Li, Benjamin Ma, Sharmila Majumdar 1:55 PM Paper No. 38 Autologous Bone Marrow Aspirate Enhanced Microfracture Counteracts The Early Loss of Subchondral Bone in a Translational Model of Osteochondral Repair Liang Gao, Kathrin Müller Brandt, Patrick Orth, Lars Goebel, Magali Cucchiarini, Henning Madry Paper No. 41 Identification and Characterization of Adult Mouse Meniscus Stem/Progenitor Cells Laura Gamer, Rui Rui Shi, Ashira Gendelman, Dylan Mathewson, Jackson Gamer, Vicki Rosen Paper No. 56 The Alpha Angle Does Not Predict Hip Motion to Impingement Charles M. Lawrie, Hani A. Mayassi, Andrew J. Murphy, Rikin V. Patel, Sabir K. Ismaily, Melvyn A. Harrington, Joshua D. Harris, Philip C. Noble 2:05 PM Paper No. 39 Super-Healer Mice Exhibit Improved Cartilage Regeneration Due to Enhanced Psmad1/5 Signaling Xueqin Gao, Aiping Lu, Sarah Amra, Ping Guo, Charles A. Huard, Xuying Sun, Johnny Huard Paper No. 42 Nuclear Softening Enhances Meniscus Cell Migration into Dense Fiber Networks and Native Tissue Su-Jin Heo, Kwang Hoon Song, Breanna N. Seiber, Feini Qu, Jason A. Burdick, Robert L. Mauck Paper No. 57 Lower Lumbar Spine Trabecular Bone Score (TBS) in Patients with Diabetes Mellitus Yunfeng Xue, Andrea L. Baker, Shahla Nader, Anthony J. Sanchez, James F. Kellam, Nahid J. Rianon, Catherine G. Ambrose 31

32 MONDAY MEETING HIGHLIGHTS MONDAY 7:00 AM 6:00 PM Registration Open City-Side Corridor 7:30 AM 8:30 AM SESSION: Muscle Room 7AB 7:30 AM 9:00 AM Industry Connect: A Conversation with the FDA Room 2 7:30 AM 9:00 AM WORKSHOPS: Taper Corrosion in THA: Clinical Impact and Applying the Best Evidence into Practice Room 6A Bone Marrow Lesions What Lies Beneath? Room 6CF Scaffolds, Bioreactors and Biologics in Orthopaedic Research Room 6B Current Status and Future Needs of Pediatric Orthopaedic Pharmacology Room 5AB 9:15 AM 10:15 AM SPOTLIGHT SESSION: ACL Repair Room 6B SESSIONS: Modulating Fracture Healing Room 6A Arthroplasty Wear and Osteolytes Room 5AB Spine Implants Room 7AB NIRA PRESENTATION: Cartilage, Meniscus and Osteoporosis Room 6CF 10:00 AM 5:30 PM Innovation Central Open Sails Pavilion Innovation Theater 10:30 AM 11:00 AM TA Instruments ElectroForce Techniques Workshop Sails Pavilion Innovation Theater 11:15 AM 12:15 PM SESSIONS: Hip and Knee Arthroplasty Kinematics and Function Room 5AB Osteocytes Biology Room 6A Poster Teaser Session I Room 7AB SPOTLIGHT SESSION: Novel Targets in OA Room 6CF NIRA PRESENTATION: Tendon, Ligament, Muscle and Trauma Room 6B 12:15 PM 1:15 PM PROFESSIONAL ADVANCEMENT SESSION: Networking Across Global Boundaries West Terrace 12:15 PM 2:15 PM Lunch Provided Sails Pavilion 1:15 PM 1:45 PM Innovation Theater: Micro Photonics, Inc. Sails Pavilion Innovation Theater 2:15 PM 3:15 PM SESSIONS: Cartilage Matrix Proteins Room 6CF Infection and Inflammation Room 6B Hip and Knee Arthroplasty Clinical Outcomes Room 5AB Spine: Imaging Mechanics and Kinematics Room 7AB SPOTLIGHT SESSION: Ligament and Tendon Engineering Room 6A 3:30 PM 4:30 PM ORS Keynote Speaker: Jennifer Doudna, PhD Room 6CF 4:45 PM 5:00 PM Innovation Theater: Zwick USA Sails Pavilion Innovations Theater 5:00 PM 6:15 PM ORS General Session and Presidential Address Room 6CF 6:30 PM 8:00 PM Research Interest Group: Articular Cartilage Repair Room 5AB 6:30 PM 8:00 PM Research Interest Group: Growth Factors Room 3 6:30 PM 9:00 PM ORS Women s Leadership Forum Reception Bayside Corridor 32

33 MONDAY PROGRAM DETAIL 7:30 AM 9:00 AM Industry Connect: A Conversation With the FDA Room 2 Organized by the ORS Industry Engagement Committee Successful development of new medical technology requires a detailed understanding of the possible regulatory pathways and the current standards and regulations necessary to market innovative medical devices that are safe and effective for their intended use. This session will provide a continuation of the discussion initiated at last year s Industry Connect, including presentations from the FDA and from industry, and discussion of timely regulatory topics relevant to orthopaedic product development. Participants will gain a better understanding of the most recent regulations and hot topics and have an opportunity to network with various ORS members from government, industry, and academia. Speakers: Scott Bruder, MD, PhD, Bruder Consulting International, LLC; Steven Oh, PhD, Center for Biologics Evaluation and Research (CBER); Theodore Stevens, MS, RAC, Center for Biologics Evaluation and Research (CBER) 7:30 AM 9:00 AM WORKSHOP Taper Corrosion in THA: Clinical Impact and Applying the Best Evidence into Practice Room 6A Organized by The Hip Society and ORS Organizers: Harry Rubash, MD, Massachusetts General Hospital and Young-Min Kwon, MD, PhD, Massachusetts General Hospital Adverse local tissue reactions (Pseudotumors, ALVAL, ALTR) due to tribocorrosion of modular taper junctions in contemporary THA are emerging as an important reason for failure requiring revision surgery. The clinical presentation of tribocorrosion include unexplained pain in THA patients with CoCr femoral head-neck modularity as well as patients with dual taper femoral stems with interchangeable neck-stem modularity. This workshop will highlight clinical challenges in diagnosis and treatment of patients with tribocorrosion of contemporary THA, review up-to-date evidence and identify the areas for future research. Tribocorrosion in THA 2017: What s New? Joshua J. Jacobs, MD, Rush University Medical Center Do Taper Materials and Designs Matter? Jeremy Gilbert, PhD, FBSE, Clemson University What Do Implant Retrieval Studies Tell Us? Michael Morlock, PhD, Hamburg University of Technology How to Optimize Clinical Evaluation of Taper Corrosion: Risk Stratification Approach Young-Min Kwon, MD, PhD, Massachusetts General Hospital MONDAY 33

34 MONDAY PROGRAM DETAIL MONDAY 7:30 AM 9:00 AM WORKSHOP Bone Marrow Lesions What Lies Beneath? Room 6CF A workshop based on the ORS/AAOS symposium: Tackling Joint disease by Understanding Crosstalk between Cartilage and Bone, April 2016 Organizers: Oran D. Kennedy, PhD, New York University and Tamara Alliston, PhD, University of California San Francisco It is now widely accepted that osteoarthritis (OA) is not limited to articular cartilage but is a disease of the entire joint. While there are treatments to reduce pain associated with OA, there are no treatments that reverse cartilage degeneration. This highlights the need for early diagnosis, prior to degeneration of cartilage, and early treatment options. Magnetic resonance image (MRI) abnormalities known as bone marrow lesions (BMLs) have been identified as an early indicator and/or contributor to cartilage degeneration. This workshop has assembled an excellent panel of speakers to address this topic from a clinical, biological and bioengineering perspective. They will present and discuss the emerging data linking BMLs to knee pathologies, and the basic science behind their potential contribution to OA initiation and progression. There will also be discussions of potential ways to therapeutically target the basic mechanisms that underpin the early stages of disease. This workshop will finish with a statement of important burning questions that must be addressed to better understand this problem. Bone Marrow Lesions in Osteoarthritis David Felson, MD, Boston University Bone Cartilage Crosstalk: A Biological Perspective David Findlay, PhD, University of Adelaide Hospital The Role of Microdamage, and Bone Turnover, in Osteoarthritic Joint Crosstalk Christopher Hernandez, PhD, Cornell University 7:30 AM 9:00 AM New Horizon Workshop: Scaffolds, Bioreactors and Biologics in Orthopaedic Research Room 6B Organized by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and ORS Organizers: Dimitrios Zeugolis, PhD, NUI Galway and Mauro Alini, PhD, AO Foundation We have entered the era of biofunctional biomaterials. These are materials that are used to not only provide mechanical support, but to also positively interact with the host and promote functional repair and regeneration, largely due to their cargo (e.g. cells, biologics, drugs). Cell-based therapies require removal of cells from their optimal in vivo tissue context and propagation in vitro to attain suitable cell numbers. However, bereft of their optimal in vivo tissue niche, cells lose their phenotype, function and therapeutic potential. In vitro microenvironment modulators, such as bioreactors, surface topography, substrate rigidity, oxygen tension, are essential in maintaining permanently differentiated cell phenotype and/or directing stem cells towards specific lineages. Gene therapy offers new solutions in the clinical management of orthopaedic conditions, where traditional surgical or medicinal approaches fail to recapitulate native tissue function. Although recent data clearly demonstrate the beneficial effect of gene transfer in bone, cartilage, tendon and intervertebral disk, numerous studies have also raised concerns with respect to safety of such therapeutic approaches. This symposium will elucidate recent advancements and shortfalls in the fields of biomaterials, bioreactors and gene delivery for orthopaedic applications. Bioreactors for Musculoskeletal Research Martin Stoddart, PhD, AO Foundation Gene Therapy for Musculoskeletal Pathophysiologies Christopher Evans, PhD, Mayo Clinic Biomimetic Scaffolds for Musculoskeletal Clinical Indications Alicia El Haj, PhD, Keele University 34

35 MONDAY PROGRAM DETAIL 7:30 AM 9:00 AM WORKSHOP Current Status and Future Needs of Pediatric Orthopaedic Pharmacology Room 5AB Pediatric Bone Regeneration: Current Concepts and Therapies: Lessons Learned from Neurofibromatosis Benjamin Alman, MD, Duke University Pediatric Bone Metaplasia: Bone Where You Don t Want It: Current Concepts and Therapies: Lessons Learned from FOP and Myopathies Jonathan G. Schoenecker, MD, PhD, Vanderbilt Children s Hospital Organized by the Pediatric Orthopaedic Society of North America (POSNA) and ORS Organizer: Jonathan G. Schoenecker, MD, PhD, Vanderbilt Children s Hospital Pediatric orthopaedic surgeons treat a variety of conditions that include traumatic injuries, developmental and genetic skeletal manifestations, and musculoskeletal infections. Additionally, pediatric orthopaedic surgeons regularly encounter premature skeletal degeneration from pathological (such as osteogenesis imperfecta, cerebral palsy, or Duchenne s muscular dystrophy) or environmental (such as diet, obesity, and vitamin D deficiency) causes. Therefore, there is a significant need for pharmaceuticals designed to: 1) Prevent infection 2) Provide analgesia 3) Prevent musculoskeletal degeneration 4) Enhance musculoskeletal regeneration 5) Prevent complications from coagulation/inflammation This workshop will provide a broad overview of the common therapeutics employed in pediatric orthopaedics within these categories. Specific detail will provide members of the ORS key information regarding areas of clinical significance for which existing pharmaceuticals are effective, the complications of current pharmaceuticals and to highlight areas where novel therapies are needed. Pediatric Bone Degeneration: Current Concepts and Therapies: Lessons Learned from Osteogenesis Imperfect and Disuse Osteopenia Michelle Caird, MD, University of Michigan 10:30 AM 11:00 AM ORS Techniques Workshop: Fracture Mechanics of Rodent Bones: Evaluating Bone Material Quality Innovation Theater Sails Pavilion Organized by the ORS Strategic Initiatives Committee Organizer: Deepak Vashishth, PhD, Center for Biotechnology and Interdisciplinary Studies, Department of Biomedical Engineering, Rensselaer Polytechnic Institute Mouse models offer the possibility of naturally achieving or genetically engineering a skeletal phenotype and determining the resulting changes in bone size and matrix properties. Recent developments, including nano- and micro-indentation testing and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small animal bone and investigate the effects of aging, therapeutic treatments, disease, and genetic variation. In contrast to traditional strength tests, fracture mechanics tests on whole bone, display smaller variation and offer the possibility of reducing sample sizes for determining bone matrix quality. This techniques workshop will provide an interactive forum for audience to learn a novel fracture mechanics based test to determine bone s resistance to initiation and propagation of fracture from whole bone testing. Examples will be provided to demonstrate where strength tests fail and why fracture mechanics based tests are successful in capturing bone fragility. Equipment for the Techniques Workshop provided by TA Instruments ElectroForce MONDAY 35

36 MONDAY PROGRAM DETAIL MONDAY 12:15 PM 1:15PM Networking Across Global Boundaries West Terrace Organized by the ORS New Investigator Mentoring Committee ORS is the leading global organization representing a diverse membership which is a potent strength in our field. Take advantage of this opportunity to interact with colleagues over lunch to increase creativity in research thinking, collaboration, and the overall strength of our organization. This is a great way for the early career investigator who is forming their research questions, seeking connections with mentors and strong collaborations. This will be a roundtable speed dating style designed to generate engaging and exciting conversation and interactions! Lunch is provided to all ORS meeting registrants in the Exhibit Hall. Please plan to pick up your lunch and join us in the West Terrace! 1:15 PM 1:45 PM Innovation Theater: Micro Photonics Inc. Sails Pavilion Innovation Theater Innovations in Micro-Computed Tomography: Extracting Meaningful Analysis from Micro-CT Images Quality micro-ct analysis starts with great images! Learn how innovations in the SkyScan X-ray micro-computed tomography systems allow for better analysis of even the most difficult samples bones with metal implants. We will discuss how the latest systems achieve superior images with reduced artifacts from the implants and how advancements in software automation streamline results. 3:30 PM 4:30 PM ORS Keynote Speaker: Jennifer Doudna, PhD Room 6CF Rewriting the Language of Life: Impacts and Challenges of DNA Editing Jennifer Doudna is the Li Ka Shing Chancellor s Chair in Biomedical and Health Sciences at UC Berkeley and an Investigator of the Howard Hughes Medical Institute. Prof. Doudna s research seeks to understand how RNA molecules control the expression of genetic information. Her research led to insights about CRISPR- Cas9-mediated bacterial immunity that enabled this system to be harnessed for efficient genome engineering in animals and plants, creating a transformative technology that is revolutionizing the fields of genetics, molecular biology and medicine. She is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine and the National Academy of Inventors. She is a recipient of awards including the NAS Initiatives in Research Award, the NSF Waterman Award, the FNIH Lurie Prize, the Paul Janssen Award for Biomedical Research, the Breakthrough Prize in Life Sciences, the Princess of Asturias Award (Spain), the Gruber Prize in Genetics, the Massry Prize, the Gairdner Award, the Nakasone Prize, the Warren Alpert Foundation Prize and the L Oreal-UNESCO International Prize for Women in Science. 4:45 PM 5:00 PM Innovation Theater: Zwick USA Sails Pavilion Innovation Theater Comprehensive Mechanical Testing Solutions for Orthopaedic Applications The mechanical characterization of orthopedic devices and their materials often proves a challenging task. Whether confronted with static or dynamic applications, the comprehensive range of testing systems and accessories offered by Zwick helps quality engineers and researchers alike in meeting their test requirements. With a patented drive system, Zwick s LTM solution features optimized travel measurement positioning, low friction, and a maintenance-free piston brake system. 36

37 MONDAY PROGRAM DETAIL Journal of Orthopaedic Research JOR Awards ORS/OREF Distinguished Investigator Award Clare Rimnac, PhD ORS Women s Leadership Forum Award Susanna G. Chubinskaya, PhD ORS Outstanding Achievement in Mentoring Award Henry J. Donahue, PhD The Journal of Orthopaedic Research Excellence in Basic Science Award Hongbin Lu, PhD The Effect of Low-Intensity Pulsed Ultrasound on Bone-Tendon Junction Healing: Initiating After Inflammation Stage International Combined Orthopaedic Research Societies The Journal of Orthopaedic Research Excellence in Clinical Science Award Kharma C. Foucher, MD, PhD Identifying Clinically Meaningful Benchmarks for Gait Improvement After Total Hip Arthroplasty Honoring China, 2017 Guest Nation The Journal of Orthopaedic Research Excellence in Translational Science Award Sharmila Majumdar, PhD Kartogenin Treatment Prevented Joint Degeneration in a Rodent Model of Osteoarthritis: A Pilot Study MONDAY The Journal of Orthopaedic Research Early-Career Award Spencer P. Lake, PhD Development and Use of an Animal Model to Study Post-Traumatic Stiffness and Contracture of the Elbow ORS Presidential Address Farshid Guilak, PhD Washington University in St. Louis 37

38 MONDAY PROGRAM DETAIL 6:30 PM 8:00 PM Research Interest Group: Articular Cartilage Repair Room 5AB Organizers: Daniel A. Grande, PhD, The Feinstein Institute for Medical Research; Jos Malda, PhD, UMC Utrecht, Netherlands; Lawrence Bonassar, PhD, Cornell University; Lucienne Vonk, PhD, UMC Utrecht, Netherlands; Lisa Fortier, DVM, PhD, Cornell University The articular cartilage repair RIG will be a platform for introducing new concepts and studies in the field of articular cartilage repair. This will include the use of cell based approaches, biomaterials, 3-D bioprinting, surgical techniques, gene therapy, growth factors, to name but a few of the many variants being explored in vitro, pre-clinical, and clinical across the globe. 6:30 PM 8:00 PM ORS Women s Leadership Forum Reception West Terrace Join us in celebrating women in science! Join the members of the Women s Leadership Forum (WLF) at this event to celebrate many accomplishments of all women in the field. This reception is an excellent opportunity to discuss the challenges facing today s female scientists. The 2017 Women s Leadership Forum Award recipient will be honored for her role as an outstanding mentor to fellow female scientists. The 2017 ORS/RJOS Young Female Investigator Travel Grant Recipient will briefly talk about her research. Limited availability Registration required: $65/person MONDAY 6:30 PM 8:00 PM Research Interest Group: Growth Factors Room 3 Organizer: Henning Madry, MD, Saarland University The growth factor research interest group is designed to disseminate the latest advances in growth factor research and its role in the study of musculoskeletal tissues. The meeting is open to all scientists and clinicians with an interest in repair, regeneration and development of these tissues. 38

39 MONDAY, MARCH 20, 2017 SESSIONS 7:30 AM 8:30 AM TIME ROOM SESSION 11 Muscle 7AB Moderators 7:30 AM Thomas Laumonier, PhD and Frank Petrigliano, PhD Paper No. 58 Sodium Nitrite Mitigates Skeletal Muscle and Bone Phenotypes in Dystrophic Mice Justin J. Hicks, Baoli Qian, Shumin Zhou, Dukens LaBaze, Jennifer Miller, MaCalus V Hogan, Hongshuai Li 7:40 AM Paper No. 59 Pick Your Poison: Multi-Scale Evaluation and Comparison of Common Muscle Injury Models Michael C. Gibbons, Viviane Minamoto, Hiroshi Okuno, Simon Schenk, Richard Lieber, Samuel Ward 7:50 AM Paper No. 60 Mesenchymal Stem Cell Delivery Ameliorates the Regenerative Niche for Muscle Repair Marissa A. Ruehle, Hazel Y. Stevens, Robert E. Guldberg, Jarrod A. Call 8:00 AM Paper No. 61 Rotator Cuff Muscle Regeneration Is Improved Through Brown Fat Signaling Anna R. Bryniarski, Gretchen A. Meyer 8:10 AM 8:20 AM Paper No. 62 Time Course of Focal Adhesion Protein Expression and Tissue Composition of Rotator Cuff Muscle After Tendon Release in Sheep Severin Ruoss, Christoph B. Möhl, Mario C. Benn, Brigitte Von Rechenberg, Karl Wieser, Dominik C. Meyer, Christian Gerber, Martin Flück Paper No. 63 Genetic Reduction of Myd88 Improves the Differentiation of Muscle Derived Stem/progenitor Cells in the Ercc1-/Δ Mouse Model of Accelerated Aging Aiping Lu, Haiying Pan, Jing Zhao, Sara McGowan, Laura Niedernhofer, Paul Robbins, Johnny Huard MONDAY 39

