REGIONAL WORKSHOP FINAL PROGRAMME. Ovarian stimulation strategies: Nurturing efficiency in ART. 9 December Dubai, United Arab Emirates

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1 REGIONAL WORKSHOP FINAL PROGRAMME Ovarian stimulation strategies: Nurturing efficiency in ART 9 December Dubai, United Arab Emirates

2 GENERAL INFO 2 3 GENERAL INFORMATION

3 Ovarian stimulation strategies: Nurturing efficiency in ART Overview Success rates following IVF treatment have increased significantly since the early days, mainly contributed by the introduction and use of ovarian stimulation. Controlled ovarian stimulation (COS) has a vital role in IVF by allowing control of the various events and increasing the number of oocytes to optimise outcomes. The aim of COS is to achieve maximal success with minimal side effects. Other important aspects to be considered are cost-effectiveness and patient compliance. Progress in or understandings of ovarian physiology and new advances in ovarian stimulation strategies have made it possible to achieve the best outcomes with COS. The aim of this workshop is to lay out ideal outcomes desired by patients, embryologists, clinicians following (ART) and finetuned, individualised approaches towards attaining these goals. Learning objectives By attending this live educational workshop, participants will be able to: Define laboratory and clinical outcomes for defining success in ART Key factors influencing the success of ART Tailor the best stimulation protocol for patient undergoing ART Discuss and debate changing approaches to ART Target audience This programme is designed for clinicians and biologists working in assisted reproductive medicine, who want to acquire up-to date information for improving their current practice. CME Provider EXCEMED is a non profit foundation dedicated, since the last four decades, to the development ofhigh-quality medical education programmes all over the world. EXCEMED adheres to the guidelines and standards of the European Accreditation Council for Continuing Medical Education (EACCME ) which states that continuing medical education must be balanced, independent, objective and scientifically rigorous. EXCEMED adheres to the principles of the Good CME Practice group (gcmep). Chair Robert Fischer Fertility Centre Hamburg Hamburg, Germany 4 5

Venue This live educational workshop will take place at the: Le Méridien Dubai Hotel & Conference Centre Airport Road, PO Box 10001 Dubai, United Arab Emirates Language The official language of this

4 Venue This live educational workshop will take place at the: Le Méridien Dubai Hotel & Conference Centre Airport Road, PO Box Dubai, United Arab Emirates Language The official language of this live educational course is English. FACULTY CME Provider EXCEMED - Excellence in Medical Education Senior Programme Manager: Chloé Xilinas T F chloe.xilinas@excemed.org Medical Advisor: Sesh Kamal Sunkara For any logistic inquiry, please contact Meridiano Congress International Event Manager: Giorgia Di Egidio T F giorgia.diegidio@meridiano.it 6 7 FACULTY

5 Faculty Salem El Shawarby UK Consultant & Subspecialist in Reproductive Medicine Director of Corniche Fertility Centre Corniche Hospital Abu Dhabi, UAE Robert Fischer Fertility Centre Hamburg Hamburg, Germany Sesh Kamal Sunkara Reproductive Medicine Unit Queen s Hospital Essex, UK Filippo Maria Ubaldi G.EN.E.R.A Centre for Reproductive Medicine Rome, Italy PROGRAMME 8 9 PROGRAMME

6 Saturday, 9 December Registration Opening and introduction R. Fischer (Germany) Session I Fine tuning COS Session II Current debates in ART Chair: R. Fischer (Germany) L1: What is success in ART? (Laboratory and clinical outcomes for defining success in ART) F.M. Ubaldi (Italy) L2: Number of oocytes for optimising IVF outcomes S.K. Sunkara (UK) L3: Female age, ovarian reserve and ovarian reserve tests: implications for ART F.M. Ubaldi (Italy) Panel discussion Coffee break L4: What kind of gonadotropins to use? S. El Shawarby (United Arab Emirates) L5: Ovarian response groups, suboptimal response and The POSEIDON concept S.K. Sunkara (UK) Chair: R. Fischer (Germany) L7: Is there a place for mild stimulation and modifying natural cycle in ICOS? F.M. Ubaldi (Italy) L8: Is the time ready for all freeze strategy for all patients? S.K. Sunkara (UK) Panel discussion Coffee break Two interactive case studies S.K. Sunkara (UK) S. El Shawarby (United Arab Emirates) Concluding remarks R. Fischer (Germany) End of the workshop L6: Stimulation strategies for overcoming impaired response S. El Shawarby (United Arab Emirates) Panel discussion Lunch Legend L : Lecture : Interactive case studies : Panel discussion 10 11

