Neuroscience Center of Excellence College: Case Western Reserve University Kresge Hearing Labs Degree: BA in Chemistry ( )

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1 NAME: ANTHONY RICCI, PH.D. PRESENT POSITION AND ADDRESS: EDUCATION: Assistant Professor High School: Cathedral Prep (NYC) Neuroscience Center of Excellence College: Case Western Reserve University Kresge Hearing Labs Degree: BA in Chemistry ( ) LSU Medical Center Minor in Biology and Sociology 2020Gravier Street Suite D Grad. School: Tulane University, New Orleans, LA New Orleans LA Degree: Ph.D. Neuroscience ( ) Phone: Major in Physiology Fax: Minor in Pharmacology aricci@lsuhsc.edu RESEARCH EXPERIENCE: : Undergraduate Research, Case Western Reserve University, : Research Assistant, Case Western Reserve University in the Department of Neurosurgery : Graduate Student, Tulane University Neuroscience Program 1991: Independent Contractor for Nikon Inc., in New Orleans, Louisiana : Post-doctoral Fellow, University of Texas Medical Branch at Galveston : Post-doctoral Fellow, University of Wisconsin : Assistant Scientist, University of Wisconsin, Department of Physiology : Scientist, University of Wisconsin, Department of Physiology present: Assistant Professor, Lousiana State University, Neuroscience Center of Excellence. SERVICE ORIENTED ACTIVITES: Reviewer for: Journal of Neuroscience, Journal of Physiology, Journal of Pharmacology and Experimental Therapeurtics, Journal of Neurophysiology Journal of Vestibular Research, Journal of the Association for Research in Otolaryngology, Brain Research, Journal of Biological Chemistry, American Journal of Physiology, European Journal of Neuroscience Ad Hoc Reviewer for National Science Foundation Special Emphasis Panel NIDCD Ad Hoc Reviewer NIH IFCN 6, IFCN 3 Deafness Research Study section Grant reviewer for Welcome Trust FELLOWSHIPS AND AWARDS: Graduate School Chancellor's Fellowship, Tulane University NASA Research Fellowship, University of Texas Young Investigators Travel Fellowship to the 1994 Gordon Conference Young Investigator Award, 1999, Deafness Research Foundation Burt Evans Young Investigator Award, 2002, National Organization for Hearing Invited speaker at Case Western Reserve University (1994); title Characterization of the electrical properties of vestibular hair cells. Invited speaker at University of Bristol (1996) Electrical Properties of Vestibular Type I hair cells. Invited speaker at Tulane University Neuroscience Center (1997), title Calcium regulation of the Mechano-electric transducer channels in auditory hair cells. Invited Speaker at University of Kentucky (1998), Calcium Permeation of Mechanoelectric Transducer Channels Invited Speaker at Oregon Health Science Center (1998), Calcium Regulation of Mechano-electric Transducer Adaptation.

2 PAGE 2 Invited Speaker at Baylor College of Medicine (2001) Fast adaptation, mechanical correlates and physiological significance Invited Speaker Rice University Department of Biomedical Engineering (2002) Active Processes in Sensory Hair Bundles Invited Speaker, Tulane University Medical Center Physiology Department (2002) Active Processes in Sensory Hair Bundles. FUNDING: SOCIETIES AND ORGANIZATIONS: RO1 entitled Endogenous factors regulating transducer adaptation, (1-99 thru 1-03) Renewed 1-03 thru 1-08, 1,050,000 direct costs 6-02, Administrative Supplement for purchase of UV laser, 50, Adminstrative supplement to develop mouse model for physiological investigations R21 entitled- Mouse cochlear culture model for physiological investigations, 1-02 thru ,000 per year Tinnitus Foundation: Salicylate effects on Mechano-electric transducer currents 50,000, 1-02 thru Deafness Research Grant Generation of oscillations of the mechano-electrical transducer current and their importance in hair cell tuning. (4-99 thru 4-01), 50,000 Young Investigator s Award (Deafness Research Foundation, 4-99 thru 1-00) Biophysical Society Association for Research in Otolaryngology Society for Neuroscience Tulane University Medical School Alumni Association Sigma Xi, The Scientific Research Society Audubon Society Alpha Chi Sigma Chemistry Fraternity PUBLICATIONS: Book Chapters: HARRINGTON, J., BUCZEK, M., WHITTINGHAM, T., LUST, W., RICCI, A., ASSAF, H., STERNAU, L.., LAMANNA, J., RATCHESON, R. (1989). Effects