GUMBORO FIELD EXPERIENCES IN SPAIN THINGS WE HAVE LEARNT!

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1 GUMBORO FIELD EXPERIENCES IN SPAIN THINGS WE HAVE LEARNT! JOSÉ LUIS VALLS GARCIA Veterinario consultor avícola Barcelona, 15th March 2016

2 GUMBORO is an Enzootic disease : Challenge will come immediately after protection by MDA has reached unprotective level IBDV will persist, cycle after cycle IN OTHER WORDS : If a farm was with Gumboro IBDV yesterday, then, it will have it again tomorrow

3 ACTIONS REQUIRED BUT NOT ENOUGH CLEANING DISINFECTION DANGER IBDV DISINSECTION RODENT CONTROL BIOSECURITY

4 WHICH IS THE OBJECTIVE OF GUMBORO VACCINATION? PROTECT THE CHICKENS LOWER THE CHALLENGE AVOID PRESSURE ON FARM OF IBDV POPULATION

5 INMUNE COMPLEX VACCINE Following administration, the protection starts immediately after vaccine virus replication, which occurs after MDA have reached moderate level. Vaccine adapts to the level of MAD The protection against infection and re-excretion of the challenge virus most of the time reaches 100%.

6 DOUBTS OF VETERINARY HATCHERY vs FIELD VACCINE APPLICATION INJURIES IN THE BURSA: INMUNOSUPRESSION?? INMUNE COMPLEX: RETURN OF INVESTMENT THIS PRESENTATION ATTEMPTS TO CLARIFY THESE QUESTIONS

7 CHICK PROGRAM FIELD SERVICES SPAIN CEVA CONTINUOUS MONITORING AGAINST GUMBORO

8 OBJECTIVE of CEVA SPAIN TEAM CHECK THE HEALTH STATUS OF COMPANIES AND ASSESS THE EFFECTIVENESS OF VACCINATION PLANS SET

9 THINGS WE HAVE LEARNT WORKING WITH INMUNO-COMPLEX VACCINE SINCE 2009 WITH A LOT OF TRIALS AND INFORMATION IT IS WORKING WITH DATA 62,4 MILLION CHICKENS / YEAR

10 C. CAZABAN

11 SAMPLES SEROLOGY SPANISH TEAM CEVA

12 BIOCHEK TEST COMPANY A

13 COEFFICIENT OF VARIATION Is the dispersión of titles of the flocks in the histogram Measuring uniformity of titles Ideal; to present CV% lower in lots Coefficient of variation Interpretation < 40 % Excellent response to vaccination < % correct immune response > 60 % There are birds without proper vaccine response > 80 % Many non-uniformity Recent outbreak field

14 FLOCKS VACCINATED : TRM: 34 FARMS; 17% CV between midpoints - Slaughter bloods INTERMEDIATE VACCINE DW: 37 FARMS; 61% CV between midpoints - Slaughter bloods BIOCHECK TEST

15 2014 TRM: 58 FARMS; 26% CV between midpoints - Slaughter bloods BIOCHECK TEST

16 ELISA TESTING ( TRANSMUNE VAXXITEK )

17 ELISA TESTING TRANSMUNE - VAXXITEK

18 BIOCHEK TEST

19 BIOCHEK TEST

20 BIOCHEK TEST

21 BIOCHEK TEST

22 CECAV - SPAIN IBD CEVA Biochek d o more

23 CECAV - SPAIN IBD CEVA Biochek d o more

24 INMUNO COMPLEX INJURIES IN THE BURSA: INMUNOSUPRESSION?

25 COMPANY B

26 All samples were taken from healthy chickens in routine visits by the technical team of CEVA Spain

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29 PCR RESULTS & LYMPHOID DEPLETION vs VACCINATION PLAN SAMPLES TAKEN CRESA Y CECAV VACCINATION PLAN: - DRINK OF WATER ( 71 samples ) - INMUNO COMPLEX ( 248 samples ) - HVT-VP2 ( 35 samples )

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32 DRINKING WATER VACCINATION vs HATCHERY INMUNO COMPLEX Average detectable vaccine replication (RT-PCR) after drinking water vaccination was delayed compared to that of the average hatchery vaccinated flocks Average vaccine antibody response after drinking water vaccination was delayed compared to that of the average hatchery vaccinated flocks Most likely due to the timing or quality of the application

33 INMUNO COMPLEX RETURN INVESTMENT?

34 PRODUCTION DATA 2013 COMPANY C chickens DW VACCINE chickens TRM VACCINE Vs WEIGHT FCR DAYS ADG MORT. IEE COST FINAL / Kg 5,06% -1,47% 0,91% 3,98% 8,82% 5,66% -1,73%

35 RETURN OF INVESTMENT COMPANY C Nº CHICKENS / YEAR = AVERAGE WEIGHT = 2,645 Kg / CHICKEN COST DIFFERENCE BETWEEN PLANS VACCINE = 0,018 EU/KG TOTAL RETURN CHICKENS RETURN OF INVESTMENT INMUNO COMPLEX 47,61 EUROS

36 PRODUCTION DATA COMPANY D chickens DW VACCINE chickens TRM VACCINE Vs WEIGHT FCR DAYS ADG MORT. IEE COST FINAL / Kg +1,47 % -6,33 % -5,69 % +8,00 % +5,15 % +14,69 % -1,52 %

37 RETURN OF INVESTMENT COMPANY D COST DECREASE 1,52 % AVERAGE WEIGHT = 2,701 Kg / CHICKEN COST DIFFERENCE BETWEEN PLANS VACCINE = 0,014 EU/KG TOTAL RETURN CHICKENS RETURN OF INVESTMENT INMUNO COMPLEX 37,80 EUROS

38 RETURN INVESTMENT INMUNO COMPLEX VACCINE COMPANY RETURN euros / KG RETURN euros / CHICKENS RETURN euros / 20 MILLIONS YEAR C 0,018 47, D 0,014 37, AVERAGE 0,016 42,

39 CONCLUSIONS WHAT WE HAVE LEARNT? BETTER RESULTS (PCR AND SEROLOGY) WITH INMUNO COMPLEX VACCINE AND HATCHERY APPLICATION INTERMEDIATE VACCINES vs INMUNO COMPLEX: THE LYMPHOID DEPLETION IS SIMILAR THE INJURIES OF THE BURSA ARE REVERSIBLES

40 CONCLUSIONS WHAT WE HAVE LEARNT? ONCE BURSA IS COLONIZED BY INMUNO COMPLEX VACCINE, FIELD IBD VIRUS CANNOT INFECTED BIRDS HOMOGENEUS BURSA COLONIZATION: ALL SAMPLES POSITIVE SMOOTH TRANSTION FROM PASSIVE TOWARDS ACTIVE INMUNITY RETURN OF INVESTMENT IS BETTER INMUNO COMPLEX

41 THANKS TO THE CEVA SPAIN TEAM WONDERFUL PEOPLE!

42 THANK YOU VERY MUCH FOR YOUR ATTENTION