Dear Participants, Yours sincerely, Silvia Cristofanelli EXCEMED
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1 EXCEMED Blended Education 16 th practice teaching course in MS knowledge Live intervention in November 2018
2 Dear Participants, On behalf of EXCEMED, it is our pleasure to welcome you to the live intervention element of your Learning Journey, 16 th practice teaching course in MS knowledge. This face-to-face learning experience consists of frontal lectures, discussions, clinical cases and visit to the premises. learning experience consists of frontal lectures, discussions, clinical casessit The learning continues after the live intervention. Visit your Learning Journey page after the face-to-face meeting to access the in-depth interactive tutorials. You will access two video contributions by Professor Maria Pia Amato and Professor Anthony Feinstein. We also welcome your presence in the private Facebook group which is accessible through your personal Journey Page. Network with colleagues and discuss what you learned here in Barcelona. Complete the entire journey including the assessment surveys and get access to a Diploma signed by the Chairs as well as the final Outcomes & Feedback Report. We look forward to seeing you in person and online! Yours sincerely, Silvia Cristofanelli EXCEMED
3 PREPARATORY October 2018 LIVE INTERVENTION November 2018 IN-DEPTH December th practice teaching course in MS knowledge Overview The field of Multiple Sclerosis is rapidly evolving year by year requiring continuous education on all the main aspects of the disease from pathogenesis to treatment. The aim of the course, which has come to its 16th edition, is to provide a comprehensive overview of all the most recent advancements in MS through the voice and experience of local and international speakers through a blended educational approach. Participants will be also actively involved in the discussion of clinical cases about hot topics in MS, such as pregnancy management in the current treatment scenario. An EXCEMED Learning Journey The EXCEMED blended education approach explores concepts from different angles using diverse formats which reinforce the learning experience. A multistep approach is used, encompassing web- based and live activities. All activities in-person and online involve the full interactivity of learners. At three stages throughout the process, you will be asked to give your feedback on the learning experience through the 3 surveys. The aim of this learner-centered programme is to enhance clinical practice by exploring the ideal outcomes desired by patients, neurologists, and clinicians following MS, with individualized approaches toward attaining these goals. After completing your Learning Journey with EXCEMED, you will receive a Diploma signed by the Chairs and a final Outcomes and Feedback Report. Learning objectives By attending this programme, you will be able to: Describe immunopathogenesis of MS considering recent discoveries Illustrate disease modifying and symptomatic treatment strategies in the current therapeutic scenario Describe how to diagnose and treat less visible MS-related damage (i.e. cognition) Target audience This programme is designed for neurologists working in the field of multiple sclerosis, who want to acquire up-to date information for improving their current practice. Chair Xavier Montalban Department of Medicine Division of Neurology St. Michael's Hospital Toronto, Canada Jaume Sastre-Garriga EXCEMED designed this programme in partnership with Cemcat (Multiple Sclerosis Centre of Catalonia) Local scientific and organising coordination Teaching & Training department Multiple Sclerosis Centre of Catalonia formacio@cem-cat.org 2 3
4 Continuing medical education EXCEMED is a non profit foundation dedicated, since the last four decades, to the development of high-quality medical education programmes all over the world. EXCEMED adheres to the guidelines and standards of the European Accreditation Council for Continuing Medical Education (EACCME ) which states that continuing medical education must be balanced, independent, objective and scientifically rigorous. EXCEMED - Excellence in Medical Education Programme Manager: Silvia Cristofanelli T F silvia.cristofanelli@excemed.org Medical Advisor: Doriana Landi doriana.landi@gmail.com EXCEMED adheres to the principles of the Good CME Practice group (gcmep). PREPARATORY October
