A ONE-DAY SYMPOSIUM DNA Damage Response and Repair in Radiation Therapy Karolinska Institutet June 2013

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1 A ONE-DAY SYMPOSIUM DNA Damage Response and Repair in Radiation Therapy Karolinska Institutet June 2013 Organisers: Hooshang Nikjoo, Rolf Lewensohn, Thomas Walz Invited Speakers Penelope Jeggo, Sussex Thomas Helleday, KI Marco Zaider, MSKCC Jiri Bartek, Copenhagen Mats Ljungman, Michigan Ingela Turesson, Uppsala Michael Weinfeld, Alberta Bo Stenerlow, Uppsala Rolf Lewensohn, KI Anders Brahme, KI Kristina Viktorsson, KI Reza Taleei, KI Hooshang Nikjoo, KI Topics DNA repair in mammalian cells; Multidisciplinary approach in cancer therapy; DNA repair and targeted therapy; Targeting DNA damage response in cancer therapy; Role of polynucleotide kinase in cancer therapy; Personalised medicine and radiotherapy Role of radiation physics in modern approach to cancer therapy; New approaches to hadrons therapy; Measurements of DNA damage response by heavy ions; Modelling of DNA damage and repair in mammalian cells; DNA damage and biological response to radiation therapy; Regulation of DNA damage response. For further information contact

2 A ONE-DAY SYMPOSIUM DNA Damage Response and Repair in Radiation Therapy June 2013 Leksell Auditorium, T3 Karolinska Institutet Modern and future cancer treatment techniques, such as intensity modulated radiation therapy (IMRT), of this mini-symposium is to examine recent development and progress in physics of low energy electrons and ions and in particular the prominent role these particles play in radiation biology and radi Organisers Hooshang Nikjoo, PhD, Professor, Radiation Biophysics Group, Dept. of Oncology-Pathology, Karolinska Institutet Rolf Lewensohn, MD, PhD, Professor, Dept. of Oncology-Pathology, Karolinska Institutet Thomas Walz, MD, PhD, MBA, Head of Department of Oncology, Karolinska University Hospital Participation is free but Registration is required by 1 June 2013 Send to hooshang.nikjoo@ki.se Interactions of radiation with human cell induce genomic instability, and DNA damage. What are the consequences of the damage to the cell and the organism in which it resides and perceived as an irreducible system? Radiation is a double edge sword, a harmful agent in need of protection against exposure, but on the other hand a tool vastly used to eradicate cancer. Use of ionising radiation in cancer treatment, and protection against its harmful effect requires a multi disciplinary approach including Medical Radiation Physics, and Molecular Radiation Biology. The perturbation introduced by radiation activates protective processes of the cell to restore the genome integrity. Advances in knowledge of DNA repair processes, cell signaling pathways, and human genome research have opened up unprecedented opportunities to develop bottom-up approaches to targeted cancer therapy. These approaches are aimed at linking induced DNA double-strand breaks through cellular DNA repair processes with deletions, duplications or other potential rearrangements that may ensue. The one-day symposium on DNA damage response and repair in radiation therapy and biology brings together some of the most active researchers in the field from basic research in experimental and theoretical approaches and clinic for discussion.

3 Scientific Programme: Wednesday 12 June SESSION I: 16:50 17:00 Opening Address: :00 18:00 Session I: Opening Lectures Thomas Walz, MD, PhD, Karolinska University Hospital, Penny Jeggo, PhD, Sussex DNA Repair in mammalian cells :00 21:00 Reception Thursday 13 June SESSION II: Future of Oncology 08:00 10:00 1. Rolf Lewensohn, MD PhD, Karolinska Personalised medicine and radiation therapy rolf.lewensohn@ki.se 2. Anders Brahme, PhD, Karolinska New approaches to Hadrons Therapy anders.brahme@ki.se 3. Marco Zaider, PhD, MSKCC, NY Aspects of focal therapy zaiderm@mskcc.org SESSION III: DNA damage response and modelling 10:30-12:30 1. Kristina Viktorsson, PhD, Karolinska Role and sensitivity of a new tyrosine kinase receptor kristina.viktorsson@ki.se family to ionising radiation

4 2. Bo Stenerlow, PhD, Uppsala DNA damage kinetics by heavy ions 3. Hooshang Nikjoo, PhD, Karolinska Modelling of DNA damage induced by electrons, photons and ions: physical, biological and therapeutic implications SESSION IV: DNA Repair in mammalian cells 14:00 16:00 1. Jiri Bartek, PhD, Copenhagen Regulation of DNA damage response 2. Ingela Turesson, MD, Uppsala Damage response in patients with head and neck cancers 3. Reza Taleei, Karolinska Mechanistic model of DNA repair in mammalian cells SESSION V: Targeted Radiotherapy 16:30-18:30 1. Thomas Helleday, PhD, Karolinska DNA repair as a target in cancer therapy thomas.helleday@ki.se 2. Mats Ljungman, PhD, Michigan Radiation Genomics ljungman@umcih.edu 3. Michael Weinfeld, PhD, Alberta Role of polynucleotide kinase in cancer therapy michael.weinfeld@albertahealthservices.ca 4. Discussion V Moderator:

5 Notice of PhD Thesis Examination Candidate: Reza Taleei, Radiation Biophysics Group, Dept., of Oncology-Pathology, Karolinska Institutet Modelling and calculations of DNA damage and repair in mammalian cells induced by ionising radiation of different qualities Time & date: 12:00 pm, Wednesday 12 June 2013 Place: CCK Lecture Hall, Karolinska Institutet Opponent: Committee: Supervisor: Co-Supervisors: Professor Penny Jeggo, University of Sussex Professor Bo Stenerlow, Uppsala University (chair) Professor Anders Brahme, Karolinska Institutet Professor Andrea Ottolenghi, Pavia University Professor Hooshang Nikjoo, Karolinska Institutet Professor Mats Harms-Ringdahl, Stockholm University Professor Michael Weinfeld, Cross Cancer Centre, Alberta