SUNDAY, Lunch for Scholars in Training. Session 1: "Career Development" "Science ethics"

Transcription

1 SUNDAY, Registration: Sunday to Wednesday, 8:00-16:00 13:30-14:30 14:30-15:15 Host and Chair: J. Hess Bernd Pulverer Lunch for Scholars in Training Special Primer for Scholars in Training Deichmann Auditorium Session 1: "Career Development" "Transparent publishing, preprints and open science" 15:15-16:00 Julia Verse Berlin, Germany "Science ethics" 16:00-16:30 Session 2: "Applied Science" and Round Table Discussion Chairs: K. Al-Refae and A. Krysztofiak 16:30-17:15 Nicholas McGranahan "Tumor heterogeneity and therapy outcome" London, United Kingdom 17:15-18:00 M.H. Barcellos-Hoff, M. Foiani, T. Helleday N. McGranahan, B. Pulverer, J. Verse and E. Rogakou "Round Table Discussion on career paths in science" 18:30-19:00 19:00-20:00 20:00-22:00 Chair: G. Iliakis Silvia Formenti New York, United States Opening Ceremony Audimax Keynote Lecture 1 "Immune effects of radiation therapy" Welcome Reception 43rd Annual Meeting of ERRS and 20th Annual Meeting of GBS,, 2017

2 8:15-9:00 Chair: V. Jendrossek Mary Helen Barcellos-Hoff "Radiation induced lung fibrosis-a dynamic interplay between immune response, angiogenesis..." Poster Session 1 MONDAY, "Looking for Achilles' heel: HPV, TGFβ, and DDR" Chair: 9:00-9:20 Silvia Formenti "TREX1 regulates radiation immunogenicity: clinical implications" New York, United States 9:20-9:40 Udo Gaipl "Immune modulatory properties of radiotherapy - rationales for Erlangen, Germany combination with immunotherapy" 9:40-10:00 Gabriele Niedermann "Preclinical evaluation and imaging of immunoradiotherapy Freiburg, Germany approaches" 10:00-10:20 Conrad Rauber "Gut microbiota in radioimmunotherapy" Villejuif, France 10:20-10:40 Lisa Sevenich "Effects of ionizing radiation on brain metastasis-associated Frankfurt am Main, Germany inflammation" 10:40-11:00 11:00-11:15 11:15-11:30 11:30-11:45 11:45-12:00 12:00-12:15 12:15-12:30 12:30-14:30 San Francisco, United States S01, "Immune Response" S02, "DNA Damage Response 1" Ruth Muschel Beate Volkmer Peter Huber Oxford, United Kingdom Buxtehude, Germany "FGF2 is a switch controling the tumor "Epigenetic alterations in skin cancer "CTGF (connective tissue growth response to radiation through tissue and UV-exposed skin" factor) in radiation tumor and normal macrophage polarization" tissue response" Benjamin Frey Erlangen, Germany "Pre-clinical and clinical hints for immune modulation by low loses of ionizing radiation" "Increased DSB end resection causes enhanced formation of chromosomal translocations through Parp-1..." "Imaging hypoxia in prostate cancer" Veronica Olivo Pimentel Jagdish Paithankar Emmy Rogakou Maastricht, Netherlands Mangalore, India Athens, Greece "Radiotherapy causes long-lasting antitumor immunological memory when combined with immunotherapy" "Nek1 depletion modulates apoptosis, DNA repair and radiation survival of 3D-cultured colorectal and cervix..." Amir Abdollahi Aashish Soni Heidi Lyng Oslo, Norway "Variations in radiation tolerance in life stages of D. melanogaster provide clues to radiation tolerance..." "Modeling tumour and normal tissue effects of combination treatments" Ludwig Dubois Klaudia Al-Refae Simone Moertl Maastricht, Netherlands "Radiotherapy and immunocytokines: a perfect match for abscopal effects with long-lasting memory?" Roman Hennel "Immunostimulatory effects induced by radiotherapy of breast cancer cells" Keynote Lecture 2 Plenary Session 1, "Radiation Exposure and Immune Response" Stephanie Hehlgans Frankfurt am Main, Germany "Impact of Akt1 phospho-mutants on the cellular response to ionizing radiation" Aadhya Tiwari Tübingen, Germany "Y-box binding protein-1 stimulates repair of ionizing radiation-induced DNA double strand breaks..." S03, "Tumor Response" Marc Vooijs Maastricht, Netherlands "Exosomes from irradiated squamous head and neck cancer cells with altered protein cargo boost..." Sofia Ferreira Orsay Ville, France "Dbait and radiation treatments in pediatric brain tumors" "20 years after the discovery of the γh2ax biomarker" (Lunch will be provided)

