The thickening. embryonic neural tube. Preview: Fig 1.3. Forebrain (prosencephalon)
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1 9.14 Worksheets Courtesy of MIT Press. Used with permission. Schneider, G. E. Brain structure and its origins: In the Development and in Evolution of Behavior and the Mind. MIT Press, ISBN:
2 1 Preview: a The thickening d c b embryonic neural tube Courtesy of MIT Press. Used with permission. Schneider, G. E. Brain structure and its origins: In the Development and in Evolution of Behavior and the Mind. MIT Press, ISBN: Fig 1.3 e a. Endbrain (telencephalon) b. Tweenbrain (diencephalon) c. Midbrain (mesencephalon) d. Hindbrain (rhombencephalon) e. Spinal cord Forebrain (prosencephalon) 2
3 1 Preview: c b a The thickening embryonic neural tube d e a. Endbrain (telencephalon) b. Tweenbrain (diencephalon) c. Midbrain (mesencephalon) d. Hindbrain (rhombencephalon) e. Spinal cord Forebrain (prosencephalon) Courtesy of MIT Press. Used with permission. Schneider, G. E. Brain structure and its origins: In the Development and in Evolution of Behavior and the Mind. MIT Press, ISBN:
4 2 Synapses: varied structural arrangements: Consider the functional possibilities 1. Axo-somatic 2. Axo-dendritic (to dendritic shaft or dendritic spine) Fig 1-13a 4
5 3 Synapses: varied structural arrangements: Consider the functional possibilities 6. Serial synapses Gating mechanisms 7. Synapses without a postsynaptic site (not illustrated) Fig 1-13c 5
6 4 Synapses: varied structural arrangements: Consider the functional possibilities 3. Axo-axonal Presynaptic inhibition and facilitation 4. (Also: dendro-dendritic, dendro-axonal ) 5. Reciprocal synapses Cell 1 Cell 3 Cell 2 Fig 1-13b 6
7 5 Hamster Brain (similar to rat) Fig.1-5 Adult Newborn 7
8 5 Hamster Brain (similar to rat) A B C D E F Adult Newborn 8
9 6 Pallium (medial, dorsal, lateral) Study the names of these subdivisions. Learn which is which. Schematic of premammalian brain 9
10 7 Sketch of a pre-mammalian brain 10
11 7 Locate a local reflex channel. What function might such a pathway serve? 11
12 8 Mammalian brain diagrams Schematic side view Top view, embryonic brain (with spinothalamic tract) 12
13 8 Mammalian brain diagrams Schematic side view Top view, embryonic brain (with dorsal root axon) 13
14 Brain diagrams 8. 14
15 9 Closure of neural tube with formation of sympathetic ganglia: Learn the terms! Neural plate Ectoderm Notochord Neural groove Neural tube and neural crest Dorsal root ganglion Ganglia of sympathetic NS Roof plate Alar plate Basal plate Floor plate 15
16 9 Closure of neural tube with formation of peripheral ganglia: Neural X stage A B Neural Y stage Neural Z and neural ZZ Ganglia of J nervous system I C D E F G H 16
17 REVIEW Some neurodevelopment terms to be familiar with ectoderm (vs. mesoderm and endoderm), ventricular layer, intermediate layer, marginal layer (= matrix layer, mantle layer, zonal layer) modes of migration, radial glia (radial astrocytes), ependyma, sulcus limitans, separating alar and basal plates, neural crest, dorsal and ventral roots and rootlets. See Nauta & Feirtag, ch.10, and other texts 17
18 10 Internal Structure Spinal Cord Segment C1 Segment C5 Internal structure of spinal cord: Note the lateral horn Segment C8 Segment T2 Segment T10 Segment L1 Segment L4 Segment S4 Image by MIT OpenCourseWare. 18
19 11 Termination of dorsal root fibers Figures removed due to copyright restrictions. Please see course textbook or: Rexed, Bror. "A Cytoarchitectonic Atlas of the Spinal Coed in the Cat." Journal of Comparative Neurology 100, no. 2 (1954):
