Inner Life of a Cell. Harvard Fall Video. ml
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1 Inner Life of a Cell Video ml Harvard Fall 2010 Lecture 1: Framing the Problem 10/2/2010 Zhi Dong 1
2 Lecture 1 Outline Introduction to the course Course content, format and expectations Framing the problem: What is cancer? Treatment and Research Molecular Biology and Disease Fundamental building blocks of the cell Macromolecules and organelles Discussion: The RNA World Hypothesis Course Objectives Understand fundamental principles in molecular and cellular biology. Familiarize with basic building blocks and processes inside cells. Conceptualize what cancer is and how it arises. Develop scientific inquiry through discussions of current research and discoveries. Focus on understanding how biological principles operate in cancer. Less emphasis on clinical management. 2
3 Class Format and Logistics Lectures Biological principle Examples in cancer Discussions Weekly readings Media (videos, animations and applets) Final Project DNA and Protein Meet in Lyman 330 Time: Sat 10:00am--12:00pm Brain Cancer Cell Background and Expectations No background in biology is necessary! Do the weekly reading Preview and Review key terms and concepts Actively engage in discussion Breast Cancer Cell 3
4 About me Phoenix, Arizona Junior at Harvard College Molecular and Cellular Biology Concentrator Secondary in East Asian Studies Mather House Research on Medulloblastomaat Children s Hospital Boston What is cancer? Perspective from patients Perspective from researchers Current state of cancer research A look at the molecular biology of cancer 4
5 Bibliography- Cancer Videos Two best friends, one form of cancer It's Our Time - American Association for Cancer Research (AACR) Pamela Martin, Cancer Biology Lab Manager Cancer Research Laboratory Cancer Treated with Radiation Therapy What is cancer? Discussion: What are the features of cancer? What do you notice from the last video? 5
6 Can signal itself to keep growing Evade Programmed Cell Death Stop responding to stop signals The Hallmarks of Cancer Growing blood vessels Hanahanet al. (2000) Can t stop dividing Spread to other parts Of the body 6
7 Lecture 2 What s wrong with the cancer cell? Principle: Central Dogma, introduction to molecular genetics, gene regulation, epigenetic regulations Cancer: Mutation, gene regulation, repair, p53 gene 7
8 Lecture 3 Why can t they stop dividing? Principle: Cell cycle, regulation of cellular processes, protein degradation. Cancer: limitless replicativepotential, current therapy, retinoblastoma, Rb gene Lecture 4 How do the cells know what to do? Principles of cell signaling, phosphorylation Cancer: self-sufficiency in growth signals and insensitivity to anti-growth signals. Chronic Myelogenous Leukemia, Philadelphia chromosome 8
9 Lecture 5 The life story of a cell called George. Differentiation, cell aging, and apoptosis. Cancer: Evading apoptosis, cancer stem cell theory, Multiple Myeloma, Medulloblatoma, Bclgene, SHH gene Lecture 6 How do your arms and legs know where to grow? Principles of development, organogenesis, morphogenesis. Cancer: sustained angiogenesis, tissue invasion and metastasis, Bicoidto Hoxgenes. Teratocarcinoma. 9
10 Lecture 7 Final Project We will see an example soon Macromolecules Monomer vs. Polymer 10
11 Macromolecules Carbohydrates (sugar) 11
12 12
13 Macromolecules Lipids 13
14 Macromolecules Phospholipid bilayer ature=related eature=fvw Macromolecules Proteins 14
15 15
16 Proteins Macromolecules Nucleic Acid 16
17 Nucleic acid ture=related II0eZvk&feature=fvw 17
18 Structure of Cells Structure the cells ture=related 18
19 Discussion Where do these components come from? 19
20 Next Lecture: Central Dogma DNA Replication Song 20
21 Reading Assignments Review: Macromolecules, Cellular Components and RNA World Hypothesis, Read Preview: Central Dogma- Replication, Transcription and Translation. Structure of DNA, RNA and Protein The Lac Operon, Transcription factors. DNA wrapping, histoneprotein, DNA methylation, DNA acetylation What is mutation and what causes it? How does the cell try to fix this?
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