EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy

Transcription

1 Annual Meeting, Karlsruhe 27 th February 2 nd March 2017 EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy Roger Harrison (Chair), on behalf of WG9

2 WG9 progress since AM2016: Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

3 Outline 1. Meetings Plenary meeting: CERN th October Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

4 Meetings 2016 Joint meeting with CERN colleagues involved in medical applications of CERN technology GEMPix: J. Leidner et al. Visualisation of energy deposition in a proton beam Photon spectrometry (Dosepix): W Wong et al

5 Meetings 2016 Joint meeting with CERN colleagues involved in medical applications of CERN technology FLUKA applications: W. Kozłowska A neutron detector for pulsed mixed fields : M. Caresana Dose reduction in PET scans: P. Lecoq

6 Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

7 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.1 Brain tumour treatment using 3DCRT & IMRT 1.2 Brain Tumour treatment using Gammaknife 1.3 Craniospinal treatment. Marija Majer, Liliana Stolarczyk, Saveta Miljanic et al. Marija Majer, Marijke de San Hubert, Saveta Miljanić, Liliana Stolarczyk et al. Željka Knežević, Natalia Adamek, Saveta Miljanić, Marijke de San Hubert, Liliana Stolarczyk, Jan Kubancak et al. Paper accepted for publication in Radiation Measurements Paper in preparation Analysis in progress

8 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.1 Brain tumour treatment using 3DCRT & IMRT 1.2 Brain Tumour treatment using Gammaknife 1.3 Craniospinal treatment. Marija Majer, Liliana Stolarczyk, Saveta Miljanic et al. Marija Majer, Marijka de San Hubert, Saveta Miljanić, Liliana Stolarczyk et al. Željka Knežević, Natalia Adamek, Saveta Miljanić, Marijke de San Hubert, Liliana Stolarczyk, Jan Kubancak et al. Paper accepted for publication in Radiation Measurements Paper in preparation Paper in preparation

9 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.1 Brain tumour treatment using 3DCRT & IMRT 1.2 Brain Tumour treatment using Gammaknife 1.3 Craniospinal treatment. Marija Majer, Liliana Stolarczyk, Saveta Miljanic et al. Marija Majer, Marijke de San Hubert, Saveta Miljanić, Liliana Stolarczyk et al. Željka Knežević, Natalia Adamek, Saveta Miljanić, Marijke de San Hubert, Liliana Stolarczyk, Jan Kubancak et al. Paper accepted for publication in Radiation Measurements Paper in preparation Paper in preparation

10 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.4 Out-of-field doses in brachytherapy (Porto experimental campaign) 1.5 Joint WG9 / 12 action on experimental determination of complete dose specifications in radiotherapy 1.6 EURADOS report on Dosimetry for second cancer risk estimation in radiotherapy Joao Santos, Saveta Miljanic et al. Željka Knežević, Marijke de San Hubert, Roger Harrison, Argiro Boziari, Marija Majer, Jad Farah Roger Harrison et al. Data analysis in progress Planning stage. Experimental campaign planned for 2017 final editing stage 1.7 Modelling out-of-field doses: contribution of experimental data for testing and validation 1.8 Compilation of current doserisk models in spreadsheet form Chris Schneider, Wayne Newhauser (LSU), Roger Harrison, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk et al. Marijke de San Hubert et al Paper accepted by Med. Phys. Most current models incorporated

11 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.4 Out-of-field doses in brachytherapy (Porto experimental campaign) 1.5 Joint WG9 / 12 action on experimental determination of complete dose specifications in radiotherapy 1.6 EURADOS report on Dosimetry for second cancer risk estimation in radiotherapy Joao Santos, Saveta Miljanic et al. Željka Knežević, Marijke de San Hubert, Roger Harrison, Argiro Boziari, Marija Majer, Jad Farah Roger Harrison et al. Data analysis in progress Planning stage. Experimental campaign planned for 2017 final editing stage 1.7 Modelling out-of-field doses: contribution of experimental data for testing and validation 1.8 Compilation of current doserisk models in spreadsheet form Chris Schneider, Wayne Newhauser (LSU), Roger Harrison, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk et al. Marijke de San Hubert et al Paper accepted by Med. Phys. Most current models incorporated