20 12 Adult spinal cord, schematic frontal section: reflex and lemniscal channels Dorsal columns Dorsal root fibers of various sizes Spinothalamic tract Spinoreticular axons 20
21 12 Adult spinal cord, schematic frontal section: reflex and lemniscal channels A Dorsal root fibers of various sizes B C D 21
22 13 The body surface represented at the hindbrain-spinal cord boundary 22
23 13 The rostral-most end of the spinal cord A B D C 23
24 14 Dorsal Funiculus Dorsal Median Sulcus Lissauer's Zone Lateral Funiculus Clarke's Column (nucleus dorsalis) Lateral Horn Central Canal Substantia Gelatinosa Dorsal Spinocerebellar Tract Ventral Funiculus Anterior White Commissure Ventral Median Fissure 1 millimeter Fig 9-9 Image by MIT OpenCourseWare. Clarke s Column and dorsal spino-cerebellar tract 24
25 15 Adult spinal cord: some descending and intrinsic axons Propriospinal axons Corticospinal axons (after their decussation) Rubrospinal axons Reticulospinal, Vestibulospinal, Fastigiospinal (from Cb), Tectospinal Corticospinal axons, uncrossed (variable in quantity) 25
26 15 Adult spinal cord: some descending and intrinsic axons (fill in the blanks) A axons B axons (after their decussation) C axons D spinal, E spinal, Fastigiospinal (from Cb), F spinal G axons, uncrossed (variable in quantity) 26
27 16 Dorsal root ganglion Sympathetic nervous system axons, schematic section of spinal cord, thoracic level x Descending reticulospinal fibers xxxx xxxxx xx Paravertebral ganglion Prevertebral ganglion, e.g., celiac Spinal nerve Smooth muscle: Glands; intestinal tract; blood vessels, erector pili (hairs); sweat glands. Cardiac muscle To striated muscles. 27
28 17 Thoraco -lumbar Vagus nerve (10 th cranial nerve) 28
29 17 A. Which ganglion is this? Thoraco -lumbar X nerve (10 th cranial nerve) C. Which ganglia are these? 29
30 18 Interventricular Foramen Choroid Plexus of Third Ventricle Choroid Plexus of Lateral Ventricle Aq Lateral Aperture Choroid Plexus of Fourth Ventricle Median Aperture Central Canal Ventricular system Fig 9a-1 Image by MIT OpenCourseWare. 30
31 19 Meninges & Glia Astrocyte Dura Arachnoid Pia Pial-glial membrane Ependymal cells lining the ventricle Satellite oligodendrocytes (oligodendroglia) 31
32 19 Meninges & Glia (Identify structures indicated) A B C D E A F cells lining the ventricle Satellite oligodendrocytes 32
33 20 a Basic subdivisions, embryonic neural tube: Where is the rhombus? What is it? e a. Spinal cord a. Sp inal cord a. Endbrain b. Hindbrain b. Hi (rhombencephalon) ndbrain (telencephalon) (rhombencephalon b. Tweenbrain c. Midbrain c. Midbrain (diencephalon) (mesencephalon) (mesencephalon) c. Midbrain d. Tweenbrain d. T(diweenbrain (mesencephalon) encephalon) (di encephalon) d. Hindbrain (rhombencephalon d c b e. Spinal cord Forebrain (prosencephalon) Reminder: Students should understand and know this figure! 33
34 21 Embyonic spinal cord & hindbrain compared: identify the indicated structures Embryonic spinal cord (in cross section) C zone D zone E zone A_ plate B plate Embryonic hindbrain Secondary sensory cell groups in D zone of A plate Motor neuron cell groups in D zone of B plate Sulcus F B plate A plate 34
35 22 Notes on hindbrain origins: definitions Segmentation above the segments of the spinal cord: The somitomeres & branchial arches in the mesoderm, and the rhombomeres of the CNS See Nauta & Feirtag, ch.11, p. 170, on the branchial motor column -- in addition to the somatic and visceral motor columns. Sulcus limitans Visceral motor column Somatic motor column Alar plate Branchial motor column Reticular formation Basal plate 35