40 MONDAY, MARCH 20, 2017 SESSIONS 9:15 AM 10:15 AM TIME ROOM SESSION 12 Modulating Fracture Healing Room 6A NIRA PRESENTATIONS 13 Cartilage Meniscus and Osteoarthritis Room 6CF Moderators Alessandra Carriero, PhD and Louis Gerstenfeld, PhD Susanna G. Chubinskaya, PhD, and Peter van der Kraan, PhD 9:15 AM Paper No. 64 Local Denervation of Fracture Delays Endochondral Repair Sarah A. Wong, Jaselle M. Perry, Gabriella P. Sugerman, Sarah M. Almubarak, Yotvat Marmor, Kai M. Pu, Theodore Miclau, Ralph S. Marcucio, Sarah M. Knox, Chelsea S. Bahney 9:15 AM Paper No. 70 Meniscal Tissue Engineering by Simultaneously Electrospraying Cells and Electrospinning Nanofibers Jihye Baek, Shawn Grogan, Martin Lotz, Darryl D. D Lima 9:25 AM Paper No. 65 The Selective Serotonin Re-uptake Inhibitor Fluoxetine Directly Inhibits Osteoblast Differentiation and Mineralization During Fracture Healing in Mice Vivian Bradaschia Correa, Anna M. Josephson, Matthew M. Mizrahi, Shane S. Neibart, Chao Liu, Devan Mehta, Oran Kennedy, Alesha B. Castillo, Philipp Leucht 9:22 AM Paper No. 71 Development of a Continuous Dual-Gradient Peptide Scaffold for Directed Osteochondral Spatial Differentiation Jennifer L. Puetzer, Lesley W. Chow, Hélène Autefage, Anu K. Solanki, Molly M. Stevens 9:35 AM Paper No. 66 Selective Inhibition of Endochondral Fracture Healing by External Beam Irradiation: Delayed Acquisition of Biomechanical Strength in a Rat Femur Fracture Model Zilan Lin, Yongren Wu, E. Lex Hanna, Robert Holmes, Raymond Boaz, Daniel McDonald, William Barfield, Kenneth Vanek, Vincent Pellegrini 9:29 AM Paper No. 72 Novel Roles of NOTCH and HES1 Signaling in Cartilage Maintenance and Osteoarthritis Yinshi Ren, Jianquan Chen, Zhaoyang Liu, Anthony Mirando, Matthew Hilton 9:45 AM Paper No. 67 Teriparatide Therapy Improves Critical Defect Healing via Osteogenesis and Inhibition of Mast Cells in a Murine Cranial Window Model Longze Zhang, Jason Kim, Xinping Zhang, Edward M. Schwarz 9:36 AM Paper No. 73 Forkhead Box O Transcription Factors Control Postnatal Articular Cartilage Growth, Maturation and Homeostasis and Expression of Proteoglycan 4 Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Kohei Miyata, Merissa Olmer, Hiroshi Asahara, Martin K. Lotz MONDAY 9:55 AM 10:05 AM Paper No. 68 Platelet Rich Plasma as a Vehicle for Endothelial Progenitor Cell Delivery in Critical Size Bone Defects David J. Ramnaraign, Charles Godbout, Brent D. Bates, Emil H. Schemitsch, Aaron Nauth Paper No. 69 WITHDRAWN 9:43 AM Paper No. 74 Therapeutic Targeting of the SIRT1-Autophagy Pathway Protects Against Injury Induced and Aged-Related Osteoarthritis Pradeep K. Sacitharan, Tonia Vincent, James Edwards 9:50 AM Paper No. 75 SHP2 Regulates Endochondral Ossification by Modulating Osteogenic Differentiation of Hypertrophic Chondrocytes Lijun Wang 9:57 AM Paper No. 76 Chondrocyte Death, Mitochondrial Dysfunction, and Apoptosis Are Mediated by Friction and Local Shear Strain Edward D. Bonnevie, Michelle L. Delco, Lena R Bartell, Naveen Jasty, Itai Cohen, Lisa A. Fortier, Lawrence J. Bonassar 10:04 AM Paper No. 77 Voxel-based Relaxometry Reveals Local Patterns in T1ρ, T2 and R2 R1ρ Longitudinal Progression 12 Months After Acl Reconstruction in Both Injured and Contralateral Knees: A Multicenter Pilot Study Valentina Pedoia, Colin Russell, Xiaojuan Li, Benjamin C. Ma, Matthew Koff, Hollis Potter, Kimberly K. Amrami, Aaron J. Krych, Scott Rodeo, Sharmila Majumdar 40

41 MONDAY, MARCH SESSIONS 9:15 AM 10:15 AM TIME SPOTLIGHT SESSION 14 ACL Repair SESSION 15 Arthroplasty Wear and Osteolysis SESSION 16 Spine Implants ROOM Room 6B Room 5AB Room 7AB Moderators Dianne Little, DVM, PhD and Edward Wojtys, MD Hannah Lundberg, PhD and Edward Purdue, PhD Aaron Fields, PhD and Daisuke Sakai, MD, PhD 9:15 AM Paper No. 81 Correlations Between Macrophage Polarizing Cytokines, Inflammatory Mediators, Osteoclast Activity, and Toll-like Receptors in Tissues Around Aseptically Loosened Hip Implants Eemeli Jämsen, Vesa-Petteri Kouri, Mari Ainola, Stuart B. Goodman, Dan C. Nordström, Kari K. Eklund, Jukka Pajarinen Paper No. 87 Interbody Implant Loading as a Measure of Fusion Maturity Joshua M. Peterson, Carolyn Chlebek, Ashley M. Clough, Alexandra K. Wells, Kathleen E. Batzinger, Darryl J. DiRisio, Joseph C. Glennon, Eric H. Ledet 9:25 AM SPOTLIGHT SPEAKER Martha Murray, MD Bench-to-Bedside for a Tissue Engineered Approach to ACL Repair Paper No. 82 Priming of the NLRP3 Inflammasome by Orthopaedic Wear Particles Depends on Adherent PAMPs and Their Cognate Toll-like Receptors Givenchy Manzano, Brian Fort, George R. Dubyak, Edward M. Greenfield Paper No. 88 Evaluation of a Novel PEEK Titanium Composite (PTC) Interbody Cage in an Ovine Lumbar Interbody Fusion Erik I. Waldorff, Jeremiah Easley, Christian M. Puttlitz, Howard B. Seim, Nianli Zhang, James T. Ryaby, Kirk C. McGilvray 9:35 AM Paper No. 83 Combined vs. Single Drug Treatment (Methotrexate and Anti-TNF or Anti-IL-1r) Was Not More Effective at Mitigating UHMWPE Particle-Induced Inflammatory Osteolysis In Vitro and In Vivo Lauryn Samelko, Kyron McAllister, Joshua Jacobs, Nadim J. Hallab Paper No. 89 Effects of Lowest Instrumented Vertebrae for Spinal Fusion of Idiopathic Scoliosis on Lower Body Kinematics During Gait Karen M. Kruger, Nikhil T. Kurapati, Joseph J. Krzak, Adam Graf, Sahar Hassani, Peter F. Sturm, Kim W. Hammerberg, Purnendu Gupta, Gerald F. Harris 9:45 AM Paper No. 78 Regenerative Capacity and Functional Performance of an Acellular Human Bone- Patellar Tendon-Bone Graft in an Ovine Model of Anterior Cruciate Ligament Repair Jennifer H. Edwards, Anthony Herbert, Hazel L. Fermor, John Kearney, Paul Rooney, John Fisher, Eileen Ingham Paper No. 84 Electrochemically Generated Tribolayer On CoCrMo Metal for Hip Implant Applications: In Vitro Evaluation of Stability tribocorrosion Kinetics) and Biocompatibility Mary Lyvers, Divya Bijukumar, Annebelle Moore, Pamela Saborio, Dmitry Royhman, Markus Wimmer, Kenneth Shull, Mathew Thoppil Mathew Paper No. Effects of Multilevel Facetectomy and Screw Density on Postoperative Changes in Spinal Rod Contour in Thoracic Adolescent Idiopathic Scoliosis Surgery Terufumi Kokabu, Hideki Sudo, Yuichi Abe, Manabu Ito, Norimasa Iwasaki MONDAY 9:55 AM Paper No. 79 The Influence of Ruptured Scar Pattern on Healing Potential of Anterior Cruciate Ligament Remnant Cells Shinsuke Kirizuki, Tomoyuki Matsumoto, Takao Inokuchi, Toshikazu Tanaka, Kyohei Nishida, Daisuke Araki, Koji Takayama, Takehiko Matsushita, Ryosuke Kuroda Paper No. 85 Head Taper Corrosion in Total Hip Arthroplasty Causing Head Bottoming Out and Consecutive Stem Taper Failure Michael M. Morlock, Nicholas E. Bishop, Gerd Huber, Dennis Bünte Paper No. 91 Total Disc Replacement Using Tissueengineered Intervertebral Discs Combined with a Bio-resorbable Stabilization System a Proof of Concept Study in an Ex Vivo Beagle Model Gernot M. Lang, Jorge Mojica Santiago, Rodrigo Navarro-Ramirez, Ibrahim Hussain, Lawrence J. Bonassar, Roger Härtl Weill 10:05 AM Paper No. 80 Stem Cell and Growth Factor Administration in Combination Facilitates Tendon Repair Hua Shen, Richard H Gelberman, Stephen W. Linderman, Rohith Jayaram, Anna D. Dikina, Matthew J. Silva, Shelly Sakiyama-Elbert, Eben Alsberg, Stavros Thomopoulos Paper No. 86 Does Implant Alloy Microstructure Influence Corrosion Modes in THR Modular Junctions? Robin Pourzal, Deborah Hall, Luis F. Simoes, Stephanie McCarthey, Jennifer Wright, Joshua Jacobs, Mathew Mathew, Robert M. Urban Paper No. 92 Stem Cell Seeded Injectable Hydrogels for Intervertebral Disc Regeneration in a Preclinical Animal Model Sarah E. Gullbrand, Thomas Schaer, Justin R. Bendigo, Prateek Agarwal, Zosia Zawacki, George Dodge, Edward Vresilovic, Dawn Elliott, Robert Mauck, Neil R. Malhotra, Lachlan J. Smith 41

42 MONDAY, MARCH SESSIONS 11:15 AM 12:15 PM TIME ROOM SESSION 17 Osteocytes Biology Room 6A SPOTLIGHT SESSION 18 Novel Targets in OA Room 6CF Moderators Donna Pacicca, MD and Deepak Vashishth, PhD Donald Anderson, PhD and Shuiliang Shi, PhD 11:15 AM Paper No. 93 Estrogen Inhibition Downregulates [Ca2+]i Oscillations and Alters Secondary Mediators NO and PGE2 Release During Mechanical Loading in Osteocytes Resulting in Reduced Mechanosensitivity Vishwa Deepak, Pushpalata Kayastha, Laoise M. McNamara 11:25 AM 11:35 AM Paper No. 94 Retention of Osteocytic Structure and Morphology by Sclerostin Antibody in an OVX Rat Model with Concurrent Mechanical Unloading Dongye Zhang, Nancy Rojas, Minyi Hu, Xiaodong Li, Hua Zhu Ke, Yi-Xian Qin Paper No. 95 Altered Bone Formation Response to Mechanical Loading in a Mouse Model of the Progeroid Disorder Gerodermia Osteodysplastica Haisheng Yang, Anne Seliger, Michael Thelen, Wing Lee Chan, Uwe Kornak, Bettina M. Willie SPOTLIGHT SPEAKER Peter Clegg, PhD Systems Approaches in Osteoarthritis: Identifying Novel Diagnostic and Therapeutic Strategies 11:45 AM Paper No. 96 Abnormal Mir-145-5p Expression Impairs Osteocytogenic Differentiation Through Beta-catenin Signaling Pathway in Adolescent Idiopathic Scoliosis Jiajun Zhang, Huan-xiong Chen, Elisa Man-shan Tam, Gene Chi-wai Man, Tsz-ping Lam, Simon K.M. Lee, Bobby K.W. Ng, Jack C.Y. Cheng, Wayne Y.W. Lee Paper No. 99 Treatment Related Changes in Synovial Fluid Proteome in Posttraumatic Osteoarthritis Following ACL Injury Reveals New Potential Biomarkers and Treatment Targets: A Proteomic Analysis of Porcine Knee Synovial Fluid Ata M. Kiapour, Jakob T. Sieker, Benedikt L. Proffen, Braden C. Fleming, Martha M. Murray MONDAY 11:55 AM Paper No. 97 The Effect of Estrogen on Osteocyte Ca2+ Signaling in Response to Mechanical Load In Vivo Karl Lewis, Joyce Louis, Samuel Stephen, David C. Spray, Mia M. Thi, Zeynep Seref-Ferlengez, Robert J. Majeska, Sheldon Weinbaum, Mitchell B. Schaffler 12:05 PM Paper No. 98 Mechanical Stimulation of Bone Marrow Alters Kinase Signaling to Induce Bone Formation in Trabecular Bone Kimberly J. Curtis, Thomas Coughlin, Tyler Kreipke, Joel Boerckel, Glen Niebur Paper No. 100 Metabolomic Profiles of Synovial Fluid from OA and RA Patients Alyssa K. Carlson, Ronald K. June Paper No. 101 Identification of Synovial Expression Patterns that Are Associated With Pain and Progression of Joint Damage in Early Osteoarthritis Arjen B. Blom, Martijn H. Van den Bosch, Hans Cats, Frank Van den Hoogen, Floris P. Lafeber, Wim B. Van den Berg, Peter L. Van Lent, Peter M. van der Kraan 42

43 MONDAY, MARCH SESSIONS 11:15 AM 12:15 PM TIME ROOM NIRA PRESENTATIONS 19 Tendon, Ligament, Muscle and Trauma Room 6B SESSION 20 Hip and Knee Arthroplasty Kinematics and Function Room 5AB Moderators Braden Fleming, PhD and Johnny Huard, PhD Robin Queen, PhD and Ryan Willing, PhD 11:15 AM Paper No. 102 Human Subacromial Bursa Cells Display Superior Engraftment vs. Bone Marrow Stromal Cells in Murine Tendon Repair Felix Dyrna, Leo Pauzenberger, Philip Zakko, Mary Beth McCarthy, David W. Rowe, Augustus Mazzocca, Nathaniel Dyment 11:15 AM Paper No. 110 Anatomical Shaped Tibial Baseplate Reduced Rotational Alignment Compromise in Total Knee Arthroplasty: Clinical Evaluation with Asian Knees Hideki Mizu-uchi, Ken Okazaki, Makoto Nakagawa, Satoshi Hamai, Yukio Akasaki, Koji Murakami, Darryl D Lima, Yasuharu Nakashima 11:22 AM Paper No. 103 Differentiated Tenocytes Revert to a Progenitor-like State in Mice with Targeted Disruption of TGF-beta Type II Receptor Guak-Kim Tan, Anna G. Stabio, Doug R. Keene, Brian A. Pryce, Ronen Schweitzer 11:25 AM Paper No. 111 Intra-operative Characterization of Knee Laxity During Total Knee Arthroplasty Joseph Ewing, Erin Hutter, Rachel Baker, Xueling Pan, Matthew Beal, Jeffery Granger, Andrew Glassman, Robert Siston 11:29 AM Paper No. 104 The Role of NF-kB Signaling in Rotator Cuff Tendinopathy Shivam A. Shah, Yousef Abu-Amer, Stavros Thomopoulos 11:35 AM Paper No. 112 The Anterior Cruciate Ligament Functioning in Bi-Cruciate Retaining Total Knee Arthroplasty Yohei Okada, Atsushi Teramoto, Satoshi Yamakawa, Tetsuya Takagi, Yuzuru Sakakibara, Hiroaki Shoji, Tomoyuki Suzuki, Kota Watanabe, Mineko Fujimiya, Hiromichi Fujie, Toshihiko Yamashita 11:36 AM Paper No. 105 Genetic Inhibition of NF-κB to Improve Mdx Skeletal Muscle Function Xi Yin, Ying Tang, Jian Li, Anna Dzuricky, Chuanqiang Pu, Freddie Fu, Bing Wang 11:45 AM Paper No. 113 Does ACL Retention Affect Muscle Recruitment in Total Knee Replacement? Jacqueline C. Simon, Craig Della Valle, Markus Wimmer 11:43 AM 11:50 AM Paper No. 106 Il17 A & B and Their Respective Receptors Are Regulated by Runx3 During Fracture Healing David N. Paglia, Satoko Matsumura, Joseph Lorenzo, Mark F. Hansen, Hicham Drissi Paper No. 107 Local Application of Microvascular Fragments by Thermoresponsive Hydrogel Impairs Fracture Healing Marcel Orth, Maximilian Altmeyer, Benedikt Braun, Nils Veith, Jörg Holstein, Tim Pohlemann, Matthias Laschke, Michael Menger 11:55 AM Paper No. 114 In Vivo Total Hip Arthroplasty Kinematics During a Range of Dynamic Activities Using Stereo Radiography Casey A. Myers, Kevin B. Shelburne, Peter J. Laz, Wystan Schmidt, Holly Morrison, Charlie Yang, Kirk Kindsfater, Paul Rullkoetter 12:05 PM Paper No. 115 Inter-joint Coordination of Kinematics and Kinetics Before and After Total Hip Arthroplasty Jessica Longworth, Sebastian Chlostra, Kris Dapiton, Kristin Tayag, Kharma Foucher MONDAY 11:57 AM Paper No. 108 Three-times-weekly Administration of Parathyroid Hormone (1-34) Accelerates Bone Healing in a Rat Refractory Fracture Model Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takahiro Niikura, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Ryosuke Kuroda 12:04 PM Paper No. 109 Delivery of β-catenin Agonists via Targeted Nanoparticles to Enhance Fracture Healing Yuchen Wang, Michael P. Baranello, Maureen Newman, Tzong-Jen Sheu, J. Edward Puzas, Danielle S.W. Benoit 43

