Neuropathology CC Exam Module Study Guide. CC NP General Neuropathology I (Mandatory 50-Question Module)
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1 Registrants for the NP only or combined Primary/NP CC exam must take the mandatory general NP module plus any elective NP modules selected during registration. CC NP General Neuropathology I (Mandatory 50-Question Module) A-beta related angiitis. leptomeningeal opacifications abnormal corticospinal tracts/pyramids leukodystrophies acute hemorrhagic leukoencephalopathy motor cortex; smear prep anaplastic astrocytoma multicystic encephalopathy angiitis; vasculitis astrocytomas; chemotherapeutic resistance myxopapillary ependymoma axonal injury; IHC orbital plate fractures borderzone hypoxic-ischemic damage Pick disease cervical spinal cord tracts pituitary gland histology postmortem artifacts CNS neoplasms; loss of heterozygosity primary angiitis of the CNS deep (basal) nuclei; tracts ragged red fibers dermatomyositis retinal hemorrhage diffuse axonal injury retinoblastoma dysembryoplastic neuroepithelial tumor skeletal muscle ultrastructure fetal and neonatal hypoxic-ischemic lesions spinal cord anatomy fetal developmental; neuroanatomy status marmoratus Steele-Richardson-Olszewski syndrome GM1 and GM2 gangliosidoses substantia nigra hereditary sensory-motor neuropathies tauopathies Huntington disease TORCH infections hypoxic injury tract degeneration infant developmental neuropathology; cerebellum trinucleotide repeat disorders infant spinal cord; sequence of myelination vascular malformations Lafora progressive myoclonic epilepsy Page 1
2 CC NP General Neuropathology II (Elective 50-Question Module) adrenoleukodystrophy fungal infections aspergillosis Herpesvirus infections auditory system; tracts heterotopic neurons axonal (Wallerian) degeneration HIV encephalitis/leukoencephalitis Binswanger disease holoprosencephaly; trisomies blood-brain barrier integrity hypertensive vascular changes blood-brain barrier; neuroanatomy iatrogenic cerebral injuries borderzone hypoxic-ischemic damage microglia and mononuclear cells brain development; weight at term multiple sclerosis CADASIL central chromatolysis Negri bodies central neurocytoma neural tube defects cerebral capillaries; ultrastructure paragangliomas cerebral malaria pineal gland cerebral toxoplasmosis retina and vitreous; normal histology cholinergic input to cerebral cortex sarcoidosis chronic hypoxic-ischemic encephalopathy schwannoma contusions skeletal muscle; IHC patterns of staining craniopharyngioma spinal muscular atrophy cysticercosis tauopathies; progressive supranuclear palsy decomposition artifacts vitamin B12 deficiency diffuse axonal injury; IHC Von Hippel-Lindau disease fat embolism Zebra bodies; storage products in neurometabolic diseases fatal familial/sporadic insomnia fatal familial/sporadic insomnia fetal cerebellum; histology CC NP Degenerative I (Elective 25-Question Module) Alzheimer disease Huntington disease; IT15 gene amyotrophic lateral sclerosis astrocytic plaques neurofibrillary tangles axonal degeneration neuronal inclusions Bunina bodies Pick disease chronic traumatic encephalopathy progressive supranuclear palsy Creutzfeldt-Jakob disease prion diseases; tissue handling granulovacuolar degeneration spinal cord; atrophy hepatolenticular degeneration spondylosis hereditary motor and sensory neuropathies synucleinopathies tauopathies; IHC Huntington disease Page 2
