Unit 1: Level of organization Chemistry (macromolecules)
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1 Unit 1: Level of organization hemistry (macromolecules)
2 Levels of organization: Unit 1 Small to large: atoms molecules macromolecules Then larger (microscopic stuff): cells and their parts (organelles) Then the types of tissues cells can build, and the specializations and functions of each tissue
3 Levels of rganization hemical/molecular (simple) ell Tissue rgan rgan system rganism (complex)
4 Figure 1.4 Levels of rganization Size rganism Level All of the organ systems must work together for a person to remain alive and healthy. 1.7m rgan System Level Integumentary Skeletal Muscular Nervous Endocrine ardiovascular Lymphoid Respiratory Digestive Urinary Reproductive The cardiovascular system includes the heart, the blood, and blood vessels. rgan Level The heart is a complex threedimensional organ. 120mm Tissue Level ardiac muscle tissue constitutes the bulk of the walls of the heart. 1mm ellular Level ardiac muscle tissue is formed from interlocking heart muscle cells. 1mm hemical or Molecular Levels eart muscle cells contain within them contractile protein fibers. 10 m omplex contractile protein fibers are organized from molecules. 10nm Molecules are formed from interacting atoms..1nm
5 Levels of rganization hemical atoms combined to form molecules ver a dozen elements in the body Four of them make up 99% of the body ydrogen, oxygen, carbon, and nitrogen Major classes of compounds Water arbohydrates Proteins Lipids Nucleic acids
6 Figure 1.4 Levels of rganization (Part 3 of 3) hemical or Molecular Levels eart muscle cells contain within them contractile protein fibers. 10 m omplex contractile protein fibers are organized from molecules. 10nm Molecules are formed from interacting atoms..1nm
7 Levels of rganization ell made of molecules The smallest living unit in the body Tissue consists of similar types of cells Many cells and some surrounding material rgan ombination of tissues that work closely together
8 Figure 1.4 Levels of rganization (Part 2 of 3) rgan Level The heart is a complex threedimensional organ. 120mm Tissue Level ardiac muscle tissue constitutes the bulk of the walls of the heart. 1mm ellular Level ardiac muscle tissue is formed from interlocking heart muscle cells. 1mm
9 Levels of rganization rgan System ombination of various organs make up a specific system For example: the stomach, small intestine, large intestine, liver, gallbladder, and pancreas make up the digestive system rganism made up of the organ systems umans are composed of 11 organ systems
10 Figure 1.4 Levels of rganization (Part 1 of 3) Size rganism Level All of the organ systems must work together for a person to remain alive and healthy. 1.7m rgan System Level Integumentary Skeletal Muscular Nervous Endocrine ardiovascular Lymphoid Respiratory Digestive Urinary Reproductive The cardiovascular system includes the heart, the blood, and blood vessels.
11 Molecules: (more than one atom) Molecules containing carbon + other atoms = organic Larger molecules (macromolecules) are built of linked molecules ategories: arbohydrates (built from simple sugars) Lipids (built from fatty acids) Protein (built from amino acids) Nucleic acids (built from nucleotides)
12 Molecules and macromolecules We eat mostly macromolecules, and digest them to molecules We use molecules to build components of our tissues Each molecule and macromolecule has uses and chemical properties
13 rganic Molecules Always contain: arbon () and ydrogen () A carbon atom may share electrons with another carbon atom or other atoms. opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display.
14 rganic Molecules Macromolecules contain many molecules joined together Monomers: Simple organic molecules that exist individually Polymers: Large organic molecules form by combining monomers
15 rganic Molecules opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. Polymer carbohydrate (e.g., starch) protein nucleic acid Monomer monosaccharide amino acid nucleotide
16 A meal containing carbohydrates, lipids, and proteins.
17 rganic Molecules ells have common mechanisms Dehydration Reaction: an - and - are removed as a water molecule ydrolysis Reaction: the components of water are added
18 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. monomer monomer dehydration reaction 2 monomer monomer a. monomer monomer hydrolysis reaction 2 monomer monomer b.
19 arbohydrates Function for quick fuel & short-term energy storage -- Simple arbohydrates Monosaccharides are sugars with 3-7 carbon atoms Pentose refers to a 5-carbon sugar exose refers to a 6-carbon sugar opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display
20 arbohydrates Disaccharides contain two monosaccharides. Examples maltose, sucrose, lactose opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display dehydration reaction + + hydrolysis reaction 2 glucose glucose maltose water monosaccharide + monosaccharide disaccharide + water
21 arbohydrates Polysaccharides are long polymers that contain many glucose subunits. Starch is the storage form of glucose in plants. Glycogen is the storage form of glucose in animals. ellulose can be found in the cell walls of plants.