3 MONDAY, :30-14:45 14:45-15:00 15:00-15:15 15:15-15:30 15:30-15:45 15:45-16:00 16:00-16:30 16:30-17:10 17:15-18:30 18:30-20:00 S04, "DNA Repair in Chromatin Context" Timothy Humphrey Gillies McKenna Christian Streffer Oxford, United Kingdom Oxford, United Kingdom "Histone H3K36 trimethylation, genome stability and cancer" Claudia Rübe Homburg, Germany "Hair follicle stem cell fate is dependent on chromatin remodeling capacity following low-dose radiation" Burkhard Jakob "Dynamics of DNA repair proteins in response to radiation induced DNA damage of different complexity" Alexander Rapp "Identification of the elementary structural chromatin units of the DNA damage response" Lovisa Lundholm Stockholm, Sweden "The role of chromatin in response to alpha and gamma radiation in breast cancer cells" Nataša Anastasov "Non-coding RNAs as regulators of cellular epigenome and response to radiation" S05, "Novel Radiosensitizers" "High-throughput screens for drugs to modify hypoxia" Martin Pruschy Zurich, Switzerland "Targeting ADAM17 for radiosensitization" Peter Sminia Amsterdam, Netherlands "The MAPK targeted agent MEK162 acts as radiosensitizer in glioblastoma therapy" Simon Magin "ATR dependent reactivation of suppressed alt-ej in G0" Mike Atkinson "Do non-coding RNAs play a role in the response to radiation?" Bodo Laube "Impact of glutamate receptor mediated signaling on the induction and repair of DNA DSBs " S06, "Radiation Protection" "LNT-model for radiological protection: reasonable use and misuse" Wolfgang-Ulrich Müller "Attributing health effects to ionizing radiation exposure and inferring risks" Ulrike Kulka Oberschleißheim, Germany "Research for radiation protection " Herbert Braselmann "A 9-feature genomic copy number signature is associated with radiation exposure in post-chernobyl breast " Niels Belmans "Age-related biological effects of dental cone-beam CT exposure" "Best Paper of the Year/Dieter Frankenberg Award Lecture", Deichmann Auditorium "GBS Mitgliederversammlung", Deichmann Auditorium Get Together with Beer and Snacks 43rd Annual Meeting of ERRS and 20th Annual Meeting of GBS,, 2017

4 8:15-9:00 Chair: M. Löbrich Simon Boulton "Developing a CRISPR/Cas9 model system to investigate the repair of DSB clusters with increased TUESDAY, "Mechanics of homologous recombination and its exploitation in cancer therapy" Chair: 9:00-9:20 Markus Löbrich "ATRX promotes DNA repair synthesis and cross-over formation during homologous recombination" 9:20-9:40 Haico van Attikum "Regulation and dynamics of DNA repair in a chromatin context" Leiden, Netherlands 9:40-10:00 George Iliakis "Logic and necessities in the repair of DNA double strand breaks in higher eukaryotes" 10:00-10:20 Dik van Gent "Modulation of DNA repair enhances the ionizing radiation effect in Rotterdam, Netherlands anti-tumor treatment" 10:20-10:40 Ester Hammond "Understanding and exploiting the hypoxia-induced DNA damage Oxford, United Kingdom response" 10:40-11:00 11:00-11:15 11:15-11:30 11:30-11:45 11:45-12:00 12:00-12:15 12:15-12:30 12:30-14:30 London, United Kingdom S07, "DNA Damage Response 2" S08, "Particle Radiation Modalities 1" Carsten Herskind Beate Timmermann Carmel Mothersill Mannheim, Germany Hamilton, Canada "A possible role of cell-cycle "The pediatric program at the West "Harnessing radiation induced checkpoints in radioresistance and the German Proton Therapy Centre Essen bystander signalling mechanisms for shape of cell survival curves: (WPE): aiming to reduce late effects radiotherapy" Wael Mansour Hamburg, Germany "Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances "Clustering of double-strand breaks following high-let irradiation perturbs DNA repair and is associated "Intracranial or local thorax irradiation-induced non-targeted effects in bone-marrow-derived Ramon Lopez Perez Elke Beyreuther Werner Rühm Dresden, Germany "Towards a better understanding of the ultrastructural organization of DNA double-strand break repair foci" "Proton minibeam radiation therapy is a novel approach to minimize normal tissue damage" "Analysing methods of animal irradiation experiments with deviations from prescribed dose" "Radiation-induced bystander effects in the haematopoietic system mediated by extracellular vesicles" Emil Mladenov Sara Timm Géza Sáfrány Homburg, Germany Budapest, Hungary Michael Ensminger Katrien Konings Colin Seymour Hamilton, Canada "Nek1 coordinates the repair of oneended DSBs with cell-cycle progression" Stefanie Mosel "A novel role for the anti-apoptotic protein Survivin in DNA repair and replication" Keynote Lecture 3 Plenary Session 2, "DNA Damage Response and DNA Repair" Thomas Schmid "How do different radiation qualities affect the Hedgehog signaling pathway?" Ralf Kriehuber Jülich, Germany "Geno- and cytotoxicity of DNAassociated Auger electron emitters" S09, "Intercellular Comm./Bystander Effects" Katalin Lumniczky Budapest, Hungary "Low doses and non-targeted effects in environmental radiation protection; where are we now and where should An Aerts "Effect of ionizing radiation on intercelluar communication in vascular endothelial cells" "Relevance of low dose and low dose rate research for radiation protection" Poster Session 2 (Lunch will be provided)

