E - Staff availability issues. Delays

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1 Date of Pemiss ion Fist Recuit ed? Date of Fist Recuited Duation between VRA Pemission Duation between Pemission Fist Duatio n betwee n VRA Fist Benchmak Met A - Pemissions delayed/denied B - Suspended by C - Closed by sponso sponso D - Sponso Delays E - Staff availability issues F - No G - No patients patients seen consented H - I - Rae Contacting diseases delays J - Othe Reasons fo delay Comments coespond to: /EM/0 094 SHT166 A 26- week extension study of the safety clinical effects of EVP-6124 in subjects with Alzheimes Disease cuently o peviously eceiving an Acetylcholin estease Inhibito medication 08/05/ /05/2015 Yes 09/06/ Yes Y Complete clinical hold of tial Sponso following ugent safety measue /SS/0 032 SHT182 Romised, doubleblind, paallelgoup, placebocontolled, fixed-dose study of Lu 13/04/ /04/2015 Yes 24/11/ No AE58054 in patients with mildmodeate Alzheime's Disease teated with donepezil; Study 2 closed -in follow up Povide

2 /IEC0 8/0004 SHT168 Investigatio n of multipofessional involvement in the advance cae planning (ACP) pocess within nusing homes 24/02/ /05/2015 No 77 No Sponso /IEC0 8/0017 SHT170 Independent Advocacy: impact outcomes fo childen young people 21/04/ /05/2015 Yes 30/06/ Yes Y 13 paticipants (9 patients 4 staff) /EM/0 212 SHT172 Knowledge attitude of the MDT towads epilepsy in LD Sevices 29/04/ /05/2015 Yes 25/05/ Yes Y 24 paticipants completed the online suvey /SW/0 036 SHT176 Designing infomation suppot sevices in the UK to incease physical activity paticipation amongst individuals with schizophen ia 09/06/ /06/2015 Yes 23/09/ No Y Initial delays in set up; study has now ecuited 23 paticipants to date /LO/1 359 SHT158 Visualizing Uncetainty Among Laypesons Expets (VISUALizE) 19/12/ /01/2015 Yes 12/01/ Yes

3 /EM/1 082 SHT138 DeNDRoN 3120 Pfize (ICON) B /02/ /02/2015 No 5 No Y Y Y Y Sponso suspended 27/3/2015. SHT157 AD /9/030 GENETICS 13/03/ /03/2015 Yes 07/07/ No Y Y Y 1st patient ecuited 07/07/2015Co mplicated sceening pocess- Stict patient eligibility citeia. Paticipants pesceened, sceened some visits booked. Staff annual leave duing govenance eview /SS/1 018 SHT145 DeNDRoN 3129 Lundbeck STARBEAM 13/04/ /04/2015 No 2 No Fist patient consented Neithe SHT150 An exploation of pessue Unives ulce ity of 31/10/2014 pevention Southa in a mpton community 18/05/2015 Yes 05/06/ No Neithe setting

4 /ES/0 091 SHT175 TRIumPH/ Teatment Recovey in Psychosis 27/07/ /08/2015 Yes 25/08/ Yes SHT178 DRN 844 Woking 14/WM/0 Memoy 056 Taining in Type 2 Diabetes 31/07/ /08/2015 Yes 31/10/ No Y Y Fist patient consented 31/10/ SHT181 Recoveing 14/WM/1 Quality of 062 Life (ReQoL) Stage 4b 24/07/ /08/2015 Yes 01/09/ Yes Fist patient consented 1/9/ /EE/0 370 SHT200 DIAB 4563 SUSTAIN-7 25/11/ /12/2015 Yes 11/01/ Yes /NW/0 654 SHT189 Adapting Dialectical Behaviou Theapy fo clients in a foensic Leaning Disability sevice: What woks? 26/08/ /09/2015 No 26 No delays due to esouces/w okloads ove Sponso Decembe/Ja n. Fist paticipant taget by Feb

5 /YH/1 153 Open label extension study of LMTM in Alzheimes & bvftd patients 15/09/ /09/2015 Yes 17/11/ Yes SHT185 Unives Ethical ity of Decision Southa making mpton 21/09/ /09/2015 Yes 02/11/ Yes /H050 5/85 SHT 179 DRN 552 (Incident high isk type 1 diabetes cohot - ADDRESS-2) 07/10/ /10/2015 No 8 No Difficulty identifying ecuiting eligible paticipants due to study inclusion exclusion citeia /SW/0 271 SHT197 Daily activity motivation 07/10/ /10/2015 Yes 20/11/ Yes pefomance in dementia

6 /YH/0 019 SHT137 Stuctued lifestyle education fo people with schizophen ia 01/04/ /04/2015 Yes 03/06/ Yes Recuitment has now ended at site /LO/1 876 Evaluation of Physiothea pist Podiatist independent Pescibing 16/03/ /04/2015 Yes 11/05/ Yes /SW/0 358 SHT169 Leaning motivational inteviewing 14/04/2015 fo use in 15/04/2015 Yes 07/05/ Yes pulmonay ehabilitiato n 7 staff memebs ecuited. Povide N/A SHT171 Effective Home suppot in dementia cae: Components, impacts costs of tetiay pevention 13/04/ /04/2015 No 7 No Povide

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