Program. Workshop on Oral, Gastrointestinal and Pulmonary GvHD. Workshop. November 17 18, 2017 University Hospital Regensburg Regensburg, Germany

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1 Workshop Workshop on Oral, Gastrointestinal and Pulmonary GvHD November 17 18, 2017 University Hospital Regensburg Regensburg, Program Awarded with 7 CME credits

2 Preface... 4 Scientific Program List of Speakers... 9 Information credit hours (CME) have been awarded to the Workshop by the European Union of Medical Specialists (UEMS) European Board of Gastroenterology (EBG). 3

3 Preface Dear colleagues, We are pleased to invite you to the Workshop on oral, gastrointestinal and pulmonary GvHD 2017 held in Regensburg. Acute and chronic GvHD continues to be associated with significant morbidity and mortality representing an ongoing challenge in clinical care. Recently, new insights in the pathophysiology of microbial changes associated with different organ GvHD (oral mucosa, gastrointestinal tract and lung) and their impact on immunoregulation have been achieved, their translation into clinical success remains challenging. The workshop on oral, gastrointestinal & pulmonary GvHD will provide a comprehensive overview on pathophysiology including microbiological changes, and will provide an update on diagnosis, immunosuppressive and supportive treatment of the latter organ manifestations. The workshop is supported by the Falk Foundation e.v. E. Holler, M. Edinger, W. Herr, M. Evert, D. Weber, A. Gessner, D. Wolff (Regensburg, ) H. Greinix (Graz, Austria), A. Lawitschka (Vienna, Austria), J. Halter (Basel, Switzerland) G.C. Hildebrandt (Lexington, USA), S.Z. Pavletic (Bethesda, USA) 4

4 Workshop Workshop on Oral, Gastrointestinal and Pulmonary GvHD November 17 18, 2017 University Hospital Regensburg Regensburg, Start of Registration: Friday, November 17, h at the congress office Congress Venue: University Hospital Regensburg -Großer Hörsaal- Franz-Josef-Strauß-Allee 11 The Workshop is organized by Falk Foundation e.v. Scientific Organization: Prof. Dr. Daniel Wolff Department of Hematology and Oncology University Hospital Regensburg Franz-Josef Strauss-Allee 11, Tel: +49 (0) Fax: +49 (0) daniel.wolff@ukr.de Scientific Co-Organization: H. Greinix, Graz (Austria) J. Halter, Basel (Switzerland) W. Herr, Regensburg () G.C. Hildebrandt, Lexington (USA) E. Holler, Regensburg () S.Z. Pavletic, Bethesda (USA) Official Language: English 5

5 Friday, November 17, Welcome W. Herr, Regensburg Session I Pathophysiology of acute and chronic GvHD I Chair: G.R. Hill, Brisbane; P.R. Reddy, Ann Arbor Role of APC s in GvHD G.R. Hill, Brisbane Effector T cell programs in GvHD R. Chakraverty, London Innate lymphoid cells in graft-versus-host disease M.-C. Brueggen, Zurich CD4 + CD25 + regulatory T cells in allogeneic stem M. Edinger, cell transplantation Regensburg Coffee break Session II Pathophysiology of acute and chronic GvHD II Chair: R. Chakraverty, London; M. Edinger, Regensburg The role of B cells in chronic GvHD T. Winkler, Erlangen Innate immunity R. Zeiser, Freiburg Role of antimicrobial peptides and Paneth cells J.L.M. Ferrara, New York Pathophysiology of intestinal tolerance P.R. Reddy, Ann Arbor Coffee break 6

6 Friday, November 17, 2017 Session III Lung GvHD Chair: H. Greinix, Graz; A. Lawitschka, Vienna Pathophysiology of lung GvHD G.C. Hildebrandt, Lexington Diagnosis of lung GvHD J. Halter, Basel Treatment of lung GvHD S.Z. Pavletic, Bethesda End of afternoon session 7

