PENN BRAIN TUMOR ACADEMY:

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1 F R I D AY, MAY 13, :30 AM 4:30 PM Smilow Center for Translational Research 3400 Civic Center Blvd Philadelphia, PA Penn Medicine s Abramson Cancer Center and Brain Tumor Center P R E S E N T PENN BRAIN TUMOR ACADEMY: INNOVATION MEETS BEST PRACTICE A CME/CNE-Certified Course R E G I S T E R O N L I N E AT PennMedicine.org/CME/Brain

2 Penn Medicine s Abramson Cancer Center and Brain Tumor Center P RESENT PENN BRAIN TUMOR ACADEMY: INNOVATION MEETS BEST PRACTICE ARTHUR RUBENSTEIN AUDITORIUM SMILOW TRANSLATIONAL RESEARCH CENTER The Arthur Rubenstein Auditorium is located on the first floor of the Smilow Translational Research Center, which is adjacent to the Perelman Center for Advanced Medicine. Enter through the Perelman Center. For public transportation, directions, and parking information, go to PennMedicine.org/ Perelman/visitor_info Perelman Center is conveniently reached by several public transportation routes. Amtrak, 30th Street Station Septa Regional Rail (University City Station) LUCY - Loop Through University City NJ PATCO Trains Parking is available at the Perelman Center parking garage. Parking fees are not covered. All conference materials will be available online. Please bring your electronic device to view presentations in real time. FRIDAY, MAY :30 AM 4:30 PM OVERVIEW The purpose of this activity is to provide new treatment options in neuro-oncology, including surgical techniques and intraoperative imaging that have improved patient outcomes. Sessions will feature the latest advances in state-ofthe-art care for practicing physicians treating patients with brain tumors. Cutting-edge topics in precision medicine, including genetic, translational, and clinical research will also be featured. Each section will conclude with an audience interactive panel discussion with question and answer session. WHO SHOULD ATTEND This symposium is designed for neurosurgeons, neuro-oncologists, neurologists, radiologists, medical oncologists, radiation oncologists, pathologists, neuropsychologists, primary care physicians, oncology nurses, and other healthcare professionals involved in the treatment of patients with brain tumors.

3 LEARNING OBJECTIVES At the completion of this course, participants should be able to: Describe emerging concepts in the diagnosis and management of patients with brain tumors Explain the risks and benefits of proton beam therapy and stereotactic radiation therapy for brain tumors Describe advances in the clinical application of cancer gene panel sequencing Explain developments from the first human CAR-T cell trial for glioblastoma targeting EGFRviii Review results of the Phase 3 Trial for Tumor Treating Fields for Glioblastoma Discuss the emerging field of connectomics and its impact on neuro-oncology Identify novel biomarkers including circulating glioma cells and advanced neuroimaging Describe advances in neurosurgery of brain tumors including the use of fluorescence, laser thermocoagulation, awake craniotomies, and fiber tractography Review updates in new clinical trials from the NCI-sponsored ABTC consortium Discuss the role of anti-angiogenic therapy and new concepts REGISTRATION Non- Penn Physicians...$ Non- Penn residents, fellows, nurses, and other healthcare professionals...$50.00 Faculty, staff, residents, fellows and/or students of the University of Pennsylvania...$50.00 Registration fee includes admission to the course, breakfast, lunch and course syllabus. Parking fees are not covered. For additional information please contact Barbara Lopez at lopezb@mail.med.upenn.edu or Jamie Burrell at REGISTER ONLINE AT PennMedicine.org/CME/Brain