22 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display branched nonbranched starch granule cell wall potato cells Jeremy Burgess/SPL/Photo Researchers, Inc.
23 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display glycogen granule liver cells Don W. Fawcett/Photo Researchers, Inc.
24 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. plant cell wall cellulose fiber cellulose fibers microfibrils glucose molecules Science Source/J.D. Litvay/Visuals Unlimited
25 Lipids Lipids function as energy storage molecules diverse in structure and function. ne common characteristic they do not dissolve in water (hydrophobic) Types Fats and oils Phospholipds Steroids
26 Lipids Fats Usually of animal origin Solid at room temperature ils Usually of plant origin Liquid at room temperature Triglycerides ne glycerol and 3 fatty acid molecules
27 A fatty acid is a hydrocarbon chain that ends with the acidic group Saturated fatty acids have no double covalent bonds between carbon atoms. Unsaturated fatty acids have 1 or more double bonds between carbon atoms. * Which one is better to eat? opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display glycerol 3 fatty acids fat molecule dehydration reaction hydrolysis reaction 3 water molecules
28 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. polar end + nonpolar end emulsifier fat emulsification Emulsification Fat droplets disperses in water. Emulsifiers contain molecules with a polar and nonpolar end. Ex. Bile salts secreted by the liver
29 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. Lipids Phospholipids omprised of 2 fatty acids + a phosphate group Primary components of cellular membranes They spontaneously form a bilayer in which the hydrophilic heads face outward toward watery solutions and the tails form the hydrophobic interior. Purpose of bilayer? inside cell outside cell a. Plasma membrane of a cell glycerol Polar ead phosphate Fatty acids R P Nonpolar Tails b. Phospholipid structure
30 Steroids Lipids All have a backbone of four fused carbon rings. Examples: holesterol, Testosterone, Estrogen opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display a. Testosterone b. Estrogen
31 Proteins Proteins have various functions in the body Some are enzymes that speed chemical reactions polymers composed of amino acid monomers. Amino acids entral carbon bonded to a hydrogen atom Amino group (-N 2 ) Acidic group (-) R group varies opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. amino group acidic group R N N R amino acid amino acid
32 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. 3 N N N + 2 S 3 N + 2
33 Peptides Proteins A polypeptide is a single chain of amino acids. A peptide bond joins two amino acids. amino group opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. acidic group peptide bond N R N dehydration reaction R N N 2 R hydrolysis reaction R amino acid amino acid dipeptide water
34 Proteins Levels of Protein rganization The structure of a protein has at least 3 levels of organization. Primary, Secondary & Tertiary Some can have four. The final shape of a protein is very important to its function. Denatured A protein loses structure and function due to heat or p.
35 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. Linear amino acid peptide bond N R N R hydrogen bond R N N R N R N R N R hydrogen bond (alpha) helix (beta) pleated sheet
36 (alpha) helix opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. (beta) pleated sheet Globular disulfide bond More than 1 polypeptide chain
37 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. amino acid peptide bond N R N R hydrogen bond R N N R N R N R N R hydrogen bond (alpha) helix (beta) pleated sheet disulfide bond
38 Nucleic Acids DNA (deoxyribonucleic acid) DNA stores genetic information in the cell and in the organism. RNA (ribonucleic acid) Both are polymers of nucleotides omponents of a nucleotide Phosphate Pentose sugar (ribose or deoxyribose) Nitrogen-containing base (1 of 5)
39 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. P phosphate nitrogencontaining base 5' 4' S 1' Nucleotide structure 3' 2' pentose sugar
40 DNA is a double helix 2 strands held together by hydrogen bonding omplementary base pairing Adenine (A) always pairs with thymine (T) ytosine () always pairs with guanine (G) RNA is single stranded Several types involved in carrying information in DNA to make proteins
41 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. A A T T G G S S S P P P P S P S P S S P S P P A A A T T T G G S S P a. b. c. one nucleotide a: Radius Images/Alamy RF
42 opyright The McGraw-ill ompanies, Inc. Permission required for reproduction or display. YU ARE WAT YU EAT!!! Fig. 2B GRAINS Eat 6 oz. every day VEGE TABLES FRUITS MILK MEAT & BEANS Eat 21 / 2 cups Eat 2 cups onsume 3 Eat 51 / 2 oz. every day every day cups every every day day; ages 2 8, 2 cups
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