36 23 Columns in spinal cord Columns in Hindbrain Fig
37 24 Adult caudal hindbrain of mammal principle cell columns and fiber tracts (schematic) 4 th ventricle Vestibular, auditory (VIII); caudally nuc. gracilis & cuneatus (dorsal column nuclei) Trigeminal (V, sensory from face) Descending pathways: Rubrospinal Vestibulospinal Tectospinal Reticulospinal: not shown Fig Corticospinal = pyramidal tract Medial lemniscus Spinothalamic tract Visceral sensory & motor (III in midbrain; VII, IX & X parasympathetic Branchial motor column: nuc. ambiguus (IX, X swallowing & vocalization) facial (VII), masticatory (V) Somatic motor column: III, IV (midbrain) & VI eye movements XII tongue movements 37
38 25 Evolution of Brain 4 Expansion of midbrain with evolution of distance-receptor senses: visual and auditory, receptors with advantages over olfaction for speed and sensory acuity, for early warning and for anticipation of events... Motor side: 1) escape locomotion; 2) turning of head and eyes with modulation by motivational states, including those triggered by olfactory sense. Endbrain tweenbrain Midbrain Anti-predator behavior: turning away, fleeing Orienting: turning of head & eyes toward 38
39 26 Review of earlier figure: Note the pathway from neocortex to cerebellum 1 1. Dorsal columns 2. Nuclei of the dorsal columns 3. Medial lemniscus 4. Ventrobasal nucleus of thalamus (n. ventralis posterior) 5. Thalamocortical axon in the internal capsule nucleus 6. Corticofugal axons, including corticospinal components. Called pyramidal tract in hindbrain below pons. 7. Pons 39
40 27 Frontal section, middle of mammalian midbrain: Superior Colliculus Central Gray Area (periaqueductal gray) Red Nucleus Ventral Tegmental Area 40
41 27 Frontal section, middle of mammalian midbrain: Identify the indicated structures A F B C D E 41
42 28 Midbrain Locomotor Region (MLR): Localization in cat by electrical stimulation studies Th Parasagittal section M Hypothalamic Locomotor Area NR SC P IC Midbrain Locomotor Area Frontal section BC P IC LL Inferior Colliculus Midbrain Locomotor Area Fig 14-1 Th = thalamus BC = brachium conjunctivum M = mammillary body (axons from cb) NR = nuc. ruber (red nuc.) LL = lateral lemniscus III = oculomotor nerve (auditory) P = pons SC = superior colliculus 42
43 29 Midbrain neurons projecting to spinal cord and hindbrain for motor control Superior Colliculus (optic tectum) Red nucleus (n. ruber) Tectospinal tract Rubrospinal tract 43
44 30 Midbrain areas that influence moods and motivational states: Central gray area (CGA) Oculomotor nucleus Superior Colliculus Brachium of Inferior Colliculus (auditory pathway, midbrain to thalamus) Spinothalamic tract (some fibers terminate in SC) Red nucleus (n. ruber) Tectospinal tract Rubrospinal tract Medial lemniscus Cerebral peduncle: contains corticospinal + corticopontine fibers, + cortex to hindbrain fibers Ventral Tegmental Area (VTA) Connections to the CGA, also called the Periaquaductal Gray (PAG), and to the VTA enabled control of or influence on moods/motivations crucial for survival: defensive, aggressive, sexual. Activation of these areas is accompanied by feelings of pain (CGA) or pleasure (VTA). 44
45 31 Midbrain: Species comparisons Note the great differences in the size of the cerebral peduncles at the base of the brain Rodent Human (Sections are not drawn to the same scale) Tree Shrew (Squirrel is similar) Fig
46 32 Rostral end of the thickening neural tube in mammals: descriptive terms LVA LG MG Thickened Ventricular Layer Midbrain Hindbrain Forebrain LVA = Lateral ventricular angle region LG = Lateral Ganglionic Eminence MG = Medial Ganglionic Eminence 46