4 AGENDA 7:30 am Registration and Continental Breakfast 8:00 am Welcome and Introduction Chi V. Dang, MD, PhD M. Sean Grady, MD MORNING SESSION TRANSLATING SCIENTIFIC LEADS TO CLINICAL PROGRESS: INNOVATIVE NEURO-ONCOLOGY Moderator: Steven Brem, MD 8:10 am T-Cell Immunotherapy for Brain Tumors Using CAR Technology for Glioblastoma Carl June, MD, and Donald O Rourke, MD 8:40 am Recent Advances in the Treatment of Gliomas Patrick Wen, MD 9:10 am Molecular Profiling in the Diagnosis of Gliomas Maria Martinez-Lage, MD 9:25 am Clinically Useful Next Generation Sequencing in Glioblastoma Maclean Nasrallah, MD, PhD 9:40 am Circulating Glioma Cells: Potential Biomarker for Response to Therapy Jay Fitzgerald Dorsey, MD, PhD 10:05 am Break 10:30 am Brain Tumor Microvesicles: Biomarkers in Small, Circulating, Cellular Packages Sydney Evans, VMD, MS 10:45 am Computational Neuro-oncology: Leveraging the Power of Neuroinformatics to Enhance Diagnosis, Prognosis, and Neurosurgical Planning Christos Davatzikos, PhD 11:15 am Connectomics The Convergence of Brain Wiring and Brain Tumors Birkan Tunc, PhD 11:30 am Advanced MR Spectroscopy and Perfusion to Detect Metabolism and Response to Therapy in Gliomas Suyash Mohan, MD, PDCC 11:45 am Lunch AFTERNOON SESSION 1 CLINICAL TRIALS: DISCOVERING NEW WAYS TO TAME CNS MALIGNANCY Moderator: Arati Desai, MD 12:30 pm Clinical Trials in Neuro-Oncology Fred Barker II, MD 1:00 pm Molecular Strategies for Treatment of Glioblastoma Emerging Concepts and Results of Trials from ABTC and SNO Arati Desai, MD

5 1:15 pm Electric Field Therapy: Results of the Phase 3 Trial (EF-14): A New Standard for the Treatment of Glioblastoma? Robert Lustig, MD 1:30 pm The Basis for Bevacizumab Based Therapy: Current and Future Use of Anti-Angiogenic Therapy for the Treatment of Brain Tumors Steven Brem, MD 1:45 pm Quality of Life and Neurocognitive Function in Brain Tumor Survivors Carol Armstrong, PhD AFTERNOON SESSION 2 NEW APPROACHES TO ENHANCE THE PREVENTION, DIAGNOSIS, AND TREATMENT OF BRAIN TUMORS Moderator: Donald M. O Rourke, MD 2:00 pm Seizure Management for Brain Tumor Survivors: Current Concepts Kathryn Davis, MD 2:15 pm Update on Proton Therapy for Brain Tumors Helen Shih, MD 2:45 pm Radiation Treatment of Intracranial Metastases and Leptomeningeal Disease Michelle Alonso-Basanta, MD / Goldie Kurtz, MD 3:00 pm Break AFTERNOON SESSION 3 ENGINEERING SOLUTIONS TO ENHANCE NEUROSURGICAL SAFETY AND EFFICACY Moderator: Robert Lustig, MD 3:15 pm fmri and Fiber Tractography in Preoperative Neurosurgical Planning Ronald Wolf, MD, PhD 3:30 pm Preserving Neurological Function in Brain Tumor Surgery: Individualized Signatures Using Connectomics Steven Brem, MD 3:45 pm Awake Craniotomies for Optimizing Outcomes in the Eloquent Areas of the Brain Donald O Rourke, MD 4:00 pm Laser Thermocoagulation: A New Tool for Epilepsy and Brain Tumor Surgery Timothy Lucas, MD, PhD 4:15 pm Seeing Beyond the Visible: Fluorescent Imaging of Brain Tumors John Y.K. Lee, MD 4:30 pm Summary and Meeting Adjournment Steven Brem, MD; Robert Lustig, MD; Arati Desai, MD; Donald O Rourke, MD; John Y.K. Lee, MD

