Dear Participants, Yours sincerely, Alessia Addessi Senior Programme Manager EXCEMED

Transcription

1 EXCEMED Blended Education Cardiometabolic disorders in clinical practice: a comprehensive update Ho Chi Minh City, Vietnam 8-9 September 2018

2 Dear Participants, On behalf of EXCEMED, it is my pleasure to welcome you to the live intervention element of your Learning Journey, Cardiometabolic disorders in clinical practice: a comprehensive update. This face-to-face learning experience consists of five plenary sessions and one parallel session in working groups with frontal lectures, interactive debates and clinical case discussions. The learning continues after the live intervention. Visit your Learning Journey page after the face-to-face meeting to access the in-depth interactive tutorials. Review key messages from the meeting with a concept map video and delve into blood pressure targets after SPRINT with a video contribution by Prof. S. Taddei (Italy). We also welcome your presence in the private Facebook group which is accessible through your personal Journey Page. Network with colleagues and discuss what you learned here in Ho Chi Minh City. Complete the entire journey including the assessment surveys and get access to a Diploma signed by the Chairs as well as the final Outcomes & Feedback Report. We look forward to seeing you in person and online! Yours sincerely, Alessia Addessi Senior Programme Manager EXCEMED

3 ONLINE PREPARATORY TUTORIALS July 2018 LIVE INTERVENTION 8-9 September 2018 ONLINE IN-DEPTH TUTORIALS October 2018 Cardiometabolic disorders in clinical practice: a comprehensive update Overview Cardiometabolic disorders are the major cause of morbidity and mortality worldwide, and are intrinsically linked with diabetes, a devastating disease affecting more than 400 million people. Diabetes is the leading cause of cardiovascular disease, end-stage renal disease, blindness and non-traumatic lower-limb amputation, as well as negatively affecting pregnancy outcomes and the nervous system. However, diabetes and its complications can be avoided. A huge number of people suffer from initial alterations in glucose metabolism, known as "pre-diabetes". These people are at higher risk of developing overt diabetes in the coming years, but evidence shows the progression towards diabetes can be halted. Prompt intervention, with significant changes in lifestyle and/or implementation of appropriate pharmacotherapy, are effective strategies to prevent diabetes in at-risk people. To facilitate this, healthcare professionals should be updated with the most recent and compelling evidence about diabetes prevention. For those with overt diabetes, relentless effort should be expended to avoid the debilitating complications of the disease and to increase life expectancy. Knowledge and understanding of the complex pharmacological mechanisms and their clinical implementation will facilitate successful management of diabetes. Like diabetes, thyroid disorders are among the most prevalent endocrine diseases that also impact cardiovascular homeostasis. Unfortunately, a great number of patients with thyroid diseases are undiagnosed, contributing to increased morbidity and reduced quality of life. Therefore, there is a need for clear recommendations allowing for effective and prompt recognition of the most frequent thyroid disorders in order to adequately treat patients and avoid adverse clinical outcomes. Finally, hypertension is still the primary cause of death in the world and medicine is far from establishing adequate control of this cardiovascular risk factor. Recently, new aggressive targets for antihypertensive treatment were proposed, but it is not clear if scientific evidence justifies this therapeutic strategy. Additional discussion surrounds the issue of applying the results of controlled clinical trials to daily life. The role of combination treatment in hypertension and recent novelties in the availability of fixed dose formulations will also be discussed. Xxx Xxx An EXCEMED Learning Journey EXCEMED is involved in a comprehensive educational blended journey to increase knowledge in cardiometabolic diseases. This programme will address the most recent advancements of research in the areas of cardiometabolic medicine and will discuss the best approaches for clinical management of the complex cardiometabolic patient in daily practice. A multistep approach will be used, encompassing web-based and live activities. All activities in-person and online will involve the full interactivity of learners. Learning objectives By attending this programme, you will be able to: Implement the most cost-effective strategies for diabetes prevention Correctly diagnose thyroid disorders in the general population Identify specific blood pressure targets for each patient with hypertension Target audience This programme is designed for general practitioners, cardiologists, endocrinologists and internists managing diabetes and cardiometabolic diseases in the Asia-Pacific region. Chairs Thy Khue Nguyen University of Medicine and Pharmacy Ho Chi Minh City, Vietnam Ho Huynh Quang Tri Heart Institute Ho Chi Minh City, Vietnam 2 3

