CIRCADIAN DISRUPTION AND CANCER

Transcription

1 The Mushett Family Foundation present: CIRCADIAN DISRUPTION AND CANCER June 19, 2009 The New York Academy of Sciences Conference Center New York, NY Free for Academy Members Exhibitor and Sponsorship Opportunities Available. See Page 10 for Details Poster Submission Deadline April 10 th

2 Welcome Dear Colleague, The New York Academy of Sciences and the Mushett Family Foundation are hosting a 1-day symposium entitled Circadian Disruption and Cancer. We hope you will join us. Circadian disruption produced by altered nocturnal sleep, chronic rotating shift work, constant light exposure or other interference with circadian clock functioning, increases the incidence of breast, prostate, endometrial and colon cancer. Circadian disruption is, in turn, ubiquitously caused by advanced cancer and causes severe symptoms, decreasing quality of life and patient survival. In June 2009, both established and young career cancer biologists, epidemiologists, geneticists, molecular biologists, oncologists and chronobiologists will convene to explore the systemic, cellular and molecular mechanisms by which circadian disruption increases cancer incidence and growth rate. Participants will discuss: The complex relationship between circadian rhythm disruption and cancer The melatonin-based mechanisms that link circadian rhythm and cancer biology The implications of this comorbidity for cancer therapy and prevention The meeting will include two main topics: Circadian disruption as a cause of cancer Cancer as a cause of circadian disruption Please join us for an in-depth examination and discussion of cancer and circadian disruption. We look forward to seeing you in June. Best regards, Kathy Granger, PhD Senior Program Manager, Life Sciences The New York Academy of Sciences 2

3 Scientific Organizing Committee David E. Blask, PhD, MD; Professor and Head, Laboratory of Chrono-Neuroendocrine Oncology, Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana. For the past 30 years, Dr. Blask s research has focused on the circadian control and therapeutics of cancer by melatonin as well as the consequences of the circadian disruption of melatonin production by light at night on cancer risk. He has published over 250 journal articles, reviews, chapters and abstracts on this topic. His research has been supported by funding agencies such as the National Cancer Institute, National Institute of Child Health and Human Development, National Institute of Environmental Health Sciences and The Edwin Pauley Foundation. He currently serves on the editorial boards of the Journal of Pineal Research, Neuroendocrinology Letters and Integrative Cancer Therapies and is a consultant for the photobiology group of the International DarkSky Association. Dr. Blask has also served as a member of the working group on shift work for the International Agency for Cancer Research of the World Health Organization. William J. M. Hrushesky, MD; Senior Clinician Investigator at the WJB Dorn Department of Veterans Affairs Medical Center; Research Professor at the University of South Carolina s School of Medicine s Department of Cell and Developmental Biology and Anatomy; and Adjunct Professor at the Norman J Arnold School of Public Health s Department of Epidemiology and Biostatistics as well as the School of Computer Engineering s Department of Computer Science and Engineering, Columbia. Dr. Hrushesky is a founder of Medical Chronotherapeutics (optimally timing medical preventatives, diagnostics, and treatments relative to rhythmic human biologic time structure). His research interests include the study of several important biological rhythms and especially of how these rhythms interact; drug delivery systems and particularly their temporal control; and solid tumor oncology. He is a medical expert in the care of patients with breast, lung, kidney, ovary, prostate, colorectal and head and neck cancer. To date, Dr Hrushesky has mentored more than eighty physician scientists and scientists at all career levels. He has given several hundred invited lectures, and published over 700 scientific articles, chapters or abstracts; holds several patents and is editor of several books and monographs. Current projects include: determining how the circadian clock within cancer cells orders proliferation, apoptosis and the expression of related therapeutic targets; determining the mechanisms by which surgical injury associated with primary tumor resection differentially impacts breast cancer dormancy depending upon the fertility cycle stage of that resection. Kathy Granger, PhD; Senior