Matthew Eschbach Robert Sterling Nesbitt Joseph Ouellette Sarah Roberge

Transcription

1 Matthew Eschbach Robert Sterling Nesbitt Joseph Ouellette Sarah Roberge

2 Bone Remodeling Osteocytes act as mechanoreceptors Biochemical reactions Osteoclasts resorb bone Osteoblasts rebuild bone Edentulism no mechanical stimulation from teeth

3 Douglass, Chester W. DMD, PhD, Annie Shih MS, DDS and Larry Ostry, DDS. Will there be a need for complete dentures in the United States in 2020? The Journal of Prosthetic Dentistry (2002): 5 8.

4 Previous Work Ultreo Ultrasound Toothbrush University of Alberta: Low-Intensity Pulsed Ultrasound Device (LIPUS) Aims to regrow teeth Operates for 20 minutes per day

5 Electric Circuit & Piezoelectric The creation of an ultrasonic mechanical signal for use in the prevention of bone loss of the maxilla and mandible

6 Introduction Edentulous persons lack the mechanical stress to maintain bone density Ultrasound stimulates bone growth Design mouthpiece that produces ultrasound

7 Electric Circuit Constraints 18watts 9Volt battery Design boost converter inductor principle

8 Electric Circuit Multisim Simulation bode plot phase shift power output Circuit Produces 18watts at 1MHz

9 Electric Circuit

10 ransducer Fabrication Barium Titanate Crystalline structure changes volume to external voltage Transducer converts voltage signal into mechanical ultrasound

11 Transducer Fabrication Aluminum Mold transducer for animal test built at machine shop Transducer 40% weight Barium Titanate 60% weight Polyethylene glycol melted and poured into mold sintered at 1200C poled at 1000V coated in gold leaf

12 Transducer Fabrication Oven sintering of Barium Titanate/PEG mixture Archimedes Principle measuring density 240A power supply polarizing transducer

13 Electric Circuit Voltage oscillator Creates a voltage signal with specific frequency Typically has quartz crystal Low power P=V*I

14 Electric Circuit Power amplifier Converts low power signal into high power signal i.e. increases voltage and current amplitude MOSFET metal oxide semiconductor field-effect transistor

15 Piezoelectric Piezoelectric chip converts voltage signal into mechanical signal Two conductive plates with crystalline structured material between Has a capacitive load

16 Piezoelectric Barium Titanate BaTiO 3 Dipoles attracted by external voltages Crystalline structure changes volume Can operate at ultrasonic frequencies

17 Denture Design Mouthguard made with thermoplastic Transducers in mouthguard Circuit outside mouth -mo-141.jpg

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19 Device Testing RX Meter Oscilloscope Multimeter Hydrophone

20 Animal Testing BatGal Transgenic Mice Transducers 10 minutes, twice a day Measure gene activity (β-gal)

21 Finite Element Analysis Simulia s Abaqus Simulate Ultrasound Propagation Human and Mouse models Gum and bone under ultrasound stimulation Analyze effectiveness of the device Inspect for errors before conducting trials

22 Product Price Quantity Total Price Circuit $500 2 $ Barium Titanate $150/500g 1Kg $ Mold for Transducer $25 4 $ Gold Palladium Spluttering $6/transducer 25 $ Sintering $10/hour 10 $ Mice $30/mouse 6 cages/56 36 $ Mice upkeep $0.35/cage/day days $ Power Mouthguard Supply for Aligning $35/mouthguard 3 $ Transducers $3,000 1 $ $

23 Acknowledgements Dr. John Enderle David Price Dr. Shiva Kotha Tristan Ramas

24 References Roberts, Shepard. Dielectric and Piezoelectric Properties of Barium Titanate. Laboratory for Insulation Research, MIT. Cambridge, MA. (March 6, 1947). Berlincourt, D. and Jaffe, H. Elastic and Piezoelectric Coefficients of Single-Crystal Barium Titanate. Clevite Research Center. Cleveland, OH. (January 8, 1958). Image courtesy of ( ) Funasaka, T. Furuhata, M. Hashimoto, Y. Nakamura, K. Piezoelectric generator using a LiNbO 3 plate with an inverted domain. Seiko Epson Corp., Nagano. Image courtesy of ( ). Nusse, Roel. The Wnt Homepage. (September 1, 2008). Nomura, Shintaro, Teruko Takano-Yamamoto. Molecular events caused by mechanical stress in bone. Matrix Biology. 19 (2000): Douglass, Chester W. DMD, PhD, Annie Shih MS, DDS and Larry Ostry, DDS. Will there be a need for complete dentures in the United States in 2020? The Journal of Prosthetic Dentistry (2002): 5 8. Ultreo Ultrasound Toothbrush. MedGadget: Internet Journal of Emerging Medical Technologies. 20 April September Horaczek, Stan. New low intensity pulsed ultrasound device helps re-grow teeth. Engadget. 30 June September