5 PREPARATORY October 2018 LIVE INTERVENTION November 2018 IN-DEPTH December 2018 PREPARATORY October 2018 VIDEO LECTURE The online preparatory tutorial is a video lecture by Professor Wiendl on Immunological rationale behind immune system reset. It will enable to: Define the concept of immune reset in MS Illustrate the role of B cells and T cells in MS Describe clinical trials design and results supporting the efficacy pharmacological immune reset VIDEO LECTURE This video lecture by Professor Bar Or concerns the Compartmentalized Immune Responses in MS and will enable to: Illustrate the anatomical localization of immune cells infiltrates in the CNS and the main route of CNS infiltration Describe the molecular mechanisms by which compartmentalized response contribute to MS progression Enlighten the role of resident immune cells with respect to inflammation and neurodegeneration LIVE INTERVENTION November
6 PREPARATORY October 2018 LIVE INTERVENTION November 2018 IN-DEPTH December 2018 LIVE INTERVENTION November 2018 The live component of this Learning Journey is a combination of frontal lectures, panel discussions and interactive clinical cases. LEARNING OBJECTIVES By attending this live intervention you will be able to: Describe the main pathological findings in MS Apply new diagnostic criteria for MS Explain how to specific clinical challenges in MS (i.e. pregnancy, paediatric MS) Illustrate new treatment targets in MS Venue This live intervention takes place at the: Centre d'esclerosi Múltiple de Catalunya (Cemcat) Edifici Cemcat Hospital Universitari Vall d'hebron Pg. Vall d'hebron, Continuing medical education The 16 th practice teaching course in MS knowledge, to be held on November 2018 in, has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME ) with 13 (thirteen) European CME credits (EACCME s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits TM. Information on the process to convert EACCME credit to AMA credit can be found at Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME for ECMEC s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada. Language The official language of the live intervention is English. 8 9
7 FACULTY Georgina Arrambide Manuel Comabella Tobias Derfuss Department of Neurology University of Basel Basel, Switzerland Herena Eixarch Óscar Fernández Department of Neurology Hospital Regional Universitario Carlos Haya Malaga, Spain Nicolás Fissolo Unit of Clinical Neuroimmunology Institut de Recerca Letizia Leocani Institute of Experimental Neurology University Vita-Salute IRCCS San Raffaele Hospital Milan, Italy E. Roger Meza Multiple Sclerosis Center of Catalonia (Cemcat) Department of Neurology-Neuroimmunology Vall d'hebron University Hospital Xavier Montalban Department of Medicine Division of Neurology St. Michael's Hospital Toronto, Canada Susana Otero Multiple Sclerosis Center of Catalonia (Cemcat) Department of Epidemiology Vall d'hebron University Hospital Lluís Ramió i Torrentá Department of Neurology Multiple Sclerosis Unit Dr. Josep Trueta Hospital in Girona Girona, Spain Marta Renom Guiteras Jordi Río Alex Rovira Unit of Magnetic Resonance Department of Radiology -IDI Carme Santoyo Jaume Sastre-Garriga Christine Stadelmann Institute for Neuropathology University Medical Center Göttingen Göttingen, Germany Alan J. Thompson Department of Brain Repair and Rehabilitation Institute of Neurology University College London National Hospital for Neurology and Neurosurgery London, UK Mar Tintoré 10 11
8 PROGRAMME Monday, 12 November Opening Jaume Sastre-Garriga (Spain) Introduction to MS Centre of Catalonia (Cemcat) Jaume Sastre-Garriga (Spain) Session I What is MS Session III Clinical challenges Chair: Manuel Comabella (Spain) L1: Epidemiology of MS Susana Otero (Spain) L2: Immunopathogenesis of MS Tobias Derfuss (Switzerland) L3: Pathology of MS and other demyelinating disorders Christine Stadelman (Germany) L4: Genetics of MS Manuel Comabella (Spain) Coffee break Session II Diagnosis and differential diagnosis Chair: Jaume Sastre-Garriga (Spain) L9: Impact of hormonal factors on MS risk and prognosis Susana Otero (Spain) L10: Pediatric and Juvenile MS Mar Tintoré (Spain) L11: Primary Progressive MS Alan J. Thompson (UK) Coffee break L12: Neuromyelitis Optica - NMO - and anti MOG disease Georgina Arrambide (Spain) End of the first day Chair: Mar Tintoré (Spain) L5: The clinical work up of patients suspected of having MS Jaume Sastre-Garriga (Spain) L6: Diagnostic criteria: what changes in practice Mar Tintoré (Spain) L7: Imaging in MS: the value of multimodal approach Alex Rovira (Spain) L8: Neurophysiology in MS: diagnostic and prognostic use Letizia Leocani (Italy) Lunch Legend: : Introduction L : Lecture SS : Snapshot : Site visit : Course wrap-up 12 13