Program Manager, Life Sciences, The New York Academy of Sciences, New York, New York. Dr. Granger manages the Life Science conferences at The New York Academy of Sciences. Dr. Granger received her PhD from the Department of Medicine, Monash University, Australia. She worked as a postdoctoral associate at Weill Cornell Medical College in New York City before joining The New York Academy of Sciences. WHY THIS MEETING IS UNIQUE: An opportunity for experts to come together to discuss cutting-edge, novel scientific and clinical research about cancer and circadian disruption An intimate setting accommodating 250+ delegates, providing ample networking and collaboration opportunities A neutral platform for young scientists entering the field of cancer and chronobiology Location in New York City enables easy access for US and international participation The New York Academy of Sciences is a neutral environment providing opportunities among scientists from academia, government and industry to network, fostering new collaborations among complimentary research groups and advancing scientific progress 3

4 Friday, June 19, :30 AM 8:00 AM REGISTRATION AND BREAKFAST 8:00 AM 8:15 AM WELCOME ADDRESS Kathy Granger, PhD, The New York Academy of Sciences William JM Hrushesky, MD, University of South Carolina 8:15 AM 11:00 AM SESSION I: How does circadian disruption and/or light at night increase cancer risk? Is melatonin suppression by light at night an important potential cause of increased cancer risk? 8:15 AM 8:45 AM The Melatonin Hypothesis Richard Bugs Stevens, PhD; University of Connecticut Health Center PART 1: CIRCADIAN DISRUPTION AS A CANCER CAUSE 8:45 AM 9:15 AM Epidemiology of circadian disruption and cancer risk: The Nurses Health Study and beyond Eva Schernhammer, MD, DrPH; Harvard Medical School 9:15 AM 9:35 AM The Yin and Yang of light and melatonin George C. Bud Brainard, PhD, Jefferson Medical College of Thomas Jefferson University 9:35 AM 9:55 AM Melatonin receptors and their function Margarita L. Dubocovich, PhD; Buffalo School of Medicine and Biomedical Sciences 9:55 AM 10:15 AM Molecular mechanisms of melatonin anticancer effects Steve M. Hill, PhD, Tulane Cancer Center 10:15 AM 10:45 AM Circadian stage-dependent metabolic and anticancer effects of melatonin in rats and women and their disruption by light at night David Blask, MD, PhD, Tulane University School of Medicine 10:45 AM 11:00 AM Discussion 11:00 AM 11:30 AM COFFEE BREAK AND POSTER VIEWING 11:30 AM 1:00 PM SESSION II: The cellular molecular clock and cancer risk and biology 11:30 AM 12:00 PM Molecular clock mechanisms by which circadian disruption causes colon and breast cancer Patricia A. Wood, MD, PhD, University of South Carolina, Dorn VA Medical Center 12:00 PM 12:15 PM Clock gene, Per1 and Per2, tumor suppression Xiaoming Yang, PhD, University of South Carolina, Dorn Research Institute 12:15 PM 12:35 PM The circadian clock in acute myelogenous leukemia H. Phillip Koeffler MD, University of California, Los Angeles (UCLA). 12:35 PM 12:45 PM Cancer clock manipulation for prevention and control: what we know and what we need to know William J.M. Hrushesky, MD, University of South Carolina 1:45 PM 1:00 PM Discussion 4

5 1:00 PM 2:30 PM LUNCH AND POSTER SESSION 2:30 PM 4:10 PM SESSION III: Strategies for understanding and correcting cancer associated circadian disruption and relieving cancer patient suffering PART 2: CANCER AS A CAUSE OF CIRCADIAN DISRUPTION 2:30 PM 3:00 PM Lung cancer William J.M. Hrushesky, MD, University of South Carolina 3:00 PM 3:30 PM Colorectal cancer Georg A. Bjarnason, MD, Toronto-Sunnybrook Regional Cancer Center 3:30 PM 3:50 PM Cytokine-based mechanisms by which cancer interferes with circadian organization Tyvin Rich, MD, University of Virginia 3:50 PM 4:10 PM Circadian phase setting effects of melatonin in free living people Steve Lockley, PhD, Harvard Medical School, Brigham and Women s Hospital 4:10 PM 4:40 PM Meal timing, circadian organization, and cancer growth rate health and longevity Elisabeth Filipski, PhD, French Institute of Health and Medical Research (INSERM), University of Paris 4:40 PM 5:00 PM Making circadian cancer therapy practical Keith Block, MD, Block Center for Integrative Cancer Treatment, Chicago 5:00 PM 5:25 PM Panel discussion (all speakers) 5:25 PM 5:55 PM COFFEE BREAK AND POSTER VIEWING 5:55 PM 6:00 PM INTRODUCTION OF KEYNOTE SPEAKER David Blask, MD, PhD, Tulane University School of Medicine 6:00 PM 6:45 PM KEYNOTE ADDRESS Cancer Circadian Disruption, Melatonin and the Clock Russ Reiter, PhD, The University of Texas Health Science Center, San Antonio 6:45 PM 7:00 PM CLOSING REMARKS William J.M. Hrushesky, University of South Carolina David Blask, MD, PhD, Tulane University School of Medicine 7:00 PM 8:00 PM RECEPTION 5

