The Advanced Science of Health

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Marian Casey
5 years ago
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1 The Advanced Science of Health 10 years ago, the food pyramid taught us that fats, proteins, carbohydrates, vitamins, and minerals were all the nutrients necessary for good health. Modern research scientists have discovered that another group of nutrients are necessary for optimal health - phytonutrients. The phytonutrients that give fruits and vegetables their multiple colors also provide benefits to human health. Today, fertilizers, pesticides and genetic modifications of fruits and vegetables (GMO) cause genetic changes in plant cells which can alter the composition and concentration of vital phytonutrients. The old adage an apple a day keeps the doctor away, no longer holds true- genetic changes can require MANY apples to perform the same protective functions that only one did 50 years ago. Diet alone is no longer enough to stay ahead of the man-made and environmental changes we face since the very foods we eat are also at risk. Scientists have been researching these changes for the past 5 years and have developed a product that compensates for the lack of phytonutrients created by physical (stress, poor diet, aging), environmental (pesticides, pollution) and GMO farming factors. GYV s cutting edge science extracts the most important phytonutrients from fruits and vegetables to bring you a concentrated serving of the nutrients that scientists have determined most essential to adult health. Phytonutrients: They do it All Phytonutrients protect the body, fight disease and are essential for cell health. They help the cells repair themselves by stimulating the release of protective enzymes or those that rebuild damaged cells. Other phytonutrients inhibit cancer-producing substances, reducing their ability to damage cells. Phytonutrients improve cardiac health. Antioxidant phytonutrients can interfere with the damaging effects of LDL cholesterol on arteries. LDLs, the bad cholesterol, become harmful after an encounter with a free radical, during which they are oxidized. When artery walls are damaged by free radicals, it s easier for oxidized LDLs to build up. Antioxidant phytonutrients, especially beta carotene, can block this process and help prevent cardiovascular disease. At the same time, too many antioxidants can prevent your cells from functioning the way they should. Our scientists designed GYV to work in multiple metabolic pathways to give your cells the exact balance they need to be in good working order.

2 Phytonutrients: They do it All, Continued Phytonutrients are a physiologic defense. Carcinogens (cancer-causing substances) can enter the body from all kinds of sources: tobacco smoke, pollution, fertilizers and pesticides. Carcinogens attempt to enter cells and change how they develop- but antioxidant phytonutrients can stop the carcinogens before they have a chance to cause cancer in the cell. If the carcinogen manages to get through the internal controls of the cell, other kinds of phytonutrients help shut down the precancerous cells so they does not multiply. Don t just take our word for it- See what scientists from top research institutions around the world say about our ingredients. Effects of GYV: Modern Scientific Laboratory Research LIFE EXTENSION several of the molecules in GYV have very potent effects on several of the genes (AMPK, Nrf2, and the Sirtuin family) associated with life extension. The effects of these molecules are very similar to effect of chronic calorie restriction, which is the mechanism best-known to cause these longevity genes to be activated. As these genes are activated, the proteins they make interact with a wide variety of metabolic pathways well known to result in cell life extension. ROS SCAVENGING the normal process of oxidative metabolism results in the production of reactive oxygen species (ROS). These ROS are the extremely damaging atoms and molecules associated with the Oxygen Radical Theory of Aging. The effects of several of the ingredients in GYV are to either: (1) Act directly as anti-oxidants; or (2) Increase the number of mitochondria so that the mitochondria can absorb oxygen molecules, preventing the creation of ROS in the first place. ANTI-INFLAMMATORY as a generalized anti-inflammatory, GYV will allow someone to train harder with little or no delayed onset muscle soreness (DOMS). This will allow someone to train hard and come back the next day to train hard again. This is a particularly important effect for those performing heavy resistance (weight) training. ANTI-OXIDANT a generalized anti-oxidant, GYV exhibits a diversity of effects. The most potent ergogenic effect is to lessen any muscle damage induced by training or exercise. The most potent generalized effect is to lessen any tissue damage induced by the accumulation of reactive oxygen species. MITOCHONDRIAL BIOGENESIS mitochondria have several ergogenic roles in muscle. Stimulating the growth of new mitochondria (1) increases muscle endurance and (2) lessens any tissue damage induced by the accumulation of reactive oxygen species