44 MONDAY, MARCH SESSIONS 11:15 AM 12:15 PM SESSION 21 POSTER TEASER SESSION 1 (continued on next page) Room 7AB Moderators: George R. Dodge, PhD and Kristy Weber, MD Poster Teaser No. 116 Differential Effects of Hydrogels on In Vitro Meniscus Regeneration Gokhan Bahcecioglu, Nesrin Hasirci, Vasif Hasirci, Bahar Bilgen Poster Teaser No. 125 Longitudinal Changes in T1Rho and T2 Signal of Meniscus in ACL-Injured Patients Post ACL Reconstruction Joseph Knox, Valentina Pedoia, Amy Wang, Xiaojuan Li, Benjamin Ma Poster Teaser No. 134 Collagen Pathobiochemistry of Ehlers Danlos Syndrome Type VI Phenocopied in P3h3 and Sc65 Null Mice David M. Hudson, MaryAnn Weis, Jyoti Rai, Kyu Sang Joeng, Brendan Lee, Roy Morello, David Eyre Poster Teaser No. 117 Notch1-antagonistic Aptamer for Chondrogenic Differentiation of Bone Marrow Derived Stromal Cells Mi-Lan Kang, Ji-Eun Kim, Se-Young Jeong, Gun-Il Im Poster Teaser No. 126 A New Factor Promotes Matrix Organization in Tendon Tissue Yang Liu, Jinfang Zhang, Gang Li Poster Teaser No. 135 Foxo Transcription Factors Are Essential for Intervertebral Disc Maturation Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Martin K. Lotz Poster Teaser No. 118 PEO-PPO-PEO Micelles As raav Carriers for Effective Transduction of Human Articular Chondrocytes In Vitro and in a Human Osteochondral Defect Model Ana Rey Rico, Janina Frisch, Jagadeesh Venkatesan, Gertrud Schmitt, Isabel Rial-Hermida, Pablo Taboada, Angel Concheiro, Henning Madry, Carmen Alvarez-Lorenzo, Magali Cucchiarini Poster Teaser No. 127 Molecular Damage to Collagen is a Critical Feature of Mechanical Damage in Tendon Jared L. Zitnay, Yang Li, Zhao Qin, Markus J Buehler, S. Michael Yu, Jeffrey A. Weiss Poster Teaser No. 136 Residual Circumferential Strain in the Intervertebral Disc Annulus Fibrosus Varies with Anatomical Region Sarah E. Duclos, Arthur J. Michalek Poster Teaser No. 119 Enhancer Network for Ihh Transcription in Chondrocytes Akira Yamakawa, Hironori Hojo, Ung-il Chung, Shinsuke Ohba Poster Teaser No. 128 Achiles Tendon Mechanical and Compositional Properties Differ Drastically in Early Healing Between Repaired and Non-repaired Tendons Benjamin R. Freedman, Tyler R. Morris, George W. Fryhofer, Pankti R. Bhatt, Nabeel S. Salka, Daniel C. Farber, Louis Soslowsky Poster Teaser No. 137 Pretreatment with a Gamma-Secretase Inhibitor Prevents Tumor-Like Overgrowth in Human ipsc-derived Transplants for Spinal Cord Injury Toshiki Okubo, Narihito Nagoshi, Jun Kohyama, Go Itakura, Morio Matsumoto, Hideyuki Okano, Masaya Nakamura MONDAY Poster Teaser No. 120 Lgr5-dependent Wnt Signaling Is Essential for Late Stages of Chondrogenic Differentiation Piera Smeriglio, Catherynn Vuong, Nidhi Bhutani Poster Teaser No. 121 Sprifermin Maintains the Local Mechanical Properties of Articular Cartilage During Extended In Vitro Culture Gregory R. Meloni, Alexandra J.E. Farran, Emilie Rabbut, Anne Gigout, Robert L. Mauck, George R. Dodge Poster Teaser No. 129 The Consumption of Plasminogen Following Severe Burn and Its Implications in Muscle Calcification Breanne H.Y. Gibson, Stephanie N. Moore-Lotridge, Gregory D. Hawley, Nicholas A. Mignemi, William K. Oelsner, Jonathan G. Schoenecker Poster Teaser No. 130 Fluid Shear Induces TRPV4 Mediated Calcium Influx Contributing to Osteogenic Responses in MSCs Michele A. Corrigan, Marie-Noelle Labour, Mathieu Riffault, David A. Hoey Poster Teaser No. 138 Scale Up of Disc-Like Angle Ply Structures (DAPS) for Total Disc Replacement in Preclinical Animal Models Sarah E. Gullbrand, Beth G. Ashinsky, Dong Hwa Kim, John T. Martin, Dawn Elliott, Lachlan Smith, Robert Mauck, Harvey Smith Poster Teaser No. 139 Measures of Behavior and Pain-Related Sensitivities at Acute and Chronic Timepoints in a Rodent Model of Intervertebral Disc Degeneration Elizabeth M. Leimer, Matthew G. Gayoso, Liufang Jing, Adam I. Elkhayat, Munish C. Gupta, Lori A. Setton Poster Teaser No. 122 Non-Destructive Spectroscopic Assessment of Articular Cartilage Correlates with Mechanical Properties James P. Karchner, Farzad Yousefi, Kurosh Darvish, Nancy Pleshko Poster Teaser No. 131 Bone Quality Across Different Phases of Pediatric Skeletal Growth Elizabeth A. Zimmermann, Christoph Riedel, Yuriy Chushkin, Eric Schaible, Felix N. Schmidt, Bernd Gludovatz, Eik Vettorazzi, Federico Zontone, Klaus Püschel, Michael Amling, Robert O. Ritchie, Björn Busse Poster Teaser No. 140 Biomechanical and Histologic Comparison of a Novel 3-D Printed Titanium Interbody Cage to Standard PEEK Cages Kirk McGilvray, Howard Seim, Sigurd Berven, Wellington Hsu, Thomas Mroz, John Rhee, Christian Puttlitz, Jeremiah Easley Poster Teaser No. 123 Nbqx, an Ampa-kainate Glutamate Receptor Antagonist, Alleviates Inflammation, Degeneration and Pain Related Behaviour in Two Models of Osteoarthritis Cleo Bonnet, Sophie Gilbert, Anwen Williams, Emma Blain, David Walsh, Deborah Mason Poster Teaser No. 132 Enhanced Bone Formation In Vivo by Pharmacologically Targeted Primary Cilia-mediated Mechanotransduction Milos Spasic, Michael P. Duffy, Christopher R. Jacobs Poster Teaser No. 141 The Effects of Anterior Cruciate Ligament Reconstruction on Tibiofemoral Subchondral Bone Congruency During Dynamic Functional Movement Tom Gale, Kanto Nagai, James Irrgang, Freddie Fu, Scott Tashman, William Anderst Poster Teaser No. 124 MicroRNA-146a Is Necessary and Sufficient to Prevent Osteoarthritis Through Targeting Notch1 In Vivo Yingjie Guan, Qian Chen Poster Teaser No. 133 Glutaminase Acts in Osteoblasts to Regulate Bone Formation Yilin Yu, Everett Knudson, Risigan Logendran, Fanxin Long, Courtney M. Karner Poster Teaser No. 142 Effects of Sex and Injury Mechanism on Anterior-Posterior Knee Laxity in Mice Carina Blaker, Nathan Doran, Christopher Little, Elizabeth Clarke 44

45 MONDAY, MARCH SESSIONS 11:15 AM 12:15 PM SESSION 21 POSTER TEASER SESSION 1 (continued from prior page) Room 7AB Moderators: George R. Dodge, PhD and Kristy Weber, MD Poster Teaser No. 143 Knee Kinematics in Bi-Cruciate Stabilized Total Knee Arthroplasty During Weight-Bearing Activities Koji Murakami, Satoshi Hamai, Ken Okazaki, Yefeng Wang, Hidehiko Higaki, Hideki Mizu-uchi, Yukio Akasaki, Umito Kuwashima, Yasuharu Nakashima, Yasuharu Nakashima Poster Teaser No. 152 Inhibition of PDGFR Signaling Prevents Muscular Fatty Infiltration After Rotator Cuff Tear in Mice Hideyuki Shirasawa Poster Teaser No. 144 Risk Factors for Residual Anterolateral Rotational Instability After Anterior Cruciate Ligament Reconstruction: Evaluation by Quantitative Assessment of the Pivot Shift Phenomenon Using Triaxial Accelerometer Mai Katakura, Hideyuki Koga, Kaori Nakamura, Ichiro Sekiya, Toshifumi Watanabe, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Toshiyuki Ohara, Takeshi Muneta Poster Teaser No. 145 EEvaluation of the Sclerotic Subchondral Bone Boundary as a Surgical Resection Guide in the Treatment of Cam-type Femoroacetabular Impingement Penny Atkins, Stephen Aoki, Shireen Elhabian, Praful Agrawal, Ross Whitaker, Jeffrey Weiss, Christopher Peters, Andrew Anderson Poster Teaser No. 153 Regional Variation in Bone Density And Volume Fraction in the Proximal Humerus Jacob M. Reeves, George S. Athwal, James A. Johnson Poster Teaser No. 154 Scaphoid and Lunate Kinematics Following Sequential Sectioning of the Scapholunate Ligament and Secondary Stabilizers Helen Stoesser, Clare Padmore, G. Daniel G Langohr, Nina Suh, James Johnson, Graham King Poster Teaser No. 146 Adipose Tissue Derived Mesenchimal Stem Cell Therapy for the Treatment of Chondral Lesions in the Hip A 2 Year Follow-up Comparison Study with Microfractures Andrea Fontana Poster Teaser No. 155 Transplantation of Achilles Allograft in Rats: With or Without Incorporation of Autologous Mesenchymal Stem Cells Zijun Zhang, Michael Aynardi, Talal Zahoor, Reed Mitchell, Lew Schon Poster Teaser No. 147 Similarities Between Reported Inflammatory Cell Induced Corrosion Features and Electrocautery Damage Patrick Aldinger, Chenxi Li, Vivek Pawar Poster Teaser No. 148 Neurotoxic Effect of CoCr Wear Particles Generated from Hip Simulator Using Induced Pluripotent Stem Cells (ipsc) Derived Neurons: Initial Outcomes Divya R. Bijukumar, Poojitha Vellore Jaysukumar, Chong Chong Xu, Xue-Jun Li, Ramaswamy Kalyanasundaram, Mathew Thoppil Mathew Poster Teaser No. 149 Differential Proteomic Analysis of Hip Synovial Fluid from Patients with a Pseudotumor vs. Periprosthetic Osteolysis Isabelle Catelas, Eric A. Lehoux, Zhibin Ning, Daniel Figeys, Stephen J. Baskey, Paul E. Beaulé Poster Teaser No. 156 Quantifying Staphylococcus Aureus Motility Through Submicron Pores via an In Vitro Nanoporous Transwell System that Mimics Canaliculi Colonization Karen De Mesy Bentley, Mark Ninomiya, Kohei Nishitani, John Daiss, Stephen L. Kates, Hung Li Chung, James L. McGrath, Edward M. Schwarz Poster Teaser No. 157 Chyluria as an Early Predictor for Fat Embolism in Fracture Patients Yun Che Wu, Chih Hui Chen Poster Teaser No. 158 Effect of Mental Health Conditions on Complicaitons, Revision and Readmission Rates Following Tibial Shaft Fracture Brock Foster, Zorica Buser, Anthony D Oro, Jeffrey C. Wang, Geoffrey S. Marecek MONDAY Poster Teaser No. 150 Phospholipid Polymer Grafted and Vitamin E Blended Cross-linked Polyethylene Brought High Resistance for Wear and Oxidation Under Controlled Load Bearing Conditions Masayuki Kyomoto, Toru Moro, Shihori Yamane, Kenichi Saiga, Kenichi Watanabe, Sakae Tanaka, Kazuhiko Ishihara Poster Teaser No. 151 Il-1β Production in Response to Wear Particles Depends on Lysosome Destabilization but Not on Extracellular ATP Brian Fort, Givenchy Manzano, Matthew Hoffa, George Dubyak, Edward Greenfield Poster Teaser No. 159 Shear Wave Velocity Measurement of Upper Trapezius Muscle by Color Doppler Shear Wave Imaging Atsushi Yamamoto, Yoshiki Yamakoshi, Takashi Ohsawa, Hitoshi Shitara, Tsuyoshi Ichinose, Hiroyuki Shiozawa, Tsuyoshi Sasaki, Noritaka Hamano, Yasushi Yuminaka, Haku Iizuka, Kenji Takagishi Poster Teaser No. 160 Clinicopathologic Features and Outcomes of CIC- and BCOR-rearranged Sarcomas Makoto Endo, Masato Sugawara, Akihiko Yoshida, Eisuke Kobayashi, Shuichi Toki, Takeshi Hirose, Takenori Uehara, Tomoaki Mori, Koki Shimizu, Yoshikazu Tanzawa, Fumihiko Nakatani, Hirokazu Chuman, Akira Kawai 45

46 MONDAY, MARCH SESSIONS 2:15 PM 3:15 PM TIME SPOTLIGHT SESSION 22 Ligament and Tendon Engineering SESSION 23 Cartilage Matrix Proteins SESSION 24 Infection and Inflammation SESSION 25 Hip and Knee Arthroplasty Clinical Outcomes SESSION 26 Spine: Imaging Mechanics and Kinematics ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Jason Shearn, PhD and James H. Wang, PhD Russell Fernandes, PhD and Nancy Pleshko, PhD Thomas Bauer, MD, PhD and Noreen Hickok, PhD Stuart B. Goodman, MD, PhD and Robin Pourzal, PhD Grace O Connell, PhD and Benjamin Walter, PhD 2:15 PM Paper No. 164 Type III Collagen Is Critical to the Proper Functioning of Knee Cartilage and Meniscus Chao Wang, Becky K. Brisson, Qing Li, Kevt her Hoxha, Motomi Enomoto-Iwamoto, Susan W. Volk, Lin Han Paper No. 170 Vancomcyin-Loaded Polymethylmethacrylate Spacers Fail to Eradicate Periprosthetic Joint Infection in an Innovative, Clinically-Representative Mouse Model of PJI Treatment Alberto V. Carli, Samrath Bhimani, Xu Yang, Karen L. de Mesy Bentley, F. Patrick Ross, Mathias P.G. Bostrom Paper No. 176 Direct Anterior Approach for Total Hip Arthroplasty Results in Quicker Functional Recovery Compared to the Mini-Posterior Approach Kenton Kaufman, Michael Taunton, Robert Trousdale, Rafael Sierra, Mark Pagnano Paper No. 182 Fractal Analysis of Rabbit Vertebral Endplate Canal Network Kazuaki Iida, Taka Iida, Yasuhiro Nishigaki, Tomonori Yamaguchi, Alejandro A. Espinoza Orias, Nozomu Inoue 2:25 PM SPOTLIGHT SPEAKER Helen Lu, PhD Soft Tissue to Bone Integration via Interface Tissue Engineering Paper No. 165 Direct Investigation of the Roles of Decorin in Cartilage Pericellular Matrix via Immunofluorescence-guided AFM Daphney R. Chery, Samuel J. Rozans, Biao Han, Ling Qin, David E. Birk, Renato V. Iozzo, Motomi Enomoto-Iwamoto, Lin Han Paper No. 171 Bacterial Aggregation in Equine Synovial Fluid Shows Morphological Similarities to Biofilm and Increase Antimicrobial Recalcitrance In Vitro Jessica Gilbertie, Thomas P. Schaer Paper No. 177 Heterotopic Ossification After the Direct Anterior Approach Total Hip Arthroplasty Eric Cohen, Scott Ritterman, John Tuttle, Daniel Eisenson, Valentin Antoci, Lee Rubin Paper No. 183 Diagnostic Accuracy of Zero Echo Time Magnetic Resonance Imaging for Cervical Spine Neuroforaminal Stenosis Darryl B. Sneag, Parina H. Shah, Ryan E. Breighner, Matthew F. Koff MONDAY 2:35 PM 2:45 PM Paper No. 161 The Fibre-Level Load Response and Composition of the Rabbit Medial Collateral Ligament Femoral Enthesis Johnathan Sevick, Ziad Abusara, Omokhowa Agbojo, Stephen Andrews, Nigel Shrive Paper No. 166 Emerging Role of Periostin in Extracellular Matrix Synthesis and Degradation in Human Articular Chondrocytes Nobuaki Chinzei, Linda J. Sandell, Duan Xin, Robert H. Brophy, Muhammad F. Rai Paper No. 167 Tracking In Vitro Cartilage Degeneration and Biosynthesis Based on Bioorthogonal Chemistry Shongshan Fan, Yilu Zhou, Mengxi Lv, X. Lucas Lu Paper No. 172 S. Aureus Adaptation to the Hypercoagulable State of the Obese, Type 2 Diabetic Host Increases Virulence and Persistence in Orthopaedic Infection Christopher Farnsworth, Eric Schott, Edward Schwarz, Michael Zuscik, Robert Mooney Paper No. 173 Drug Delivery System of Antibiotics by Phosphorylated Pullulan for Staphylococcus Osteomyelitis Noriyuki Watanabe, Aki Yoshida, Toshifumi Ozaki Paper No. 178 Total Joint Arthroplasty in HIV Patients: Predictive Factors Jeffrey J. Olson, Youssra Marjoua, Victor Novack, Douglas K. Ayres, Ayesha Abdeen Paper No. 179 Matched Cohort Analysis of Total Knee Arthroplasty in Patients with and Without Parkinson s Disease: Complications, Mortality, Length of Stay, and Hospital Charges Justin E. Kleiner, Adam Eltorai, Lee E. Rubin, Alan H. Daniels Paper No. 184 Nondestructive Assessment of the Biomechanical Properties of the Intervertebral Disc Using Both Cationic and Anionic Contrast-Enhanced µct Michael D. Newton, Samantha E. Hartner, Karissa Gawronski, Erik Davenport, Shannon Timmons, Kevin C. Baker, Tristan Maerz Paper No. 185 Lumbar Spine Postures in Marines During Simulated Operational Positions David B. Berry, Ana E. Rodriguez-Soto, Sara Gombatto, Bahar Shahidi, Christine Chung, Samuel R. Ward 2:55 PM Paper No. 162 Engineering Fibrocartilaginous Matrix Gradient Interfaces for Rotator Cuff Repair/Regeneration Solaiman Tarafder, Richard H. Clough, John A. Brito, Abrar A. Nadroo, Chang H. Lee Paper No. 168 Tough to Crack: The Superficial Layer of Articular Cartilage Resists Crack Initiation Lena R. Bartell, Monica C. Xu, Lawrence J Bonassar, Itai Cohen Paper No. 174 Is IL-1 Signaling Essential for Promoting TH17-cell Induced Metal-Hypersensitivity Immune Responses? Lauryn Samelko, Marco Caicedo, Kyron McAllister, Joshua J. Jacobs, Nadim J. Hallab Paper No. 180 Spinopelvic Alignment and Low Back Pain (LBP) Before and After Total Knee Arthroplasty (TKA) Atsushi Kitagawa, Jyunya Yamamoto, Mitsunori Toda, Tstsuhiro Iguchi Paper No. 186 MRI-based Measurements of Acidic ph in Intervertebral Discs Correlate with Pain Markers in a Minipig Model of Disc Degeneration Wafa Tawackoli, Maxim Bez, Zhengwei Zhou, Dmitriy Sheyn, Joseph C Giaconi, Zulma Gazit, Gadi Pelled, Debiao Li, Dan Gazit 3:05 PM Paper No. 163 Capturing Endogenous Growth Factors Through Synthetic Peptides to Enhance Healing of Tendons and Ligaments João Crispim, Hugo Fernandes, Angel Lee, Bruma Fu, Pascal Jonkheijm, Daniel Säris Paper No. 169 Recombinant Human Proteoglycan 4 Modulates Expression of Pro-inflammatory Cytokines and Matrix Degrading Enzymes in Unstimulated and Interleukin-1 Stimulated Osteoarthritic Fibroblast-like Synoviocytes Ali Alquraini, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid Paper No. 175 Chimera Decoy Oligodeoxynucleotide Attenuates Inflammatory Response in Cultured Rabbit Articular Cartilage Kenji Kato, Shingo Miyazaki, Mary E. Lenz, Jun Mizutani, Makoto Sakaguchi, Takahiro Nakazawa, Koichi Masuda Paper No. 181 Analysis of Outcomes Following TKA: Do All Databases Produce Similar Findings? Nicholas Bedard, Andrew Pugely, Michael McHugh, Nathan Lux, Jesse Otero, Kevin Bozic, Yubo Gao, John Callaghan Paper No. 187 Longitudinal Changes in Midrange Cervical Spine Kinematics After Anterior Cervical Arthrodesis William Anderst, Tyler West, William Donaldson, Joon Lee, James Kang 46

47 TUESDAY MEETING HIGHLIGHTS 7:00 AM 6:00 PM Registration Open City-Side Corridor 7:00 AM 7:45 AM ORS Business Meeting Room 7AB 8:00 AM 9:30 AM PROFESSIONAL ADVANCEMENT SESSIONS: Negotiating for Success Room 2 Commercializing Your Idea: What You Need to Know Room 7AB WORKSHOPS: Driving Vascularization: The Key to Bone Repair Room 6A Functional Properties of Chondrocytes in Articular Cartilage Using Optical Imaging to Scanning Probe Microscopy Room 6CF Drug Resistance: New Challenges and Opportunities in Biomaterials-Associated Orthopaedic Infection Room 6B PRP Enigma Biology and Clinical Use Room 5AB 9:00 AM 11:30 AM Innovation Central Open Sails Pavilion 10:00 AM 10:30 AM Innovation Theater: AMTI Sails Pavilion Innovation Theater 10:30 AM 11:30 AM SESSIONS: Bone OA and Microbiome Room 6CF Tendon and Ligament Biology Room 6B Hip Reconstruction Room 5AB Spine Pathogenesis and Therapeutics Room 7AB SPOTLIGHT SESSION: Fracture Healing Room 6A 11:45 AM 12:45 PM Biomaterials, Biomechanics and Bio-Imaging in Orthopaedics Research Interest Group Room 7AB 11:45 AM 1:15 PM PROFESSIONAL ADVANCEMENT SESSION: Understanding the NIH Opportunities and Collaboration Room 3 Job Connect Room 8 1:30 PM 2:30 PM SESSIONS: Bone Matrix Room 6A OA Pathogenesis and Molecular Targets Room 6CF Knee Ligament and Mechanics Room 5AB Disc Biology and Engineering Room 7AB SPOTLIGHT SESSION: Stem Cells and Bone Repair Room 6B 2:00 PM 5:00 PM Innovation Central Open Sails Pavilion 2:45 PM 3:45 PM SESSIONS: Bone Therapeutics Room 6A Mechanotransduction Room 6CF Biomaterials and Tissue Regeneration Room 6B Knee Kinematics and Computational Modeling Room 5AB SPOTLIGHT SESSION: Disc Repair Room 7AB 4:00 PM 4:30 PM Scanco MicroCT Techniques Workshop Sails Pavilion Innovation Theater 4:45 PM 5:45 PM ORS Debate: Will Regenerative Medicine Make Orthopaedic Implants Obsolete in Our Time? Room 6CF 6:00 PM 8:00 PM Networking Event for Early Career Investigators Connecting for Collaboration West Terrace TUESDAY 47