6 Speakers Georg A. Bjarnason, MD; Senior Scientist, Toronto-Sunnybrook Regional Cancer Center, Toronto. Dr. Bjarnason s research focuses on the potential clinical applications of chronobiology and chronopharmacology in oncology. Dr. Bjarnson has shown that the timing of radiotherapy can impact the severity of oral mucositis in patients with head and neck cancer. Dr. Bjarnason is working to define the 24-hour variation of new cancer therapy targets both at the gene level and protein level in human tissue to allow for the design of intelligent clinical trials to optimize the effect and minimize the toxicity of these drugs. He is currently studying the expression of clock genes in cancer tissue, looking for both mutations and an abnormal circadian variation. Dr. Bjarnason is also conducting clinical trials using melatonin to normalize the circadian rhythm in patients with breast cancer and colorectal cancer. Keith I. Block, MD; Medical/Scientific Director, Block Medical Center, Chicago. Dr. Block is an internationally recognized integrative cancer treatment specialist, researcher, and educator. A leader in laying the foundation for what is now called integrative medicine, Block is Medical/ Scientific Director of the Block Center for Integrative Cancer Treatment and the Institute for Cancer Research and Education, which he and Penny B. Block, PhD, co-founded in 1980 in Evanston, Illinois. Block Center uses research-based treatment methodologies that integrate the best of Western medicine with scientifically-sound complementary therapies. The focus is not only on eradication of disease, but on rebuilding biological integrity while honoring each person s psychosocial and spiritual needs. Dr. Block is a member of the National Cancer Institute s Physician Data Query (PDQ) Cancer CAM Editorial Board, the Editor-in-Chief of the peer-reviewed journal Integrative Cancer Therapies, director of Integrative Medical Education at the University of Illinois College of Medicine, Adjunct Assistant Professor of Pharmacognosy in the Department of Medicinal Chemistry and Pharmacognosy in the College of Pharmacy at the University of Illinois, and Clinical Assistant Professor in the Department of Medical Education at the University of Illinois College of Medicine. In collaboration with the University of Illinois and other university facilities in the US and Israel, Dr. Block conducts research in nutrition and in the use of natural medicines in cancer treatment. George C. Brainard, PhD; Professor, Departments of Neurology, Pharmacology and Experimental Therapeutics at Jefferson Medical College of Thomas Jefferson University, Philadelphia. Dr. Brainard has directed Jefferson s Light Research Program since This program s research studies the effects of light on neuroendocrine physiology and circadian regulation in humans. Using the techniques of photobiology, radioimmunoassay, and performance testing, his group has documented how various visible and nonvisible light sources influence both hormonal balance and behavior. Current studies include elucidating the action spectrum of melatonin regulation, investigating the phase shifting capacities of light, studying the influence of light on tumor progression, and testing new light treatment devices for winter depression. Margarita L. Dubocovich, PhD; Chair of the Department of Pharmacology and Toxicology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo. An internationally recognized expert in molecular pharmacology and drug discovery, Dr. Dubocovich specializes in the neurobiology of the hormone melatonin and its receptors. Ongoing studies focus on the localization and molecular and pharmacological characterization of melatonin receptors, modulation of signal transduction pathways, role of light-melatonin interactions on visual function and circadian rhythms, and function of melatonin receptors in cardiovascular regulation and cell proliferation. Her studies on molecular-based drug design aim to discover novel and selective melatonin receptor agonists and antagonists with therapeutic potential to treat insomnia and circadian rhythms disturbances of mood and sleep due to endogenous (blindness, aging, delay sleep phase syndrome) and exogenous (jet lag, phase shift) causes, cardiovascular disease, cancer and aging. Elisabeth Filipski, PhD; Senior researcher, French Institute of Health and Medical Research (INSERM), University of Paris, Paris. Dr. Filipski s interests