3 CC NP Degenerative II (Elective 25-Question Module) Alzheimer disease; limbic system argyrophilic grain disease Hirano bodies cerebellar degeneration Lewy body disease spectrum disorders concentric sclerosis multiple sclerosis congophilic angiopathy corticobasal degeneration neuromyelitis optica Creutzfeldt-Jakob disease olivopontocerebellar degeneration cytoplasmic inclusions Pelizaeus-Merzbacher disease dystrophic calcifications progressive supranuclear palsy frontotemporal lobar degeneration trinucleotide repeat disorders hepatolenticular degeneration ubiquitin IHC CC NP Developmental/Pediatric/Congenital I (Elective 25-Question Module) acute/subacute white matter lesions megalencephaly neurodegeneration with brain iron accumulation; alobar holoprosencephaly mutations arachnoid cyst neuronal heterotopias; mutations Chiari type II malformation neuronal migration defects pachygyria congenital fiber-type disproportion myopathies polymicrogyria Dandy-Walker syndrome reactive gliosis defects of neural tube closure schizencephaly diastematomyelia Sturge-Weber syndrome fetal neuroanatomy; gestational age subependymal germinal plate/matrix hemorrhage hypothalamic hamartoma traumatic spinal cord injuries lobar holoprosencephaly tuberous sclerosis CC NP Developmental/Pediatric/Congenital II (Elective 25-Question Module) angiomatosis of meninges hydranencephaly bundle of Probst kernicterus Meckel-Gruber congenital hydrocephalus multicystic encephalopathy CSF cytopathology; leukemias and lymphomas myelomeningocele defects of neural tube closure; dysraphic state myotonic dystrophy, type I diastematomyelia neuroblastoma double cortex syndrome/x-linked lissencephaly pilocytic astrocytoma Down syndrome; neuroanatomy status marmoratus germ cell tumors Sturge-Weber syndrome syringomyelia/hydromyelia trauma; falls; subdural hemorrhage holoprosencephaly; trisomy Page 3
4 CC NP Neoplastic I (Elective 25-Question Module) anaplastic oligodendroglioma malignant lymphoma central neurocytoma medulloblastome; IHC metastatic neoplasms choroid plexus papilloma neuroblastoma CNS PNET paraganglioma craniopharyngioma perineurioma cysts pilomyxoid astrocytoma diffuse astrocytomas pineocytoma ependymoma pituicytoma ; FISH rosette-forming glioneuronal tumor hemangioblastoma von Hippel-Lindau disease intraoperative diagnosis of CNS tumors CC NP Neoplastic II (Elective 25-Question Module) anaplastic astrocytoma atheroemboli metastatic neoplasms atypical teratoid/rhabdoid tumor neuronal and mixed neuronal-glial tumors cerebellar liponeurocytoma pineal neoplasms; IHC ; mutations primary CNS lymphoma choroid plexus tumors radiation induced neoplasms circumscribed astrocytomas schwannoma Cowden disease tumors of the meninges cysts of the CNS tumors of the meninges; recurrence ependymal tumors tumors of the sellar region CC NP Neuromuscular I (Elective 25-Question Module) astrocytoma McArdle disease congenital muscular dystrophy; IHC muscle group atrophy and target fibers core myopathies myoclonic epilepsy; mitochondrial encephalomyopathy dermatomyositis myopathic histopathologic features; type 2 atrophy dermatomyositis; pediatric myopathic histopathologic features; ultrastructure dystrophinopathies; IHC nemaline myopathies glycogenoses neuropathic histopathologic features in muscle; ATPase inclusion body myositis normal muscle, MHC class I IHC inclusion body myositis; ultrastructure parasitic myositis lipid storage myopathies schwannomas lysosomal and peroxisomal disorders; enzyme spinal muscular atrophy; diagnosis replacement therapy macrophagic myofasciitis spongiform changes Page 4
5 CC NP Neuromuscular II (Elective 25-Question Module) amyloidosis mitochondrial myopathy autophagic vacuolar myopathies myofibrillar myopathies axonal degeneration myophagocytosis centronuclear myopathies neuropathic histopathologic features; acute denervation demyelinating diseases; optic nerve non 5q spinal muscular atrophy (SMA); genetics facioscapulohumeral dystrophy (FSHD); diagnosis plexiform neurofibroma inclusion body myositis schwannoma inflammatory myopathies skeletal muscle ultrastructure leprosy toxic myopathies; Type 2 atrophy limb-girdle muscular dystrophy tubular aggregate myopathy Lisch nodules type II glycogenoses; ultrastructure lysosomal disorders; ultrastructure Page 5
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