Semester. Numbers of credits Total number of Total number of hours from. Total number of individual hours per curriculum

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1 SYLLABUS Total number of hours (per semester) from curriculum (84) Name of discipline PHYSIOLOGY Year of study I Semester Type of final evaluation (E / V / II * C) Discipline regime (Co compulsory, Op optional F - facultative) Co Numbers of credits Total number of Total number of hours from Total number of individual hours per curriculum study hours semester Head of the discipline Prof. Dr. Simona Mihaela Slatineanu E Faculty Departament Profile Specialisation Morpho-functional Sciences * If the discipline has more semester of study, fill one syllabus for each semester Total C** S L P ** C course, L labs activities, P project or practical lessons Minimum knowledge needed by students to understand the course concepts / internships / practical lessons Basic knowledge (high school) about: anatomy and physiology of the body; cell structure and function; concepts of biochemistry, biophysics (from the first semester) Objectives of the discipline General objective: The students will gain knowledge about the normal functions of the body and will be able to understand into an integrative manner physiological processes, from cell to organism, thus gaining a solid foundation for clinical medical sciences. Educational offer of the discipline: - theoretical training of the students in order to assimilate knowledge through systematic information on functional integration phenomena from cell to organism - presentation of some theoretical concepts during the practical classes by classic experiments (video) and various computer simulations (mostly interactive);

2 - acquiring the practical skills by the students on proper execution of some maneuvers, based on accurate procedures and understanding the issues explored; - education of medical students in the spirit of the accurateness of the medical act, and the understanding of the basic science crucial role for its level and for their professional training. Lecture syllabus Hours No. PHYSIOLOGY AND FUNCTIONAL EXPLORATIONS 42 LECTURE 1. Structural and functional organization of living matter from molecule to organism; functional systems of the organism. Fundamental properties of living matter. Principles of functional integration (adjustment mechanisms, signalling and control concepts in physiology). Functional involvement of chemical elements. LECTURE 2. Functional systems of the cell. Membrane transport mechanisms. PBL: transport mechanisms. LECTURE. Resting membrane potential and its modifications; Excitability and conductibility. Structural and functional organisation of the synapses; postsynaptic responses types; neuromediators classes. LECTURE 4. Control of the cellular functions; intercellular communication, transduction of the extracellular signals and intracellular signalling. Membrane receptors types. LECTURE 5. The structure of the skeletal muscle and its functional organisation (motor unit, motor plate). Mechanical properties of the skeletal muscle. Mechanisms of the muscle contraction: excitation, excitation-contraction coupling, molecular mechanism of the muscle contraction. PBL: muscle fatigue LECTURE 6. Smooth muscle contraction. Morphological and functional organisation of the vegetative nervous system. Physiology of the vegetative nervous centres: sympathetic and parasympathetic nervous system. Thermoregulation LECTURE 7. Blood physiology: Blood plasma and blood cells. Haematopoiesis. Red blood cells physiology. PBL: red blood cells parameters and types of anemia. LECTURE 8. Blood physiology: the body's defence systems against microorganisms; leukocytes types and functions, inflammation. LECTURE 9. Blood physiology: lymphocytes types and functions; antibodies and their types of action; immunity. LECTURE 10. Blood physiology. Haemostasis: Platelets physiology and coagulation. PBL: blood transfusion rules, blood groups. LECTURE 11. Digestion physiology. Morphological and functional features of the digestive system. Mechanical and physical phenomena along digestion and their control. LECTURE 12. Digestion physiology. Chemical transformations of food constituents along digestion process. Digestive secretions and their regulation. LECTURE 1. Digestion physiology. Absorption. Regulation of food intake: hunger, satiety, energy metabolism and weight status. LECTURE 14. Liver physiology. Roles of the liver: digestive, metabolic, excretory.