include the role of circadian timing system in cancer proliferation and in anticancer treatment activity. Her research aims at understanding the molecular and physiologic mechanisms of interactions between the circadian system, cancer growth, and drug pharmacology pathways in order to establish the experimental bases for personalized cancer chronotherapy. She was first to show that the suprachiasmatic nuclei, the hypothalamic circadian pacemaker, was a control point of tumor progression. She then identified the physiologic and molecular disruption brought about by chronic jet lag in experimental models and showed that such functional circadian disorder was responsible for malignant growth acceleration. 6

7 Speakers Steven M. Hill, PhD; Edmond & Lily Safra Chair for Breast Cancer Research Chairman of Structural and Cellular Biology (Anatomy), Tulane Cancer Center, New Orleans. Dr. Hill s research focuses on understanding how hormones and factors cross-talk regulate breast cancer cell growth. Dr. Hill s laboratory has demonstrated that melatonin has significant inhibitory effects on the development and growth of human breast cancer. Furthermore, his studies have elucidated that melatonin can potentiate the actions of retinoic acid, a vitamin A derivative, to induce tumor cell death and prevent tumor formation. These studies are currently being moved into human clinical trials. Dr. Hill is a reviewer for a variety of journals including Cancer Research, Breast Cancer Research and Treatment, and Molecular Endocrinology and has served on NIH, DOD, and NSF grant review panels. H. Phillip Koeffler, MD; Director of the Division of Hematology/Oncology at Cedars-Sinai Medical Center, Mark Goodson Chair in Oncology Research at Cedars-Sinai, Hematologist/Oncologist with the Cedars-Sinai Thyroid Cancer Center, and Professor of Medicine in the Division of Hematology/Oncology at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Having developed a program in breast cancer research, Dr. H. Phillip Koeffler is looking at the molecular causes of the disease and researching novel forms of therapy. He researches the basic biology of leukemias, preleukemias and lymphomas, and is developing novel forms of therapy such as vaccines for these diseases. Dr. Koeffler has also developed a program in prostate cancer research and is looking at novel forms of therapy. He and his colleagues are also working to identify novel tumor suppressor genes using extensive tumor DNA banks from over twenty tumor types with matched normal control DNA from the same individual and over 300 microsatellites. Dr. Koeffler s group is sub-localizing the site of tumor suppressor genes that are mutated in a variety of cancers. Dr. Koeffler is a member of editorial boards for numerous peer-reviewed journals, including Cancer Research, the International Journal of Oncology, Journal of Molecular Medicine, Cytokines and Molecular Biology, Leukemia, Cancer Molecular Biology, Leukemia Research and Hematologic Pathology. Steve Lockley, PhD; Assistant Professor of Medicine, Harvard Medical School, Associate Neuroscientist, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston. Dr. Lockley s research focuses on basic and applied aspects of human circadian biology, using epidemiology, field-based physiological studies and inpatient intensive physiological monitoring. He has a particular interest in human circadian photoreception and the effects of light on the circadian pacemaker and other non-image forming responses. Dr. Lockley s studies include investigations of the effects of timing, duration, intensity and wavelength of light exposure on circadian resetting, melatonin suppression and the acute alerting effects of light. He also studies visually impaired individuals to examine the effects of the severity and type of blindness on circadian photoreception, the periodicity of the circadian pacemaker and development of circadian rhythm sleep disorders. These basic studies have led to the development of novel therapeutic strategies to treat sleep disorders with melatonin administration in blind patients. He examines the role of visual impairment on endocrinology and breast cancer risk in blind women. With the Harvard Work Hours Health and Safety Group, Dr. Lockley s group assesses the impact of extended work hours on health and safety of workers and the public, including the development of interventions in hospital residents, and the implementation of large-scale occupational fatigue management and sleep disorders screening programs in several police forces nationwide. Eva Schernhammer, MD, DrPH; Assistant Professor of