of Metabolic Stress On the Release of Glutamate and GABA from Hippocampal Slices. IN: Neurotransmission and Cerebral Vascular Function I, eds. SEYLAZ, J. and MACKENZIE, E.. pp Baltimore: Elsevier Science Publishers. LUST, W., RICCI, A., SELMAN, W., RATCHESON, R. (1989) Methods of Fixation of Nervous Tissue for Use in the Study of Cerebral Energy Metabolism. IN: Neuromethods, eds. BOULTON, A., BAKER, G., and BUTTERWORTH, R. pp Clifton: Humana Press. RICCI, AJ (2000) Fast transduceer adaptation, physiological implications and underlying mechanisms. IN: Hair Cells: Micromechanics and Hearing eds. C.Berlin Singlular Publishing Group, San Diego CA. RICCI, AJ (2002) Mechanical correlates of fast transducer adaptation, implications toward function and underlying mechanism. In Hair Cells: Micromechanics and Hearing. Eds. C.Berlin, AJ Ricci Singluar Publishing group, San Diego CA. FETTIPLACE, R. and RICCI, A.J: (in press) Papers: 1- LUST, W., ASSAF, H., RICCI, A., RATCHESON, R., STERNAU, L. (1988) A Role for Y-Aminobutyric Acid (GABA) in the Evolution of Delayed Neuronal Death Following Ischemia. Metabolic Brain Disease, 3: STERNAU, L., LUST, W., RICCI, A., RATCHESON, R. (1989) Role for Y-Aminobutyric Acid in Selective Vulnerability in Gerbils. Stroke, 20:

3 PAGE 3 3- ASSAF, HM.,RICCI, AJ., WHITTINGHAM,TS., LAMANNA, JC., RATCHESON, RA., LUST, WD, (1990) Lactate compartmentalization in hippocampal slices: evidence for a transporter. Metabolic Brain Disease, 3: SELMAN WR., RICCI, AJ., CRUMRINE, RC, LAMANNA, JC., RATCHESON, RA. LUST, WD (1990) The evolution of focal ischemic damage: a metabolic analysis. Metabolic Brain Disease 1: SELMAN, WR., CRUMRINE, RC., RICCI, AJ., LAMANNA, JC., RATCHESON, RA., LUST, WD. (1990) Impairment of metabolic recovery with increasing periods of middle cerebral artery occlusion in rats. Stroke 3: RICCI, A., NORRIS, C., GUTH, P. (1991) Cyclic AMP Modulates Sensory Neural Communication at the Vestibular End Organ. Brain Research, 565: GUTH, P., AUBERT, A., RICCI, A., NORRIS, C. (1992) Differential Modulation of Spontaneous and Evoked Neurotransmitter Release from Hair Cells: Some Novel Hypotheses. Hearing Research, 56: NORRIS, C., RICCI, A., HOUSLEY, G., GUTH, P. (1992) The Inactivating Potassium Channels of Hair Cells From the Frog Semicircular Canal. Journal of Neurophysiology, 68: RICCI, A., EROSTOGUA, C., BOBBIN, R., NORRIS, C. (1994) A Comparison of Hair Cell Electrophysiologic and Morphologic Characteristics. J. of Comparative Biochemistry and Physiology, 107: RICCI, A.J., RENNIE, K.J., CORREIA, M.J. (1996) The delayed rectifier, IKI, is the major conductance in type I vestibular hair cells across vestibular end organs Pflugers Arch. Eur. J. Physiol. 432: RICCI A.J., RENNIE K.J., CORREIA M.J. (1996) A delayed rectifier conductance shapes the voltage response of type I hair cells. Annals of the New York Academy of Sciences 781: CORREIA M.J., RICCI A.J., RENNIE K.J. (1996) Filtering properties of vestibular hair cells: An Update. Annals of the New York Academy of Sciences 781: RENNIE, K.J., RICCI, A.J., CORREIA, M.J. (1996) Electrical Filtering in Gerbil Isolated Type I Semicircular Canal Hair Cells. Journal of Neurophysiology, 75: *RICCI, A.J., FETTIPLACE, R. (1997) The effects of calcium buffers and cyclic AMP on mechanoelectrical transdcution in turtle auditory hair cells. Journal of Physiology, 501: RICCI, A.J., RENNIE, K.J., KEVETTER, G.A., CORREIA, M.J. (1997) Morphologic Identification of Vestibular Type I and Type II Hair Cells in the Pigeon and Gerbi.l Journal of Vestibular Research 7(5): RICCI, A.J., RENNIE, K.J., COCHRAN, S.L., CORREIA, M.J. (1997) Morphologic Comparisons of Dissociated Avian Type I and Type II Vestibular Hair Cells. Journal of Vestibular Research 7(5): *RICCI, A.J., FETTIPLACE, R (1998) Calcium Permeation of the Hair Cell s Mechanotransducer Channel and its Relation to the Composition of Endolymph. Journal of Physiology 506: * = subject of a Perspectives article in J. Physiol. 18- RICCI, A,.J., WU, Y-C., FETTIPLACE, R (1998) The endogenous Ca 2+ buffer and the time course of transducer adaptation in hair cells. J. Neuroscience 18: RICCI A.J., CORREIA, M.J. (1999) Electrical Response Properties of Avian Lagena Type II Hair Cells. Am. J. Physiology 45: R943-R953.