3 Ingredients- Mechanisms of Effects RESVERATROL has several ergogenic and biochemical effects. It is (1) an exercise mimetic; (2) a stimulator of testosterone production; (3) an anti-inflammatory; (4) an anti-oxidant; (5) a cardioprotector; and (6) a life-extender. QUERCETIN has three primary ergogenic effects. It is (1) an anti-inflammatory; (2) an antioxidant; and (3) stimulates mitochondrial biogenesis. There is some limited evidence that it is an anti-hypertensive. UBIQUINOL COENZYME Q10 Ubiquinol is the reduced form of CoQ10. CoQ10 is a generalized anti-oxidant (particularly in combination with ascorbate and tocopherol) and is a redox transfer agent at sites I-II of the electron transport chain. CoQ10 supplementation has been closely associated with a healthy cardiovascular system and its depletion has been associated with premature aging. ASCORBATE SELENIUM this supplementation augments the functionality of the glutathione your cells already makes. This supplementation has the effect of ensuring that endogenous glutathione can function as an anti-oxidant. N-ACETYLCYSTEINE there is laboratory evidence that this molecule functions as an antioxidant (by augmenting intracellular glutathione concentration). Via this effect, it also acts as a hepatic-protective by inactivating liver-oxidants such as N-acetyl-p-benzoquinone imine. There is some evidence that it may also lessen muscle fatigue. ACETYL-L CARNITINE this molecule enhances the ability of cells to metabolize fats. ALPHA LIPOIC ACID this molecule is an essential component of four mitochondrial enzyme complexes. It may also have an anti-oxidant effect. GYV Ingredients Research QUERCETIN Quercetin is a plant-derived flavanoid. Flavonoids are reddish pigments, found in red grape skins and citrus fruits, and isoflavones can be found in peanuts, lentils, soy, and fava beans. Quercetin has been proven to modulate lipid peroxidation involved in atherogenesis, thrombosis, and carcinogenesis. Known properties of flavonoids include free radical scavenging, strong antioxidant activities in preventing oxidation, inhibition of low density lipoproteins (LDL), inhibition of hydrolytic and oxidative enzymes (phospholipase A2, cyclooxygenase, lipoxygenase), and anti-inflammatory actions.

4 QUERCETIN SCIENTIFIC RESEARCH PAPERS 1. Boots AW, GR Haenen, and A Bast. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 582(2-3):325-37, Cai J, KC Nelson, M Wu, et al. Oxidative damage and protection of the RPE. Prog Retin Eye Res. 19(2): , Davis JM, CJ Carlstedt, S Chen, et al. The dietary flavonoid quercetin increases VO2max and endurance capacity. Int J Sport Nutr Exerc Metab. 20(1):56-62, Davis JM, EA Murphy, MD Carmichael, and B Davis. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol R296, , Egert S, A Bosy-Westphal, J Seiberl, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo controlled crossover study. Br J Nutr 102 (7): , RESVERATROL Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Food sources of resveratrol include the skin of grapes, blueberries, raspberries, and mulberries and Japanese knotweed. The effects of resveratrol are currently a topic of numerous animal and human studies. Its effects on the lifespan of many model organisms remain controversial, with uncertain effects in fruit flies, nematode worms and short lived fish. In mouse experiments, anti-cancer, anti-inflammatory, bloodsugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported. Chronic administration of resveratrol has been shown to extend the lifespan of yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), and the fruit fly Drosophila melanogaster. More recently, chronic resveratrol has been shown to have similar effects in vertebrates. The first positive result of resveratrol supplementation in a vertebrate was demonstrated in the short-lived fish (Nothobranchius furzeri). A maximal dose of resveratrol increased the median lifespan by 56%. More recently, resveratrol counteracted the detrimental effects of a high-fat diet in mice. This result may be due to the demonstration that quercetin and resveratrol (in vitro) inhibit production of fat cells.

5 RESVERATROL Although the mechanisms of resveratrol s apparent effects on life extension are not fully understood, by scientists, they appear to mimic several of the biochemical effects of calorie restriction. The French paradox, that moderate drinking of red wine reduces the risk of heart disease, is well known. The role of resveratrol may produce this effect via the following functions: inhibition of vascular cell adhesion molecule expression, inhibition of vascular smooth muscle cell proliferation, stimulation of endothelial nitric oxide synthase (enos) activity, inhibition of platelet aggregation inhibition of LDL peroxidation. RESVERATROL SCIENTIFIC RESEARCH PAPERS 1. Bass TM, D Weinkove, K Houthoofd, et al. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev. 128(10):546-52, Baur JA and DA Sinclair. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5 (6): , Baur JA, KJ Pearson, NL Price, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (7117): , Bhat KP, D Lantvit, K Christov, et al. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Research 61 (20): , Duffy SJ and JA Vita JA. Effects of phenolics on vascular endothelial function. Curr Opinion Lipidology 14 (1): 21 7, Elmali N, O Baysal, A Harma, et al. Effects of resveratrol in inflammatory arthritis. Inflammation 30 (1-2): 1 6, UBIQUINOL COENZYME Q10 Coenzyme Q10 is a 1,4-benzoquinone (Q refers to the quinone chemical group and 10 refers to the number of isoprenyl chemical subunits in its tail). CoQ10 and related ubiquinones were first isolated and extracted from beef heart. Its function was then elucidated by Peter Mitchell. This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain thus is an essential component for O2-dependent cellular respiration. Therefore, those organs with the highest energy requirements (such as the heart, muscle, liver, and kidney) have the highest CoQ10 concentrations. Because it can exist in one of three different redox states (fully oxidized ubiquinone, partially oxidized ubisemiquinone, and fully reduced ubiquinol), it can perform its functions both within the electron transport chain and as an antioxidant.