3 PBL: jaundice types. Practical lessons syllabus - 42 ORE PL 1. Introduction to the study of physiology; fundamental properties and organization levels of the living matter; experimental method in physiology: principles, experiments types, experimental models; investigation of functional parameters (data acquisition, storage, data analysis). PL 2: Cellular physiology. Membrane transport: classification, characteristics; osmosis: red blood cells fragility test. PL : Cellular physiology. Excitability and conductibility - study on the frog neuromuscular preparation; resting membrane potential, action potential; conduction velocity; electronervogram PL 4: Cellular physiology. Excitability and conductibility - Global electromyography and motor unit electromyography; cronaxy PL 5: Cellular physiology. Contraction of skeletal and smooth muscles; in vitro study (twitch, tetanus, isometric and isotonic contraction); dynamometry, ergometry muscle fatigue; relative infatigability of the nerve. PL 6: Smooth muscle contraction: in vitro intestinal motility. Vegetative nervous system: vegetative reflexes with clinical importance. PL 7: Blood physiology, respiratory function: blood plasma and blood cells: hematocrite, erithrocyte sedimentation rate; RBC count PL 8: Blood physiology, respiratory function: Hemoglobin determination; blood spectroscopy; blood detection; red blood cells parameters; blood typing PL 9: Blood physiology, defence function: WBC count; leukocyte formula PL 10. Blood physiology, hemostasis: platelet count; bleeding time; coagulation time; prothrombin time (Quick) PL 11. Oral digestion: sampling of saliva; secretory mechanisms; chemical examination of saliva; digestive role and thermolability of the salivary amylase PL 12. Gastric digestion: gastric juice sampling; secretory mechanisms; HCl and lactic acid determination, measurement of the gastric juice acidity; action of labferment PL 1. Intestinal digestion: bile, pancreatic and intestinal juice sampling; Differentiation of gastric and intestinal proteolysis products; secretory mechanisms; determination of the pancreatic amylase. Bile: chemical and emulsifying properties of bile. PL 14: Revision Practical skills achieved by the end of the year/semester 1. Haematocrit determination. 2. Erythrocytes sedimentation rate determination. Red blood cell count 4. Haemoglobin determination by Gowers-Sahli method

4 5. Haemoglobin spectroscopy: pathologic haemoglobins determination 6. Methods of blood detection 7. Blood typing systems determination: ABO and Rh systems 8. White cell blood count. Differential white blood cell count (leucocytes formula). 9. Platelets count 10. Bleeding time determination 11. Coagulation time determination. 12. Prothrombin time determination. 1. Measurement of the gastric juice acidity and secretory flows. 14. Biliary pigments detection 15. Pancreatic amylase assessment The final grade results from exam / colloquium answers (final evaluation): MCQ test Oral and practical exam Percentage of final grade (Total = 100%) 50% 5% - final answers at the practical lessons 15.00% - revision s tests during the semester 7.50% - activities like subjects / papers / essays / translations / projects etc. - - other activities (SPECIFY): colloquium 7.50% Describe the practical final evaluation E / V (eg written paper (descriptive and / or multiple choice test and / or problems, etc.), oral examination, individual or group colloquium, project, etc.). - Oral practical exam followed by unique MCQ test Estimate the total time (hours per semester) of the individual study activities required (fill with 0 activities not required) 1. Reading and study of the lecture notes 8. Preparing oral presentations 1 2. Study after book, lecture handouts. Study of the minimal references indicated 4. Suplimentary documentation at the library 5. Specific activity training Seminars and / or LABORATORY 7 9. Preparing final examination Consultations Practical documentation Internet documentation 1

5 6. Making of themes, essays, translations, etc Other activities Preparing control papers Other activities... 0 TOTAL number of hours of individual study (per semester) =50 Compulsory references: 1. Berne RM, Levy MN, Koeppen BM, et al: Berne & Levy: Principles of Physiology, 5 th ed. St. Louis, Elsevier Mosby, Guyton AC, Hall JE: Textbook of Medical Physiology, 11 th Ed. Philadelphia, Saunders, Slatineanu SM, Dumitriu IL, Vata LG, Cojocaru E, Gurzu B: Principles and methods for practical lessons of physiology, 1 st ed. Iasi, Gr T Popa, Slatineanu SM, Dumitriu IL, Vata LG, Cojocaru E, Gurzu B: Handbook of practical physiology and functional explorations, 1 st ed. Iasi, Gr T Popa, 2012 Supplementary references for Physiology lectures and practical lessons 1. Despopoulos A, Silbernagl S: Color Atlas of Physiology, 5 th ed. Thieme, Ganong WF: Review of Medical Physiology, 22 nd ed. New York, McGraw-Hill, Sherwood L: Fundamentals of physiology: a human perspective, rd ed. Belmont, Calif., Brooks/Cole, Date: Signature of Didactic activity coordinator