4 PAGE WU, Y-C, RICCI A.J., FETTIPLACE, R (1999) A model of calcium and transducer adaptation in auditory hair cells. Journal of Neurophysiology 82: RICCI, A.J., GRAY-KELLER, M., FETTIPLACE, R. (2000) Tonotopic variations of calcium signalling in turtle auditory hair cells. Journal of Physiology 524 (2) RICCI, A.J., CRAWFORD, A.C., FETTIPLACE, R. (2000) Active hair bundle motion linked to fast transducer adaptation in auditory hair cells. Journal of Neuroscience 20 (19) FETTIPLACE, R., RICCI, AJ., HACKNEY, CM., (2001) Clues to the cochlear amplifier from the turtle ear. Trends in Neuroscience 24(3) RICCI, AJ., CRAWFORD,AC., FETTIPLACE,R. (in press) Mechanisms of active hair bundle motion in auditory hair cells. Journal of Neuroscience 25- RICCI, AJ (in press) Fast adaptation regulates mean open time of transducer channels Journal of Neurophysiology 26- SCHNEE, M, RICCI, AJ (submitted) Biophysical and Pharmacological Characterization of Calcium Currents in Turtle Auditory Hair Cells. J. Physiology 27- RICCI, AJ (in press) Active Processes in Auditory Hair Cell Bundles, Journal of Audiology 28- RICCI, AJ, CRAWFORD, AC, FETTIPLACE, R (in preparation) Single Channel Properties of Mechano- Electric Transducer Currents. 29- RICCI, AJ, CRAWFORD, AC, FETTIPLACE, R (in preparation) Tonotopic Kinetic Differences in Mechanoelectric transducer channel properties. 30- LEBLANC, C, RICCI, AJ (in preparation) Salicylate implicates mechano-electric transduction in cochlear amplification. Abstracts: SELMAN, W., LAMANNA, J., RICCI, A., CRUMRINE, R., LUST, W., RATCHESON, R. (1987) Evolution of Ischemic Brain Damage Following Middle Cerebral Artery Occlusion in the Rat. Journal of Cerebral Blood Flow and Metabolism, 7: s12. LUST, W., RICCI, A., STERNAU, L., WHITTINGHAM, T., RATCHESON, R. (1987a) Metabolic Response to a Glial Enriched Region of the Brain to Ischemia. Stroke, 18: 14. LUST, W., RICCI, A., LAMANNA, J., STERNAU, L., RATCHESON, R. (1987b) Metabolic Response of a Glial Enriched Region of the Hippocampus to Stroke. Journal of Cerebral Blood Flow and Metabolism, 7: s127. RODZIEWICZ, G., SELMAN, W., RICCI, A., LUST, W., RATCHESON, R. (1987c) Metabolic Penumbra: A Small Volume. Stroke, 18: 14. ASSAF, H., RICCI, A., WHITTINGHAM, T., LAMANNA, J., RATCHESON, R., LUST, W. (1989) Factors Affecting Lactate Release from Hippocampal Slices. Abstracts for the Society of Neuroscience 15, 855. STERNAU, L., LUST, W., RICCI, A., RATCHESON, R. (1989a) Pharmacological Protection Against Delayed Neuronal Death Elicited by Ischemia. Journal of Cerebral Blood Flow and Metabolism, 7: s147.