48 TUESDAY PROGRAM DETAIL TUESDAY 8:00 AM 9:30 AM Negotiating for Success Room 2 Organized by the ORS New Investigator Mentoring Committee and ORS Women s Leadership Forum Organizers: Devina Purmessur, PhD, Ohio State University and Robin M. Queen, PhD, Virginia Tech Negotiation is a crucial skill for professional success; however academic training does not typically prepare us to negotiate successfully. Negotiation can be regarded as an interactive communication process that has significant impact on career development and advancement. Many scientists believe they are unable to negotiate their position, and as a result, they do not negotiate to improve their professional circumstances. This program will focus on useful techniques and strategies for negotiating in the workplace based on ORS members own experiences and will include an introduction, short talks and negotiation-based exercises to model negotiating strategies. Introduction to Negotiating and Negotiating in Academics: New Faculty Hire/Promotion and Tenure Marjolein C.H. van der Meulen, PhD Negotiating in Industry Gloria Matthews, DVM, PhD, Histogenics Corporation 8:00 AM 9:30 AM Commercializing your Idea: What You Need to Know Room 7AB Organized by the ORS Industry Engagement Committee and ORS Women s Leadership Forum Organizers: Michael Ominsky, PhD, Radius Health, Inc.; Sally LiArno, PhD, Stryker Orthopedics; Robin M. Queen, PhD, Virginia Tech; Jennifer Woodell-May, PhD, Zimmer Biomet You are developing a novel new orthopaedic technology; the science is solid, but is the business? As researchers and engineers we aim to innovate and develop new products to help improve patients lives. Achieving this requires a product that is technologically robust but also requires the PI to have an understanding of how to commercialize their idea. It is useful to have an understanding of the latter early on in the development process to ensure the product is meeting market needs. In this session participants will better understand the process through the review of three important facets of commercializing your idea: 1) Obtaining Intellectual Property for your orthopaedic technology 2) Creating a start-up company 3) Collaborating with industry Obtaining Intellectual Property for Your Orthopaedic Technology: What Patents, Trademarks and Copyrights Can Do For You Eric Hanscom, Hanscom, Alexeev Neil Thompson, McDaniel LLP Have You Got What it Takes to Start a Business? The Nitty Gritty of Being an Entrepreneur in Orthopaedics Suzanne Maher, PhD, Hospital for Special Surgery Industry Funded Research in an Academic Environment Paul Rullkoetter, PhD, University of Denver CME is not available for this session. 48

49 TUESDAY PROGRAM DETAIL 8:00 AM 9:30 AM WORKSHOP Driving Vascularization: The Key to Bone Repair Room 6A Organized by the ORS Women s Leadership Forum Organizer: Sophie Verrier, PhD, AO Foundation Bone repair is a complex mechanism that involves many wellorchestrated events. It is widely accepted that blood vessels and blood flow brings oxygen and nutrients, but cells and specific molecular factors are also crucial in this process. Impaired vascularization often occurs following trauma as well as or in specific health conditions (e.g. diabetes), can compromise the course of bone repair leading to delayed healing, mal union or non-union which results in an increase in patient burden and related healthcare costs. Ensuring an adequate blood supply for bone healing still constitutes a clinical challenge and is therefore a clinical therapeutic target. This workshop will first give insight into the clinical problems associated with poor or no vascularization, and the current clinical methods used to improve vascularization. In addition, this workshop will facilitate an exchange of knowledge and stimulate discussion between renowned keynote speakers, scientists and clinicians at all career levels with an interest in bone healing. Vascularization and Bone Healing: Limits and Solutions From a Clinician Perspective Theodore Miclau, MD, Orthopaedic Trauma Institute Cellular Key Players in Angiogenesis The Tissue Engineering Approach Sabine Fuchs, PhD, University Schleswig-Holstein Is VEGF the Key Factor for Bone Healing and Regeneration? (Regenerative Approach) Louis C. Gerstenfeld, PhD, Boston University 8:00 AM 9:30 AM New Horizon Workshop: Functional Properties of Chondrocytes in Articular Cartilage using Optical Imaging to Scanning Probe Microscopy Room 6CF Organizers: Yang Xia, PhD, Oakland University and Eric Darling, PhD, Brown University Chondrocytes and their pericellular matrix (PCM) in articular cartilage are organized as chondrons, which are responsible for the maintenance of the extracellular matrix (ECM) of cartilage over its lifetime. Chondrocytes in their native environment receive constant loading externally, which plays a critical role in regulating their metabolic activities. The functional (biomechanical) properties of the chondrons can be studied by the application of external loading, either to a whole-thickness tissue or to isolated chondrons. Understanding the deformation of chondrons and their ECM, both collectively and individually, will improve our understanding regarding how external force is transmitted via these matrices to the cells, and how these matrices protect the cells during loading. Commonly, optical microscopies and other advanced techniques such as scanning probe microscopy are used in such investigation. This workshop aims to summarize the new development in the technology and latest results in the functional properties of the chondrocytes in cartilage, and to discuss possible applications based on the recent studies. Three presentations are planned, ranging from the functional studies of chondrons that are in situ in their native ECM by optical imaging without staining, probing of the chondrons and chondrocytes directly by micropipette and atomic force microscopy, to measuring dynamic cell deformations and cell signaling in intact joints loaded by muscular contraction using two-photon excitation microscopy. Functional Imaging of Chondrocytes in Cartilage by Light Microscopies Yang Xia, PhD, Oakland University Physical Probing of Chondrocytes and Their Peri- and Extra-Cellular Matrices Eric Darling, PhD, Brown University Dynamic In Situ and In Vivo Chondrocyte Mechanics and Signaling Walter Herzog, PhD, University of Calgary TUESDAY 49

50 TUESDAY PROGRAM DETAIL TUESDAY 8:00 AM 9:30 AM New Horizon Workshop: Drug Resistance: New Challenges and Opportunities in Biomaterials-associated Orthopaedic Infection Room 6B Organizers: Bingyun Li, PhD, West Virginia University and Thomas Webster, PhD, Northeastern University The dramatically increased incidence of drug-resistant bacterial strains has made the choices of drugs for infection treatment and control increasingly limited and more expensive. Modern medical procedures, including orthopaedic implantations, likely would be accompanied by a much greater risk of developing a difficultto-treat or untreatable antibiotic resistant infection. Controlling the development and spread of antibiotic resistance is a top national security and public health priority in the US. Funding agencies have been calling for efforts to stimulate innovative research to reduce drug resistance. This workshop will highlight the drug discovery and mechanisms of antimicrobial resistance, cutting-edge immunotherapeutic approaches, clinical translational potential, and the challenges and opportunities in nanomedicine in reducing biomaterial-associated orthopaedic infection. Emerging Immunotherapeutic Approaches Against Biomaterial-Associated Infection Bingyun Li, PhD, West Virginia University Nanotechnology in Drug-Resistant Biomaterials Infection: Past, Present, and Future Thomas Webster, PhD, Northeastern University Pathogenesis of Drug-Resistant Bacteria Dacheng Ren, PhD, Syracuse University Drug Discovery and Antibiotic Resistance: Challenges and Opportunities Stuart B. Goodman, MD, Stanford University Medical Center 8:00 AM 9:30 AM New Horizon Workshop: PRP Enigma: Biology and Clinical Use Room 5AB Organizers: Scott Rodeo, MD, Hospital for Special Surgery and Jeremy Mao, PhD, Columbia University In musculoskeletal medicine, Platelet-Rich Plasma (PRP) is used as interventional treatments for arthritis (intra-articular injections), rotator cuff repair, focal articular cartilage defects, carpal tunnel syndrome, fracture repair, acute muscle injuries and intervertebral disk degeneration. In this workshop, several therapeutic examples will be provided. Current Status of PRP Use in Sports Medicine Scott Rodeo, MD, Hospital for Special Surgery Precision Assessment of PRP for the Treatment of Early Osteoarthritis Constance Chu, MD, Stanford University PRP Proteomics: The Whole and the Sum of Parts Jeremy Mao, PhD, Columbia University 10:00 AM PM 10:30 AM Innovation Theater: AMTI Sails Pavilion Innovation Theater Synergistic Soft Tissue: Knee Modeling with Empirical Verification AMTI s VIVO joint motion simulator and VivoSim software offer a multi-fiber ligament model that can replicate the 6-DOF force behavior of the knee much more accurately than previous approaches. SCORE has leveraged the VIVO s unique motion and recording capabilities to measure ligament forces in-situ, and developed a virtual ligament model to reproduce normal knee kinematics. We have used this model in VivoSim to optimize placement of an implant, an application with direct surgical relevance. 50

51 TUESDAY PROGRAM DETAIL 11:45 AM 12:45 PM Biomaterials, Biomechanics and Bio-Imaging in Orthopaedics RIG Room 7AB This will be the inaugural meeting of the Biomaterials, Biomechanics and Osseointegration RIG. Anyone with interest in orthopaedic biomaterials, biomechanics, osseointegration, musculoskeletal diseases, rehabilitation, and bioengineering is welcome to attend. This RIG aims to develop and strengthen collaborative research, to support young investigators, to establish international networks, and to engage clinicians, scientists and industry experts. The theme for this year s RIG is Approaches to Multiscale Integration: Science and Clinic. Our invited speakers will include researchers and clinicians in biomaterials/bioengineering, bioimaging, biomechanics, biology, representing medical practice, academics, government, and industry. 11:45 AM 1:15 PM Understanding the NIH Opportunities and Collaboration Room 3 Organized by the ORS New Investigator Mentoring Committee Join us for a casual luncheon and take advantage of this opportunity to meet with representatives from the National Institutes of Health. This will be an excellent opportunity to find out about NIH grant opportunities, ask questions, and participate in small group discussion. Limited availability Pre-registration is required. Fee: $25.00 per person, includes lunch 11:45 AM 1:15 PM ORS Job Connect Room 8 Organized by the New Investigator Mentoring Committee Organizers: X. Lucas Lu, University of Delaware and Hicham Drissi, University of Connecticut This session provides a platform for potential employers to meet job seekers. The employers will be invited from academia (PI or department head with postdoc or junior faculty position) as well as from industry to interface with job seekers of both postdoctoral fellowships and graduate students. We will implement a speed dating format in which the potential employers introduce themselves and the nature of position they have. Following that, each job seeker will introduce themselves, their education, their research and what they are looking for. Employers will change tables once. The event will be finished with a free social time. 4:00 PM 4:30 PM ORS Techniques Workshop: Novel Applications of MicroCT in Orthopaedic Research Sails Pavilion Innovation Theater Organized by the ORS Strategic Initiatives Committee In vivo MicroCT Imaging of Bone Dynamics and Vascular Characteristics X. Sherry Liu, PhD, McKay Orthopaedic Research Laboratory Department of Orthopaedic Surgery, University of Pennsylvania Multi-Scale mct Imaging of Cartilage Characteristics and Regeneration George R. Dodge, PhD, Translational Musculoskeletal Research Center, Philadelphia Crescenz Veterans Administration Medical Center, Department of Orthopaedic Surgery, University of Pennsylvania Equipment for the Techniques Workshop provided by Scanco Medical ( Switzerland. TUESDAY 51

52 TUESDAY PROGRAM DETAIL 4:45 PM 5:45 PM ORS Debate: Will Regenerative Medicine Make Orthopaedic Implants Obsolete in Our Time? Room 6CF The ORS Program Committee invites you to participate in our first Annual Meeting Debate. ORS Past President Brian Johnstone will propose the motion that advances in tissue engineering are on the horizon to replace our dependence on artificial implants in orthopaedic clinical care. AAOS and ORS Past President Joshua Jacobs will argue that dependence on prosthetic implants will remain for the foreseeable future. ORS Past President Linda Sandell will manage proceedings, and the session will involve strong audience participation, including questions from the floor and key audience votes before and after the debaters have each made their case. Come along and get involved in the ORS Great Debate! Moderator: Linda Sandell, PhD, Washington School of Medicine, Department of Orthopaedics Arguing For the Motion: Brian Johnstone, PhD, Oregon Health & Science University Arguing Against the Motion: Joshua J. Jacobs, MD, Rush University Medical Center TUESDAY Why did I accept the challenge of arguing for the proposition? It s quite simple. Amara s law states that we tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run. A perfect example of this is the Human Genome Project. In the short run, we overestimated what it was going to accomplish we would read the code and solve the challenges of complex diseases quickly that didn t happen. However, we are now underestimating its long-term effect the control of, and even creation of stem cells, the design of effective gene therapy, and the amazing development of CRISPR gene editing are all happening because we gained the ability to read, write and edit the genetic code. I make the same case for regenerative medicine we have been busy overestimating the field in the short run, with claims made that we have not been able to fulfill. The effect of the overestimation is to convince those comfortable with the status quo that they have nothing to worry about. The reality is that orthopaedic surgeons, and the orthopaedic industry, had better become smarter biologists soon, because we are underestimating the myriad of things that regenerative medicine will do in the long run. Advancements in developmental biology have raised hopes that orthopaedic implants, specifically joint replacement components, fabricated from engineering materials will be added to the heap of discarded and anachronistic medical devices. Yet despite over 20 years of research and development, a viable long-term solution to simple isolated cartilage defects, much less endstage osteoarthritis, has yet to emerge. Our understanding of the complex ontogeny of musculoskeletal tissues is incomplete and our tools for manipulation of this multifaceted ontogeny are in their infancy. Metal, polymer and ceramic solutions for musculoskeletal diseases are here to stay at least for our lifetimes. 52

53 TUESDAY PROGRAM DETAIL 6:00 PM 8:00 PM Connecting for Collaboration: A Networking Event for Early Career Investigators West Terrace ORS is holding an exclusive Early Career Investigators networking event. Keep the fun going at an after-party exclusively for ORS Associate Members, Resident, Fellow, Student and PhD Candidate attendees. This is a great opportunity to meet ORS members, engage in conversation and learn about how you can become involved in the ORS community. Fee: $25.00 non-members TUESDAY 53

54 TUESDAY, MARCH SESSIONS 10:30 AM 11:30 AM TIME SPOTLIGHT SESSION 27 Fracture Healing SESSION 28 Bone OA and Microbiome SESSION 29 Tendon and Ligament Biology SESSION 30 Hip Reconstruction SESSION 31 Spine Pathogenesis and Therapeutics ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Michael Hast, PhD and Edward Schwarz, PhD Ron June, PhD and Stephen B. Trippel, MD Jenna Galloway, PhD and Hua Shen, PhD Michael Harris, PhD and Mario Lamontagne, PhD Nadeen Chahine, PhD and Stephen Richardson, PhD 10:30 AM Paper No. 191 An In Vivo Model of Load Induced Bone Marrow Lesions Jonathan B. Matheny, Matthew G. Goff, Sarah L. Pownder, Matthew F. Koff, Kei Hayashi, Marjolein C.H. van der Meulen, Christopher J. Hernandez Paper No. 197 Scleraxis is Essential for Tenocyte Recruitment to Enable Tendon Growth Deepanwita Pal, Alice Huang, Lingyan Wang, John Brigande, Ronen Schweitzer Paper No. 203 Early Migration of Cementless Highly Porous Tantalum Compared to Titanium Fibre Acetabular Components: A Randomised Controlled Trial Donald W. Howie, Oksana Holubowycz, Stuart Adam Callary, Thomas S. Robertson, Lucian Bogdan Solomon Paper No. 209 Curcumin Alleviates Radiculopathy via Suppressing Neuroinflammation and Reactive Oxygen Species Li Xiao, Mengmeng Ding, Andrew Fernandez, Li Jin, Xudong Li 10:40 AM SPOTLIGHT SPEAKER Regis O Keefe, MD, PhD Improving Fracture Healing by Targeting Key Processes During Bone Regeneration Paper No. 192 Age- and Sex-Related Characteristics of Bone Cysts in Hip Osteoarthritis Young Guang, Kyle Lybrand, Jordan Desautels, Kathryn Gikas, Amelia Wise, Brian Silvia, Louis Gerstenfeld, Elise Morgan Paper No. 198 Tendon Cell Remodeling is Regulated by Paracrine Signaling of Macrophages, Depending on Their Polarized State and is Further Modulated by the Extracellular Matrix Niche Angelina D. Schoenenberger, Jasper Foolen, Unai Silvan, Jess G. Snedeker Paper No. 204 Augmentation of Revision Implant Fixation with Combination of Allograft, BMP-2 and Local or Systemic Bisphosphonate Rasmus Cleemann, Mette Soerensen, Joan E. Bechtold, Kjeld Soballe, Jorgen Baas Paper No. 210 Epigenome Editing of Nociceptive Neurons Abolishes Degenerative IVD Induced Sensitization Joshua D. Stover, Niloofar Farhang, Brandon Lawrence, Robby D. Bowles 10:50 AM Paper No. 193 Subchondral Osteocyte Apoptosis and Bone Remodeling in a Model of Post Traumatic Osteoarthritis Thomas R. Coughlin, Anthony Scarallo, Matin Lendhey, YouJin Lee, Jessica Lavery, Oran D. Kennedy Paper No. 199 Co-culture of Fibroblasts and Macrophages Results in Early Pro-fibrotic Activation Danielle R. Bogdanowicz, Claire E. Segar, William N. Levine, Edward A. Botchwey, Helen H. Lu Paper No. 205 Bone Architecture is a Marker of Successful Cancellous Osseointegration in Compromised Murine Bone Arvinth Sethuraman, Xu Yang, Benjamin F. Ricciardi, Aleksey Dvorzhinskiy, Yuo-yu Lee, Joseph E. Koressel, Joseph Choi, Zachary Lane, Kevin Nishida, Matthew B. Shirley, Zhiwei Wang, Caroline Brial, Amanda Wach, Marjolein C.H. van der Meulen, Mathias P.G. Bostrom Paper No. 211 Blockade of Osteoclast-Mediated Bone Resorption with a RANKL Inhibitor Enhances Spinal Fusion Karin A. Payne, Michelle Sauque, Nichole Shaw, Christopher Erickson, Peter Yarger, Todd Baldini, Christopher J. Kleck, Vikas Patel, Evalina Burger TUESDAY 11:00 AM 11:10 AM Paper No. 188 A Sox9 Positive Cell Population in the Periosteum Contributes to Adult Long Bone Fracture Repair Sofia Bougioukli, Xinjun He, Brandon Ortega, Eric Arevalo, Jay Lieberman, Andrew McMahon Paper No. 189 The Fate of the Chondrocyte During Bone Fracture Healing: Rebirth of the Stem Cell Compartment Ralph Marcucio, Chelsea S. Bahney, Theodore Miclau, Frank Yang, Diane Hu Zuckerberg Paper No. 194 Prebiotic Manipulation of the Gut Microbiome Confers Protection Against Osteoarthritis in Obese, Type 2 Diabetic Mice Eric Schott, Christopher Farnsworth, Sarah Soniwala, Madison Doolittle, Jun Zhang, Alex Grier, Steven Gill, Robert Mooney, Michael Zuscik Paper No. 195 Enrichment of Endogenous Omega-3 Fatty Acids In Fat-1 Transgenic Mice Attenuates Post-traumatic Arthritis Kelly A. Kimmerling, Chia-Lung Wu, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Farshid Guilak Paper No. 200 The Role of Innate and Adaptive Immunity in Regenerative and Non-regenerative Tendon Healing Kristen Howell, Alice H. Huang Paper No. 201 Extracellular Vesicles Derived from Reprogrammed Mscs Promote Tenogenesis and Mitigate Tendinopathy Zhiyong He, Daniel J. Leong, Teresa Doerre, Zhuo Zhang, Lidi Liu, David Gonzalez, Konrad I. Gruson, Hui B. Sun Paper No. 206 Comparison of Transphyseal Neck-Head Drilling (TNHD) vs. Multiple Epiphyseal Drilling (MED) on Femoral Head Healing Following Ischemic Osteonecrosis Olumide O. Aruwajoye, Felipe Monte, Audrey Kim, Matthew C. Phipps, Harry K.W. Kim Paper No. 207 Analysis of the Relationship Between Proximal Femur 3D Shape and Cartilage Health in Patients with Hip Osteoarthritis Gaurav P. Inamdar, Valentina Pedoia, Matthew C. Gallo, Richard Souza, Sharmila Majumdar Paper No. 212 Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development Rebecca A. Rolfe, Michelle L. Oyen, James C. Iatridis, Niamh C. Nowlan Paper No. 213 Necroptosis Contributes Secondary Neural Tissue Damage After Spinal Cord Injury: Comparisons of Incidence and Time Course with Apoptosis Haruo Kanno, Takehiro Sugaya, Michiharu Matsuda, Kyoichi Handa, Eiji Itoi, Hiroshi Ozawa 11:20 AM Paper No. 1 Inhibition of 15-PGDH Increases Early Callus Size and Mineralization in a Murine Model of Fracture Repair Christopher D. Collier, Bryan S. Hausman, Hamzah Zulqadar, Kevin C. Allan, Randall E. Marcus, James M. Anderson, Ozan Akkus, Sanford D. Markowitz, Edward M. Greenfield Paper No. 196 Periodontal Pathogens Are Associated with Osteoarthritis in a Miniature Pig Model Joanne E. Haughan, Raju Indugun, Bonnie Vecchiarelli, Julie Engiles, Dipti Pitta, Thomas P. Schaer Paper No. 202 Targeting Danger in Human Tendinopathy: The Role of HMGB1 Moeed Akbar, Susan Kitson, Lindsay A.N. Crowe, George A.C. Murrell, Iain B. McInnes, Derek S. Gilchrist, Neal L. Millar Paper No. 208 Development and Calibration of a Probabilistic Hip Capsule Representation Casey A. Myers, Clare K. Fitzpatrick, Peter J. Laz, Paul J. Rullkoetter Paper No. 214 Intravenous Infusion of Mesenchymal Stem Cells Promotes Functional Recovery in a Model of Chronic Spinal Cord Injury Tomonori Morita, Masanori Sasaki, Yuko Kataoka-Sasaki, Masahito Nakazaki, Hiroshi Nagahama, Shinichi Oka, Tsutomu Oshigiri, Tsuneo Takebayashi, Toshihiko Yamashita, Jeffery D. Kocsis, Osamu Honmou 54 11:30 AM Paper No. 196A Human Recombinant Fibroblast Growth Factor-18 (sprifermin), Enhances Cartilage Healing After Microfracture (MFX) in an Equine Cartilage Injury Model Honey Hendesi, Suzanne Stewart, Michelle Gibison, Bhavana Mohanraj, Gregory Meloni, Hans Guehring, Dean W. Richardson, George R. Dodge

