Computational Classification Approach to Profile Neuron Subtypes. from Brain Activity Mapping Data
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1 Computational Classification Approach to Profile Neuron Subtypes from Brain Actiity Mapping Data Meng Li, 1,+ Fang Zhao, 1,+ Jason Lee, 1 Dong Wang, 1 Hui Kuang, 1,2 and Joe Z. Tsien 1,2,* 1 Brain and Behaior Discoery Institute and Department of Neurology, Medical College of Georgia, Georgia Regents Uniersity, Augusta, GA 30912, USA. 2 The Brain Decoding Center, Banna Biomedical Research Institute, Xi-Shuang-Ban-Na Prefecture, Yunnan Proince , China. + Co-first author * Correspondence should be addressed to Joe Z. Tsien, Brain and Behaior Discoery Institute and Department of Neurology, Medical College of Georgia, Georgia Regents Uniersity, Augusta, GA 30912, USA. jtsien@gru.edu.
2 Figure S1 (a) Neural actiity patterns of the primary neuron types were recorded in four well-studied brain regions, that is, pyramidal cells in the ACC, medium spiny neurons in the striatum, pyramidal cells in the CA1 region of hippocampus and DA neurons in the VTA. (b) Neural actiity patterns of these four primary neuron types show massie ariations, and these ariations can be well described by and c. Red cures are the Probability Distribution Function of Gamma distribution for each neuron.
3 Figure S2 Profiling the hippocampal CA1 pyramidal cells based on neural actiity patterns under the SWS state. (a) Distributions of k and c under the SWS state. p alues from the D Agostino and Pearson omnibus normality test indicated that there are discrete sub-populations within hippocampal CA1 pyramidal cell population. (b) Distances from two cluster centers reealed a significant separation of two pyramidal cell subtypes. (c) A hierarchical clustering analysis showed that the inter-cluster distance of two clusters was significantly higher than the intra-cluster distance. (d) Distributions of k and c for two pyramidal cell subtypes. The bar graphs showed that these two pyramidal cell subtypes had significant differences in and c.
4 Figure S3 The ISIHs of both pyramidal cell sub-populations showed no significant difference under the quiet awake state.
5 Figure S4 Profiling the VTA DA neurons based on neural actiity patterns under the awake and SWS state. (a) Distributions of k and c under the awake state. p alues from the D Agostino and Pearson omnibus normality test indicated that there are discrete sub-populations within VTA DA neuron population. (b) Distances from two cluster centers reealed a significant separation of two DA neuron subtypes. (c) A hierarchical clustering analysis showed that the inter-cluster distance of two clusters was significantly higher than the intra-cluster distance. (d) Distributions of k and c for two DA neuron subtypes. The bar graphs showed that these two DA neuron subtypes had significant differences in and c. (e) Distributions of k and c under the SWS state. (f) Distances from two cluster centers reealed a significant separation of two DA neuron subtypes. (g) The inter-cluster distance of two clusters was significantly higher than the intra-cluster distance. (h) Distributions of k and c for two DA neuron subtypes. The bar graphs showed that these two DA neuron subtypes had significant differences in and c.
6 Figure S5
7 Dierse responses of VTA DA neurons upon aersie stimuli. (a), The responses of four representatie VTA DA neurons upon aersie stimuli, shown as the format of peri-eent raster. The color bars aboe denote four different periods, the red/black arrows indicate that the firing rates of neurons increase/decrease significantly. Red bars in the middle of peri-eent raster plots show the time periods of stimuli (0.5s earthquake). (b), Scatter plot of responses of four DA neuron subcategories upon aersie stimuli. (c), One-way ANOVA analysis of the mean firing rates of four VTA DA neuron subcategories during four periods. The firing rates of DA neurons during Early, Middle and Late periods were normalized as the percentages of the firing rates during Baseline period.
8 Figure S6 Classification of CA1 pyramidal cells and interneurons based on their firing rates and waeform width. The top-right subplot shows the waeform of pyramidal cells and interneurons, dashed lines denote SD.
9 Figure S7 Waeforms of neuron subtypes. (a), Mean waeforms of two CA1 pyramidal cell subtypes. (b), Mean waeforms of two VTA DA neuron subtypes. Dashed lines denote SD.
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