4 Xxx Xxx CME Provider EXCEMED is a non profit foundation dedicated, since the last four decades, to the development of high-quality medical education programmes all over the world. EXCEMED adheres to the guidelines and standards of the European Accreditation Council for Continuing Medical Education (EACCME ) which states that continuing medical education must be balanced, independent, objective and scientifically rigorous. ONLINE PREPARATORY TUTORIALS EXCEMED - Excellence in Medical Education Senior Programme Manager: Alessia Addessi T F alessia.addessi@excemed.org Medical Advisors: Ernesto Maddaloni and Stefano Taddei EXCEMED adheres to the principles of the Good CME Practice group (gcmep). This programme has been endorsed by the Vietnam National Heart Association (VNHA) of the HCMC Cardiology Association and the HCMC Association of Diabetes and Endocrinology. ONLINE PREPARATORY TUTORIALS July

5 ONLINE PREPARATORY TUTORIALS July 2018 LIVE INTERVENTION 8-9 September 2018 ONLINE IN-DEPTH TUTORIALS October 2018 ONLINE PREPARATORY TUTORIALS July 2018 PREPARATORY INTERVIEW The first exclusive tutorial is an interview with Prof P. Pozzilli (Italy) which highlights the importance of diabetes prevention. This online educational tool is facilitated by the video-scribing technique and it enables to: Understand the importance of an effective diabetes screening Learn how to identify subjects at increased risk of diabetes LIBRARY The second exclusive tutorial helps illuminate the content of the live intervention, giving you the head start you need to be fully engaged during the in-person learning. You are also able to share your research and publications with the rest of the community using the library platform, and submit questions directly to faculty ahead of the live intervention. You can look forward to your question being addressed by faculty during theliv Q&A sessions. Features of the interactive library: Literature corner: summarises the key points and related publications for each of the lectures being presented during the live intervention in Ho Chi Minh City. Publications exchange: contains a section for learners to share their research and publications related to your Learning Journey. Question time: a chance for leaners to submit a question for the faculty to answer during the live intervention. LIVE INTERVENTION 8-9 September 2018 LIVE INTERVENTION 6

6 ONLINE PREPARATORY TUTORIALS July 2018 LIVE INTERVENTION 8-9 September 2018 ONLINE IN-DEPTH TUTORIALS October 2018 LIVE INTERVENTION 8-9 September 2018 The live component of the Learning Journey is a combination of frontal lectures followed by interactive Q&A sessions, case-study-based debates, interactive clinical cases and working groups. You will be notified by when the video lectures, slide kits and a scientific highlights publication from the live intervention are available online. LEARNING OBJECTIVES By attending this live educational conference you will be able to: Acquire knowledge about the obesity and pre-diabetes emergency Personalize diabetes treatment Manage most prevalent thyroid disorders Tailor the appropriate treatment in hypertensive patients Venue This conference takes place at the: Intercontinental Saigon hotel Hai Bà Trưng, Bến Nghé, Quận 1 Ho Chi Minh City, Vietnam Continuing medical education The Cardiometabolic disorders in clinical practice: a comprehensive update, Ho Chi Minh City, Vietnam, 08/09/ /09/2018 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME ) with 9 (nine) European CME credits (ECMEC s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits TM. Information on the process to convert EACCME credit to AMA credit can be found at Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME for ECMEC s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada. Language The official language of the live intervention is English. For any logistic inquiry, please contact: Meridiano Congress International Event Manager: David H. Slangen T F david.slangen@meridiano.it 8 9