55 TUESDAY, MARCH 21, 2017 SESSIONS 1:30 PM 2:30 PM TIME SESSION 32 Bone Matrix SESSION 33 OA Pathogenesis and Molecular Targets SPOTLIGHT SESSION 34 Stem Cells and Bone Repair SESSION 35 Knee Ligaments and Mechanics SESSION 36 Disc Biology and Engineering ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Kenneth Kozloff, PhD and Ryan Ross, PhD Mary Goldring, PhD and Raghunatha Yammani, PhD Chris Evans, PhD and Oran Kennedy, PhD Clare Fitzpatrick, PhD and John Williams, PhD Robert Bowles, PhD and Nam Vo, PhD 1:30 PM Paper No. 215 Improving the Ability of Raman Spectroscopy to Assess the Fracture Resistance of Human Bone Mathilde Granke, Alexander Makowski, Oscar Ayala, Sasidhar Uppuganti, Anita Mahadevan-Jansen, Jeffry S. Nyman Paper No. 221 Early Zoledronic Acid Treatment Attenuates Cartilage Degradation in a Small Animal Model of PTOA Austin J. Ramme, Matin Lendhey, Jurinus Lesporis, Thomas R. Coughlin, Oran D. Kennedy Paper No. 230 The Influence of Variations of Blumensaat s Line on the Evaluation of the ACL Tunnel Position Using Quadrant Method Koji Iwasaki, Masayuki Inoue, Naoki Seito, Tomoya Matsuhashi, Norimasa Iwasaki, Kazunori Yasuda Paper No. 236 Regulation of Beta-Catenin in Adult Nucleus Pulosus as a Target of Murine Intervertebral Disc Degeneration Nilsson Holguin, Matthew Silva 1:40 PM Paper No. 216 Loss of Bone Stiffness at a Distant Skeletal Site Following Femoral Fracture in Mice Stephanie M. Telek, Armaun J. Emami, Hailey C. Cunningham, David P. Fyhrie, Blaine A. Christiansen Paper No. 222 Small Molecule Library Screening for Modulators of Post- Traumatic Osteoarthritis Bhavana Mohanraj, Mieke Sinneseal, Robert Mauck, George Dodge SPOTLIGHT SPEAKER Bruno Péault, PhD Perivascular Native Mesenchymal Stem Cells Paper No. 231 Neuroplastic Changes Measured by Transcranial Magnetic Stimulation Are Evident Early After Anterior Cruciate Ligament Reconstruction Ryan Zarzycki, Adam Marmon, Charalambos Charalambous, Susanne Morton, Lynn Snyder-Mackler Paper No. 237 Defining the Human Fetal Notochordal Cell Phenotype Stephen M. Richardson, Ricardo Rodrigues-Pinto, Andrew Berry, Karen Piper-Hanley, Neil Hanley, Judith A. Hoyland 1:50 PM Paper No. 217 PTH(1-34) Reduces Microdamage in the Mouse Femur Under Fatigue Loading Niloufar Rostami, David Kohn, Joseph Gardinier Paper No. 223 Intraperitoneal Injection of the Sirt1 Activator Srt1720 Aattenuates the Progression of Experimental Osteoarthritis in Mice Kyohei Nishida, Takehiko Matsushita, Koji Takayama, Toshikazu Tanaka, Nobuaki Miyaji, Kazuyuki Ibaraki, Daisuke Araki, Noriyuki Kanzaki, Ryosuke Kuroda Paper No. 232 Comparison of Male and Female Knee Kinematics at the Time of Non-Contact Anterior Cruciate Ligament Injury Determined via Bone Bruises Kwadwo A. Owusu-Akyaw, Sophia Y. Kim, Charles E. Spritzer, Amber T. Collins, Gangadhar M. Utturkar, William E. Garrett, Louis E. DeFrate Paper No. 238 RANK/RANKL/OPG System in the Human Intervertebral Disc Tomohiko Sano, Koji Akeda, Norihiko Takegami, Junichi Yamada, Kazuma Nakase, Akihiro Sudo 2:00 PM Paper No. 218 Thrombospondins 1 and 2 Affect Collagen Matrix Maturation, Lysyl Oxidase and Tgf-beta Bioavailability via Distinct Bone Tissue Specific Mechanisms Dylan Shearer, Allie Brodsky, Anita Reddy, Andrea I. Alford Paper No. 224 Identification of Galectin-3 as Upstream Regulator of Osteoarthritis Pathogenesis Stefan Toegel, Daniela Weinmann, Karin Schlangen, Sabine André, Hans-Joachim Gabius, Reinhard Windhager Paper No. 227 Notch Activation Enhances Stem Cell Sheet Osteogenic Potential by Inhibition of Cellular Senescence Guangxi Wang, Sheila Rogers, Dollie Smith, Todd Jaeblon, John V. Marymont, Massimo Max Morandi, Yufeng Dong Paper No. 233 Importance of Compression- Tension Nonlinearity of Ligaments on Human Knee Joint Biomechanics Gustavo A. Orozco, Petri Tanska, Mika Mononen, Kimmo Halonen, Rami Korhonen Paper No. 239 Mesenchymal Stem Cells Expressing the Cell Adhesion Molecule CD146 Present Increased Homing Towards Degenerative Intervertebral Discs an Organ Culture Study Sebastian Wangler, Marianna Peroglio, Zhen Li, Ursula Menzel, Lorin M. Benneker, R. Geoff Richards, Mauro Alini, Sibylle Grad TUESDAY 2:10 PM Paper No. 219 Osteocytes Response to PTH(1-34) Regulates Perilacunar Tissue Composition Joseph Gardinier, Salam Al-Omaishi, Micheal D. Morris, David Kohn Paper No. 225 MechanomiR-365 Promotes Pro-inflammatory Cytokine IL-6 Expression Through Inhibiting a Transcriptional Repressor Nr1d2 During Osteoarthritis in Mice and Human Yun Gao, Kun Yang, Nan Hu, Qian Chen Paper No. 228 Spatiotemporal Regulation of Angiogenesis is Critical for Effective Nanofiber Mediated Cranial Bone Defect Repair Tao Wang, Hong Jun Wang, Xinping Zhang Paper No. 234 The Role of Posterior Fan-Like Extension of the Anterior Cruciate Ligament Femoral Footprint on Failure Load Soheil Sabzevari, Humza Shaikh, Brandon Marshall, Junjun Zhu, Monica A. Linde, Patrick Smolinski, Freddie H. Fu Paper No. 240 Growth Factor and Extracellular Matrix Expression and Localization During Nucleus Pulposus Formation Sun H. Peck, Kendra K. McKee, Neil R. Malhotra, Brian D. Harfe, Lachlan J. Smith 2:20 PM Paper No. 220 Are QCT/FEA Strength Estimates Sensitive to Sex and Age? Asghar Rezaei, Hugo Giambini, Timothy Rossman, Dan Dragomir-Daescu Paper No. 226 The Role of Foxa2 Transcription Factor as Potential Regulator of Articular Cartilage Hypertrophy and OA Progression Andreia M. Ionescu, Lin Xu, Kailing Ho, Laura Gamer, Andrew Lassar, Elena Kozhemyakina, Yefu Li, Klaus Kaestner, Malcolm Whitman, Vicki Rosen Paper No. 229 Periosteal Progenitor Cells from the Cranial and Appendicular Skeleton Exhibit Unique Transcriptional Signatures Vivian Bradaschia Correa, Shane S. Neibart, Anna M. Josephson, Philipp Leucht Paper No. 235 Relative Engagement of the Anterior Cruciate Ligament and the Surrounding Soft Tissue Envelope Robert N. Kent, Mark J. Amirtharaj, Thomas L. Wickiewicz, Andrew D. Pearle, Carl W. Imhauser Paper No. 241 Identification of the Compositional Traits and Permeabilities of the Cartilage Endplate that Are Required for Nutrient Transport and Disc Cell Survival Jason Wong, Ann Ouyang, Sara Sampson, Jeffrey Lotz, Aaron J. Fields 55

56 TUESDAY, MARCH 21, 2017 SESSIONS 2:45 PM 3:45 PM TIME SESSION 37 Bone Therapeutics SESSION 38 Mechanotransduction SESSION 39 Biomaterials and Tissue Regeneration SESSION 40 Knee Kinematics and Computational Modeling SPOTLIGHT SESSION 41 Disc Repair ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Damian Genetos, PhD and Elise Morgan, PhD Robert Sah, MD, ScD and Jennifer Woodell-May, PhD Anne Gingery, PhD and Robert Mauck, PhD Annegret Muendermann, PhD and Jennifer Puetzer, PhD Jeffrey Lotz, PhD and Lachlan Smith, PhD 2:45 PM Paper No. 242 Synergistic Gains in Vertebral Bone Mass When Sclerostin Antibody is Combined With Bisphosphonate in Brtl/+ Mouse Model of Osteogenesis Imperfecta Diana Olvera, Rachel L. Stolzenfeld, Joan C. Marini, Michelle S. Caird, Kenneth M. Kozloff Paper No. 248 Decorin Plays an Indispensable Role in Cartilage Poroelasticity at the Nanoscale Biao Han, Qing Li, Mei Sun, Hadi Tavakoli Nia, Ramin Oftadeh, Basak Doyran, Ling Qin, Renato V. Iozzo, David E. Birk, Lin Han Paper No. 254 Antidepressants Reduce MSC Osteoblastic Differentiation and Increase Osteoclastic Activity Nancy B. Ayad, Kelly M. Hotchkiss, Rene Olivares-Navarrete Paper No. 260 The Characteristics of the Total Knee Joint Moment Change with Disease Progression in Patients with Medial Compartment Knee Osteoarthritis Jessica L. Asay, Jennifer C. Erhart-Hledik, Thomas P. Andriacchi 2:55 PM 3:05 PM Paper No. 243 Combination of Human Growth Hormone and Zoledronic Acid in a Mouse Model of Osteogenesis Imperfecta David G. Little, Tegan L. Cheng, Lauren Peacock, Bernadette Coase, Craig Munns, Aaron Schindeler Paper No. 244 Cancellous and Cortical Bone Tissue Quality in Men Are Differentially Affected by Type 2 Diabetes Mellitus Pablo M. Palomino, Heather B. Hunt, Ashley Torres, Matthew Cohn, Joseph M. Lane, Karen B. King, Christopher J. Hernandez, Eve Donnelly Paper No. 249 Regulatory Volume Decrease is Necessary for Protective Mechanical Adaptation of Articular Chondrocytes Alexander Kotelsky, Mark R. Buckley Paper No. 250 Effects of Dynamic Loading on Central Energy Metabolism in Osteoarthritic Chondrocytes Daniel Salinas, Brendan Mumey, Ronald K. June Paper No. 255 Systemically Administered Wound-homing Peptide Accelerates Wound Healing by Modulating Syndecan-4 Function Tero Järvinen, Mark Morgan, Craig Turner, Toini Valmari, Ulrike May, Maria Vähätupa, Stuart Prince, Martin Humphries, Erkki Ruoslahti Paper No. 256 Therapeutic Efficacy of Targeted TPCA-1 Loaded Nanosomes in Post-Traumatic Osteoarthritis Mouse Model Hongsik Cho, Fazal Ur Rehman Bhatti, Karen A. Hasty Paper No. 261 Assessment of Patellar Kinematics in Healthy Older Adults Vasiliki Kefala, Azhar A. Ali, Erin M. Mannen, Raymond H. Kim, Paul J. Rullkoetter, Kevin B. Shelburne Paper No. 262 Estimation of Tibiofemoral Contact Force Using Muscle Synergies Swithin Razu, Trent Guess SPOTLIGHT SPEAKER Judith Hoyland, PhD The Adult Intervertebral Disc Cell Population and Phenotype: Implications for IVD Regenerative Strategies TUESDAY 3:15 PM Paper No. 245 Increased Joint Laxity and Altered Bone and Cartilage Morphology in a Mutant Cartilage Oligomeric Matrix Protein (COMP) Mouse Model of Pseudoachondroplasia Tristan Maerz, Michael Newton, Karissa Gawronski, Lindsay Remer, Kevin C. Baker, Francoise Coustry, Jacqueline T. Hecht, Karen Posey Paper No. 251 Loading Inhibits Hypertrophy of Mesenchymal Stem Cells in a Cartilage Biomimetic Hydrogel via Smad 1/5/8 Signaling Elizabeth Aisenbrey, Karin Payne, Ganna Bilousova, Stephanie J. Bryant Paper No. 257 A Bi-layered Scaffold Derived from Decellularized Growth Plate and Articular Cartilage Extracellular Matrix for Osteochondral Defect Repair Grainne M. Cunniffe, Pedro J. Diaz-Payno, Eamon J. Sheehy, Susan E. Critchley, Henrique V. Almeida, Tanya Levingstone, Conor Moran, Robert T. Brady, Pieter A.J. Brama, Fergal J. O Brien, Daniel J. Kelly Paper No. 263 New Mechanobiological Framework for Prediction of Simultaneous Proteoglycan Loss and Collagen Degeneration During Knee Osteoarthritis Mika E. Mononen, Petri Tanska, Hanna Isaksson, Rami K. Korhonen Paper No. 266 Hyaluronic Acid Hydrogel Alleviates Nociceptive Behaviour Through Inhibition of Sensory Hyper-innervation and Nociception Markers, Attenuates the Inflammatory Response and Regulates Glycomic and Proteomic Signatures in a Novel Model of Pain Associated with Intervertebral Disc Degeneration Isma Liza Mohd Isa, Sunny A. Abbah, Michelle Kilcoyne, Kieran Wynne, Oliver Carroll, David Tiernan, Akshay Srivastava, Peter Owens, Lokesh Joshi, Peter Dockery, David P. Finn, Abhay Pandit Paper No. 267 Thermally Triggered Hydrogel Induces Nucleus Pulposus Differentiation of Mesenchymal Stem Cells and Restores Mechanical Function Following Injection into Bovine Intervertebral Disc Abbey A. Thorpe, Gary Doughill, Louise Vickers, Glen Cooper, Chris Sammon, Christine Le Maitre 3:25 PM Paper No. 246 Proteasome Inhibitor Bortezomib Is a Novel Therapeutic Target for Radiotherapy Induced Osteoporosis Abhishek Chandra, Tiffany Young, Luqiang Wang, Wei-Ju Tseng, X. Sherry Liu, Keith Cengel, Ling Qin Paper No. 252 Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage Degeneration Sotcheadt Sim, Insaf Hadjab, Laura-Alexie Chevrolat, Mathieu Masse, Aurore Li Tong, Patrick Lavigne, Martin Garon, Eric Quenneville, Michael Buschmann Paper No. 258 A Biocompatible, 3D Printed Stiff Hydrogel for Osteochondral Tissue Engineering Andrew A. Tomaschke, Callie I. Fiedler, Elizabeth A. Aisenbrey, Joseph A. Wahlquist, Eric Kleinjan, Aaron Aziz, Mark A. Randolph, Robert R. McLeod, Stephanie J. Bryant, Virginia L. Ferguson Paper No. 264 Sensitivity of Knee Joint Contact Force Predictions to Frontal Plane Alignment and Contact Locations Christopher M. Saliba, Scott C.E. Brandon, Kevin J. Deluzio 56 3:35 PM Paper No. 247 Efficacy and Safety of Osteoporosis Medications in a Rat Model of Late-stage Chronic Kidney Disease Accompanied by Secondary Hyperparathyroidism and Hyperphosphatemia Masahiro Ohta Paper No. 253 Synovial Fibroblast Mechanosensing of Fluid Shear Is Modulated by Factors in the Osteoarthritic Environment Eben G. Estell, Amy M. Silverstein, Lance A. Murphy, Evie Sobczak, Roshan P. Shah, Mukundan Attur, Gerard A. Ateshian, Clark T. Hung Paper No. 259 The Effects of a Bone Marrow Stimulation Technique Augmented by Ultra-purified Alginate Gel in a Canine Osteochondral Defect Model Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki Paper No. 265 A Modeling Framework to Estimate In Vivo Subject-Specific Patellofemoral Joint Cartilage Stress During Gait Jonathan A. Gustafson, John J. Elias, G. Kelley Fitzgerald, Scott Tashman, Richard E Debski, Shawn Farrokhi Paper No. 268 Evaluating Donor Variability in the Formation and Potency of Discogenic Cells to Treat Degenerative Disc Disease Lara I. Silverman, Gala Dulatova, Terry Tandeski, Kevin Foley

57 WEDNESDAY MEETING HIGHLIGHTS 7:00 AM 6:00 PM Registration Open City-Side Corridor 7:30 AM 9:00 AM WORKSHOPS: Cross-talk Opportunities Between Developmental Biology and Tissue Engineering Room 6A The Infected Implant in Orthopaedic Reconstruction Room 6B Advances in Identifying Early OA Room 5AB HANDS-ON WORKSHOP: Introduction to Performing Skeletal Muscle Mechanics Measurements with a Hands-On Workshop Room 7AB 9:15 AM 10:15 AM ORS Achievement Awards & 2017 Inauguration Ceremony Room 6CF 10:00 AM 4:00 PM Innovation Central Open Sails Pavilion 11:15 AM 12:15 PM SESSIONS: Shoulder Room 6CF Soft Tissue Regeneration Room 6B Poster Teaser Session II Room 7AB SPOTLIGHT SESSIONS: Bone Mechanobiology Room 6A Big Data in Orthopaedics Room 5AB 12:15 PM 1:15 PM PROFESSIONAL ADVANCEMENT SESSION: Writing a High Impact NIH Biosketch Room 8 12:15 PM 2:15 PM Lunch Provided Sails Pavilion 2:15 PM 3:15 PM SESSIONS: Osteoporosis Room 6A Upper Extremity Room 6CF Meniscus Engineering and Repair Room 5AB Late Breaking Session Room 7AB SPOTLIGHT SESSION: Tumor Animal Models Room 6A 3:45 PM 6:00 PM 2016 Research Highlights Room 6CF WEDNESDAY 57

58 WEDNESDAY PROGRAM DETAIL WEDNESDAY 7:30 AM 9:00 AM WORKSHOP Cross-talk Opportunities Between Developmental Biology and Tissue Engineering Room 6A Organizers: Joel D. Boerckel, PhD, University of Notre Dame and Ralph Marcucio, PhD, University of California San Francisco Bones develop through multicellular differentiation programs that enable progressive assembly of hierarchical structures and complex cell-cell and cell-matrix interactions that are required for the formation of function bone tissue, capable of volumetric growth, dynamic adaptation to mechanical demands, and scar-free repair. While the regulatory cascades that control bone development are becoming increasingly clarified, recapitulating the efficiency of development for post-natal bone regeneration remains a challenge. This workshop will bring together tissue engineers and basic biologists to foster cross-talk over concepts and approaches for mutual benefit and will highlight the technological and conceptual advances that have enabled the emergence of development-inspired tissue engineering, and will feature cuttingedge, transformative science from leaders in the field and educate attendees on novel interdisciplinary approaches to advance our field. Developmental Bone Biology: History, Current Concepts, and Approaches Ling Qin, PhD, University of Pennsylvania Engineering Development-mimetic Microenvironments with Biomaterials Eben Alsberg, PhD, Case Western Reserve University Applications of Bone Development in Bone Tissue Engineering Ralph Marcucio, PhD, University of California San Francisco 58 7:30 AM 9:00 AM WORKSHOP The Infected Implant in Orthopaedic Reconstruction: An Update on the Clinical and Molecular Approaches to Prevention and Diagnosis Room 6B Organized by the Musculoskeletal Tumor Society (MSTS) and ORS Organizers: Wakenda Tyler, MPH, MD, University of Rochester and Francis Lee, MD, PhD, Yale University Implant related infections in joint reconstruction are among the most devastating complications in orthopaedic surgery. The cost to the healthcare system and the patient associated morbidity demand ardent focus on the prevention and early diagnosis of these infections. This workshop will focus on three key areas of prevention and diagnosis. First, an update on the clinical evidence for systemic antibiotic prophylaxis will be presented with surprising data that does not support routine current clinical practice guidelines. Second, the latest data on serum and synovial biomarkers for the diagnosis of peri-prosthetic joint infection will be provided. Finally, an in vivo model of antimicrobial implant coating and bioluminescent imaging will provide insight into a unique and novel approach to infection prophylaxis. Overall, this workshop will be highly informative for surgeons and researchers alike who wish to learn about the newest advancements in the prevention and diagnosis of the infected orthopaedic implant. Workshop attendees will have the benefit of a focused session that combines clinical, cellular and molecular updates on this critical area of orthopaedic care. Antibiotic Prophylaxis in Tumor and Joint Reconstruction: Where Does the Evidence Lead Us? Michelle Ghert, MD, McMaster University New techniques on the Cellular and Molecular Diagnosis of the Infected Joint Carlos A. Higuera Rueda, Cleveland Clinic Foundation Novel Molecular Implant Modifications Directed at Infection Prophylaxis Nicholas Bernthal, MD, University of California Los Angeles