5 14:30-14:45 14:45-15:00 S10, "DNA Damage Response 3" Kerstin Borgmann Marie Dutreix George Don Jones Hamburg, Germany Orsay Ville, France Leicester, United Kingdom "CHK1-mediated replication fork stabilization confers radioresistance in homologous recombination deficient Claus Sørensen Copenhagen, Denmark "Novel DNA nuclease function governs cell fate decisions after ionising radiation" 15:00-15:15 Aurelie Vaurijoux Fontenay-aux-Roses, France 15:15-15:30 15:30-15:45 15:45-16:00 "Persistent ionizing radiation-induced foci in human primary cells: transmission through cell division" Fanghua Li "Suppression of CtIP-controlled DNA end-resection impairs alt-ej in quiescent cells" Michael Hausmann "Nano-probes and localization microscopy: a pointilist view on mechanisms of radiation response Moritz Frister "Ultrastructural studies on radiationinduced DNA double strand break repair foci with super-resolution TUESDAY, S11, "Radiation Therapy 1" "DNA repair inhibitors and radiotherapy" Alexander Schramm "Sensitizing MYCN-dependent tumor cells to ionizing radiation" Heike Anders "HSP90 inhibition: sensitization of aggressive soft tissue sarcomas to radiotherapy by enhancing the extent Justine Rudner "USP9x-regulated Mcl-1 stability is important for prostate cancer survival in response to ionizing radiation" Hua Jing "Combination of hypofractionated radiotherapy and IL-2/anti-IL-2 complexes and its theranostic Erika Zernikel "A synthetic lethality-based strategy for individual sensitization of lung cancer cell lines with vulnerability in S12, "Predictive Assays/Biomarkers 1" "Comet assay measures of cancer treatment cell sensitivity" Nicolaas Franken Amsterdam, Netherlands "Reduced activity of DSB Repair Genes in prostate cancer patients with late normal tissue radiation-toxicity" Pavel Lobachevsky Melbourne, Australia "γ-h2ax assay as a basis for prediction of individual radiosensitivity" Dietrich Walsh Neubiberg, Germany "Real time imaging of ROS propagation after targeted mitochondrial irradiation" Ulrike Schötz "Biomarkers and targets for personalization of radiotherapy of HNSCC: CD44v6" Michael Orth "Mechanism and biomarkers predicting the outcome of taxanebased, concurrent radiochemotherapy 43rd Annual Meeting of ERRS and 20th Annual Meeting of GBS,, 2017