12 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.4 Out-of-field doses in brachytherapy (Porto experimental campaign) 1.5 Joint WG9 / 12 action on experimental determination of complete dose specifications in radiotherapy 1.6 EURADOS report on Dosimetry for second cancer risk estimation in radiotherapy Joao Santos, Saveta Miljanic et al. Željka Knežević, Marijke de San Hubert, Roger Harrison, Argiro Boziari, Marija Majer, Jad Farah Roger Harrison et al. Data analysis in progress Planning stage: therapy and imaging for paediatric patients final editing stage 1.7 Modelling out-of-field doses: contribution of experimental data for testing and validation 1.8 Compilation of current doserisk models in spreadsheet form Chris Schneider, Wayne Newhauser (LSU), Roger Harrison, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk et al. Marijke de San Hubert et al Paper accepted by Med. Phys.. Most current models incorporated

13 D/D max (CAX) (mgy/gy) Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.4 Out-of-field doses in brachytherapy (Porto experimental campaign) 1.5 Joint WG9 / 12 action on experimental determination of complete dose specifications in radiotherapy 1.6 EURADOS report on Dosimetry for second cancer risk estimation in radiotherapy 1.7 Modelling out-of-field doses: contribution of experimental data for testing and validation Joao Santos, Saveta Miljanic et al. Željka Knežević, Marijke de San Hubert, Roger Harrison, Argiro Boziari, Marija Majer, Jad Farah Roger Harrison et al. Roger 1000 Harrison, Wayne Newhauser (LSU),Saveta Miljanić, 100 Željka Knežević, Liliana Stolarcyzk et al. 10 In/Near Field Region Data analysis in progress Planning stage: therapy and imaging for paediatric patients final editing stage Out-of-Field Region Paper submitted to Med. 6 MV, d = 10 cm Phys. Measured Primary Head Scatter Pat. Scatter Leakage Total 1.8 Compilation of current doserisk models in spreadsheet form Marijka de San Hubert et Most models incorporated 1 al x (mm)

14 Photon radiotherapy programme Task number Task Lead Status 1 Photon radiotherapy 1.4 Out-of-field doses in brachytherapy (Porto experimental campaign) 1.5 Joint WG9 / 12 action on experimental determination of complete dose specifications in radiotherapy 1.6 EURADOS report on Dosimetry for second cancer risk estimation in radiotherapy Joao Santos, Saveta Miljanic et al. Željka Knežević, Marijke de San Hubert, Roger Harrison, Argiro Boziari, Marija Majer, Jad Farah Roger Harrison et al. Data analysis in progress Planning stage: therapy and imaging for paediatric patients final editing stage 1.7 Modelling out-of-field doses: contribution of experimental data for testing and validation 1.8 Compilation of current doserisk models in spreadsheet form Chris Schneider, Wayne Newhauser (LSU), Roger Harrison, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk et al. Marijke de San Hubert et al Paper accepted by Med. Phys. Most current models incorporated

15 Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) Update on EURADOS Young Scientist Grant 2015 (Marijke De Saint-Hubert) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

16 Hadron radiotherapy programme SG9.2 List of activities Experimental campaigns in CCB IFJ PAN: mailed dosimetry in proton radiotherapy: June ,19 December 2016 WG9 Meeting in CERN, October 2016 Travel grant for Marijke De Saint-Hubert (SCK CEN/IFJ PAN), 2015

17 Hadron radiotherapy programme SG9.2 Measurement of stray neutron doses inside the treatment room from a proton pencil beam scanning system F (1.5 m) (WENDI- II) 0.21 m 0.15 m B (1.0 m) (WENDI- II) Treatment nozzle at E (2.25 m) C (2.25 m) (HAWK v. 1) D (2.25 m) (HAWK v. 2) (HAWK v. 3) Result: parametrization of environmental doses in proton therapy room with pencil scanning beam N. Mojżeszek, et al. Physica Medica 2017