59 WEDNESDAY PROGRAM DETAIL 7:30 AM 9:00 AM WORKSHOP Advances in Identifying Early OA Room 5AB Organizers: Dominik R. Haudenschild, PhD, University of California, Davis and Blaine A. Christianson, PhD, University of California, Davis Joint injuries initiate changes in joint tissue homeostasis that often culminate in osteoarthritis. Currently, many groups focus their research on mechanistically connecting the initial injury event and the eventual osteoarthritis. The primary purpose of this workshop is to highlight recent advances in the understanding of acute responses to joint injury in different joint tissues. The three presenters have each approached the identification of early OA from unique perspectives in their research. This workshop will bring together these unique perspectives. The goal is to establish a more comprehensive understanding of how the interplay between different tissues, matrix gene expression, cytokine and growth factor production, and metabolomics responses during the acute post-injury phase affects the joint. Injury-induced Changes in Small-molecule Metabolites Ronald June, PhD, Montana State University Inflammatory Cytokines and Gene Expression in Acute PTOA Steven Olson, MD, Duke University Medical Center Acute Tissue-specific Responses to Joint Injury Christopher Little, DVM, PhD, Kolling Institute, University of Sydney 7:30 AM 9:00 AM HANDS-ON WORKSHOP Introduction to Performing Skeletal Muscle Mechanics Measurements Part 1: Scientific Workshop Room 7AB Organizers: Christopher Mendias, ATC, PhD, University of Michigan and Richard Lovering, PT, PhD, University of Maryland The purpose of this workshop is to introduce scientists who have an interest in skeletal muscle research to the basics of contractile and mechanical properties measurements of skeletal muscle tissue. The workshop will have a didactic portion that will cover the fundamental theories of muscle mechanics, and the basics of performing and analyzing in vitro and in vivo measurements of skeletal muscle mechanics. There will be equipment available at the end of the workshop for attendees to gain hands on experience in performing these measurements. Fundamentals of Skeletal Muscle Mechanics Christopher Mendias, PhD, ATC, University of Michigan Performing In Vitro and In Vivo Measurements of Skeletal Muscle Contractile and Mechanical Properties Richard Lovering, PhD, PT, University of Maryland Samuel Ward, PhD, PT, University of San Diego Dr. Ward will be available to assist with the didactic session. Part 2: Technology Based Workshop Presented by Aurora Scientific This workshop aims to educate members of the society about the various techniques and instruments which presently exist to make functional measurements of active and passive stress and strain in isolated tissue. Discussion will focus on experimental methods, outcomes and why these techniques are a useful tool to have in your laboratory. Techniques for measuring stress and strain in connective tissue will also be discussed. CME is not available for this workshop. WEDNESDAY 59

60 WEDNESDAY PROGRAM DETAIL 9:15 AM 10:15 AM ORS ACHIEVEMENT AWARDS AND 2017 INAUGURATION CEREMONY Room 6CF Moderator: Farshid Guilak, PhD ORS Video Outreach Awards 3rd Place 2nd Place 1st Place Recognition of Awardees ORS Alfred R. Shands, MD Award Lecturer Van C. Mow, PhD ORS Marshall R. Urist, MD Award Lecturer Brian Johnstone, PhD ORS William H. Harris, MD Award New Investigator Recognition Awards (NIRA) 12:15 PM 1:15 PM Writing a High-Impact NIH Biosketch Room 8 Organized by the ORS New Investigator Mentoring Committee and ORS Women s Leadership Forum Organizers: Karen Troy, PhD, Worcester Polytechnic Institute and Josa Hanzlik, ZSX Medical Your Biosketch is a window into who you are as a scientist, so you need to make sure that it is telling the best story possible. This program will explore and examine the key aspects of a Biosketch, with great tips and pointers on what to do and not to do when preparing this document. Learn how to write a compelling personal statement, contributions to science section, and what details can be most effective in communicating your expertise to reviewers as a new investigator. Attendees will have the opportunity to ask the experts how to improve their individual Biosketches. This program is ideal for the early career investigator as well as those who need to transition to the new NIH format. Biosketch from the NIH Perspective Gayle Lester, PhD, NIAMS Crafting a Great Contributions to Science Section Henry J. Donahue, PhD, Virginia Commonwealth University Writing a Compelling Personal Statement Elise Morgan, PhD, Boston University Sold out SOLD OUT AAOS Women s Health Issues Advisory Board (WHIAB) Award Force and Motion Foundation/ORS Young Scientist Scholarship WEDNESDAY Force and Motion Foundation/ORS Young Scientist Travel Grants Inauguration of Rick Sumner, PhD Incoming ORS President ( ) 60

61 WEDNESDAY PROGRAM DETAIL 3:45 PM 6:00 PM 2016 Research Highlights Room 6CF Moderators: Linda Sandell, PhD and Stavros Thomopoulos, PhD This session will provide meeting attendees with a brief update on some of the key highlights and exciting new research within our field over the previous year. The session will include 10 minute presentations from each of the ORS Sections, Musculoskeletal Biology Workshop at Sun Valley, along with topics identified by the Program Committee. Introduction to Research Highlights Linda Sandell, PhD Meniscus Section Marc Levenston, PhD Orthopaedic Implant Section Joan Bechtold, PhD Preclinical Models Section Kurt Hankenson, DVM, PhD Tendon Section Peter C. Amadio, MD Spine Section Makarand Risbud, PhD Musculoskeletal Biology Workshop at Sun Valley Alexander Robling, PhD Regenerative Medicine and Biomaterials Fergal O Brien, PhD Lower Limb Braden Fleming, PhD Upper Limb Brian Feely, PhD Bone Elise Morgan, PhD Cartilage Robert Sah, MD, ScD Spine Section Awards Meniscus Section Awards Closing Session Stavros Thomopoulos, PhD WEDNESDAY 61

62 WEDNESDAY, MARCH 22, 2017 SESSIONS 11:15 AM 12:15 PM TIME SPOTLIGHT SESSION 42 Bone Mechanobiology SESSION 43 Shoulder SESSION 44 Soft Tissue Regeneration SPOTLIGHT SESSION 45 Big Data in Orthopaedics ROOM Room 6A Room 6CF Room 6B Room 5AB Moderators Jacqueline Cole, PhD and Karen Troy, PhD Richard Debski, PhD and Andrew Kuntz, MD Robert Guldberg, PhD and Megan Killian, PhD Michelle Ghert, MD and Sally LiArno, PhD 11:15 AM Paper No. 272 Osseous Shoulder Imaging Using Zero Echo Time MRI Ryan E. Breighner, Lawrence Gulotta, Yoshimi Endo, Gabrielle Konin, Matthew F. Koff, Hollis G. Potter Paper No. 278 Whole Blood Fibrin Clot Preserves the Viability and Bioactivity of Human Muscle-Derived Stem Cells Paul G. Shupe, Ryan J. Warth, Xueqin Gao, Xuying Sun, Xiaodong Mu, Sarah Amra, Walter R. Lowe, Christopher D. Harner, Johnny Huard 11:25 AM 11:35 AM SPOTLIGHT SPEAKER Matthew Silva, PhD Bone Mechanobiology: What Small Animal Models Have Taught Us About Loading-induced Bone Formation Paper No. 273 Assessment of Glenoid Anatomy and Bone Quality Using a Statistical Shape and Intensity Model William S. Burton, Irene Sintini, Jason Chavarria, James Brownhill, Peter J. Laz Paper No. 274 The Effect of Arm Loading and Plane of Elevation on Acromial Stress After Reverse Shoulder Arthroplasty Jason Lockhart, Murray Wong, G. Daniel G. Langohr, George Athwal, James Johnson Paper No. 279 Controlled Release of TGF-β3 from Nanofiber Scaffolds Induces Fibrochondrogenic Differentiation of Stem Cells Dovina Qu, Jennifer P. Zhu, Helen H. Lu Paper No. 280 Grow and Differentiate Stem Cells in Macroporous Scaffolds and the Application to Cartilage Repair Mingkun Wang, Chunxiao Cui, John Lawrence, Maurizio Pacifici, Li-Hsin Han SPOTLIGHT SPEAKER Elena Losina, PhD Using Mathematical Models, Big Data and Outcome Research to Optimize Care for Persons with Musculoskeletal Disorders 11:45 AM Paper No. 269 Mechanical Regulation of Neovascularization in Endochondral Bone Regeneration Anna M. McDermott, Samuel Herberg, James H. Dawahare, Daniel J. Kelly, Eben Alsberg, Joel D. Boerckel Paper No. 275 The Effect of Humeral Tray Placement on the Reverse Shoulder Arthroplasty Impingement Jonathan Glenday, Sudesh Sivarasu, Lawrence Gulotta, Stephen Roche, Andreas Kontaxis Paper No. 281 Enhanced Stress Relaxation in Hydrogels Promotes Cartilage Matrix Formation by Chondrocytes Hong-pyo Lee, Luo Gu, David J. Mooney, Marc E. Levenston, Ovijit Chaudhuri Paper No. 284 Prediction of Knee Osteoarthritis from Clinical MRI Using Cartilage Degeneration Algorithm: Data from Osteoarthritis Initiative Mimmi K. Liukkonen, Mika E. Mononen, Olesya Klets, Jari P. Arokoski, Simo Saarakkala, Rami K. Korhonen WEDNESDAY 11:55 AM 12:05 PM Paper No. 270 TGF-beta Regulates Fracture Toughness via Osteocytes Courtney M. Mazur, Neha S. Dole, Claire Acevedo, Bernd Gludovatz, Robert O. Ritchie, Tamara Alliston Paper No. 271 Downregulation of Sclerostin in Response to Load Is Independent of Ca2+-Mediated Mechanosensation Rachel L. Sattler, Genevieve N. Brown, Navid Mousavi, Jasmine Brite, Andrea E. Morrell, Samuel T. Robinson, X. Edward Guo Paper No. 276 Does Our Concept of Normal Shoulder Biomechanics Apply to Healthy Seniors During Activities of Daily Living Ryan M. Chapman, John-Erik Bell, Douglas Van Citters Paper No. 277 In Vivo Exercise-Induced Glenohumeral Cartilage Strains Hans Zhang, Lauren N. Heckelman, Charles E. Spritzer, Kwadwo A. Owusu-Akyaw, John T. Martin, Dean C. Taylor, C.T. Moorman III, Grant E. Garrigues, Louis E. DeFrate Paper No. 282 Effects of Intra-Articular Ultrapurified Low Endotoxin Alginate Administration on Meniscal Defects in Rabbits WooYoung Kim, Eiji Kondo, Tomohiro Onodera, Rikiya Baba, Kazutoshi Hontani, Shinji Matsubara, Zenta Joutoku, Kentaro Homan, Ryosuke Hishimura, Norimasa Iwasaki Paper No. 283 Ctgf and Tgf-β3 Enhanced Meniscus Regeneration Using Polymeric Meniscus Scaffolds in an Ovine Model Yusuke Nakagawa, Lisa A. Fortier, Jeremy J. Mao, Chang H. Lee, Tyler J. Uppstrom, Colin C. Dannaher, Goodale B. Margaret, Matthew F. Koff, Lebaschi H. Amir, Camila B. Carballo, Liang Ying, Hollis G. Potter, Scott A. Rodeo Paper No. 285 Analysis of Outcomes Following THA: Do All Databases Produce Similar Findings? Nicholas Bedard, Andrew Pugely, Nathan Lux, Michael McHugh, Jesse Otero, Yubo Gao, Kevin Bozic, John Callaghan Paper No. 286 A Multicenter North American Study of Mobility in Osteogenesis Imperfecta Karen M. Kruger, Angela Caudill, Sandesh C.S. Nagamani, Peter A. Smith, Gerald F. Harris, Brendan Lee, V. Reid Sutton, Frank Rauch, David Eyre, Francis Glorieux, Tracy Hart, Deborah Krakow, Jeffrey Krischer, Eric Orwoll, Cathleen Raggio, Jay Shapira, Laura Tosi, Anne Tsai 62

63 WEDNESDAY, MARCH 22, 2017 SESSIONS 11:15 AM 12:15 PM SESSION 46 POSTER TEASER SESSION 2 (continued on next page) ROOM 7AB Moderators: Joan Bechtold, PhD and Theodore Miclau, MD Poster Teaser No. 287 Bioactive Ti6Al4V Alloy Improves Bone Bonding and Prevents Bacterial Infection: THP Application Helena Felgueiras, Veronique Viateau, Azzam Saleh Mghir, Anne-Claude Crémieaux, Daniel Blanquaert, Véronique Migonney Poster Teaser No. 296 Absence of Decorin Exacerbates DMM-induced Post-traumatic Osteoarthritis in Mice Qing Li, Ouyang Liu, Basak Doyran, Li Fan, Wei Tong, Wei-Ju Tseng, X. Sherry Liu, Renato V. Iozzo, Ling Qin, David E. Birk, Lin Han Poster Teaser No. 305 Murine Model for Developmental Dysplasia of Hip: Ablation of Cx3cr1 Affects Gait and Acetabular Morphology George J. Feldman Jr., Arlene Offemaria, Javad Parvizi, Theresa Freeman Poster Teaser No. 288 EtO Sterilized Polyethylene: Is Oxidation A Concern? Barbara H. Currier, John H. Currier, Lindsay A. Holdcroft, Evan Carlson, Douglas Van Citters Poster Teaser No. 297 Detection of Degenerative Meniscus Changes 6 and 24 months After Anterior Cruciate Ligament Reconstruction Tom Gale, James Irrgang, Freddie Fu, Scott Tashman Poster Teaser No. 306 Muscle Paralysis Induces Changes in the Intracortical Bone Microporosities of Skeletally Mature Rats Vittorio Gatti, Michael B. Gerber, Bishoy Ghobryal, Michelle J. Gelbs, Luis Cardoso, Susannah P. Fritton Poster Teaser No. 289 Preclinical Assessment of Acellular Porcine Super Flexor Tendon Using an Ovine Model of Anterior Cruciate Ligament Repair Anthony Herbert, Jennifer H. Edwards, Gemma L. Jones, Eileen Ingham, John Fisher Poster Teaser No. 298 Simvastatin and Atorvastatin Reduce the Mechanical Properties of Tendon Constructs In Vitro and Introduces Catabolic Changes in the Gene Expression Pattern Pernilla Eliasson, Rene B. Svensson, Antonis Giannopoulos, Christian Eismark, Michael Kjær, Peter Schjerling, Katja Heinemeier Poster Teaser No. 307 A Proinflammatory and Degenerative Intervertebral Disc Organ Culture Model by Combining Tnf-α Intradiscal Injection and Detrimental Dynamic Loading Gernot M. Lang, Yishan Liu, Zhiyu Zhou, David Kubosch, Norbert Südkamp, Mauro Alini, Sibylle Grad, Zhen Li Poster Teaser No. 2 Proteomic Analysis of Early Cartilage Repair in a Chronic Cartilage Defect Model in Minipigs Casper Foldager, Morten Olesen, Bjorn Christensen, Kris Hede, Martin Lind, Johan Palmfeldt Poster Teaser No. 299 The Role of Force in Zebrafish Tendon Development Arul Subramanian, Jenna Galloway, Lauren Kanzaki, Thomas Schilling Poster Teaser No. 308 WITHDRAWN Poster Teaser No. 291 Igf-ii Regulates Postnatal Long Bone Growth Through Controlling Glucose Metabolism Li Zeng, Tomoya Uchmura, Daisy S. Nakamura, Zhiyi Liu, Clifford J. Rosen, Irene Georgakoudi Poster Teaser No. 300 Reduction in NF-кB Rescues the Aging Phenotype of Muscle Derived Stem/Progenitor Cells Alex Scibetta, Aiping Lu, Laura Niedernhofer, Paul Robbins, Johnny Huard Poster Teaser No. 309 Co-culture Cell Sheets of Bone Marrow Stromal Cells and Neural Stem/Progenitor Cells Promote Axonal Regeneration and Remyelination After Completely Transected Spinal Cord Injury in Rats Akinori Okuda, Takamasa Shimizu, Hideki Shigematsu, Eiichiro Iwata, Tadanobu Onishi, Yasuhiko Morimoto, Keisuke Masuda, Manabu Akahane, Yasuhito Tanaka Poster Teaser No. 292 Diet Induced Phosphate Deficiency Leads to a Phase Shift and a Change of Gene Expression in Circadian Oscillation During Fracture Healing Takashi Noguchi, Amira I. Hussein, Deven M. Carroll, Nina Horowitz, Louis C. Gerstenfeld Poster Teaser No. 301 Accurate Prediction of Implant Fixation Strength in a Rat Model Using µct Matthew Meagher, Rachna Parwani, Maleeha Mashiatulla, Ryan D. Ross, Amarjit Virdi, D. Rick Sumner Poster Teaser No. 310 Molecular Characterization of Intervertebral Disc Tissue by Next Generation RNA Sequencing A. Noelle Larson, Scott Riester, Andre Van Wijnen, Lin Cong, Wenchun Qu, Mohammed Bydon, Moneim Abdel, Ahmad Nassr Poster Teaser No. 293 Wnt5a Induces Catabolic Signaling and MMP Production in Human Articular Chondrocytes Guangxin Huang, Richard Loeser Poster Teaser No. 302 In Vivo Dynamic Bone Formation and Resorption Under Combined PTH and Mechanical Loading Samuel T. Robinson, X. Edward Guo Poster Teaser No. 311 Expression of Notochordal and Nucleus Pulposus Marker by Sub-Populations of Adult Human Nucleus Pulposus Cells is Maintained Through Aging and Degeneration Stephen M. Richardson, Francesca E. Ludwinski, Judith A. Hoyland Poster Teaser No. 294 Binding Is Critical to the Design and Function of Lubricin-mimetics for Cartilage Lubrication Elizabeth Feeney, Zhexun Sun, David Putnam, Lawrence Bonassar Poster Teaser No. 303 Intracellular Staphylococcus Aureus Are Resistant to Antibiotics Francis Y. Lee, Lee Song, Kelly E. Diaz, Jung Ho Back, Do Yo Soung, Saqib Nizami Poster Teaser No. 312 Growing-Rod Explants in Early Onset Scoliosis: Patient-Based Biomechanical Test Development Emily M. Olson, Peter Sturm, Viral Jain, Lindsay R. Schultz, David Glos, Donita Bylski-Austrow WEDNESDAY Poster Teaser No. 295 The Structural, Psychological, Functional and Pain Sensitization Characteristics of Presurgical Knee Osteoarthritis Patients with Evidence of Neuropathic Pain: A Prospective Observational Study Thomas Kurien, Robert Kerslake, Richard G. Pearson, Brigitte E. Scammell Poster Teaser No. 304 Elevated Levels of Serum Amyloid A in Patients With Osteonecrosis of the Femoral Head Yong Feng, GuangYi Li, ChangQing Zhang Poster Teaser No. 313 Investigation of the Impact of the Concomitant Meniscus Injury on the Rotational Laxity in the Anterior Cruciate Ligament Injured Knees Using the Quantitative Measurement of the Pivot-shift Test Yuichi Hoshino, Nobuaki Miyaji, Toshikazu Tanaka, Kazuyuki Ibaragi, Kyohei Nishida, Yuichiro Nishizawa, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda 63