7 FACULTY George J. Kahaly Department of Medicine Gutenberg University Medical Center Mainz, Germany Ernesto Maddaloni University Campus Bio-Medico (UCBM) Rome, Italy Giuseppe Mancia University of Milano-Bicocca Milan, Italy Mafauzy Mohamed University Sains Malaysia Health Campus Kelantan, Malaysia Thy Khue Nguyen University of Medicine and Pharmacy Ho Chi Minh City, Vietnam Nemencio Almare Nicodemus Jr Department of Medicine University of the Philippines-College of Medicine Manila, Philippines Dang Van Phuoc Vietnam National University School of Medicine Ho Chi Minh City, Vietnam Paolo Pozzilli University Campus Bio-Medico (UCBM) Rome, Italy Ho Huynh Quang Tri Heart Institute Ho Chi Minh City, Vietnam Kun-Ho Yoon Department of Endocrinology & Metabolism Seoul St. Mary's Hospital Seoul, Korea PROGRAMME Saturday, 8 September Welcome and introduction N.T. Khue and H.H.Q. Tri (Vietnam) Session I Chairs: N.T. Khue and H.H.Q. Tri (Vietnam) L1: The diabetes pandemic E. Maddaloni (Italy) L2: Metabolic and clinical changes of pre-diabetes P. Pozzilli (Italy) L3: How to recognize people with pre-diabetes K.H. Yoon (Korea) Discussion Coffee break Session II Chairs: N.T. Khue and H.H.Q. Tri (Vietnam) L4: Obesity a contemporary issue creating future problems N.T. Khue (Vietnam) L5: Keywords for pre-diabetes management P. Pozzilli (Italy) L6: Is treatment of pre-diabetes cost-effective? M. Mohamed (Malaysia) Discussion Lunch Why you should worry about pre-diabetes, and how to recognize it Treating pre-diabetes Legend: L : Lecture CS : Case study : Case presentation : Discussion : Working groups 10 11

8 Xxx Xxx Sunday, 9 September 2018 Session III Diabetes treatment debate different patients, different solutions Session V Management of hypertension Chairs: N.T. Khue and H.H.Q. Tri (Vietnam) CS1: Newly diagnosed type 2 diabetes Case presentation Start with lifestyle intervention only K.H. Yoon (Korea) Immediately start with drug therapy P. Pozzilli (Italy) Discussion CS2: Frail elderly patients with type 2 diabetes Case presentation Intensify monotherapy M. Mohamed (Malaysia) Add-on therapy E. Maddaloni (Italy) Discussion Coffee break Session IV Thyroid disorders: diagnosis is key Chairs: N.T. Khue and H.H.Q. Tri (Vietnam) CS3: Subclinical hypothyroidism G.J. Kahaly (Germany) CS4: Hypothyroidism during pregnancy G.J. Kahaly (Germany) CS5: Thyroid cancer N.A. Nicodemus Jr (Philippines) End of the first day Chairs: D.V. Phuoc and H.H.Q. Tri (Vietnam) L7: Blood pressure targets in hypertensive patients: European guidelines G. Mancia (Italy) L8: Are blood pressure targets proposed after the SPRINT study realistic in clinical practice? D.V. Phuoc (Vietnam) L9: New possibilities for fixed-dose combination treatment in hypertension H.H.Q. Tri (Vietnam) Discussion Coffee break Session VI Working groups on hypertension management This session includes two different parallel workshops, each lasting 1 hour. Participants will be divided into groups and will attend both workshops in rotation. By the end of the session each participant will have attended both workshops. WG1: Complex patient with hypertension: when a beta-blocker is needed H.H.Q. Tri (Vietnam) WG2: Complex patient with hypertension: when combination therapy is needed D.V. Phuoc (Vietnam) Back to plenary and take-home messages from the working groups End of the live educational conference Closing lunch 12 13

9 FACULTY DISCLOSURES EXCEMED adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME ) and all other professional organizations, as applicable, which state that programmes awarding continuing education credits must be balanced, independent, objective and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices and other products (other than those uses indicated in approved product labelling/package insert for the product) may be presented in the programme (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so that participants may form their own judgements, based on full disclosure of the facts. Further, all opinions and recommendations presented during the programme and all programme-related materials neither imply an endorsement nor a recommendation on the part of EXCEMED. All presentations represent solely the independent views of the presenters/authors. Nemencio Almare Nicodemus Jr Declared no potential conflict of interests. Dang Van Phuoc Paolo Pozzilli Ho Huynh Quang Tri Kun-Ho Yoon Declared no potential conflict of interests. Declared receipt of grants and contracts from Astrazeneca and of honoraria and consultation fees from Ely Lilly. Declared receipt of honoraria or consultation fees from Merck and Menarini. Declared to be member of an Industry advisory board, board of directors or other similar groups: MSD APAC, Sanofi, Novo Nordisk. He declared also benefit from a relationship with a commercial enterprise: MSD APAC, Sanofi, Novo Nordisk, LG, Lilly, Astellas, Astra Zeneca, J&J, Hanmi, Takeda. The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-emea/fda approved (off-label) uses of drugs: George J. Kahaly Declared no potential conflict of interests. Ernesto Maddaloni Declared receipt of grants and contracts from Astrazeneca and of honoraria and consultation fees from Merck. Giuseppe Mancia Declared receipt of honoraria or consultation fees from: Boheringer, Daiichi Sankyo, Ferrer, Medtronic, Menarini, Merck, Novartis, Recordati, Servier. Mafauzy Mohamed Declared receipt of grants and contracts from MSD, Boheringer, Abbvie and of honoraria or consultation fees from: Merck, Lilly, Pfizer, Novo Nordisk, Novartis, Servier. He declared participation in a company sponsored speaker s bureau: Merck, Lilly, Pfizer, Novo Nordisk, Novartis, Servier. Thy Khue Nguyen Declared receipt of honoraria or consultation fees from: Astrazeneca, Boheringer, Merck, Novo Nordisk, Sanofi Aventis, Novartis, Servier