7 Saturday, November 18, 2017 Session IV Oral GvHD Chair: S. Elad, Rochester; D. Wolff, Regensburg 9.00 Microbiome in oral chronic GvHD M. Mravak-Stipetic, Zagreb 9.20 Immunosuppressive treatment of oral chronic GvHD S. Elad, Rochester Supportive care E.M. Wagner, Mainz Coffee break Session V GI-GvHD Chair: A. Gerbitz, Berlin; M.R.M. van den Brink, New York Impact of microbiota in experimental GI-GvHD M.R.M. van den Brink, New York Pathophysiology of microbial changes in clinical D. Weber, GI-GvHD Regensburg Microbiota transfer as treatment of GvHD C. Högenauer, Graz Diagnosis and treatment of gastrointestinal GvHD E. Holler, Regensburg Panel Discussion: R. Chakraverty, London; H. Greinix, Graz; G.R. Hill, Brisbane; C. Högenauer, Graz; E. Holler, Regensburg; P.R. Reddy, Ann Arbor; M.R.M. van den Brink, New York Summary and closing remarks E. Holler, Regensburg Lunch 8

8 List of Speakers, Moderators and Scientific Organizers Dr. Marie-Charlotte Brueggen Department of Dermatology University Hospital Zurich Gloriastrasse Zürich Switzerland Prof. Dr. Ronjon Chakraverty Inst. of Immunity, Transplant. and Cancer School of Medicine Royal Free Hospital Rowland Hill Street London NW3 2PF Great Britain Prof. Dr. Matthias Edinger Klinik für Innere Medizin III Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee 11 Sharon Elad, DMD, MSc Professor of Dentistry Division of Oral Medicine Eastman Institute for Oral Health University of Rochester Medical Center 625 Elmwood Ave. Rochester, NY USA James L. M. Ferrara, M.D. Professor of Medicine Hematologic Malignancies Translational Research Center The Tisch Cancer Institute Division of Hematology / Medical Oncology Hess Center for Science and Medicine 1470 Madison Avenue, 6th Floor New York, NY USA james.ferrara@mssm.edu Prof. Dr. Armin Gerbitz Allogeneic Stem Cell Transplantation Dep. of Hematology/Oncology Charité CVK I Mittelallee Berlin armin.gerbitz@charite.de Prof. Dr. Hildegard Greinix Klinische Abteilung für Hämatologie Medizinische Universität Graz LKH-Univ. Klinikum Graz Auenbruggerplatz Graz Austria hildegard.greinix@klinikum-graz.at PD Dr. Jörg Halter Hämatologie Department of Medicine Universitätsspital Basel Petersgraben Basel Switzerland joerg.halter@usb.ch Prof. Dr. Wolfgang Herr Klinik für Innere Medizin III Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee 11 wolfgang.herr@ukr.de Gerhard C. Hildebrandt, M.D. Professor of Medicine Division of Hematology & Blood and Marrow Transplantation University of Kentucky 800 Rose Street Lexington, KY USA gerhard.hildebrandt@uky.edu 9

9 Prof. Dr. Geoffrey R. Hill Bone Marrow Transplantation Laboratory QIMR Berghofer Medical Research Institute 300 Herston Rd Brisbane, QLD 4006 Australia Prof. Dr. Christoph Högenauer Division of Gastroenterology and Hepatology Department of Internal Medicine Medical University of Graz Auenbruggerplatz Graz Austria Prof. Dr. Ernst Holler Klinik für Innere Medizin III Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee 11 Dr. Anita Lawitschka SCT-OUTPATIENT CLINIC St. Anna Children s Hospital Kinderspitalgasse Wien-Alsergrund Austria anita.lawitschka@stanna.at Prof. Dr. Marinka Mravak-Stipetic Clinical Department of Oral Medicine University Hospital Centre Zagreb University of Zagreb Gunduliceva Zagreb Croatia mmstipetic@gmail.com Steven Z. Pavletic, M.D. Head of GvHD and Autoimmunity Unit Experimental Transplantation and Immunology Branch National Cancer Institute 10 Center Drive Bethesda, MD USA pavletis@mail.nih.gov Pavan R. Reddy, M.D. Div. of Hematology/Oncology Dept. of Internal Medicine S.C. Mott Children s Hospital 1540 E. Hospital Dr - SPC 4257 Ann Arbor, MI USA reddypr@umich.edu Marcel R. M. van den Brink, M.D., Ph.D. Professor of Medicine and Immunology Division of Hematologic Oncology Weill Cornell Medical College 1275 York Avenue, Box 111 New York, NY USA muggeoc@mskcc.org PD Dr. Eva M. Wagner III. Medizinische Klinik Universitätsmedizin der Johannes Gutenberg-Universität Langenbeckstr Mainz eva.wagner@unimedizin-mainz.de Dr. Daniela Weber Klinik für Innere Medizin III Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee 11 daniela.weber@ukr.de 10