64 WEDNESDAY, MARCH 22, 2017 SESSIONS 11:15 AM 12:15 PM SESSION 46 POSTER TEASER SESSION 2 (continued from prior page) ROOM 7AB Moderators: Joan Bechtold, PhD and Theodore Miclau, MD Poster Teaser No. 314 The Effect of Osteochondral Implant Material and Implantation Inaccuracy on Articular Cartilage Ashley Heuijerjans, Keita Ito, Wouter Wilson, Corrinus C. Van Donkelaar Poster Teaser No. 323 Subacromial Pressure Reduction After Rotator Cuff Repair with a Biodegradable Subacromial Spacer Yan Chevalier, Matthias F. Pietschmann, Christoph Thorwaechter, Christian Schoeder, Ofir Chechik, Eliyahu Adar, Assaf Dekel, Peter E. Mueller Poster Teaser No. 315 Biomechanical and Biological Indicators of Altered Knee Loading in Pre-High Tibial Osteotomy Patients Catherine Holt, Gemma Whatling, Paul Biggs, Christopher Wilson, David Elson, Cleo Bonnet, Carole Elford, Deborah Mason Poster Teaser No. 324 Development and Validation of a Multivariable Prediction Model for Length of Stay after Shoulder Arthroplasty David Kovacevic, Ana Mata-Fink, Jacob E. Berman, Geliang Gan, Fangyong Li, Theodore A. Blaine Poster Teaser No. 316 Effect of Labrum on Computational Kinematic Simulation During Hip Motion Takehito Hananouchi, Penny R. Atkins, Stephen Kenji Aoki, Andrew Edward Anderson Poster Teaser No. 325 MRI-based Assessment of First Carpometacarpal Osteoarthritis Brent Foster, Robert D. Boutin, Stephen Henrichon, Christopher O. Bayne, Robert M. Szabo, Anand A. Joshi, Abhijit J. Chaudhari Poster Teaser No. 317 Stromal Cell-Derived Factor-1 Antibody Decreased Cancellous Osseointegration of a Murine Tibial Implant Benjamin F. Ricciardi, Kevin Nishida, Zhiwei Wang, Amanda Wach, Arvinth Sethuraman, Sophia Ziemian, Marjolein C.H. van der Meulen, F. Patrick Ross, Xu Yang, Mathias P.G. Bostrom Poster Teaser No. 326 Surface Characterisation of Total Ankle Replacement: Retrieved vs. In Vitro Simulation Ashley A. Stratton-Powell, Alexandra Smyth, Sophie Williams, Anthony C. Redmond, Joanne L. Tipper, John Fisher, Claire L. Brockett Poster Teaser No. 318 WITHDRAWN Poster Teaser No. 327 Particles from Vitamin E (VE)-diffused Highly Cross-linked (HXL) UHMWPE Increase Macrophage Viability and Immune Functions Around Implants Compared to HXL UHMWPE Weishen Chen, David A. Bichara, Jeremy Suhardi, Orhun Muratoglu Poster Teaser No. 319 Influence of Surgical Variables on Initial Taper Stability Laura Scholl, David Pierre, Jeremy Gilbert, Michael Ambrosi, Ahmad Faizan, Viswanathan Swaminathan, Reginald Lee, Kevor TenHuisen Poster Teaser No. 328 Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters Christina M. Beck, Philip Nasser, Matthew J. Gluck, Michael R. Hausman, Steven M. Koehler WEDNESDAY Poster Teaser No. 320 Osteolysis and Wear of Large and Standard Metal on Highly Cross-Linked Polyethylene Articulations Donald W. Howie, Oksana T. Holubowycz, Caroline R. Moran, Bogdan Solomon Poster Teaser No. 321 Development of a Novel Time Dependent Polyethylene Cross Shear and Wear Model for Use in the Computational Analysis of Total Knee Replacements Steven P. Mell, Markus A. Wimmer, Hannah J. Lundberg Poster Teaser No D Morphometric Analysis of the Coracohumeral Distance Using In Vivo MRI Data Taku Hatta, Nobuyuki Yamamoto, Hirotaka Sano, Yasushi Omori, Kazuomi Sugamoto, Kenji Suzuki, Eiji Itoi Poster Teaser No. 329 Objective Prediction of Post-Traumatic OA Risk Following Acetabular Fractures Based on Severity Tai C. Holland, Kevin N. Dibbern, J. Lawrence Marsh, Donald D. Anderson, Michael C. Willey Poster Teaser No. 330 Real Time In Vivo Cervical Functional Spine Unit Kinematics Evaluated by Merging Static MRI With Dynamic Ultrasound Images Mingxin Zheng, Amin Mohamadi, Thomas Szabo, Brian Snyder Poster Teaser No. 331 Diagnostic and Prognostic Significance of Circulating Cell-free MicroRNAs in Osteosarcoma Tomohiro Fujiwara, Koji Uotani, Aki Yoshida, Takuya Morita, Masahiro Kiyono, Yusuke Mochizuki, Tadashi Komatsubara, Kazuhisa Sugiu, Joe Hasei, Toshiyuki Kunisada, Yutaka Nezu, Eisuke Kobayashi, Akira Kawai, Takahiro Ochiya, Toshifumi Ozaki 64

65 WEDNESDAY, MARCH 22, 2017 SESSIONS 2:15 PM 3:15 PM TIME SESSION 47 Osteoporosis SESSION 48 Upper Extremity SPOTLIGHT SESSION 49 Tumor Animal Models SESSION 50 Meniscus Engineering and Repair LATE BREAKING SESSION ROOM Room 6A Room 6CF Room 6B Room 5AB Room 7AB Moderators Jeffry Nyman, PhD and Ryan Riddle, PhD Peter Amadio, MD and Spencer Lake, PhD Nicholas Bernthal, MD and Francis Lee, MD, PhD Melanie Haffner-Luntzer, PhD and Suzanne Maher, PhD Alison Gartland, PhD and Kurt Hankenson, DVM, PhD 2:15 PM 2:25 PM 2:35 PM Paper No. 332 Ocstamp Null Mice Exhibit a Sexually Dimorphic Skeletal Phenotype Douglas J. Adams, Seung-Hyun Hong, Renata Rydzik, Li Chen, Zhihua Wu, Caibin Zhang, Gaven Garland, John P. Sundberg, Dong-Guk Shin, David W. Rowe, Cheryl L. Ackert-Bicknell Paper No. 333 Cyclic Treatment Regime Rescues PTH Withdrawal-Induced Bone Loss and Microarchitecture Deterioration Wei-Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Chantal De Bakker, Yihan Li, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X. Sherry Liu Paper No. 334 Differential Response to a Sclerostin Neutralizing Antibody Between Two Inbred Mouse Strains Noah J. Mathis, Emily N. Adaniya, Lauren M. Smith, Stephen H. Schlecht, Alexander G. Robling, Karl J. Jepsen Paper No. 338 Relationships of Rotational Strength and Kinematics of the Shoulder in Youth Baseball Players Adam Hadro, Shayne Fehr, Derek Damrow, Michael Apolinario, Brian Butler, Xue Cheng Liu Paper No. 339 Anatomical Shape of the Shoulder as a Predictor of Rotator Cuff Injury Safa Herfat, Neil Roach, Michael Rainbow, Tim Baumer, Michael Bey, Meir Marmor, Brian Feeley, Nathan Young Paper No. 340 Shear Wave Elastography of the Human Rotator Cuff: Asymptomatic vs. Pathologic Subjects Timothy G. Baumer, Leah Davis, Veronica Mende, Daniel S. Siegal, Marnix Van Holsbeeck, Vasilios Moutzouros, Michael J. Bey SPOTLIGHT SPEAKER Wakenda Tyler, MPH, MD Transgenic Mouse Models in Sarcoma: Where We Are and Where We Can Go Paper No. 347 Induction of Mesenchymal Stem Cell Differentiation to a Meniscus Cell Phenotype by a Combination of Mohawk Transcription Factor and TGF-ß for Meniscus Repair and Regeneration Kwang-il Lee, Joe Hasei, Merissa Olmer, Jihye Baek, Oscar Alvarez-Garcia, Hiroshi Asahara, Darryl D Lima, Martin Lotz Paper No. 348 Investigating Collagen Fiber Formation for Functional Musculoskeletal Engineering: Going Beyond the Fibril Jennifer L. Puetzer, Ignacio Sallent, Amy Gelmi, Molly M. Stevens Paper No. 349 Dynamic Biomaterials that Direct Cell Migration via a Chemoattractant Gradient to Enhance Meniscal Repair Feini Qu, Julianne L Holloway, Jason A. Burdick, Robert L. Mauck 2:15 PM Paper No Reproduction-Induced Changes in Maternal Bone Confer Protective Effects Against Estrogen Deficiency Chantal M. de Bakker, Laurel Leavitt, Casey Krickus, Wei-Ju Tseng, Tiao Lin, Wei Tong, Ling Qin, X. Sherry Liu 2:22 PM Paper No Alteration of the Gut Microbiome Rescues Callus Adiposity Associated with Impaired Fracture Healing in Obesity Ashlee MacDonald, Farnsworth Christopher, Eric Schott, Jun Zhang, Alex Grier, Cheryl Ackert-Bicknell, Steven Gill, Hani Awad, Michael Zuscik, John Ketz, Robert Mooney 2:29 PM Paper No A Novel Periosteum-Containing Viable Bone Matrix Induces Angiogenesis in a Transgenic Nude Mouse Model Annie Reza, Thomas Uveges, Alla Danilkovitch, Marc Long, Jonathan N. Grauer 2:36 PM Paper No Utilizing the Antimicrobial and Immunomodulatory of Autologous Platelet Formulations to Combat Infectious Arthritis In Vitro Jessica Gilbertie, Thomas Schaer 2:43 PM Paper No Systematic Screening of Novel Long Non-coding RNA Candidates Reveals a Critical Regulator of Chondrogenic Differentiation of Bone Marrowderived Mesenchymal Stem Cells Nguyen P.T. Huynh, Catherine C. Gloss, Jonathan M. Brunger, Audrey McAlinden, Bo Zhang, Farshid Guilak 2:50 PM Paper No mtorc1 Signaling Is a Critical Regulator of Postnatal Tendon Development Kyu Sang Joeng, Joohyun Lim, Douglas R. Keene, Ronen Schweitzer, Brendan H. Lee 2:57 PM Paper No Raman Microscopy Reveals Local Morphological Features in the Meniscal Enthesis Alexander J. Boys, Jennie A.M.R. Kunitake, Lara A. Estroff, Lawrence J. Bonassar 3:04 PM Paper No Running Far and Fast: An Emerging Role of Tenomodulin Denista Docheva, Sarah Dex 2:45 PM Paper No. 335 REV-ERBs Suppress Osteoclastogenesis and Prevent Ovariectomy-induced Bone Loss Partially via FABP4 Upregulation Chao Song, Hanfeng Guan, Feng Li Paper No. 341 Carpal Tunnel Syndrome Impairment of Index Finger Reactive Response Emily L. Grandy, Kaihua Xiu, Tamara L. Marquardt, Chengliu Li, Peter J. Evans, Zong-Ming Li Paper No. 344 Schnurri-3 Deficiency Protects from Osteolysis in a Mouse Model of Metastatic Breast Cancer Sariah Khormaee, Alexander Christ, Alisha Yallowitz, Chloe Horowitz, Ren Xu, John Healey, Matthew Greenblatt Paper No. 350 Contact Stress Profile of a Fiber-Reinforced Total Meniscus Replacement Device Jay M. Patel, Andrzej Brzezinski, Tyler Lu, Rae Tarapore, Michael G. Dunn, Charles J. Gatt 2:55 PM Paper No. 336 Inhibition of Prmt5 Suppresses Osteoclast Differentiation and Partially Protects Against Ovariectomy-induced Bone Loss Through Downregulation of Cxcl10 Yonghui Dong, Chao Song, Yuting Wang, Fei Xu, Feng Li, Anmin Chen Paper No. 342 Effects of Wrist Laxity on Three-Dimensional Carpal Kinematics Ashton J. Stoop, Gordon M. Best, Michelle L. Zec, David R Pichora, Robin N. Kamal, Michael J. Rainbow Paper No. 345 Tumor-specific P53-expressing Oncolytic Adenovirus Overcomes MDR1-mediated Chemoresistance in Human Osteosarcomas Kazuhisa Sugiu, Hiroshi Tazawa, Joe Hasei, Shuhei Osaki, Yasuaki Yamakawa, Toshinori Omori, Tadashi Komatsubara, Yusuke Mochizuki, Aki Yoshida, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki Paper No. 351 Local Discontinuities in Aligned Fibrous Networks Reduce Tissue-to-Nuclear Strain Transmission Tonia Tsinman, Spencer E. Szczesny, Su-Jin Heo, Dawn M. Elliot, Robert L. Mauck WEDNESDAY 3:05 PM Paper No. 337 Exercise Therapy Mitigates Reductions in Tibial Blood Flow During Acute Stroke Recovery Nicholas J. Hanne, Andrew J. Steward, Sriharsha V. Pinnamaraju, Stephanie D. Teeter, Jacqueline H. Cole Paper No. 343 The Natural History of Cartilage Thickness in Early Thumb Carpometacarpal Osteoarthritis Joseph Crisco, Douglas Moore, Amy Morton, Amy Ladd, Arnold-Peter Weiss Paper No. 346 The Critical Role of JAB1 in the Pathogenesis of Osteosarcoma Guang Zhou, William Samsa, Lindsay Bashur, Murali Mamidi, Robin Elliot Paper No. 352 Effect of Glucose Concentration on Fiber Formation in Tissue Engineered Menisci Mary Clare McCorry, Logan Northcutt, Lawrence J. Bonassar 3:11 PM Paper No Therapeutic Targeting of Gpcr Gbetagamma-grk2 Signaling in Osteoarthritis Elijah L. Carlson, Eric M. Schott, Monaliza El-Quadi, Heather K. Le Bleu, John P. Ketz, Reyad Elbarbary, Michael J. Zuscik, Fadia Kamal 65

66 CONGRATULATIONS TO ALL 2017 AWARD RECIPIENTS 2017 Kappa Delta Young Investigator Award Robin M. Queen, PhD, FACSM Virginia Tech Using Lower Extremity Biomechanics in Patients with Ankle Osteoarthritis and Ankle Arthroplasty to Direct Clinical Care 2017 Kappa Delta Ann Doner Vaughn Award Matthew Dobbs, MD Washington University in St. Louis Advancing Precision Medicine for Clubfoot Treatment through Basic Research Co-Author: Christina Gurnett, MD, PhD, Washington University in St. Louis 2017 Kappa Delta Elizabeth Winston Lanier Award Scott W. Wolfe, MD Hospital for Special Surgery / Weill Medical College of Cornell University Kinematics of the Normal and Injured Wrist: The Importance of the Midcarpal Joint Co-Author: Joseph J. Crisco, III, PhD, Rhode Island Hospital/Brown University 2017 OREF Clinical Research Award Henrik Malchau, MD, PhD Sahlgrenska University Hospital Arthroplasty Implant Registries Over the Past Five Decades: Development, Current and Future Impact Co-Authors: Göran Garellick, MD, PhD, Swedish Hip Arthroplasty Register; Daniel Berry, MD, Mayo Clinic; William H. Harris, MD, ScD, Massachusetts General Hospital ORS Alfred R. Shands, MD Award and Lecturer Van C. Mow, PhD Stanley Dicker Professor of Biomedical Engineering and Orthopedic Bioengineering Columbia University 2017 CORR ORS Richard A. Brand Award for Outstanding Orthopaedic Research Joseph H. Schwab, MD Massachusetts General Hospital ORS Women s Leadership Forum Award Susanna G. Chubinskaya, PhD Rush University Medical Center ORS/OREF Distinguished Investigator Award Clare Rimnac, PhD Case Western Reserve University WEDNESDAY ORS William H. Harris, MD Award Isabelle Catelas, PhD, PEng University of Ottawa, Ottawa, ON, Canada Differential Proteomic Analysis of Hip Synovial Fluid from Patients with a Pseudotumor vs. Periprosthetic Osteolysis ORS Marshall R. Urist, MD Award Brian Johnstone, PhD Oregon Health & Science University ORS Outstanding Achievement in Mentoring Award Henry J. Donahue, PhD Virginia Commonwealth University AAOS Women s Health Issues Advisory Board Award Kwadwo A. Owusu-Akyaw Duke University Medical Center Comparison of Male and Female Knee Kinematics at the Time of Non-Contact Anterior Cruciate Ligament Injury Determined via Bone Bruises Co-Authors: Sophia Y. Kim, Charles E. Spritzer, Amber T. Collins, Gangadhar M. Utturkar, William E. Garrett, Louis E. DeFrate 66

67 CONGRATULATIONS TO ALL 2017 TRAVEL GRANT RECIPIENTS ORS/OREF Travel Grant in Orthopaedic Research Translation Alberto Carli, MD, PhD The Ottawa Hospital Vancomcyin-Loaded Polymethylmethacrylate Spacers Fail to Eradicate Periprosthetic Joint Infection in an Innovative, Clinically-Representative Mouse Model of PJI Treatment Paper #0170 Session 24 Infection and Inflammation Monday, March 20, :15 PM 3:15 PM ORS/OREF Travel Grant in Orthopaedic Research Translation Tomohiro Fujiwara, MD, PhD Okayama University Hospital Diagnostic and Prognostic Significance of Circulating Cell-free micrornas in Osteosarcoma Poster Teaser/Poster #0331 Session 46 Poster Teaser 2 Wednesday, March 22, :15 AM 12:15 PM Poster displayed in Poster Session 2 ORS/OREF Travel Grant in Orthopaedic Research Translation Philipp Leucht, MD New York University Langone Medical Center Periosteal Progenitor Cells From The Cranial And Appendicular Skeleton Exhibit Unique Transcriptional Signatures Paper #229 Spotlight Session 34 Stem Cells and Bone Repair Tuesday, March 21, :30 PM 2:30 PM ORS/OREF Travel Grant in Orthopaedic Research Translation Tsuneari Takahashi, MD, PhD Gunma Sports Medicine Research Center, Zenshukai Hospital Effects of Ligament Remnant Tissue Preservation on the Tendon Graft after Anterior Cruciate Ligament Reconstruction: Biomechanical and Histological Evaluations with A Sheep Model Poster #1372 Poster displayed in Poster Session 2 ORS/RJOS Young Female Investigator Travel Grant Diana Olvera, MS University of Michigan Synergistic Gains in Veterbral Bone Mass When Sclerostin Antibody Is Combined with Bisphosphonate in Btrl/+ Mouse Model of Osteogenesis Imperfecta Paper #0242 Bone Therapeutic Session March 21, 2:45 PM 2:55 PM CONGRATULATIONS TO ALL 2017 VIDEO OUTREACH COMPETITION WINNERS First Place Maria Jose Ortega Sierra Orthopaedic Research from Bench to Patient Second Place Imran Asif SAFER Joint Replacements Third Place Hernandez Research Group Explaining Orthopaedic Research WEDNESDAY 67

68 CONGRATULATIONS TO ALL 2017 FORCE AND MOTION/ORS SCHOLARSHIP AND TRAVEL GRANT RECIPIENTS Sponsored by Force and Motion Foundation Force and Motion Foundation/ ORS Young Scientist Scholarship Force and Motion Foundation/ORS Young Scientist Travel Awards Mark J. Amirtharaj, BS, MD Student Georgetown University School of Medicine, Hospital for Special Surgery Rachel Baker, BS, PhD Student Ohio State University Knee Stability with a Medially Stabilized Implant Design Christina Garman, PhD Marquette University Lower Limb Joint Dynamics in Oncology Patients with Distal Femoral Endoprostheses Michael A. Samaan, PhD University of California San Francisco Analysis of Gait Mechanics During Walking and T2 Relaxation Times in Femoroacetabular Impingement Patients After Hip Arthroscopy For more information regarding Force and Motion Foundation/ ORS Young Scientist Scholarship, please visit ors.org/forcemotionors-youngscientist-scholarship Hiroshi Tanaka, PhD Institute of Biomechanics, Nobuhara Hospital Influence of the Kinematics-only Combination on Elbow Load in High School Baseball Pitchers Adam Katchky, BESc, MD, FRCSC University of Toronto Balance and Knee Joint Kinematics After Total Knee Arthroplasty: Comparing Cruciate-retaining and Posterior-stabilized Designs Hiroshi Sasaki, MD, PhD Department of Orthopaedic Surgery, University of Pittsburgh Meniscus Repair Using Hydrogels Seeded with Stem Cells and Meniscus Extra Cellular Matrix WEDNESDAY Ryo Ueno, MS, PhD Student Faculty of Health Sciences, Hokkaido University Peak Times of Quadriceps Force and Anterior Tibial Force Significantly Later than that of Vertical Ground Reaction Force During Single Leg Landing 68 Terufumi Kokabu, MD Department of Orthopaedic Surgery,Hokkaido University School of Medicine Effects of Multilevel Facetectomy and Screw Density on Postoperative Changes In Spinal Rod Contour In Thoracic Adolescent Idiopathic Scoliosis Surgery Daniel Sturnick, MS Hospital for Special Surgery Effects of Ankle Arthroplasty Versus Fusion on Hindfoot Kinematics During Simulated Gait Vahhab Zarei, BS University of Minnesota Image-based Multiscale Mechanical Modeling Reveals the Importance of Structural Heterogeneity in Mechanical Function of Human Lumbar Facet Capsular Ligament