10 16 BIOGRAPHIES

11 George J. Kahaly Department of Medicine Gutenberg University Medical Center Mainz, Germany Ernesto Maddaloni University Campus Bio-Medico (UCBM) Rome, Italy George J. Kahaly, M.D., Ph.D. holds the rank of Professor of Medicine and Endocrinology / Metabolism and is chief physician of the endocrine outpatient clinic at the Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany. Dr. Kahaly chairs the ORPHAN JGU expert center for Graves orbitopathy and polyglandular autoimmune syndromes. Dr. Kahaly directs the Molecular Thyroid Research Laboratory of JGU and has authored 247 original papers and reviews, covering clinical and experimental aspects of endocrine autoimmunity, immunogenetics of thyroid and polyglandular autoimmunity, as well as cardiovascular involvement of metabolic disorders. Original papers and reviews have been published in the New England Journal of Medicine, Lancet, Jama, Clinical Chemistry, the Journal of Autoimmunity, the Journal of Clinical Endocrinology and Metabolism, the Journal of Nuclear Medicine, Endocrinology, Thyroid, Endocrine Reviews, Nature Reviews and Autoimmunity Reviews. Dr. Kahaly is Editor of the Journal of Clinical Endocrinology & Metabolism, official Organ of the American Endocrine Society. In the years , Dr. Kahaly served as Associate Editor of the journal Thyroid, official journal of the American Thyroid Association (ATA). Dr. Kahaly is also member of the Editorial Board of the European Thyroid Journal, official journal of the European Thyroid Association (ETA). Further, he is currently member of the scientific program organizing committee (POC) of the 2020 international thyroid congress. Dr. Kahaly served as Treasurer and principle officer of the Executive Committee of the ETA between 2007 and He currently serves on the Public Health Committee of the ATA. In the years , Dr. Kahaly has been active member of the ATA Research Committee, in , of the ATA Finance and Audit Committee, and in member of the ATA Membership and Publication Committees. Further, Dr. Kahaly is the Treasurer of the European Group on Graves orbitopathy, official subgroup of the ETA. In the years , he was member of the Executive Committee of the German Thyroid Board. Ernesto Maddaloni is a consultant endocrinologist at his home institution, Campus Bio-Medico University of Rome, Italy, were he graduated in Medicine in 2010 and completed his clinical fellowship in Endocrinology and Metabolic Disorders in In 2014, he moved to Boston for a Post- Doctoral Research Fellowship at the Vascular Cell Biology Section of the Joslin Diabetes Center (Harvard Medical School) focusing on the study of aging adults with autoimmune diabetes and the interplay between vascular complications, bone health and autoimmunity. As a Mentee of the European Foundation for the Study of Diabetes (EFSD) Future Leaders Mentorship Programme, Dr Maddaloni has joined since 2017 the Diabetes Trial Unit of the University of Oxford, Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) where he is actually pursuing his studies on clinical diabetes and cardiovascular outcomes. Dr Maddaloni has acted as study investigator and coordinator in several national and international clinical trials and has published as leading author in several top-ranked peerreviewed international medical journals. His scientific achievements have been recognized with several awards, including the "2015 Albert Renold fellowship of the European Foundation for the Study of Diabetes, the "2017 Young Investigator Award" of the Italian Society of Endocrinology (SIE) and the "2017 Early Investigator Award" of the Endocrine Society, USA