5 PAGE 5 RICCI, A., NORRIS, C., GUTH, P. (1989) 4-Aminopyridine in the Semicircular Canal. Abstracts for Society for Neuroscience, 25: 517. NORRIS, C., PANTOJA, M., RICCI, A., FERMIN, C., GUTH, P. (1989) The Influence of Transmitter-Depleting Agents on Morphology and Neurophysiology of the Semicircular Canal of the Frog. Abstracts of The Inner Ear Biology 26. RICCI, A., NORRIS, C., GUTH, P. (1990a) A Role for Cyclic AMP in the Semicircular Canal. Abstracts from the Thirteenth ARO Midwinter Meeting, 13: 52. RICCI, A., NORRIS, C., GUTH, P. (1990b) Semicircular Canal Hair Cell Response to ACh. Abstracts for the Society for Neuroscience, 20. AUBERT, A., RICCI, A., NORRIS, C., GUTH, P. (1991) Differential Modulation of Spontaneous and Mechanically- Evoked Transmitter Release: A Novel Hypothesis. Abstracts form the Association for Research in Otolaryngology, 14. GUTH, P., AUBERT, A., RICCI, A., NORRIS, C. (1991a) Differential Modulation of Spontaneous and Evoked Neurotransmitter Release from Hair Cells: Some Novel Hypotheses. Abstracts from The 28TH Workshop on Inner Ear Biology. RICCI, A., NORRIS, C., GUTH, P. (1991b) Current-Clamp Responses of Vestibular Hair Cells. Abstracts from Society for Neuroscience, 21. RICCI, A., WOOLVERTON, S., AUBERT, A., NORRIS, C., GUTH, P. (1991c) Responses of the Isolated Semicircular Canal to Electrical Stimulation. Abstracts for the Association for Research in Otolaryngology, 14. NORRIS, C., RICCI, A., GUTH, P. (1992a) Multiple Inactivating Currents can be Observed in Hair Cells Isolated from the Semicircular Canal of the Frog. Abstracts for the Biophysical Society. NORRIS, C., RICCI, A., GUTH, P. (1992b) Semicircular Canal Hair Cells Differ in Their Peak Voltage Response as Well as the Stimulus Required to Obtain this Peak Response. Abstracts for the Association for Research in Otolaryngology, 17. RICCI, A., NORRIS, C., GUTH, P. (1992) Semicircular Canal Hair Cells Fall into Three Classes Based on Their Temporal Response to Current Injection. Association for Research in Otolaryngology, 17. NORRIS, C., RICCI, A., GUTH, P. (1992) Hair Cells Isolated from the Semicircular Canal of the Frog Have Two Rapidly Inactivating Outward Conducting Potassium Channels. Meeting on the Molecular Biology of Hearing and Deafness, San Diego, Calif., May RICCI, A., EROSTOGUA, C., BOBBIN, R., NORRIS, C. (1993) A Comparison of Hair Cell Electrophysiologic and Morphologic Characteristics. Abstracts for the Association for Research in Otolaryngology. CORREIA, M., RICCI, A., RENNIE, K. (1994) Characteristics of the Basolateral Currents in Type I and Type II Hair Cells Dissociated from the Pigeon Utricle. Abstracts for the Association for Research in Otolaryngology 17th Mid-winter Meeting, 509. RICCI, A., RENNIE, K., CORREIA, M. (1994) Morphological Comparison of Hair Bundles Isolated From Avian Hair Cells. Abstracts for the Association for Research in Otolaryngology 17th Midwinter meeting, 509. RENNIE, K., RICCI, A., CORREIA, M. (1994) Potential-Driven Movements of Type I Vestibular Hair Cells. Abstracts for the Biophysical Society Meeting.