18 Hadron radiotherapy programme SG9.2 Update on Mailed Dosimetry Auditing in Proton Therapy EURADOS Young Scientist Grant, 2015 Awarded to Marijke De Saint-Hubert Collaboration of five institutions: SCK CEN (Belgium) IFJ (Poland) Hasselt University (Belgium) RBI (Croatia) ISS (Italy)

19 Dosimetry auditing Dosimetry auditing of proton therapy centres Not yet available in Europe Lack of international and national primary dose standards for proton beams Need for harmonization Dosimetry auditing of photon therapy centres International program of IAEA National programs for mail auditing radiotherapy centres Mainly using Alanine or TLD TLD Postal Dose Audit Service Copyright 2013 SCK CEN

20 Detectors Passive dosimeter systems Alanine ThermoLuminescent Dosimeters (TLD) MCP-n MTS-n Optically stimulated luminescent dosimeters (OSL) RPL Luxel GD-302M GD352M SCK-CEN RBI Technique Detector Technique Detector TLD MCP-n RPL GD-302M OSL Luxel RPL GD-352M EPR Alanine IFJ-PAN ISS Technique Detector Technique Detector TLD MTS-n EPR Alanine TLD MCP-n EPR Alanine Alanine TLDs RPL-GD Copyright 2013 SCK CEN

21 Proton spot scanning beam Cyclotron Center Bronowice (CCB) IFJ, Krakow, Poland Proteus C-235 cyclotron (Ion Beam Applications S.A., Belgium) Protons of up to 230 MeV can hence be delivered to the clinical target volume using the Pencil Beam Scanning (PBS) Cyclotron Center Bronowice (CCB) - Poland Clinical proton spot scanning Spread out Bragg peak (SOBP) Copyright 2013 SCK CEN

22 Irradiation conditions PTW water phantom Proton therapy SOBP - IFJ 10 cm x 10 cm field Different layers defining Range Modulation Theratron 780E (Co60) - IFJ TRS-398 TLD, OSL, RPL Dw=2 Gy Alanine Dw=10Gy Position the dosimeter reference point in the middle of the SOBP Copyright 2013 SCK CEN

23 Relative Dose Study design SOBP configurations Change the modulation width Range 20 Modulation 5 (R20M5) Range 20 Modulation 10 (R20M10) Range 20 Modulation 15 (R20M15) Range 20 Modulation 20 (R20M20) Change the range Range 5 Modulation 5 (R5M5) Range 10 Modulation 5 (R10M5) Range 15 Modulation 5 (R15M5) Range 20 Modulation 5 (R20M5) Range 25 Modulation 5 (R25M5) R20M10 Modulation 10 Range 20 Data analysis Depth in water (cm) Relative efficiency of the dosimeters to Co60 in the different PT configurations Dosimeter and batch reproducibility (repetitive irradiations and readings in Co60 (>5 repetitions) Copyright 2013 SCK CEN

24 Monte Carlo simulations (using MCNPx 2.7.0) Monte Carlo simulations Proton energy spectrum in the position of the dosimeter (middle of the SOBP) Average proton energy/let 1,20E+00 1,00E+00 8,00E-01 R5M5 R10M5 R15M5 6,00E-01 4,00E-01 2,00E-01 R20M5 R25M5 R20M10 R20M15 R20M20 0,00E Copyright 2013 SCK CEN

25 Relative efficiency to Co60 Response Alanine Relative response was between 6% and 4% lower in proton fields compared to Co60 With minimal rise for increased modulation (increased energy/decreased LET) No significant difference between alanine (ISS vs UH) 0,98 0,97 0,96 0,95 0,94 Alanine_ISS Alanine_UH 0,93 0,92 R20M5 R20M10 R20M15 R20M20 R5M5 R10M5 R15M5 R20M5 R25M5 Alanine Minimal rise in the response for increased modulation Institute ISS UH Dosimeter reproducibility 0.67% 0.62% Batch reproducibility 0.81% 0.38% Copyright 2013 SCK CEN