12 Giuseppe Mancia University of Milano-Bicocca Milan, Italy Mafauzy Mohamed University Sains Malaysia Health Campus Kelantan, Malaysia Giuseppe Mancia is Professor Emeritus of the University Milano-Bicocca. He is also President of the Italian Foundation on Ricerca e Innovazione su Ipertensione e Protezione Cardiovascolare and of the Foundation of the European Society of Hypertension(ESH) in Zurich. He serves since 2008 as Chairman of the Joint Board of the Italian Scientific Societies operating in the area of cardiovascular prevention. He has served as President of the International Society of Hypertension, President of the European Society of Clinical Investigation, Chairman of the Working Group on Hypertension and the Heart of the ESC, member of the Executive Scientific Committee of ESC, President of the Italian Society of Hypertension ( ) and President of ESH. He has been member ex-officio (only European) of the Executive Council of the American Society of Hypertension, Officer for the ISH Forum of National Societies, member of the Committee on Cardiovascular Drugs and Therapy of the World Heart Federation and member of the Writing Committee of the ESC guidelines on Prevention of Cardiovascular Diseases, the WHO/ISH Guidelines on Hypertension and the Guidelines on Hypertension in the Elderly of the American College of Cardiology. He has chaired the Committee on the ESH-ESC guidelines on Hypertension, the WHO/ISH Liaison Committee, and the Scientific and Organising Committees of various ESH Meetings. He is currently Chairman of the Educational Board of ESH. His research interests focus on epidemiology pathophysiology, diagnosis and treatment of hypertension, heart failure, and coronary disease, as well as on the clinical aspects of diabetes, obesity and other metabolic abnormalities. His expertise includes ambulatory blood pressure monitoring, neurohumoral control of the circulation, large artery mechanics, hemodynamic changes of cardiovascular drugs, cardiovascular regulation during stress and sleep as well as epidemiology and intervention trials in hypertension and diabetes. Mafauzy Mohamed is currently a Professor of Medicine and Senior Consultant Endocrinologist in University Sains Malaysia. He was formerly the Assistant Vice-Cancellor, Director of Campus, Director of Hospital and Dean of Medicine in the same university in Kelantan, Malaysia. He obtained his M.B.B.S. from the University of Adelaide, Australia in He was appointed as a Lecturer after he received his M.R.C.P (UK) in He also obtained his Masters of Medical Sciences from University of Sheffield in He was promoted to Associate Professor in In 1996, he was admitted as Fellow of Royal College of Physicians (Edinburgh) and in 2000 he was promoted as full Professor of Medicine. He also received an Honorary Doctor of Medicine degree from International Medical University in He is actively involved in the field of endocrinology and diabetes. He has also served as an examiner for the Royal College of Physicians, United Kingdom and has been appointed by several universities as External Examiner for Professional Examinations at both undergraduate and postgraduate levels and also as Masters and PhD theses examiner. Dr. Mafauzy is also actively involved in research and has to date obtained over 110 research grants mainly in the field of diabetes, dyslipidemia and thyroid disorders including many clinical trials, including CV and renal outcome trials, relating to diabetes and metabolism. He has supervised over 25 postgraduate students and has published over 110 papers in national and international Journals, presented over 100 papers in national and international meetings and has been invited to give over 500 lectures in national and international meetings. He has been Chief Editor of the Malaysian Journal of Medical Sciences, Journal of ASEAN Federation of Endocrine Societies and Journal of Endocrinology and Metabolism. He is also a Council Member of the Malaysian Medical Council and is actively involved in accreditation and recognition of medical programmes by the Malaysian Medical Council and Malaysian Qualifications Agency

