MBBS First Professional (Part-I Examination) BIOCHEMISTRY Model Paper
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1 MBBS FIRST PROFESSIONAL (PART I) Biochemistry (MCQs) Maximum Marks: 35 Time Allowed: 45 minutes Q 1. What is not correct about cell membrane? A. Contains two layers of phospholipids B. May contain receptor proteins C. May contain ion channels D. Is impermeable to fat-soluble substances E. May contain glycoprotein molecules Q 2. Activated Gq protein in plasma membrane activates which of the following enzymes? A. Adenylyl cyclase B. Phospholipase A2 C. Phosphodiesterase D. Phospholipase C E. Guanylyl cyclase Q 3. Which of the following is the most important buffer system in human blood plasma? A. Bicarbonate system B. Plasma proteins C. Phosphate buffer system D. Ammonia buffer system E. Acetate buffer system Q 4. What is not correct about surface tension of a liquid? A. Decreases with increase in temperature B. Bile salts can lower the surface tension C. Is measured in dynes/cm D. Soaps can decrease surface tension E. NaCl can decrease surface tension Q 5. Which of the following is a disaccharide? A. Glucose B. Maltotriose C. Trehalose D. Fructose E. Galactose Q 6. Which of the following sugar alcohols is derived from glucose? A. Mannitol B. Ribitol C. Glycerol D. Sorbitol E. Dulcitol Page 1 of 6
2 Q 7. Which of the following is not a homo-polymer of glucose? A. Dextran B. Glycogen C. Cellulose D. Amylopectin E. Inulin Q 8. Which of the following is a ketose? A. Fructose B. Xylose C. Galactose D. Glycerose E. Ribose Q 9. Which of the following is a derived lipid? A. Fatty acid B. Gagnlioside C. Wax D. Triacylglycerol E. Lecithin Q 10. Which of the following fatty acid cannot be hydrogenated? A. Linolenic acid B. Linoleic acid C. Stearic acid D. Oleic acid E. Arachidonic acid Q 11. In premature newborns, the deficiency of which lipid is associated with respiratory distress syndrome? A. Bile acid B. Thromboxane C. Leukotriene D. Dipalmitoylphosphatidylcholine E. Prostacyclin Q 12. Which of the following is not a nutritionally essential amino acid for humans? A. Leucine B. Tryptophan C. Tyrosine D. Methionine E. Phenylalanine Q 13. Which of the following amino acids has two carboxyl groups? A. Glycine B. Histidine C. Aspartate D. Methionine E. Proline Page 2 of 6
3 Q 14. The highest concentration of cysteine can be found in A. Melanin B. Chondroitin sulfate C. Myosin D. Keratin E. Collagen Q 15. Extracorpuscular hemoglobin binds to which of the following plasma proteins? A. Haptoglobin B. Albumin C. Transferrin D. Ceruloplasmin E. Alpha2-macrobglobulin Q 16. For double helical DNA, an increased melting temperature (Tm) results from a high content of A. Adenine and guanine B. Cytosine and thymine C. Adenine and thymine D. Adenine and cytosine E. Cytosine and guanine Q 17. Which of the following is a structural component of RNA but not of DNA? A. Adenine B. Uracil C. Guanine D. Thymine E. Cytosine Q 18. The decomposition of H 2 O 2 is catalyzed by A. Glutathione reductase B. Hydroxylase C. Catalase D. Trypsin E. Phosphatase Q 19. Which of the following enzymes catalyzes the exchange of -NH 2 group between an amino acid and a keto acid? A. Alanine aminotransferase (ALT) B. Creatine kinase C. Alpha-ketoglutarate dehydrogenase D. Urease E. Aminopolypeptidase Page 3 of 6
4 Q 20. Which enzymes catalyze the hydrolysis of the terminal peptide linkage in a peptide? A. Kinases B. Mixed function oxidases C. Reductases D. Exopeptidases E. Dehydrogenases Q 21. In acute pancreatitis the activity of the following enzyme in plasma is specifically elevated A. Alanine aminotransferase (ALT) B. Aspartate aminotransferase (AST) C. Creatine kinase D. Amylase E. Alkaline phosphatase Q 22. Coenzyme A (CoA) is derived from which of the following vitamins? A. Ascorbic acid B. Niacin C. Biotin D. Pantothenic acid E. Folic acid Q 23. Pernicious anemia may result due to the dietary deficiency of which of the following vitamins? A. Cholecalciferol B. Niacin C. Biotin D. Cyanocobalamin E. Pantothenic acid Q 24. Which of the following vitamins is involved in the conversion of proline present in procollagen to hydroxyproline? A. Pyridoxine B. Niacin C. Thiamine D. Ascorbic acid E. Pantothenic acid Q 25. Which of the following enzymes is involved in the activation of vitamin D in kideny? A. 25-Hydroxylase B. 1-Alpha-hydroxylase C. Catalase D. Perxodiase E. UDP-Glucuronosyltransferase Page 4 of 6
5 Q 26. Which of the following vitamins is involved in the gammacarboxylation of glutamate residues of certain clotting factors? A. Vitamin A B. Vitamin C C. Vitamin K D. Vitamin D E. Vitamin E Q 27. Diminished secretion of HCl (hydrochloric acid) in stomach is called A. Peptic ulcer B. Ulcerative colitis C. Gastritis D. Achlorhydria E. Gastric carcinoma Q 28. Which of the following lipids is not a usual component of micelles? A. Monoacylglycerol B. Diacylglycerol C. Bile salt D. Cholesterol E. Triacylglycerol Q 29. Which of the following are correctly paired? A. Histamine : Decrease in gastric acid production/secretion B. Intrinsic factor: Produced by pancreas C. Gastric HCl: Denaturation of dietary proteins D. Lactase: Pancreatic juice E. Bile salts: Digestion of proteins Q 30. Alpha 1:6 glycosidic linkage is hydrolyzed by: A. Isomaltase (dextrinase) B. Sucrase C. Lactase D. Maltase E. Trehalase Q 31. Which of the following minerals is required by glutathione peroxidase? A. Nickel B. Chromium C. Molybdenum D. Selenium E. Magnesium Q 32. Which of the following is not an action of calcium in body? A. Coagulation of blood B. Intracellular messenger of certain hormones C. Activation of certain enzymes D. Relaxation of muscle E. Bone formation Page 5 of 6
6 Q 33. Which of the following are the basic precursors for the biosynthesis of heme? A. Tryptophan and tyrosine B. Succinyl CoA and glycine C. Pyruvate and acetyl CoA D. Propionate and succinyl CoA E. Malonyl CoA and lactate Q 34. Which of the following is the rate-limiting enzyme of heme biosynthesis? A. Ferrochelatase B. ALA (delta-aminolevulinic acid) synthase C. ALA dehydratase D. Uroporphyrinogen III synthase E. Uroporphyringoen decarboxylase Q 35. In liver the conjugation of bilirubin is catalyzed by which of the following enzymes? A. Pyruvate dehydrogenase B. Pyruvate carboxylase C. Beta-glucuronidase D. UDP-glucuronosyltransferase E. Ferrochelatase Page 6 of 6
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