7 Faculty disclosures EXCEMED adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME ) and all other professional organizations, as applicable, which state that programmes awarding continuing education credits must be balanced, independent, objective and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices and other products (other than those uses indicated in approved product labeling/ package insert for the product) may be presented in the programme (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so that participants may form their own judgements, based on full disclosure of the facts. Further, all opinions and recommendations presented during the programme and all programme-related materials neither imply an endorsement nor arecommendation on the part of EXCEMED. All presentations represent solely the independent views of the presenters/authors. The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-emea/fda approved (off-label) uses of drugs: Salem El Shawarby Robert Fischer Declared no potential conflict of interest. Declared no potential conflict of interest. Sesh Kamal Sunkara Declared receipt of honoraria or consultation fees from Merck and Ferring. Participation in a company sponsored speaker s bureau Merck Europe, Ferring UK, MSD. Filippo Maria Ubaldi Declared receipt of grants from Merck (GFI) and Finox and receipt of honoraria or consultation fees from Merck, MSD, Ferring, Cook, EXCEMED. Stakeholder of Genera Health Care Srl and Flam Srl. BIOGRAPHIES BIOGRAPHIES

Salem El Shawarby UK Consultant & Subspecialist in Reproductive Medicine Director of Corniche Fertility Centre Corniche Hospital Abu Dhabi, UAE Robert Fischer Fertility Centre Hamburg Hamburg,

Government maternity hospital in UAE) since September 2014. Prior to moving to UAE, Dr.

8 Salem El Shawarby UK Consultant & Subspecialist in Reproductive Medicine Director of Corniche Fertility Centre Corniche Hospital Abu Dhabi, UAE Robert Fischer Fertility Centre Hamburg Hamburg, Germany Salem El Shawarby is a Consultant in Reproductive Medicine and is the Director of the Corniche Fertility Centre at the reputable Corniche Hospital (the largest and longest established Government maternity hospital in UAE) since September Prior to moving to UAE, Dr. El Shawarby was a Consultant in Reproductive Medicine & Surgery in the UK at the world renowned IVF Hammersmith; the IVF unit of the Hammersmith, Queen Charlotte s & Chelsea Hospitals, Imperial College London. He also ran his own private clinic at the prestigious Harley Street, where he used to treat patients from both the UK, as well as overseas patients from different parts of the world. He has over 23 years of experience in the field of Reproductive Medicine, having worked in 5 Assisted Conception units of some of the UK s leading University hospitals. He started his career in Reproductive medicine by obtaining a clinical research fellowship at IVF Hammersmith. He then became a RCOG Accredited Subspecialist in Reproductive Medicine & Surgery after completing a Subspecialty training fellowship at the IVF unit of University College London Hospital/ Centre for Reproductive & Genetic Health. He has also previously worked at the IVF units of Guy s and St. Thomas Hospital, and the University Hospitals of Leicester & Southampton. Dr. El Shawarby graduated from Cairo University- Egypt (MBBCh) with Honours in 1994, where he then obtained MSc & MD in Reproductive Medicine in 1998 and 2002 respectively, and he also holds a professor position in Obstetrics & Gynaecology in the same university. He was admitted as a member of the Royal College of Obstetricians & Gynaecologists in London in 2000, and was granted the college s fellowship in He is also a member of the RCOG Reproductive Medicine Clinical Studies Group and the British Fertility Society. Dr. El Shawarby is the author of more than 30 peer-reviewed papers published in top medical journals in the field of Reproductive Medicine. He has presented at several national and international conferences and meetings. His current clinical and research interests include: ovarian reserve tests, assisted conception, optimizing ovarian stimulation protocols and the outcome of IVF, recurrent implantation failure, and reproductive surgery. Robert Fischer is founder and Medical Director of the IVF unit at the Fertility Center Hamburg - one of Germany s largest and leading IVF centres. In July 1998 the Fertility Center Hamburg was one of the first centres ingermany, and worldwide, to introduce certified quality management according to the ISO In 2002, the IVF laboratory became ISO certified. Prior to these developments, in 1983 he pioneered and was medical director ofthe first outpatient IVF unit in Hamburg. Authorof numerous publications in national and international scientific journals and books, as wellas lecturer at conferences worldwide, he is also an active member of the American Society of Reproductive Medicine, founding member of the European Society of Human Reproduction and past member of its advisory committee as well as founding member of the German reproductive organisations, AG Gynäkologische Endokrinologie und Fortpflanzungsmedizin and Berufsverband Reproduktionsmedizinischer Zentren