26 Conclusions and future steps Response of different passive detector systems in clinically used proton spot scanning beam Alanine most promising TLD (MCP-N) Response inversely proportional to LET - Corrections will be needed High uncertainties in PT OSLd (Luxel) not promising because of large uncertainties RPL LET dependent Auditing of PT centres from different institutes (2017) PTCOG/Eurados Perform auditing of 10 centres for eye proton therapy Alanine pellets from 3 different institutes (IFJ, ISS, Uhasselt) as well as RPLs (RBI) Copyright 2013 SCK CEN

27 WG9 Tasks (hadron radiotherapy) Task Task Lead Status Finish no. 2 Hadron radiotherapy 2.1 System for mailed dosimetry audits of proton therapy radiotherapy beams 2.2 Mailed dosimetry audits of eye proton therapy radiotherapy beams 2.3 Dose distribution of scattered radiation in water phantom for proton pencil beam - EURADOS WG9 inter-comparison exercise on passive dosimetry systems (Trento) Marijke De Saint- Hubert, Jenny Kunst, Željka Knežević, Pawel Olko, Cinzia de Angelis, Liliana Stolarczyk, Renata Kopeć Marijke De Saint- Hubert, Jenny Kunst, Željka Knežević, Pawel Olko, Cinzia de Angelis, Liliana Stolarczyk, Renata Kopeć Liliana Stolarczyk et al. EURADOS Grant awarded to Marijke De Saint-Hubert. Two experimental campaigns in June June Data analysis in progress To be submitted to Medical Physics in March Copyright 2013 SCK CEN

28 WG9 Tasks (hadron radiotherapy) Task no. Task Lead Status Finish 2 Hadron radiotherapy 2.4 Dose distribution measurements in anthropomorphic pediatric phantoms for proton pencil beam in Krakow Maite Romero- Exposito, Željka Knežević, Jad Farah, Marijke De Saint- Hubert,et al. Marie Davidkova 2.5 NEUDOS-13 L. Stolarczyk Željka Knežević, Jad Farah, Maite Romero- Exposito, Sebastain Trinkl, Jenny Kunst, Pawel Olko Data analysis and papers for Phys.Med.Biol. May 14 19, 2017 Autumn 2017 December Copyright 2013 SCK CEN

29 WG9 Tasks (hadron radiotherapy) Task Task Lead Status Finish no. 2 Hadron radiotherapy (continued) 2.6 A spectrometry study of stray neutron radiation field in scanning proton therapy Liliana Stolarczyk Barcelona. Prague Neuherberg Planned for May 2017 End of 2017? 2.7 Benchmarking the analytical models of out-of-field doses Jad Farah, others In progress 2.8 Dosimetry of small fields and grid therapy NEW Topic Planning phase 2.9 Proton Therapy Group Overview Pawel Olko et al. Data analysis and paper for International Journal of Particle Therapy Copyright 2013 SCK CEN

30 Hadron radiotherapy programme SG9.2 Future work of SG9.2 Mailed dosimetry for proton radiotherapy Dosimetry for grid therapy, small beams and high gradient fields LET verification in proton radiotherapy Parametrization of out-of-field doses and its application for secondary risk calculation

31 Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

32 Computational methods in medical physics (SG9.1) Task number Task Lead Status 3 Computational methods in Medical Physics 3.1 High energy neutron benchmarking (joint action with WG6 and WG11) 3.2 MC simulations in support of Krakow pediatric phantom measurements (See 2.2) 3.3 MC simulations in support of Porto Brachytherapy measurements (e.g. TPS validation). (See 1.4) 3.4 MC simulations in support of mailed proton therapy audit measurements (see 2.1) Sebastian Trinkl, Ima Martinez and Maite Romero Exposito. Sebastian Trinkl et al. Sebastian Trinkl et al Sebastian Trinkl et al In progress Complete In progress In progress

33 Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

34 Cancer risk Future challenges The radiation protection case (low doses) Mean absorbed dose Equivalent dose Effective dose Linear dose-risk function Schematic dose-risk graph Dose (Gy)

35 Cancer risk Future challenges The radiotherapy case (high dose) Critical sub-structures (brain & cardiac arteries, GI tract, breast) Dose gradients Fractionation Non-linear dose risk functions Schematic dose-risk graph dose distance Dose (Gy)