13 Thy Khue Nguyen University of Medicine and Pharmacy Ho Chi Minh City, Vietnam Nemencio Almare Nicodemus Jr Department of Medicine University of the Philippines-College of Medicine Manila, Philippines Thy Khue Nguyen is Associate Professor Emeritus, Department of Endocrinology, University of Medicine and Pharmacy, Ho Chi Minh City. She is immediate Past President of the Vietnam Association of Diabetes and Endocrinology, President of HCMC Diabetes and Endocrinology Association, Vice President of HCMC Medical Association, Member of The Endocrine Society, United States, Senior Consultant at Hospital 115 HCMC and Head of Endocrinology Division at MEDIC HCMC. Her studies are mainly on Epidemiology of diabetes in South Vietnam diabetic nephropathy, lipid disorders in diabetes, hypoglycemia in DM, diabetic keto- acidosis, thyroid disorders in pregnancy. Nemencio Almare Nicodemus Jr obtained his degree of Doctor of Medicine at the University of the Philippines - College of Medicine. He subsequently did his residency training in Internal Medicine and fellowship training in Endocrinology, Diabetes and Metabolism at the Philippine General Hospital. Subsequently, he went to the Mayo Clinic in Rochester, Minnesota as part of the Visiting Clinician Program. He is a Professor at the University of the Philippines - College of Medicine, Department of Biochemistry & Molecular Biology, where he was awarded the Most Outstanding Medical Teacher in the Basic Sciences. He is also a Clinical Professor at the Department of Medicine of the Philippine General Hospital where he was recognized by the University of the Philippines Medical Alumni Society in America as Best Teacher. He is currently the Vice President of the Philippine Society of Endocrinology, Diabetes and Metabolism (PSEDM), a director of the Philippine Association For The Study of Overweight and Obesity, Asian Alliance for the Study of Neuroendocrine Tumors and Philippine Thyroid Association. He is the Associate Editor of the Journal of the ASEAN Federation of Endocrine Societies (JAFES)

14 Dang Van Phuoc Vietnam National University School of Medicine Ho Chi Minh City, Vietnam Paolo Pozzilli University Campus Bio-Medico (UCBM) Rome, Italy Dang Van Phuoc is currently Professor and Dean of the Faculty of Medicine Vietnam National University HCM City and Senior Consultant Cardiologist at the University Medical Center / University of Medicine & Pharmacy Ho Chi Minh City. He earned his medical degree from the Hanoi Medical University, completed his doctoral training in cardiovascular medicine in Germany in and a research fellowship in Germany in He went on to obtain a one-year fellowship in interventional cardiology at the Houston s Texas Medical Center, USA, in Professor Phuoc previously held the positions of Chancellor and Dean of the Faculty of Medicine of the University of Medicine and Pharmacy of HCM City (2006 to 2011) as well as Head of the Department of Cardiology, Vice Director of Cho Ray Hospital HCM City (2004 to 2011). Professor Phuoc is the President of the Heart Association of Ho Chi Minh City and Vice- President of the Viet Nam National Heart Association. He has served on the editorial board of several academic journals of Viet Nam and published widely in the local medical literature. Paolo Pozzilli, MD trained in Medicine and specialized in Endocrinology & Metabolic Diseases from Sapienza University of Rome, Italy, under the guidance of Professor Domenico Andreani. He worked mainly in the field of diabetes with particular focus to type 1 diabetes (T1D) pathogenesis and prevention in Rome and in the UK, and in collaboration with several investigators worldwide. Internationally he set up with others the EURODIAB study on the incidence of childhood T1D, that is the most comprehensive mapping of the incidence of T1D in Europe. He has been the regional P.I. for TRIGR, the longest trial for the primary prevention of T1D. He established a joint international PhD program in diabetes including 4 Universities (Barts & the London, Queen Mary, UK; University of Ulm, Germany; University of Barcelona, Spain and University Campus Bio- Medico, Rome, Italy). The most relevant international studies where he acted as Leader or regional P.I. include ENDIT, TRIGR, Action LADA and more recently EMPAREG, EXSCEL, CANVAS and IN-TANDEM2 trials. His collaborations with investigators in Europe, US and more recently China, have allowed him to implement joint research programs for the identification of T1D pathogenic mechanisms leading to beta cell destruction. He is the Director of the Department of Endocrinology & Diabetes, at University Campus Bio-Medico in Rome and of the Post-Graduate School of Endocrinology and Metabolism at the same University where he is also Coordinator of the PhD program in Integrated Biomedical Sciences and Bioethics. He was President of the Italian Society of Diabetes for Lazio and Rome region, founder and Chairman in the late 80 s of the IMDIAB group (immunotherapy of T1D) with participation of several diabetes hospital centers in Rome, leading to the conduction of 13 clinical trials in the specific field. Currently is the Coordinator of the Italian Society of Endocrinology for Lazio and Rome region. In the UK he has worked at the Centre of Diabetes, St. Bartholomew s and the London School of Medicine, Queen Mary, University of London, initially under the guidance of the late Professor Andrew Cudworth at St. Bartholomew s Hospital. He continued his activity at the Centre of Diabetes, Blizard Institute, Queen Mary on projects on Latent Autoimmune Diabetes in Adults (LADA) being Deputy leader of the EU funded programme ACTION LADA