Medicine, Harvard Medical School and an Assistant Professor of Epidemiology in the Department of Epidemiology, Harvard School of Public Health, Boston. Dr. Schernhammer s research interest is in exploring the exposures that influence the circadian system in humans and health consequences. She has done work on the effects of light at night on cancer risk through the melatonin pathway and demonstrated that the effects of light at night may affect not only breast cancer, but also other cancers such as colorectal cancer, generating evidence that supports a new hypothesis on the development of cancer. She has also conducted urinary melatonin measurements in the Nurses Health Study to assess the hormone s variations according to shift work status and its association with breast cancer risk in the Nurses Health Study. Current projects study the role of clock genes in these associations and melatonin s cancer preventive potential. 7

8 Speakers Richard G. Stevens, PhD; Professor and Cancer Epidemiologist, Division of Epidemiology & Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington. Dr. Stevens s research focuses on the etiology of cancer. One of his major interests has been in the possible role of iron overload. Largely on the basis of his work, published in the Journal of National Cancer Institute and the New England Journal of Medicine, the Swedish food industry decided to cease iron fortification of flour in the early 1990s. A perplexing challenge, which Dr. Stevens began to engage in the late 1970s, is the confounding mystery of why breast cancer risk rises so dramatically as societies industrialize. He proposed in 1987 a radical new theory that use of electric lighting, resulting in lighted nights, might produce circadian disruption causing changes in the hormones relevant to breast cancer risk. Accumulating evidence has generally supported the idea, and it has received wide scientific and public attention. For example, his work has been featured on the covers of the popular weekly Science News (October 17, 1998) and the scientific journal Cancer Research (July 15, 1996). Russel J. Reiter, PhD; Professor, Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio. Dr. Reiter s research interests relate to free radical aspects of disease processes and aging. Of particular interest is defining the role of oxygen derivatives in neurodegenerative diseases and their function in apoptosis, necrosis and neuronal degeneration. Besides, Dr. Reiter s group is investigating the free radical scavenging and antioxidant properties of pineal indoleamines, most notably melatonin. The investigations include the mechanisms of interaction of melatonin with free radicals and the resulting products. His group is also investigating the role of melatonin as a antitoxin against a variety of xenobiotics and environmental pollutants and the functional significance of melatonin and other indoleamines with processes of aging. Dr. Reiter is the Editor-in-Chief of the Journal of Pineal Research and on the Editorial Board of 7 other journals. He is the recipient of numerous awards including three honorary doctor of medicine degrees and, most recently, the Presidential Distinguished Scholar Award from UTHSCSA. Tyvin Rich, MD; Professor of Radiation Oncology, University of Virginia, Charlottesville. The Rich s laboratory studies the molecular mechanisms behind the fatigue that cancer causes. Their laboratory findings support the hypotheses that tumors can produced neurally active peptides (cytokines) that are capable of altering output of the biologic clock. The clinical application of their observations may be to help understand the causes and how to intervene more effectively in patients suffering with symptoms of cancer induced fatigue. Xiaoming Yang, PhD; Postdoctoral Fellow, University of South Carolina, Dorn VA Medical Center, Columbia. Dr. Yang, works at Chronobiology and Oncology Research Laboratory at Dorn Research Institute, Dorn VA Medical Center. The focus of the ongoing research in this laboratory is the effect of biologic rhythms upon host cancer balance, tumor biology, and the efficacy and toxicity of cytotoxic drugs and growth factors used in hematology and oncology. The biologic rhythms of interest include both circadian (~24 hour, daily), fertility (estrous, menstrual) cycle and seasonal rhythms. Patricia A. Wood, MD, PhD; Associate Professor, USC School of Medicine, Internal Medicine, Associate Professor, USC School of Medicine, Pathology, and Chief, Oncology/Hematology Division, Dorn VA Medical Center, Columbia. Dr. Wood s research has included studies of membrane protein and biochemical changes associated with the erythrocyte stage of malaria infection and changes with resistance to anti-malarial drugs; pre-clinical and clinical anti-cancer drug toxicity and efficacy studies; clinical cancer treatment trials through NCI, pharmaceutical and local institutional sponsored programs; and investigations of the effects of biologic rhythms, such as daily (circadian) rhythms and fertility cycle rhythms, on the balance between host and cancer in pre-clinical and clinical settings. She is the recipient of the American Cancer Society Career Development Award, Department of Veterans Affairs RAG and MERIT Review funding and National Institutes of Health research funding. 