6 8:15-9:00 Chair: T.Halazonetis Marco Foiani "Uniting ionizing radiation, DNA damage and immune response through an integrative experimental Poster Session 3 WEDNESDAY, "An integrated ATR, ATM and mtor-mechanical network controlling nuclear plasticity and cell migration" Chair: 9:00-9:20 Thanos Halazonetis Geneva, Switzerland 9:20-9:40 Christian Reinhardt Cologne, Germany 9:40-10:00 Björn Schumacher Cologne, Germany 10:00-10:20 George Garinis Heraklion, Greece 10:20-10:40 Petra Boukamp "A role for telomeres in UV-induced skin cancer" 10:40-11:00 11:00-11:15 11:15-11:30 11:30-11:45 11:45-12:00 12:00-12:15 12:15-12:30 12:30-14:30 Milan, Italy S13, "Particle Radiation Modalities 2" S14, "Radiation Toxicity and Carcinogenesis" Lorenzo Manti Christophe Badie Florian Wirsdörfer Naples, Italy Didcot, United Kingdom "Enhancement of clinical proton "Tracking pre-leukemic live cells in "Loss of CD73 prevents macrophage biological effectiveness by means of murine radiation-induced leukaemia" accumulation and phenotype changes proton-boron fusion reaction" in radiation-induced lung fibrosis" Andrzej Wojcik Stockholm, Sweden "X-rays and α-particles interact in inducing DNA damage in U2OS cells" "Investigating congenital eye defects in prenatally-irradiated mice and the efficacy of folic acid as a radio- "Dose-dependent morphological and biochemical alterations in the peripheral blood erythrocytes of Marco Durante Paul Schofield Lorena Giuranno Trento, Italy Cambridge, United Kingdom Maastricht, Netherlands "Ground-based research for space radiation protection" "IL-6 protects cells from radiation induced cell death by activating antioxidant defence and STAT-3 mediated "The STORE database; a platform for sharing experimental and epidemiological data and resources in "Bowel radiation injury: complexity of the pathophysiology and promises of cell and tissue engineering" Alexandros Georgakilas Mieke Verslegers Shwetanjali Nimker Athens, Greece Delhi, India Georgia Terzoudi André Claude M. Mfossa Arjan van Dijk Athens, Greece Bilthoven, Netherlands "Biological effectiveness of protons in comparison to α-particles and accelerated C-ions as measured Charlot Vandevoorde Cape Town, South Africa "Assessment of out-of-field DNA damage and the impact of neutron RBE on secondary cancer risk in Keynote Lecture 4 Plenary Session 3, "Mechanisms of Radiation Effects" "A vertebrate DNA replication completion checkpoint shows similarities to the spindle checkpoint" "ATM restoration in vivo induces lymphoma regression through cell autonomous and non-cell autonomous mechanisms" "Genome stability in aging and disease" "Nucleotide excision repair: from persistent DNA damage to chronic inflammation" Neeraj Kumari Delhi, India "Mechanistic analysis of radiationinduced microcephaly in mice" Emma Coninx "The hippocampus: a target for premature aging after early-life irradiation" S15, "Normal Tissue Response 1" Noëlle Mathieu Fontenay-aux-Roses, France "A mechanistic model for radiation induced atherosclerosis" Sylwia Kabacik Didcot, United Kingdom "Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE- "Improving lung cancer outcome by reducing normal lung toxicity" (Lunch will be provided)

7 WEDNESDAY, :30-14:45 14:45-15:00 15:00-15:15 15:15-15:30 15:30-15:45 15:45-16:00 16:00-16:30 16:30-17:30 17:30-18:30 19:00-22:00 S16, "Low Dose Radiation Effects" Chair: Chair: Chair: Horst Zitzelsberger Gabriel Pantelias Lisa Wiesmüller Athens, Greece Ulm, Germany "Radiation markers in breast carcinogenesis" Claudia Fournier "Immune-related, low dose effects in adipose and other joint cells and tissue" Roel Quintens "Prenatal irradiation as a potential inducer of premature differentiation during corticogenesis" Maria Gomolka Oberschleißheim, Germany "Gene expression changes in former uranium workers of the sag/sdag wismut" Claudia Dalke "A lifetime study in mice assessing several biological endpoints after exposure to low doses of ionizing Daniela Hladik "Low-dose radiation exposure leads to irreversible changes in the proteome of the murine hippocampus" S17, "Predictive Assays/Biomarkers 2" "The use of PCC for elucidating the mechanism underlying chromothripsis and for early triage biodosimetry in Malte Kriegs Hamburg, Germany "Kinomic profiling in radiation oncology: strategies towards personalized molecular targeting" Cläre von Neubeck Dresden, Germany "Using γ-h2ax Foci as potential predictors for individual radiosensitivity" Sarah Meneceur Dresden, Germany "Are residual γ-h2ax foci predictive for radiosensitivity? Evaluation of in vivo irradiated tumors and of ex vivo Judith Reindl Neubiberg, Germany "Using DNA DSB protein clusters as a potent marker for biological microdosimetry on high-let particle Kristian Unger "Prediction models in radiation oncology" "ERRS Bacq and Alexander Award Lecture", Deichmann Auditorium Catharine West Manchester, UK "ERRS General assembly", Deichmann Auditorium Conference Dinner S18, "Radiation Therapy/Stem Cells" "The MLL breakpoint cluster region: a target for chemo- and radiotherapy" Daniel Cullen Dublin, Ireland "Identification of prostate cancer patients at risk of late radiotoxicity following radiation therapy using Daniel Lopez Bogota, Colombia "Effect of NIS expression in response to treatment with external beam radiotherapy in a colon carcinoma cell Mozhgan Dehghan Harati Tübingen, Germany "Akt isoforms differently regulate ALDH activity and the expression of stem cell markers in cancer cells" Sylvia Ritter "Ionizing radiation alters the differentiation potential of human embryonic stem cells" Yannick Saintigny Caen, France "Multimodal treatments of radioresistant glioblastoma stem cells: emerging effective tryptic of "Radiobiology biomarkers and how to minimise fake news" 43rd Annual Meeting of ERRS and 20th Annual Meeting of GBS,, 2017