6 UBIQUINOL COENZYME Q10 Deficiency and Toxicity There are three major factors that lead to deficiency of CoQ10 in humans: insufficient dietary CoQ10, reduced biosynthesis, and increased utilization by the body. The literature is still inconclusive about whether biosynthesis or dietary intake is the major source of CoQ10. Biosynthesis can be attenuated by aging, some medications (statins, blood thinners, etc.), and some chronic disease conditions (cancer, heart disease, etc.). Toxicity is not usually observed with high doses of CoQ10. A daily dosage up to 3600 mg was found to be tolerated by healthy as well as unhealthy persons. However, some adverse effects are reported with very high intakes. They are mostly gastrointestinal problems. The observed safe level (OSL) risk assessment method indicated that the evidence of safety is strong at intakes up to 1200 mg/day, and this level is identified as the OSL. Factors affecting CoQ10 levels: Various factors reduce the concentration of CoQ10 in different organs; the following are known: Aging in individuals older than 20 years, aging reduces CoQ10 levels in internal organs. UV exposure UV exposure reduces CoQ10 levels in the skin. Inhibition by statins and beta blockers Coenzyme Q10 shares a common biosynthetic pathway with cholesterol. The synthesis of an intermediary precursor of coenzyme Q10, mevalonate, is inhibited by statins, a class of cholesterol-lowering drugs. Statins can reduce serum levels of coenzyme Q10 by up to 40%. Some research suggests the logical option of supplementation with coenzyme Q10 as a routine adjunct to any treatment that may reduce endogenous production of coenzyme Q10, based on a balance of likely benefit against very small risk. Additional possible medicinal properties Coenzyme Q10 helps to maintain a healthy cardiovascular system. There is evidence of CoQ10 deficiency in heart failure. Recently, CoQ10 plasma concentrations have been demonstrated as an independent predictor of mortality in chronic heart failure, CoQ10 deficiency being detrimental to the long-term prognosis of chronic heart failure. CoQ10 is available as medicine in several European countries, but is in these countries also available as a food supplement. Oxidation of the circulating LDL is thought to play a key role in the pathogenesis of atherosclerosis, which is the underlying disorder leading to cardiovascular disease. The linkage is likely due to the effect of CoQ10 in attenuating oxidative modifications of LDL, thus lowering their atherosclerotic potency.

7 UBIQUINOL COENZYME Q10 SCIENTIFIC RESEARCH PAPERS 1. Alleva R, M Tomasetti, M Battino, et al. The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. Proc Natl Acad Sci 92(20): , Bentinger M, M Tekle, G Dallner. Coenzyme Q biosynthesis and functions. Biochem Biophys Res Commun 396(1):74-79, Bhagavan HN and RK Chopra. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radical Research 40 (5): , Cooke, M., M Iosia, T Buford, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the Intl Soc Sports Nutr 5:8, Ghirlanda G, A Oradei, A Manto, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol 33 (3): 226 9, 1993.

THE SAME EFFECT WAS NOT FOUND WITH SPIRITS 3-5 DRINKS OF SPIRITS PER DAY WAS ASSOCIATED WITH INCREASED MORTALITY

THE SAME EFFECT WAS NOT FOUND WITH SPIRITS 3-5 DRINKS OF SPIRITS PER DAY WAS ASSOCIATED WITH INCREASED MORTALITY ALCOHOL NEGATIVE CORRELATION BETWEEN 1-2 DRINKS PER DAY AND THE INCIDENCE OF CARDIOVASCULAR DISEASE SOME HAVE SHOWN THAT EVEN 3-4 DRINKS PER DAY CAN BE BENEFICIAL - WHILE OTHERS HAVE FOUND IT TO BE HARMFUL