10 Prof. Dr. Thomas Winkler Sektion Hämatopoese Lehrstuhl Genetik Nikolaus-Fiebiger-Zentrum Molekulare Medizin Glueckstrasse Erlangen thomas.winkler@fau.de Prof. Dr. Robert Zeiser Klinik für Innere Medizin I Schwerpunkt Hämatologie, Onkologie und Stammzelltransplantation Universitätsklinikum Freiburg Hugstetter Str Freiburg robert.zeiser@uniklinik-freiburg.de Prof. Dr. Daniel Wolff Klinik für Innere Medizin III Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee 11 daniel.wolff@ukr.de 11

11 General Information Prior to the opening of the Workshop in Regensburg Falk Foundation e.v. Telephone: +49 (0)761/ Congress Department Telefax: +49 (0)761/ Leinenweberstr. 5 symposia@falk-foundation-symposia.org Freiburg Congress Office and Registration During the Workshop in Regensburg Congress Office Telephone: +49 (0)175/ Opening Hours: Friday, November 17, 2017 Saturday, November 18, h h University Hospital Regensburg Franz-Josef-Strauss-Allee 11 Congress Fees The participation at the Workshop is free of charge. Please be aware that the number of participants is limited. Registration is mandatory. Refreshments during the coffee breaks and lunch on November and a copy of the abstract volume of the Workshop are also free of charge. The event shall be held regardless of any decisions made by you or by your place of employment regarding the procurement, prescription or use of any products of our organization or associated companies. If you are a civil servant or salaried employee, please check whether you require permission from your employer to participate in the event. If you participate in the event, Falk Foundation e.v. presumes that you were granted permission from your employer prior to your participation. 12

12 Admission to Scientific Events For admission to scientific program your name badge should be clearly visible. Conflicts of Interest Members of the scientific committee declare following potential Conflicts of Interest: Daniel Wolff: Falk Pharma, Mallinckrodt; Hildegard Greinix: Incyte, Roche, Therakos Inc, Novartis, BMS; Ernst Holler: Incyte, Novartis, JAZZ Pharma, Neovii, Astellas. Jörg Halter, Wolfgang Herr, Gerhard C. Hildebrand and Steven Z. Pavletic declare no Conflicts of Interest. Hotel Accommodation If you would like to do a hotel reservation, please contact: Tourist-Information Altes Rathaus Rathausplatz Regensburg Tel: +49 (0)941/ Tel: +49 (0)941/ tourismus@regensburg.de Airport International Franz-Josef-Strauß-Airport Munich 13

13 Directions to University Hospital Regensburg Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, Main Entrance 14

14 Scientific Dialogue in the Interest of Therapeutic Progress Years OF SYMPOSIA HALF A CENTURY OF PROMOTING MEDICAL EXCHANGE Conferences that advance medicine and research: 50 years ago, Herbert Falk, MD, PhD, organized a week-long event in Freiburg devoted to the liver it was his first symposium and the start of an extraordinary success story. Since then, 207 additional events have been held worldwide, featuring speakers who are pioneers in their fields. To date, more than 130,000 physicians and researchers from around the world have participated in our symposia, and the strong interest in our upcoming events shows that this concept remains appealing. We take great pride in this! Since the very beginning, all of our events whether large or small have been based on the principle of providing neutral continuing medical education that benefits research, treatment, and ultimately the patient. We would like to offer our deepest thanks to everyone who has participated, and we look forward to further advancing scientific dialogue as we continue to advocate for more knowledge sharing and therapeutic progress! Allow us to welcome you to the Falk Foundation symposia now and for many years to come!

15 Organized by: FALK FOUNDATION e.v. Leinenweberstr Freiburg Congress Department Telephone: +49 (0) 761/ Telefax: +49 (0) 761/ symposia@falk-foundation-symposia.org PWSREG /2017/200 Stü