Sesh Kamal Sunkara Reproductive Medicine Unit Queen s Hospital Essex, UK Filippo Maria Ubaldi G.EN.E.R.A Centre for Reproductive Medicine Rome, Italy Sesh Kamal Sunkara is a Consultant Gynaecologist and Subspecialist in Reproductive Medicine and Surgery.

She undertook translational research in Reproductive Medicine at the Assisted Conception Unit, Guy s and StThomas NHS Foundation Trust and King s College London which formed the basis forher Research

9 Sesh Kamal Sunkara Reproductive Medicine Unit Queen s Hospital Essex, UK Filippo Maria Ubaldi G.EN.E.R.A Centre for Reproductive Medicine Rome, Italy Sesh Kamal Sunkara is a Consultant Gynaecologist and Subspecialist in Reproductive Medicine and Surgery. She specialised in the field of Obstetrics and Gynaecology and is a Member of the Royal College of Obstetricians and Gynaecologists (MRCOG), UK. She undertook translational research in Reproductive Medicine at the Assisted Conception Unit, Guy s and StThomas NHS Foundation Trust and King s College London which formed the basis forher Research degree in Reproductive Medicine; Doctor of Medicine (MD) awarded by King s College London. She has dual accreditation with the UK General Medical Council as a specialist in Obstetrics and Gynaecology as well as Reproductive Medicine. She worked as a Consultant gynaecologist and Subspecialist in Reproductive Medicine at the Aberdeen Fertility Centre, University of Aberdeen before moving to Barking Havering and Redbridge University Hospitals to set up anew IVF service. In addition to her clinical work, she has published in the field of Reproductive Medicine and authored severalbook chapters. She has organised and participated in several national and international symposia and workshops in thefield of Reproductive Medicine. She is the Associate Editor for Human Reproduction Journalby the European Society of Human Reproduction and Embryology (ESHRE). She is on the executive board for the RCOG Reproductive Medicine Clinical Studies Group which is actively involved in supporting multi-centre research studies in the UK. Filippo Maria Ubaldi is Medical Doctor, Clinical Director at the GENERA Centres for Reproductive Medicine in Rome, Marostica, Umbertide and Naples, Italy. With academic degrees in Obstetrics and Gynaecology, Masters in Andrology and Reproductive Medicine, he is also intensely dedicated to educational, editorial and practitioner activities. Co-author of 8 books on Reproductive Medicine and Co-author of 8 books on the topic of Reproductive Medicine and of 118 peer reviewed journals; author H-index is 38. Editor of the treaty on Reproductive Medicine Medicina della Riproduzione Umana published in Italy in Invited as speaker at over 300 National and International congresses on the topic of Reproductive Medicine and has been Scientific Coordinator of more than 30 congresses and courses. Member of the ESHRE Executive Committee during , he has been Chairman of the 26th ESHRE Annual Meeting held in Rome in June In 2014 received the Italian National Scientific License as full Professor in Obstetrics and Gynaecology. During has been member of the technical advisory board established by the Ministry of Health on heterologous fertilization

10 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This independent programme is made possible thanks to educational grants received from: Ferty School, MVZ Fertility Center Hamburg, Istituto di Ricerche Genetiche, Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan. 18

Improving the patient s life through medical education www.excemed.

Target audience. Chair. Robert Fischer Fertility Centre Hamburg Hamburg, Germany

Target audience. Chair. Robert Fischer Fertility Centre Hamburg Hamburg, Germany EXCEMED Blended Education Ovarian stimulation strategies: maximizing efficiency in ART Live intervention in Rio de Janeiro, Brazil PRELIMINARY PROGRAMME Ovarian stimulation strategies: maximizing efficiency