15 Ho Huynh Quang Tri Heart Institute Ho Chi Minh City, Vietnam Kun-Ho Yoon Department of Endocrinology & Metabolism Seoul St. Mary's Hospital Seoul, Korea Ho Huynh Quang Tri is the Chief of Intensive Care Unit at the Heart Institute, Ho Chi Minh city. A 1988 graduate of the Faculty of Medicine, University of Odessa, Ukraine, Dr Ho obtained a fellowship in internal medicine at Nhan Dan Gia Dinh Hospital, Ho Chi Minh city, and a fellowship in intensive care and cardiology at the Heart Institute. He honed his skills in cardiac intensive care during his 1-year-long residency at Broussais Hospital in Paris, France. He was awarded the degree of PhD in Medicine and Cardiology in 2010 at the University of Medicine and Pharmacy, Ho Chi Minh city. Dr Ho holds the position of Vice-President and Secretary-General of the Society of Cardiology, Ho Chi Minh city. He is also a member of the editorial board for the society s official journal. He has published widely in the field of cardiology in Vietnamese and international journals including the Asian Cardiovascular & Thoracic Annals and the Journal of Heart Valve Disease. Dr Ho is a visiting senior lecturer at the Department of Internal Medicine, Ho Chi Minh city University of Medicine and Pharmacy. Kun-Ho Yoon is Professor Department of Endocrinology & Metabolism at Seoul St Mary s Hospital, and chief of Department of Medical Informatics, Catholic University Medical College, Korea. Prof Yoon graduated with his medical degree and also pursued his PhD program at the Catholic University Medical College. Prof Yoon also completed a 2- year stint as a visiting scholar with the Cell biology and islet transplantation section in Joslin Diabetes Center of Harvard Medical School, US at 1996~1998. Prof Yoon was the recipient of the KDA Scientific Award three times. He was honoured with health technology Award by minister of Ministry of Health and Welfare and Innovative ICT and healthcare award by president. Prof Yoon has published more than 200 articles in international peer-reviewed journals with recent publications in Lancet, JAMA, Cell metabolism, Diabetes Care, Diabetes, and so on. His research has been focused on the betacell biology and improved diabetes patients care using the mobile and internet platform. He also led the development of treatment guideline of diabetes by KDA and he served as a vice president of KDA. He had served as Executive Director, Bureau of HT R&D Planning and Budget Management of Korea Health Industry Development Institute for two years

16 28 LEARNING OBJECTIVES

17 L1 The diabetes pandemic E. Maddaloni (Italy) L2 Metabolic and clinical changes of pre-diabetes P. Pozzilli (Italy) Describe the pandemic of diabetes and pre-diabetes Illustrate the economic and health burden associated with the increasing prevalence of diabetes Discuss the clinical and pathophysiological heterogeneity of diabetes for a prompt recognition of the disease Describe mechanisms of insulin resistance Illustrate mechanisms linking insulin resistance to end organ complications Evaluate clinical consequences of insulin resistance in pre-diabetes 30 31

18 L3 How to recognize people with pre-diabetes K.H. Yoon (Korea) L4 Obesity - a contemporary issue creating future problems N.T. Khue (Vietnam) Illustrate clinical features increasing the risk of pre-diabetes Describe strategies for pre-diabetes screening Evaluate the cost-effectiveness of pre-diabetes screening Describe the growing epidemic of obesity Identify obesity as a major driver of diabetes Evaluate the consequences of obesity in terms of healthcare costs, morbidity and mortality 32 33

19 L5 Keywords for pre-diabetes management P. Pozzilli (Italy) L6 Is treatment of pre-diabetes cost-effective? M. Mohamed (Malaysia) Describe the clinical trials supporting the ADA recommendations Illustrate the lifestyle interventions as recommended by the ADA guidelines Evaluate recommendation about pharmacotherapy in pre-diabetes Describe the costs associated with drug use for pre-diabetes Illustrate the benefits in terms of preventing the complications of diabetes 34 35