69 2017 POSTER SESSIONS SAILS PAVILION MONDAY WEDNESDAY ORS WILL HAVE TWO POSTER SESSIONS Poster Session1 (PS1): Posters will be displayed Monday and Tuesday morning Poster Session 2 (PS2): Posters will be displayed Tuesday afternoon and Wednesday MONDAY, MARCH 20 10:00 AM 5:30 PM 10:15 AM 11:15 AM Poster viewing 12:15 PM 2:15 PM Lunch and Poster Session 1 viewing Authors at posters to answer questions EVEN-number poster presenters 1:15 PM 1:45 PM ODD-number poster presenters 1:45 PM 2:15 PM TUESDAY, MARCH 21 9:00 AM 11:30 AM; 2:00 PM 5:00 PM 9:30 AM 10:30 AM Poster viewing 11:30 AM 12:00 PM Poster Session 1 Dismantle 1:00 PM 1:30 PM Poster Session 2 Set-Up 3:45 PM 4:45 PM Poster viewing WEDNESAY, MARCH 22 10:00 AM 4:00 PM 10:15 AM 11:15 AM Poster viewing 12:15 PM 2:15 PM Lunch and Poster Session 2 3:15 PM 3:45 PM Poster viewing Authors at posters to answer questions EVEN-number poster presenters 1:15 PM 1:45 PM ODD-number poster presenters 1:45 PM 2:15 PM POSTER CATEGORIES POSTER SESSION 1 # S POSTER SESSION 2 # S American Academy of Orthopaedic Surgeons (AAOS) Best Posters AAOS1 AAOS7 AAOS1 AAOS7 Biomaterial Board of Specialty Society (BOS) Best Posters BOS1 BOS10 BOS1 BOS10 Bone Cartilage and Synovium Diagnostic Imaging Foot and Ankle German Society for Orthopaedics and Trauma (DGOU) DGOU DGOU Guest Nation - China CHINA1 CHINA3 CHINA1 CHINA3 Hand and Wrist Hip Hip and Knee Arthroplasty Infection and Inflammation International Combined Orthopaedic Research Society (ICORS) Best Posters ICORS1 ICORS12 ICORS1 ICORS12 Knee Late Breaking Poster Session Meniscus Muscle NIRA Finalists 25 33, 43 51, 70 77, , 43 51, 70 77, Osteoarthritis and forms of Arthropathy Poster Teasers Shoulder and Elbow Spine Tendon/Ligament Trauma and Fracture Tumors Women s Health Issues Board (WHIAB) Best Poster WHIAB WHIAB POSTERS 69

70 ORS 2017 ANNUAL MEETING PROGRAM BOOK EXHIBITOR INFORMATION EXHIBITORS AccelLab Inc Blvd. Lionel-Bertrand Boisbrand, Quebec J7H1N8 Canada Phone (450) AccelLAB is a one-stop preclinical CRO that conducts high-quality safety and efficacy studies on medical devices following GLP. Specialized services under one roof include sophisticated surgical suites/imaging (incl. CT-scan, radiography, C-arm fluoroscopy, MRI, µct), routine/non-decalcified histology, histomorphometry, histopathology, hematology, blood biochemistry and report production by study directors & full-staff pathologists. Fully AAALAC-certified, AccelLAB was successfully FDA-audited. AMTI 176 Waltham Street Watertown, MA Phone (617) AMTI s force platforms and joint simulators are trusted for leadingedge orthopaedic research in clinics and labs worldwide. The Optima force platform offers superior accuracy for any kind of gait or balance study. Unique features of the Vivo joint simulator include 6 axes under force or displacement control, large range of motion, the patented Virtual Soft Tissue model and Digital Fixturing. Vivo can test implant or cadaveric specimens for any human joint using standard or custom protocols. ATI Industrial Automation 1031 Goodworth Drive Apex, NC Phone (919) ATI Industrial Automation is the world-leading engineeringbased developer of robotic accessories and robot arm tooling, including Automatic Tool Changers, Multi-Axis Force/Torque Sensing Systems, Utility Couplers, Robotic Deburring Tools, Robotic Collision Sensors, Manual Tool Changers, and Compliance Devices. Since 1989, ATI has been developing state-of-the-art products and solutions that improve robotic productivity and are found in thousands of successful applications around the world. 70 CORPORATE PARTNER Aurora Scientific Inc. 25 Industry Street Aurora, Ontario L4G 1X6 Canada Phone (5) CORPORATE PARTNER Aurora Scientific provides solutions for measuring the dynamic physical properties of muscle, connective tissue. Muscle mechanics systems cover the range from single myofibril to whole large-animal in-situ. Products: Muscle Lever Systems, Force Transducers, High-Current Stimulators, Test Apparatus and Software. New Products: multi-axis control of motorized micropositioners. Biomomentum Inc. 970 Michelin, Suite 200 Laval, Quebec H7L 5C1 Canada Phone (450) Biomomentum provides GLP-compliant biomechanical testing services and also manufactures and commercializes testing devices for the mechanical characterization of biomaterials and cartilage. The Mach-1 multiaxial mechanical tester is the only all-in-one device designed for compression, tension, shear, friction, torsion and indentation mapping. The Mach-1 is now used in many university labs and is deemed an excellent educational tool for students. Bone & Joint Research (BJR) 22 Buckingham Street London WC2N 6ET United Kingdom Phone +44 (0) Bone & Joint Research (BJR) is an open access journal with an Impact Factor of and is indexed in PubMed Central and included in PubMed. BJR accepts papers across the whole spectrum of the musculoskeletal sciences. Stop by our booth to collect a free USB flash drive and find out more about Bone & Joint Research!

71 EXHIBITOR INFORMATION Bruker BioSpin 15 Fortune Drive Billerica, MA Phone (978) Bruker offers advanced preclinical imaging solutions for a broad spectrum of application fields, including orthopedics. Drawing on over twenty years experience, Bruker develops and manufactures systems for 3-dimensional, non-destructive investigation of an object s internal microstructure. Cambridge Polymer Group, Inc. 56 Roland Street Boston, MA Phone (617) Cambridge Polymer Group, Inc. is a contract research laboratory specializing in materials and products. Our services range from routine analytical testing to new product research and development. We provide a high-quality rapid turnaround resource with our multi-disciplined experienced team in all sizes of projects. Cleveland Clinic BioRobotics Core 9500 Euclid Ave., ND-20 Cleveland, OH Phone (216) biorobotics.aspx simvitro seamlessly unites software and hardware components for robotic, orthopaedic, biomechanical testing. simvitro is designed for robotic testing of tissues and joints, including knee, spine, hip, shoulder, elbow, hand/wrist, and foot/ankle. Cleveland Clinic BioRobotics Lab, a center of excellence for biomechanical testing of biological structures and biomaterials, is able to build, customize, and integrate whatever robotic infrastructure you need to answer the toughest clinical questions. C-Motion Century Blvd, Suite 104A Germantown, MD Phone (301) C-Motion provides the world s leading research software tools for 3D motion capture analysis and 3D Dynamic X-ray tracking. Our software, Visual3D, is hardware independent, marker set independent and provides validated consistent results from any motion capture data which makes it a compelling product for movement assessments, visualizing 3D data and other applications. Our new DSX product is used for 3D tracking of segments from dynamic X-ray systems. Collagen Solutions 5941 Optical Court San Jose, CA Phone (408) Collagen Solutions Plc is a global provider of medical grade collagen formulations and components for use in regenerative medicine, medical devices and in-vitro diagnostics. Our capabilities include the provision of native, soluble and polymeric collagen formulations and expertise in the development and contract manufacture of collagen components for use as tissue scaffolds and medical devices. Faxitron 3440 E Britannia Drive, Suite 150 Tucson, AZ Phone (520) Faxitron is the pioneer and continues to be the most used brand in cabinet X-ray. Faxitron offers compact digital imaging and pre-clinical DEXA systems with the highest resolution (< 10 µm) and the largest field of view in the market. These systems are less expensive, expose animals to lower doses, and offer faster results than microct or 3D systems. Faxitron cabinets can be placed directly in the animal facility or surgical suite with no other shielding required. 71 EXHIBITORS

72 EXHIBITOR INFORMATION Flexcell International Corporation 2730 Tucker Street, Suite 200 Burlington, NC Phone (800) Flexcell International Corporation specializes in designing and manufacturing products to apply mechanical loads, including tension, compression, and fluid shear, to cells in monolayer and 3D culture. Flexcell has high-throughput culture plates, equipment for making 3D cell-seeded constructs, software for analyzing 3D gel compaction, microscope devices for viewing real-time response to mechanical load. Flexcell is also the distributor for AIM Biotech 3D Cell Culture Chips. Histion 2615 W Casino Road, Suite 6G Everett, WA Phone (425) Histion specializes in evaluation of medical devices (including drug/device and biologic/device combinations) with a proven track record of success providing data to support regulatory submissions. Services include consulting, design and execution of preclinical studies, soft and hard tissue histology, precision cutting/grinding, immunohistochemistry, histopathology, histomorphometry, micro-ct analysis and mechanical testing. Kubtec 270 Rowe Avenue, Unit E Milford, CT Phone (203) Kubtec continues to break new ground in imaging technology with the PARAMETER 3D with DIGIMUS, the only 3D cabinet X-ray system to offer tomosynthesis capability and BMD/BMC measurement applications. The PARAMETER 3D with DIGIMUS for science and research, also provides 2D and optical imaging, which affords unprecedented high-resolution, high-contrast imaging with multi-slice capability, making it the most powerful radiographic tool on the market. Micro Photonics, Inc Pond Road, Suite 110 Allentown, PA Phone (610) CORPORATE PARTNER Micro Photonics, and partner Bruker MicroCT, are leading the advancement in MicroCT solutions for biomaterials and life science research with a focus on bone morphology and BMD. The SkyScan product lines meet the high-resolution and versatility required for any demanding research laboratory. MPI Research N. Main Street Mattawan, MI 471 Phone (269) MPI Research is a high quality contract research organization that provides discovery and preclinical support for drugs and devices. Our experienced, highly-skilled staff conduct orthopaedic surgical studies ranging from simple to complex. Working with MPI Research on your medical device or combination product studies, allows you to rely on the most advanced methods, effective evaluations, comprehensive verifications, and accurate validation of your medical device designs. N2 Biomedical One Patriots Park Bedford, MA Phone (781) N2 Biomedical (formerly Spire biomedical) is a provider of coating and surface treatment services for a wide range of medical device applications. We have served the medical device industry for over 30 years. Our surface treatments and coatings improve wear and fretting resistance, osseointegration, corrosion resistance, fracture toughness, lubricity, infection resistance, biocompatibility, aesthetics, radiopacity, as well as electrical and optical properties. EXHIBITORS 72

73 EXHIBITOR INFORMATION Noraxon N. Greenway-Hayden Loop Suite 100 Scottsdale, AZ Phone (480) NORAXON s focus is on enabling its customers and partners in the discovery, analysis and pursuit of excellence in human movement by creating best-in-class research and analysis tools. Northern Digital Inc. (NDI) 103 Randall Drive Waterloo, Ontario N2V 1C5 Canada Phone (877) NDI is a leading innovator and manufacturer of advanced 3D measurement systems. Our active and passive optical trackers capture the real-time 3D/6DOF position and complex motion of a specimen under force. Our versatile motion tracking systems are known for their sub-millimeter spatial/millisecond temporal accuracy, recording kinematic data with minimal lag and noise. For over 35 years, NDI solutions have been trusted by thousands of researchers and cited in thousands of papers around the world. Novel Inc. 964 Grand Avenue St. Paul, MN Phone (651) Novel is quality in pressure distribution measurement systems that are accurate and reliable for all testing requirements. Novel offers three different systems; the emed platform, the pedar in-shoe, and the pliance system, which measures intraarticular pressure at the patella and tibia, hand/gripping pressures, and much more. OptiTrack 3658 SW Deschutes Street Corvallis, OR Phone (541) OptiTrack is the largest motion tracking provider in the world, delivering 3D measurement tools with unparalleled precision, easy-to-use workflows, and broad accessibility through its low prices. OptiTrack continues this tradition for Movement Science professionals by adding biomechanically-relevant toolsets, native support for force plates, EMGs and analog devices, and quick and easy reporting and analysis in Visual3D, The MotionMonitor, MATLAB or other third party biomechanics packages. OsteoMetrics, Inc Clairmont Road, Suite 100 Decatur, GA Phone (404) OsteoMetrics, with over 350 OsteoMeasure systems worldwide, has been redefining Bone Histomorphometry since OsteoMeasure is now available with outstanding live digital camera support, on-screen pen measurement, thresholding, a complete set of Cortical Bone measurements, a broad set of non-specific measurements, and a comprehensive GLP validation package. OsteoMeasure is the system of choice of most of the pioneers, the most prominent and most published scientists in bone research today. PharmaLegacy Laboratories Building 7, 388 Jialilue Road Zhangjiang High-Tech Park Shanghai China Phone PharmaLegacy is a preclinical specialty CRO that has strong track records in services to worldwide companies committing R&D in therapeutics for Bone Metabolism/Orthopaedics and Tissue Engineering, besides Autoimmune diseases/inflammation, Respiratory, Hepatic/Metabolic diseases and Tumor. We provide quality, timely and cost saving execution for experiments under GLP operation and AAALAC certification. 73 EXHIBITORS

74 EXHIBITOR INFORMATION PMI 1031 Bing Street San Carlos, CA Phone (510) PMI is a leader in preclinical medical device contract research with over 30 years of experience in experimental surgery. With four surgical suites and imaging equipment including a Cath lab, c-arms, endo & lap towers, PMI is fully equipped to handle all of your study needs from research and development to non-glp and GLP. Our longevity coupled with our expertise will help you get your device to the market more effectively and efficiently than any other preclinical medical device CRO. Pre-Clinical Research Services, Inc Webster Court Fort Collins, CO Phone (970) Pre-Clinical Research Services, Inc., located in Ft. Collins, Colorado, provides pre-clinical services including: osteoarthritis models, experimental surgery (surgical/medical device development, biomaterial implants, spine and long bone orthopedics, soft tissue models, vascular catheterization and angiography), medical imaging: CT, MRI, fluoroscopy, digital radiography, ultrasound/ echo, toxicology and pharmacokinetics. Species include swine, small ruminants, rodents, rabbits, dogs, cats. RoosterBio, Inc 4539 Metropolitan Ct Frederick, MD RoosterBio is a stem cell tools & technology company focused on accelerating the Regenerative Medicine industry. RoosterBio products are high volume, affordable and well-characterized adult human mesenchymal stem/stromal cells (hmscs) paired with highly engineered media systems. RoosterBio has simplified and standardized how stem cells are purchased, expanded, and used in development, leading to marked time and costs savings for customers. Sawbones Worldwide Inc SW 188th Street Vashon, WA Phone (206) SAWBONES WORLDWIDE, a division of Pacific Research Laboratories is the leader in orthopedic, medical education and biomechanical test models. They offer a complete range of biomechanical test materials designed to simulate the physical properties of human bone without the variability and special handling requirements of testing in cadaver specimens. They have a dedicated team of engineers and toolmakers with the know-how to design and manufacture custom products for medical device companies. Scanco Medical PO Box 646 Southeastern, PA Phone (610) CORPORATE PARTNER Scanco Medical ( is the leading global provider of high-resolution micro-ct systems from mouse to man. Scanco also provides contract based scanning services for non-destructive scanning applications at locations in the USA and Switzerland. GPU-based reconstruction, 3D image analyses, 3D visualization, Finite Element Analysis, Image/Data archiving solutions and mechanical loading stage are available for all systems. Synopsys Simpleware Bradninch Hall Castle Street Exeter EX4 3PL United Kingdom Phone +44 (0) The Simpleware business group at Synopsys develops worldleading software for the conversion of 3D scan data (MRI, CT) into high quality simulation-ready models. Simpleware provides a complete environment to visualize, process and analyses designs of orthopaedic, cardiovascular and other medical devices. Simpleware software is FDA 510(k) cleared for pre-operative simulation/ evaluation of surgical treatment options. EXHIBITORS 74

75 EXHIBITOR INFORMATION TA Instruments ElectroForce 9625 West 76th Street Eden Prairie, MN Phone (952) ElectroForce mechanical test systems by TA Instruments (formerly of Bose Corp.) deliver industry-leading performance, versatility and durability. Offered in a range of force capacities, ElectroForce test systems are ideally suited for determining mechanical or fatigue properties of biomaterials, tissues, and medical devices. BioDynamic bioreactors, the most versatile bioreactors outside the body, simultaneously stimulate and characterize tissueengineered constructs in a sterile environment. Tekscan, Inc. 307 W First Street South Boston, MA Phone (617) Tekscan manufactures a broad range of tools for better pressure offloading and enhanced gait analysis. Our systems use paperthin, high-resolution sensors to accurately measure plantar pressure distribution, timing and Center of Force (CoF) trajectory in dynamic evaluations. The unique information these systems provide helps you objectively validate treatments and improve outcomes. The MotionMonitor 6711 N Ravenswood Ave, Suite 150 Chicago, IL Phone (773) Innovative Sports Training, Inc is proud to provide The MotionMonitor, a fully-integrated 3D motion capture & analysis system for use in orthopaedic, biomechanical, and clinical applications. Data from various kinematic tracking systems, EMG, force plates, video, and other analog devices are collected through one platform, synchronized, and presented in real-time. CT/MRI registration capabilities offer subject-specific models and tracking of internal landmarks. Veterinary Transplant Services, Inc. 215 East Titus Street Kent, WA Phone (800) VTS is a dedicated animal tissue bank with expertise in processing animal tissues for clinical as well as research use. We provide animal-sourced DBM and other bone graft materials for product development and pre-clinical studies. We offer customizable processing and packaging of graft materials for a wide variety of animal models and studies. Rely on VTS to produce animal tissues processed to your unique product development or pre-clinical project specifications. Wake Forest Innovations 575 Patterson Avenue, Suite 550 Winston-Salem, NC Phone (336) Wake Forest Innovations accelerates the journey from discovery to commercialization. Through open innovation with industry we transform ideas, discoveries and inventions into valuable health care products. We provide industry access to Wake Forest s basic science scholarship, proprietary technologies for licensing and specialized preclinical and clinical research services Wiley-Blackwell 350 Main Street Malden, MA Phone (201) CORPORATE PARTNER Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical, and scholarly journals, combined with our digital learning, assessment and certification solutions help universities, learned societies, businesses, governments, and individuals increase the academic and professional impact of their work. 75 EXHIBITORS

76 EXHIBITOR INFORMATION Zwick USA 2125 Barrett Park Drive, Suite 107 Kennesaw, GA Phone (678) Zwick USA supports the development and manufacture of orthopedic devices with solutions that enable intelligent testing. Visit our booth to learn more about the new LTM product series, which leverages an electrodynamic drive based on linear motor technology to deliver exceptional performance in fatigue testing of orthopedic implants. Experts from Zwick will be on hand for product demonstrations and to discuss features of the testxpert software that support compliance with 21 FDA CFR Part 11. EXHIBITORS 76

77 N N C ' Table 6' Table COPIER N ' Table N720 N720 6'T Draped 6'T Draped 88 N720 N720 N 'T Draped 88 N720 N N720 3' 'T Draped 88 8' x 6' SCREEN N720 N720 6'T Draped C ORS 2017 ANNUAL MEETING PROGRAM BOOK EXHIBITOR FLOOR PLAN SP EXIT EXIT EXIT EXIT EXIT EXIT EXIT EXIT EXIT EXIT 3-HOUR RATED FIREDOOR FE 8' High MIS Wall x M Long AS 10' FE SV 18'-8" 60'-4" EXIT EXIT 8' High MIS Wall x M Long 89 28' CAREER CENTER Box Lunch Stations ' WOMEN 15' 8' High MIS Wall x M Long FIRE CONTROL ROOM POSTER LOCATOR EXIT 100 EXIT POSTER COLLECTION AREA POSTER COLLECTION AREA 18' POSTER COLLECTION AREA 294 posters 50' 14' AISLE 6' Table ENTRANCE EXIT TOWER EXIT 6'T Draped 164 6'T Draped 6'T Draped ORS BOOTH ' CHARGING STATION CHARGING STATION CHARGING STATION ' N N N 'T Draped 10'-1" EXIT 7'-3" 6' 5'-6" 5'-6" 5'-6" 20' POSTER COLLECTION AREA BUFFET POSTER COLLECTION AREA CARPET LINE POSTER COLLECTION AREA 13'-4" 13'-8" '-3" ' AISLE 40' THEATER 12' EXIT ENTRANCE EXIT EXIT TOWER 5'-6" '-4" 20' CARPET LINE HVAC EXIT 5'-6" EL 5'-6" 5'-6" EXIT EXIT 20' 5'-6" 6' 6' 9' 6' 6' 6' 6' 10' 12' 6' 13'-5" 6' 6' 6' 6' 6' 6' 6' 6' 21'-6" 5'-6" 6'T Draped EL MEN 19'-11" FH SP AS SV 77 EXHIBITORS

78 JOIN US BECOME A MEMBER AND PARTICIPATE in the leading global musculoskeletal research community Our members include biologists, clinicians, engineers, veterinarians, and orthopaedic surgeons everyone in the field of musculoskeletal research. Advance your career Build relationships Enhance professional skills Grow collaborations Increase your knowledge STOP BY the ORS Member Center in Innovation Central OR JOIN ONLINE at (click on MEMBERSHIP ). Sun Wed, March 19 22, 2017 San Diego Convention Center San Diego, California

79 STAY IN THE CONVERSATION ALL YEAR LONG LIKE us on Facebook on Twitter #ORS2017 JOIN the conversation on LinkedIn WATCH us on YouTube DON T FORGET TO DOWNLOAD THE ORS 2017 ANNUAL MEETING MOBILE APP! m.core-apps.com/ors_2017 Sun Wed, March 19 22, 2017 San Diego Convention Center San Diego, California