36 WG9: Future directions 1. Promoting the development of techniques for dosimetry in: gradients, heterogeneous dose regions ( edge-of-field dosimetry) and small organ sub-structures (high spatial resolution dosimetry) Small fields: o IMRT beamlets, code of practice comparisons o proton grid therapy, high gradient fields LET verification in proton radiotherapy MC modelling Applications of these techniques for testing TPS algorithms

37 WG9: Future directions 2. Parameterization of out-of-field doses Photon and proton dosimetry Risk prediction of secondary cancer and other late effects Applications in testing TPS algorithms Supported by MC modelling

38 WG9: Future directions 2. Parameterization of out-of-field doses Photon and proton dosimetry Risk prediction of secondary cancer and other late effects Applications in testing TPS algorithms Supported by MC modelling How accurately do we need to know the dose? How confident are we in the TPS algorithm? Total marrow irradiation protocol From: Beavis AW The British Journal of Radiology, 77 (2004),

39 WG9: Future directions 3. Combining therapy and imaging doses in radiotherapy On-board CBCT and treatment doses: Work in progress WG9/12 collaboration Possible future extension to other imaging systems e.g. CT

40 WG9: Future directions 4. Mailed proton dosimetry audits In progress SCK CEN (M. De Saint-Hubert) in collaboration with Univ. Hasselt (B. Reniers) RBI (Ž. Knežević) IFJ-PAN (J. Kunst, L. Stolarczykj, R. Kopec) ISS (C. De Angelis) Detectors tested for suitability in a mailed system (TLD, OSL, RPL, Alanine)

41 Outline 1. Meetings 2. Photon radiotherapy programme 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) 4. Computational methods in medical physics (Sub-Group 9.1, Sebastian Trinkl) 5. Future directions 6. Publications and presentations

42 Publications Proton therapy beams: neutron fields and detector intercomparisons Mares, Vladimir, Romero-Exposito, Maite; Farah, Jad; Trinkl, Sebastian; Domingo, Carles; Dommert, Martin; Stolarczyk, Liliana; Van Ryckeghem, Laurent; Wielunski, Marek; Olko, Pawel; Harrison, Roger. A comprehensive spectrometry study of stray neutron radiation field in scanning proton therapy. Phys. Med. Biol. 61 (2016) N. Mojżeszek, J. Farah, M. Kłodowskaa, O. Plocd, L. Stolarczyka, M.P.R. Waligórski,, P. Olko Measurement of stray neutron doses inside the treatment room from a proton pencil beam scanning system Physica Medica 2017 J. Farah, M. De Saint-Hubert, N. Mojzeszek, S. Chiriotti, M. Gryzinski, O. Ploc, F. Trompier, K. Turek, F. Vanhavere, P. Olko. Performance tests and comparison of microdosimetric measurements with four tissue-equivalent proportional counters in scanning proton therapy. Radiation Measurements 96 (2017) 42-52

43 Publications Clinical photon out-of-field simulations Marija Majer, Liliana Stolarczyk, Marijke De Saint-Hubert, Damian Kabat, Željka Knežević, Saveta Miljanić, Natalia Mojżeszek and Roger Harrison. Out-of-field dose measurements for 3D conformal and intensity modulated radiotherapy of a paediatric brain tumour. Accepted for publication in Radiation Measurements doi: /rpd/ncx015 Christopher Schneider, Wayne Newhauser, Lydia Jagetic, Uwe Schneider, Robert Kaderka, Saveta Miljanic, Zeljka Knezevic, Liliana Stolarczyk, Marco Durante, and Roger Harrison. A simple, descriptive, and broadly applicable model of therapeutic and stray absorbed dose from 6 MV to 25 MV photon beams. Med. Phys. Accepted for publication 2017 Requirements for epidemiological studies Roger Harrison. Out-of-field doses in radiotherapy: input to epidemiological studies and dose-risk models. Accepted for publication in Physica Medica: European Journal of Medical Physics