6 SPEAKERS COURSE CHAIRS Steven Brem, MD Professor, Neurosurgery Chief of Surgical Neuro-Oncology Co-Director, Penn Brain Tumor Center Arati Desai, MD Assistant Professor, Medicine (Hematology/Oncology) Co-Director, Penn Brain Tumor Center Robert Lustig, MD, FACR Professor, Clinical Radiation Oncology Chief, Clinical Operations of Department of Radiation Oncology PERELMAN SCHOOL OF MEDICINE FACULTY Michelle Alonso-Basanta, MD, PhD Helene Blum Assistant Professor, Radiation Oncology Carol Armstrong, PhD Assistant Professor, Neurology Chi V. Dang, MD, PhD John H Glick, MD Abramson Cancer Center Director s Professor, Medicine Director, Abramson Cancer Center Christos Davatzikos, PhD Wallace T. Miller, Sr. Professor, Radiology Kathryn Davis, MD Assistant Professor, Neurology Jay Dorsey, MD, PhD Assistant Professor, Radiation Oncology Sydney Evans, VMD, MS Professor, Radiation Oncology M. Sean Grady, MD Charles Harrison Frazier Professor of Neurosurgery Chairman, Neurosurgery Goldie Kurtz, MD Instructor, Radiation Oncology Carl June, MD Richard W. Vague Professor in Immunotherapy, Pathology and Laboratory Medicine Director, Center for Cellular Immunotherapies John Y.K. Lee, MD Associate Professor, Neurosurgery Timothy Lucas, MD, PhD Assistant Professor, Neurosurgery Maria Martinez-Lage, MD Assistant Professor, Pathology and Laboratory Medicine Suyash Mohan, MD, PDCC Assistant Professor, Radiology Donald O Rourke, MD Associate Professor, Neurosurgery Maclean Nasrallah, MD, PhD Neuropathology Clinical Fellow Birkan Tunc, PhD Research Associate Ragini Verma, PhD Associate Professor, Radiology Ronald Wolf, MD, PhD Associate Professor, Radiology GUEST SPEAKERS Fred Barker II, MD Associate Professor, Neurosurgery, Harvard Medical School Director, Cranial Base Center, Massachusetts General Hospital Chair, AANS/ CNS Section on Tumors; Boston, Massachusetts Helen Shih, MD Associate Professor, Radiation Oncology, Harvard Medical School Director CNS Service and Associate Medical Director of the Francis H. Burr Proton Therapy Center, Massachusetts General Hospital; Boston, Massachusetts Patrick Wen, MD Professor, Neurology, Harvard Medical School Director, Center for Neuro-Oncology, Dana-Farber Cancer Institute Editor-in-chief of NEURO-ONCOLOGY; Boston, Massachusetts

7 ACCREDITATION AND DESIGNATION OF CREDIT ACCREDITATION PHYSICIANS: The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. NURSES: The Hospital of the University of Pennsylvania, Department of Nursing Education, Innovation and Professional Development is an approved provider of continuing nursing education by the PA State Nurses Association, an accredited approver by the American Nurses Credentialing Center s Commission on Accreditation. DESIGNATION OF CREDIT PHYSICIANS: The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 7 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. NURSES: This activity has been approved for 7 contact hours. AAPA: AAPA accepts certificates of participation for educational activities certified for Category 1 credit from AOACCME, Prescribed credit from AAFP, and AMA PRA Category 1 Credits. DISCLOSURES The Perelman School of Medicine at the University of Pennsylvania, Office of Continuing Medical Education, adheres to the ACCME Standards for Commercial Support. Faculty disclosure information will be made available in the conference materials and syllabi. Faculty members are also expected to disclose to participants any discussion of off-label and/ or investigational use of pharmaceutical products or devices within their presentations. CANCELLATION POLICY The University reserves the right to cancel or postpone any course due to unforeseen circumstances. In the event of cancellation or postponement, the University will refund registration fees but is not responsible for any related costs or expenses to participants, including cancellation fees assessed by hotels, airlines and travel agencies. In order to process refunds for conference withdrawals, we must receive cancellation in writing by May 2, No refunds will be issued thereafter. SERVICES FOR THE DISABLED If special arrangements are required for an individual with a disability to attend this meeting, please contact Barbara Lopez at , no later than May 2, 2016 NONDISCRIMINATION STATEMENT The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class status in the administration of its admissions, financial aid, educational or athletic programs, or other University administered programs or in its employment practices. Questions or complaints regarding this policy should be directed to the Executive Director of the Office of Affirmative Action and Equal Opportunity Programs, Sansom Place East, 3600 Chestnut Street, Suite 228, Philadelphia, PA ;or (Voice).

8 Abramson Cancer Center 3600 Market Street Suite 210 Philadelphia, PA Penn Medicine s Abramson Cancer Center and Brain Tumor Center P RESENT PENN BRAIN TUMOR ACADEMY: INNOVATION MEETS BEST PRACTICE A CME/CNE-Certified Course MAY 13, :30 AM 4:30 PM Comprehensive Cancer Center A Cancer Center Designated by the National Cancer Institute Non-Profit Org. U.S. Postage PAID Permit No Phila, PA 19176