8

9 The New York Academy of Sciences Founded in 1817, the New York Academy of Sciences is the third oldest scientific society in the United States. It is an independent, 501(c)(3) nonprofit, scientific and educational organization. The Academy is dedicated to serving science and society through the dissemination of scientific knowledge. The mission of NYAS is to convene the world s leading scientists to facilitate the exchange of ideas, advocate scientific literacy, and resolve global societal challenges. The Academy is widely recognized as one of the world s foremost organizers of scientific conferences and symposia, and publisher and communicator of scientific information. Members have included Charles Darwin, Louis Pasteur, Presidents Thomas Jefferson and James Monroe, Margaret Mead and Albert Einstein. The Academy has become a uniquely neutral nexus between industry, academia, and government, unlike many not-for-profit professional organizations. Today, the Academy s powerful programs in science, technology, medicine, and education have attracted close to 24,000 members in 140 countries. This elite cadre includes on its President s Council alone - 28 Nobel Prize Laureates and a score of industry, financial and government agency leaders from throughout the world. Every year the Academy hosts 12 to 14 conferences and scores of smaller meetings on the most pressing current scientific issues. In addition to conferences on frontier areas of science, the Academy in recent years has sponsored conferences on topics such as: the unity of knowledge, nature of self, expression of emotions, neurobiology of music, roots of mental illness in children, climate change, approaches to poverty and hunger reduction, and the ethics of mood (synopsis of thesemeetings are available at The Mushett Family Foundation The Mushett Family Foundation Inc. is a non-profit private foundation which strives to carry out the mission of its founder Dr. Charles W. Mushett. It seeks to foster advances in healing the human spirit and body by making contributions to medical, scientific, environmental and poverty sensitive organizations. The foundation s relationship with the New York Academy of Sciences is the result of Dr. Mushett s role as Vice Chairman at the Academy. The Mushett Family Foundation Inc. has previously sponsored conferences and symposiums at the Academy, including last year s Targeted Therapies for Gastrointestinal Cancer. In its mission dealing with medical and poverty issues, the foundation has supported Doctors without Borders in Uganda, Darfur and Haiti and disaster relief in New Orleans, Biloxi and Indonesia with other crisis management organizations. It has been actively promoting asthma healthcare for disadvantaged children in Elizabeth, New Jersey with the assistance of Rutgers University and a local community health center. The beneficiaries of its contributions include homeless shelters, food banks, prescription programs for the poor and immigrants and a Haiti outreach program. Since the foundation is based in New Jersey, it promotes environmental organizations such as the New Jersey Audubon Society in their grassland and stewardship programs, Nature Conservancy of New Jersey and other organizations involved in beach and water protection programs and wildlife preservation. Thus, the scope of its multi-faceted humanitarian efforts extend from local, state, national to international needs. The Mushett Family Foundation 9