6 PAGE 6 RENNIE, K., RICCI, A., CORREIA, M. (1994) Calcium Currents in Isolated Mammalian Semicircular Canal Hair Cells. Abstracts for the First International Symposium on Inner Ear Neuropharmacology in Montpellier, France. RENNIE, K.J., RICCI, A.J., CORREIA, M.J. (1994) Voltage-Dependent Motility in Type I Vestibular Hair Cells. Presented at the 31st Workshop on Inner Ear Pharmacology in Montpellier, France. RENNIE, K.J., RICCI, A.J., CORREIA, M.J. (1994) Calcium Currents in Isolated Mammalian Semicircular Canal Hair Cells. Abstracts for the First International Symposium on Inner Ear Neuropharmacology in Montpellier, France. RICCI, A., CORREIA, M., RENNIE, K. (1994) Morphological Characteristics of Isolated Avian Type I Hair Cells. Abstracts for the 31st Workshop on Inner Ear Pharmacology in Montpellier, France. RICCI, A., RENNIE, K., CORREIA, M. (1994) Electrophysiology of Avian Lagena Type I and Type II Hair Cells. Abstracts for the First International Symposium on Inner Ear Neuropharmacology in Montpellier, France. CORREIA, M.J., RENNIE, K.J. RICCI, A.J. (1994) Potassium Currents in Type I and Type II Vestibular Hair Cells in Pigeon and Gerbil. Presented at the First International Symposium on Inner Ear Neuropharmacology in Montpellier, France. CORREIA, M., RICCI, A., RENNIE, K. (1994) Ionic Currents in Type I and Type II Vestibular Hair Cells in the Pigeon Utricle. Abstracts for the 31st Workshop on Inner Ear Pharmacology in Montpellier, France. RICCI, A.J. CORREIA, M.J. (1994) Frequency Response of Avian Vestibular Hair Cells to Mechanical Stimulation. Abstracts for the Annual ASGSB Meeting in San Francisco, Calif. RICCI, A.J., RENNIE, K.J., CORREIA, M.J. (1995) An Electrophysiologic Comparison Between Type I Avian Vestibular End Organs. Abstracts for the Fifth Annual Spring Brain Conference in Sodona, Arizona. RICCI, A.J., RENNIE, K.J., CORREIA, M.J. (1995). An Electrophysiologic Comparison of Type I Avian Hair Cells of Different Inner Ear End Organs. Abstracts from the Eighteenth ARO Midwinter Meeting, 18: 162. RICCI, A.J., FETTIPLACE, R. (1997) The effects of calcium buffers on mechanoelectrical transduction currents in turtle hair cells Biophysical Journal (abstract) 72: A266. RICCI, A.J., FETTIPLACE, R. (1997) Calcium permeation of the mechanotransducer and its relation to the composition of endolymph. Abstracts from the Society for Neuroscience. RICCI, A.J., FETTIPLACE, R. (1998) Factors which regulate the rate of transducer adaptation. Association for Research in Otolaryngology (Abstract) FETTIPLACE, R., RICCI, A.J. (1998) Adaptation of mechanotransducer currents in turtle hair cells. Association for Research in Otolaryngology (abstract) RICCI, A.J., FETTIPLACE, R. (1999) Variations in the endogenous Calcium buffering in hair cells. Association for Research in Otolaryngology. (abstract) RICCI, A.J., GRAY-KELLER, M., FETTIPLACE, R. (1999) Tonotopic variations in hair cell calcium signalling. Society for Neuroscience (Abstract). RICCI, A.J., FETTIPLACE, R., CRAWFORD, A.C. (2000) Active hair bundle movements during hair cell depolarization. Association for Research in Otolaryngology. (abstract)

7 PAGE 7 FETTIPLACE, R., RICCI, A.J., CRAWFORD, A.C. (2000) Calcium, fast transducer adaptation and active hair bundle movements. Association for Research in Otolaryngology. (abstract) RICCI, A.J., CRAWFORD, A.C., FETTIPLACE, R (2000) Hair bundle movements and fast transducer adaptation in auditory hair cells. Society for Neuroscience (abstract). RICCI,AJ., CRAWFORD,AC., FETTIPLACE,R. (2001) Mechanisms of active hair bundle motion in auditory hair cells. Association for Research in Otolaryngology. FETTIPLACE, R, HACKNEY, C.M., JONES E.M.C. AND RICCI, A.J., (2001) Molecular Correlates of Tonotopy in the Turtle Cochlea. Molecular Biology of Hearing and Deafness. SCHNEE, M., RICCI, AJ (2001) Calcium channel in turtle auditory hair cells. Association for Research in Otolaryngology RICCI, A.J. (2001) Differences in mechano-electric transducer channel kinetics underlie tonotopic distribution of fast adaptation in turtle auditory hair cells. Sociey for Neuroscience (abstract) SCHNEE, M., RICCI, AJ (2002) Calcium channel inactivation in turtle auditory hair cells. Association for Research in Otolaryngology RICCI, AJ (2002) Pharmacological Clues to the Nature of the Mechano-electric Transducer Channel. Association for Research in Otolaryngology LEBLANC, C., RICCI, AJ (2002) Salicylate affects on mechano-electric transduction. Association for Research in Otolaryngology