44 Conference presentations Proton therapy beams: neutron fields and detector intercomparisons Željka Knežević on behalf of EURADOS WG9. Secondary radiation dose measurements in scanning proton therapy. Overview of activity within EURADOS WG9 (SG2). AAMPM, Zagreb May, 2016 Željka Knežević, Liliana Stolarczyk, Marija Majer, Saveta Miljanić, Pawel Olko. Dose dependence of different solid state detectors in high energy proton beam. 18th International Conference on Solid State Dosimetry (SSD18) July 3-8, Munich. Pawel Olko. Proton beams and detector response 12th International Workshop on Radiation Monitoring, Oarai, Japan 3-4 Dec Clinical out-of-field simulations Marijke De Saint-Hubert, Liliana Stolarczyk, Marija Majer, Željka Knežević, Hrvoje Hršak, Natalia Adamek, Saveta Miljanić, Pawel Olko, Roger M Harrison, Filip Vanhavere, Lara Struelens. Proton spot scanning reduces the secondary doses of paediatric brain irradiations compared to photon techniques. Belgian Hospital Physicists Association symposium (BHPA 2016), Liege February 2016

45 Conference presentations Clinical out-of-field simulations S. Miljanić, N. Adamek, I. Ambrožová, M. De Saint-Hubert C. Domingo, H. Hršak, D. Kabat, Ž. Knežević, M. Majer, P. Olko, O. Ploc, M. Romero-Expósito, L. Stolarczyk, F. Vanhavere and R. Harrison. Out-of-field dose distributions in active scanning proton versus photon radiotherapy: An overview of research within EURADOS WG 9. 18th International Conference on Solid State Dosimetry (SSD18) July 3-8, Munich Saveta Miljanić, João A. M. Santos on behalf of EURADOS WG9. Peripheral doses in gynaecological brachytherapy treatment in phantom measurements versus TPS calculations preliminary results. The 12 th International Workshop on Ionizing Radiation Monitoring, December 3-4, 2016, Oarai, Japan. Marijke De Saint-Hubert, Željka Knežević, Natalia Adamek, Marija Majer, Liliana Stolarczyk, Remy Savelli, Vedran Rajevac, Saveta Miljanić, Pawel Olko, Roger M Harrison, Filip Vanhavere, Dirk Verellen, Lara Struelens. Out-of-field dose and risk of radiogenic second cancer for children treated with craniospinal 3D- Conformal Radiotherapy or TomoTherapy. IRPA 14, 9-13 May 2016, Cape Town.

46 Conference presentations Requirements for epidemiological studies Roger Harrison. Input to epidemiological studies and dose-risk models. Invited speaker, Workshop on Risk of Secondary Cancer following Radiotherapy. 8-9 September 2016, The Royal Swedish Academy of Sciences, Stockholm, Sweden. Mailed proton dosimetry audit M. De Saint-Hubert, B. Reniers, L. Stolarczyk, C. De Angelis, Ž. Knežević, J. Kunst, A. Parisi, M. Majer, F. Vanhavere, L. Struelens, R. M. Harrison, Pawel Olko. Mailed dosimetry auditing in Proton Therapy. EURADOS intercomparison of passive dosimeter response in proton spot scanning beam. NPL PPRIG Proton Therapy Physics Workshop 2016 Željka Knežević, C. De Angelis, M. De Saint-Hubert, J. Kunst, L. Stolarczyk, P. Olko. Mailed dosimetry auditing in proton therapy - evaluation of RPL detectors in proton therapy beam- EURADOS-WG 9 preliminary results. 12th International Workshop on Ionizing Radiation, Monitoring, Oarai, Japan, 2016

47 Thank you

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49 Summary of future work of WG9 Out-of-field dosimetry for paediatric brain tumour treatments Validation of analytical out-of-field models Total dose from radiotherapy and imaging: the complete dose specification (WG9/12 collaboration) Active & passive detector intercomparisons in proton facilities In-phantom scattered radiation measurements in proton pencil beam therapy, using passive dosimetry systems Inter-centre proton dose intercomparisons & mailed dosimetry audits of proton dosimetry Monte Carlo support & joint WG activities (WG9, 6, 11)