47 32 Rostral end of the thickening neural tube in mammals: identify the abbreviations shown LG LVA MG Midbrain Forebrain Thickened Ventricular Layer Hindbrain LVA = X LG = Y MG = Z 47
48 33 a The lateral forebrain bundle: major origins and course c b a Note the different names at different levels. All these names occur frequently in discussions of brain structure and connections Schneider, G. E. Brain structure and its origins: in the development and in evolution of behavior and the mind. MIT Press, ISBN: Fig 12-6 e d a. Endbrain (telencephalon) b. Tweenbrain (diencephalon) c. Midbrain (mesencephalon) d. Hindbrain (rhombencephalon) e. Spinal cord Cortical white matter to Internal capsule Cerebral peduncles (includes fibers to tweenbrain, midbrain, pons, remainder of hindbrain, spinal cord) Pyramidal tract Corticospinal tract 48
49 33 a Descending axons from somatosensory and motor cortical areas: a Note the different names at different levels. Fill in the blanks. e d c b a. Endbrain (telencephalon) b. Tweenbrain (diencephalon) c. Midbrain (mesencephalon) d. Hindbrain (rhombencephalon) Cortical white matter to A capsule Cerebral B (includes fibers to tweenbrain, midbrain, pons, remainder of hindbrain, spinal cord) C tract e. Spinal cord D tract Fig
50 34 Tweenbrain and Endbrain limbic & MFB Medial forebrain bundle Lateral forebrain bundle Lateral forebrain bundle Medial forebrain bundle 50
51 34 Tweenbrain and Endbrain --Identify the axon groups indicated What bundle of axons are all these? What group of axons are these? What bundle of axons are these? D C A B What group (bundle) of axons? 51
52 Check your knowledge of brain structures: Neuroanatomy review Subdivisions of CNS; definitions of cell types Shapes of the neural tube at various levels Sensory channels of conduction; dermatomes Diaschisis: lesion-produced deafferentation causes a functional depression of neurons Evolution of neocortex with major ascending and descending pathways to it and from it Spinal cord structure; differences between levels Propriospinal system Autonomic N.S. and its components Hindbrain organization; distortions of the basic plan Cranial nerves: the 5 th (trigeminal nerve) 52
53 Neuroanatomy review continued Midbrain: tectum and tegmentum; species differences; outputs for three major types of movement Diencephalon: two major and two additional subdivisions (functional/structural) Telencephalon: the endbrain (cerebral hemispheres and basal forebrain); origins of two major pathways for descending axons (Both contain some ascending axons also.) Some major axonal pathways in mammals: Spinoreticular, trigeminoreticular tracts (mostly ipsilateral) Spinothalamic tract; longest axons reach the ventrobasal nuc. of thalamus (VB = VPM and VPL) Dorsal columns, connecting to the medial lemniscus pathway, which projects to the ventrobasal nuc. of thalamus Corticospinal & corticopontine pathways (the former connect to all levels of CNS, the latter connecting to the pons, hence to cerebellum) 53
54 35 Telencephalon OB Eye Stalk Diencephalon 1) Embryonic brain with curved longitudinal axis D R D V Mesencephalon D D C Rhombencephalon P1 P2 MP DP P3 P4 Str. P5 OB P6 2) Puelles & Rubenstein, 93 Mes. 1st R1 R2 R3 R4 R5 R6 R7 Neuromeric models of embryonic mammalian brain DP LP VP Str. Pa MP P3 P4 P5 P6 3) Revision of the model Fig 12-8 Image by MIT OpenCourseWare. 54
55 MIT OpenCourseWare Brain Structure and Its Origins Spring 2014 For information about citing these materials or our Terms of Use, visit:
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