10 About This Meeting REGISTRATION Online: Tel: (toll free) Fax: Mail: NYAS Membership & Customer Services Suite 1NO1 2 Huntington Quadrangle Melville, NY, USA CONFERENCE LOCATION New York Academy of Sciences 7 World Trade Center, 40th floor 250 Greenwich Street New York, NY Visit the Academy at: This conference will be published as a special issue of Integrative Cancer Therapies. CANCELLATION POLICY Registration fees are not refundable. The New York Academy of Sciences complies with the public accommodation requirements of the Americans with Disabilities Act and the rules and regulations thereof. Please let us know if you will require any assistance during this meeting by contacting Claire Whalen or cwhalen@nyas.org. CALL FOR ABSTRACTS Deadline for abstract submission is April 10, For complete abstract instructions, please cancercircadian@nyas.org. Type the words Abstract Information in the subject line - no need to type a message. Instructions will be forwarded automatically. Any questions, please call BENEFITS FOR SPONSORS AND EXHIBITORS As a sponsor of the meeting you will have access to a scientific audience in search of the latest advancements and research information available. Sponsorship benefits include: Extensive visibility to a highly-targeted, expert audience via the conference s pre-event promotional campaign, on-site exposure during the event, and post-event information dissemination Unique one-on-one networking opportunities during the event Increasing in your brand s value by affiliating with this unique, premier educational event through high visibility positioning For Sponsorship Opportunities, please contact Nancy Wong at nwong@nyas.org or at Registration Fees and Categories Fee Includes: Breakfast, breaks and lunch on the day of the symposium. Registration fee also includes a complimentary one-year individual membership to the New York Academy of Sciences. One-year individual membership only applies to non-members and cannot be used to extend membership for current members. 1. NYAS member FREE 2. Non-member (Not-for-Profit/Academia) $ Non-member (Corporate/Other) $ Student/Postdoc/Fellow $ 25 Join over 24,000 distinguished science professionals from 140 countries and enjoy the many Academy benefits, including: Complimentary admission to dozens of Academy meetings and reduced registration fees for all others Exclusive access to more than 500+ Academy ebriefings Unlimited access to thousands of scientific articles in Annals Online and Annals PrePrints Access to excellent career development resources from the Science Alliance One volume of the Annals of the New York Academy of Sciences A certificate of membership suitable for framing Member Magazine in print and online (3 times a year) Visit the Academy at: * Students receive a one year Student & Postdoc Membership. One year individual membership only applies to non-members, and cannot be used to extend membership for current members. 10

11 CIRCADIAN DISRUPTION AND CANCER - Registration Form Contact Information: * Information is required in order to complete your membership Name* Dr. Mr. Ms. (Circle one) First* Last* Degree* I wish to register as (Please select only one) Student/Postdoc/Fellow NYAS Member Non-member (Not-for-Profit/Academia) Non-member (Corporate) Affiliation/Organization* Title/Position* Mailing Address* Indicate if this is your office address* or home address* Enclosed is my payment of $ *Payment by: U.S. Bank Check or International Money Order made payable to: The New York Academy of Sciences Credit Card (specify) Visa MasterCard American Express Card#: Expiration Date: City* State* Print Name of Cardholder: Country* Telephone* * Fax Zip Cardholder Signature: Enter Your Tax ID: (Required only for non-profit affiliations*): Your priority code from the mailing label: Please tell us your primary area of interest (you may only select one)*. LIFE SCIENCES & BIOMEDICAL RESEARCH Behavioral Sciences Biochemistry, Biophysics & Structural Biology Biotechnology Cell & Molecular Biology Medical Science Computational Biology Developmental Biology Drug Discovery & Development Evolutionary Biology Genetics & Genomics Microbiology, Immunology & Infectious Disease Neuroscience Physiology Public Health & Epidemiology Translational Research PHYSICAL SCIENCES & ENGINEERING Astronomy, Astrophysics & Cosmology Chemistry Computer Sciences Engineering Materials Science Mathematics Nanotechnology Physics ENVIRONMENTAL SCIENCES & SUSTAINABILITY Agricultural Earth Sciences Environmental Sciences, Health & Policy SOCIAL SCIENCES Anthropology Economics Psychology SCIENCE, SOCIETY, & CULTURE Art & Science Bioethics History & Philosophy of Science Science Education Science Policy CAREER DEVELOPMENT Career Development Other (please specify): Please check this box if you would like to receive communications from the New York Academy of Sciences about events and publications related to the area of interest you selected above?* Please fax or mail this form to the attention of: The New York Academy of Sciences PO Box , St. Louis, MO *Telephone: *Fax: * nyasmembership@aip.org 11