9 FACULTY DISCLOSURES Tuesday, 13 November 2018 Session IV Chair: Lluís Ramió i Torrentá (Spain) L13: Overview of MS treatments and treatment algorithms Óscar Fernández (Spain) L14: New treatment targets and clinical trial results Óscar Fernández (Spain) Coffee break Session V How to manage MS Prognosis Chair: Jordi Río (Spain) L15: Prognostic factors at MS diagnosis Jaume Sastre-Garriga (Spain) L16: Prognostic factors during treatment Jordi Río (Spain) SS1: Snapshot #1 on gene therapy in MS Herena Eixarch (Spain) SS2: Snapshot #2 on DNA vaccines in MS Nicolás Fissolo (Spain) Working Lunch L17: Overview on symptomatic therapy and rehabilitation E. Roger Meza (Spain) SS3: Symptomatic Therapy Snapshot #3 on gait rehabilitation Carme Santoyo (Spain) SS4: Symptomatic Therapy Snapshot #4 on Management of dysphagia Marta Renom Guiteras (Spain) Cemcat and Vall d Hebron Hospital premises visits Course wrap-up End of the live intervention EXCEMED adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME ) and all other professional organizations, as applicable, which state that programmes awarding continuing education credits must be balanced, independent, objective and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices and other products (other than those uses indicated in approved product labelling/package insert for the product) may be presented in the programme (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so that participants may form their own judgements, based on full disclosure of the facts. Further, all opinions and recommendations presented during the programme and all programme-related materials neither imply an endorsement nor a recommendation on the part of EXCEMED. All presentations represent solely the independent views of the presenters/authors. The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-emea/fda approved (off-label) uses of drugs: The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-emea/fda approved (off-label) uses of drugs: Georgina Arrambide Herena Eixarch Nicolás Fissolo Declared receipt of grants and contracts from: Biogen, Sanofi and declared otherwise benefit from a relationship with a commercial enterprise: research support from Novartis. Declared no potential conflict of interest. Declared no potential conflict of interest. Marta Renom Guiteras Declared no potential conflict of interest. Alex Rovira Jaume Sastre-Garriga Declared receipt of grants and contracts from: Biogen, Novartis, Bracco. Declared to be member of a company advisory board, board of directors and similar group: Olea, Novartis and participation in a company sponsored speaker s bureau: Biogen, Novartis. Declared receipt of honoraria from Roche, Merck, Sanofi, Celgene, Novartis
10 Alan J. Thompson Declared receipt of grants and contracts from: MS Society of GB∋ German Aerospace Center; ERA NET NEURON; Welcome Trust and honoraria or consultation fees from: Eisai; Biogen (MAPI). Declared to be member of a company advisory board, board of directors or other similar group: IMANOVA; PMSA; NMSS and declared otherwise benefit from a relationship with a commercial enterprise: Honorarium from SAGE Publishers for role as Editor-in- Chief, Multiple Sclerosis Journal. The following faculty have provided no information regarding significant relationship with commercial supporters and/or discussion of investigational or non-emea/fda approved (offlabel) uses of drugs as of 6 November Manuel Comabella Tobias Derfuss Óscar Fernández Letizia Leocani E. Roger Meza Xavier Montalban Susana Otero Lluís Ramió i Torrentá Jordi Río Carme Santoyo Christine Stadelmann Mar Tintoré IN-DEPTH December
11 PREPARATORY October 2018 LIVE INTERVENTION November 2018 IN-DEPTH December 2018 IN-DEPTH December 2018 All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This independent programme is made possible thanks to educational grants received from: Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan. Continue your Learning Journey after the live intervention! VIDEO LECTURE This in-depth tutorial by Professor M.P. Amato elaborate on pharmacological and nonpharmacological approach to cognitive impairment. It will enable to: Describe the neuropsychological pro le of MS patients according to MS subtypes and its evolution over time Illustrate the neuropsychological batteries validated for the assessment of cognition in MS in different countries Provide an overview of pharmacological and non-pharmacological approaches to cognitive impairment VIDEO LECTURE Professor A. Feinstein describes in this on-line tutorial the role of emotional burden and disturbances in MS. It will enable to: Illustrate the most prevalent psychiatric disturbances associated to MS Define the neurobiological bases underling psychiatric disorders in MS Describe how to treat psychiatric disorders in MS
12 Improving the patient's life through medical education EXCEMED - Excellence in Medical Education 14, Rue du Rhône Geneva, Switzerland Copyright EXCEMED, All rights reserved.
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