20 CS1 Newly diagnosed type 2 diabetes P. Pozzilli (Italy) and K.H. Yoon (Korea) CS2 Frail patients with type 2 diabetes E. Maddaloni (Italy) and M. Mohamed (Malaysia) Illustrate ADA recommendations for initial treatment of diabetes Discuss lifestyle intervention to be implemented at the point of diabetes diagnosis Discuss whether metformin should be started at the point of diabetes diagnosis Describe the relationship between frailty and diabetes Identify the challenges in diabetes management due to frailty Illustrate the impact of co morbidities in choosing anti-diabetic drugs 36 37

21 CS3 Subclinical hypothyroidism G. Kahaly (Germany) CS4 Hypothyroidism during pregnancy G. Kahaly (Germany) Illustrate the prevalence of subclinical hypothyroidism Discuss when subclinical hypothyroidism should be screened Evaluate pros and cons of treating subclinical hypothyroidism Grasp the consequences of hypothyroidism during pregnancy Discuss the most recent evidence about management of hypothyroidism and subclinical hypothyroidism during pregnancy Discuss the necessity of L-thyroxin and understand when it should not be prescribed in pregnant women 38 39

22 CS5 Thyroid cancer N.A. Nicodemus Jr (Philippines) L7 Blood pressure targets in hypertensive patients: European guidelines G. Mancia (Italy) Understand the prevalence of thyroid nodules and thyroid cancer Discuss the diagnostic stepwise approach to thyroid nodules Illustrate the ATA guidelines for differentiated thyroid cancer Grasp the new ESH/ESC guidelines Detect blood pressure values which identify the presence of hypertension Identify blood pressure targets that require antihypertensive treatment Discuss results of controlled clinical trials which justify the choice of blood pressure targets 40 41

23 L8 Are blood pressure targets proposed after the SPRINT study realistic in clinical practice? D.V. Phuoc (Vietnam) L9 New possibilities for fixed-dose combination treatment in hypertension H.H.Q. Tri (Vietnam) Understand results of the SPRINT study Evaluate how such aggressive blood pressure control was achieved Illustrate possible biases of SPRINT study Predict implications of suggesting aggressive blood pressure control in clinical practice Evaluate the difficulty of reaching blood pressure targets in hypertensive patients Grasp the pharmacological principles of combination therapy Illustrate the most important trials addressing the efficacy of different combination strategies Identify advantages of combinations not including RAS blockers 42 43

24 WG1 Complex patient with hypertension: when a beta-blocker is needed H.H.Q. Tri (Vietnam) WG2 Complex patient with hypertension: when combination therapy is needed D.V. Phuoc (Vietnam) Evaluate the clinical history of patients Define the cardiovascular risk of patients as well as the diagnostic procedures that should be performed Illustrate possible options for pharmacological treatment Identify clinical differences among the various molecules within the beta-blocker class Evaluate the clinical history of the patient Discuss whether high heart rate values might contribute to increasing a patient s cardiovascular risk Identify the rationale for combination therapy Understand whether it is appropriate to prescribe combination therapy including a betablocker 44 45

25 LIVE INTERVENTION 46 ONLINE IN-DEPTH TUTORIAL October ONLINE IN-DEPTH TUTORIALS

26 ONLINE PREPARATORY TUTORIALS July 2018 LIVE INTERVENTION 8-9 September 2018 ONLINE IN-DEPTH TUTORIAL October 2018 ONLINE IN-DEPTH TUTORIALS October 2018 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This independent programme is made possible thanks to educational grants received from: Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan. Continue your Learning Journey after the live intervention! Online tutorials following the live intervention will help you delve deeper into content and put the key messages of this Learning Journey into clinical practice. CONCEPT MAP This in-depth tutorial will help you summarize the key points of the Learning Journey and turn scientific concepts into a visual format. Concept mapping will be facilitated through the video scribing and will offer you a representative summary of the entire learning path. VIDEO-LECTURE The final online tutorial is a video contribution by Prof. S. Taddei (Italy) on blood pressure targets after SPRINT study. The following topics will be addressed in this talk: Limitations of blood pressure targets in hypertension defined by Guidelines Evidence in favour of lower blood pressure values Strong and weak aspects of SPRINT 48 49

27 Improving the patient's life through medical education EXCEMED - Excellence in Medical Education 14, Rue du Rhône Geneva, Switzerland Copyright EXCEMED, All rights reserved.