8 8:15-9:00 Chair: R. Coppes Thomas Helleday "Ionizing radiation negatively affects cardiac differentiation of pluripotent stem cells" THURSDAY, "Novel regulators of IR-induced DNA repair and dntp generation at DNA damage sites, and implications for cancer treatments" Chair: 9:00-9:20 Penny Jeggo "Double-strand breaks repair disorders " Sussex, United Kingdom 9:20-9:40 Wolfgang Dörr "Stem cells for amelioration of radiation-induced oral mucositis: Vienna, Austria preclinical studies" 9:40-10:00 Verena Jendrossek "Adaptation to the adverse tumor environment - towards novel combined treatment strategies" 10:00-10:20 Franz Rödel "PD-1/PD-L1, CD8 and FOXP3 expression and human papilloma virus Frankfurt am Main, Germany load in patients with anal squamous cell carcinoma treated with 10:20-10:40 Rob Coppes "Use of organoid cultures in the study of radiation response and Groningen, Netherlands regeneration" 10:40-11:00 11:00-11:15 11:15-11:30 11:30-11:45 11:45-12:00 12:00-12:15 12:15-12:30 12:30-13:30 Stockholm, Sweden S19, "Normal Tissue/Stem Cells Response" S20, "Low Dose Radiation Effects/Countermeasures" Diana Klein Carmen Rios Michael Scholz Rockville, United States "Radioprotection of normal lung "Expediting the drug development "Modelling the impact of cell cycle tissue by mesenchymal stem cell process by repurposing licensed dependent repair mechanisms and therapy" products a NIAID/RNCP viewpoint" repair deficiencies based on Lara Barazzuol Groningen, Netherlands "A coordinated DNA damage response activates adult quiescent neural stem cells in a niche-position "Gamma-tocotrienol as a promising radiation countermeasure for acute radiation syndrome: efficacy and Closing Ceremony and Farewell "From track structure to systems biology: How many roads must a man walk down..." Harry Schertan Serge Candéias Thomas Friedrich Grenoble, France "DNA damage in leukocytes after internal exposure to beta and alpha emitters" "Pre-exposure gene expression in baboons with and without pancytopenia after radiation "Low dose radiation accelerates ageing of the T cell receptor repertoire in mice" "Modelling of DNA damage by light ions from radiotherapy-relevant energies down to stopping" Insa Sigrid Schröder Vijay Singh Andrea Ottolenghi Bethesda, United States Pavia, Italy Felix Meyer Johanna Mirsch Mario Pietro Carante Hamburg, Germany Pavia, Italy "Interplay of DNA repair and stem-like phenotype determines the sensitizing effect of CHK1, RAD51 and PARP1 Danuta Galetzka Mainz, Germany "Molecular karyotyping and DNA methylation pattern analysis in primary fibroblasts of patients with Keynote Lecture 5 Plenary Session 4, "Clinical Translation of Radiation Biology" Michael Abend "Efficient DSB repair after low irradiation doses requires a critical cellular radical level" Lisa Deloch Erlangen, Germany "Low-dose irradiation has an impact on bone metabolism and reduces fibroblast-like synoviocytes in S21, "Modelling of DNA Damage Responses" Werner Friedland "Full predictions of cell death and chromosome damage along hadrontherapy dose profiles by the Kohei Sasaki Sapporo, Japan "A simulation study for both of the targeted and untargeted effect on the uniformly irradiated cells" "Which spatial dimensions of radiation damage interaction are relevant for the high effectiveness of

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