Patrick: An Introduction to Medicinal Chemistry 5e Chapter 09
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1 01) Proflavine is an intercalating agent which was used to treat wounded soldiers in the Far East during the second world war. Which of the following statements is false regarding proflavine? a. It a useful systemic antibacterial agent. b. Its planar shape is important to intercalation. c. The primary amine groups are protonated and interact with phosphate groups of the DNA backbone. d. When inserted into DNA, the tricyclic system can form van der Waals interactions with base pairs above and below it. 02) The following antibiotic structure (Dactinomycin) is an intercalating agent. Which region of the molecule is chiefly responsible for its ability to intercalate into DNA? a. The tricyclic system. b. One of the macrocyclic peptide rings. c. Both of the macrocyclic peptide rings. d. The amide bonds. 03) What term is used to describe the strategy where an oligonucleotide is designed such that it base pairs with a segment of messenger RNA and blocks protein translation? a. Sense therapy. b. Anticodon therapy. c. Codon therapy. d. Antisense therapy.
2 04) The following compounds (i), (ii) and (iii) are antiviral drugs which mimic natural nucleosides. What nucleosides do they mimic? a. Deoxythymidine b. Deoxyguanosine c. Deoxycytidine d. Deoxyadenosine 05) Which statement is false regarding the fluoroquinoline antibacterial agents? a. They target enzymes called helicases. b. They inhibit replication. c. They inhibit transcription. d. They stabilise an enzyme-dna-drug complex where four fluoroquinoline molecules are stacked together. 06) Proflavine is an antibacterial agent that was used in the Second World War. Which one of the following structures is proflavine? a. Structure A. b. Structure B. c. Structure C. d. Structure D.
3 07) Dactinomycin is an intercalating anticancer agent. Interactions with particular base pairs are favoured in the intercalation of this compound. Which base pairs are favoured? a. Cytosine-guanine. b. Adenine-thymine. c. Adenine-uracil. d. Thymine-guanine. 08) Dactinomycin is an intercalating anticancer agent. Which region of the molecule interacts with the sugar phosphate backbone of DNA? a. The cyclic peptides. b. The amide groups. c. The tricyclic system. d. All of the answers are correct.
4 09) The following group of structures (tetracyclines) are intercalating anticancer agents. To which family of compounds do these structures belong? a. Podophyllotoxins. b. Camptothecins. c. Anthracyclines. d. Bleomycins. 10) The following group of structures are intercalating anticancer agents. How many rings of the tetracyclic system are involved in the intercalation? a. 1 b. 2 c. 3 d. 4
5 11) The following group of structures are intercalating anticancer agents. What role does the ammonium ion play in the molecule's mode of action? a. It makes the molecule water soluble. b. It prevents the molecule crossing cell membranes. c. It forms a hydrogen bond to a deoxyribose sugar moiety on the DNA backbone. d. It forms an ionic bond to a phosphate group on the DNA backbone. 12) The following is representative of a group of natural products which are intercalating anticancer agents. What are these group of compounds called? a. Podophyllotoxins. b. Camptothecins. c. Anthracyclines. d. Bleomycins.
6 13) Bleomycins are natural products which are intercalating anticancer agents. Which region of the molecule is involved in intercalation? a. The carbohydrate ring system. b. The pyrimidine ring. c. The imidazole ring. d. The bithiazole ring system. 14) Bleomycins are natural products which are intercalating anticancer agents. They chelate a ferrous ion as part of their mechanism of action. Which region of the molecule is important in chelating ions? a. The pyrimidine ring. b. The imidazole ring. c. The primary amine groups. d. All of the answers are correct.
7 15) Identify the following structures: Patrick: An Introduction to Medicinal Chemistry 5e A B C D a. Structure A b. Structure D c. Structure C d. Structure B 16) The following structure (etoposide) is used as an anticancer agent. Etoposide is a semi-synthetic derivative of which compound? a. Epipodophyllotoxin. b. Teniposide. c. Etoposide. d. Podophyllotoxin.
8 17) The following structure (etoposide) is used as an anticancer agent. Which enzyme is targeted by etoposide? a. Topoisomerase II. b. DNA polymerase. c. DNA ligase. d. Topoisomerase I. 18) Etoposide is used as an anticancer agent. Which of the following groups is crucial to the mechanism of etoposide in producing radical species? a. The bicyclic substituent at position 4. b. The lactone. c. The methoxy substituents at positions 2' and 5'. d. The phenolic substituent at position 4'.
9 19) The following group of compounds are cytotoxic alkaloids used as anticancer agents. a. Bleomycins. b. Camptothecins. c. Podophyllotoxins. d. Anthracyclines. 20) Camptothecins are cytotoxic alkaloids used as anticancer agents. What is the target for these compounds? a. Topoisomerase II. b. DNA polymerases. c. DNA ligase. d. Topoisomerase I. 21) The following agent is used for the treatment of Hodgkin's lymphoma as part of a multi-drug regime. What sort of agent is it? a. A topoisomerase inhibitor. b. An alkylating agent. c. An antimetabolite. d. A receptor antagonist.
10 22) The following agent is used for the treatment of Hodgkin's lymphoma as part of a multi-drug regime. What is the name of the activated species which is formed from the above structure and which acts as the actual alkylating agent? a. A quaternary ammonium ion. b. An iminium ion. c. A cyclopropylamine ion. d. An aziridinium ion. 23) The following structure is called lomustine, and is used in the treatment of brain tumours. To which group of compounds does it belong? a. Nitrosoureas. b. Nitrogen mustards. c. Camptothecins. d. Podophyllotoxins. 24) The following structure is called lomustine and is used in the treatment of brain tumours. Which of the following statements is true regarding the above structure? a. It cannot cross the blood brain barrier. b. It is activated by an enzymatic metabolic reaction. c. It cannot be given orally. d. It is a prodrug for both an alkylating agent and a carbamoylating agent.
11 25) The following agent (busulfan) is used in the treatment of chronic granulocytic leukaemia: Which of the following statements is not true regarding the above agent? a. The sulfonate groups are good leaving groups. b. It readily alkylates guanine residues. c. It produces interstrand cross linking of DNA. d. The mechanism involves an S N 1 nucleophilic substitution. 26) The following agent (dacarbazine) is used in the treatment of a variety of cancers including melanoma. Which of the following statements is true regarding dacarbazine? a. It is a prodrug which is activated by peptidases. b. The active agent is a methyldiazonium ion. c. Acetaldehyde is lost during degradation of the compound. d. The active agent acts as an enzyme inhibitor. 27) The following agent is called mitomycin C and is used as an anticancer drug against a variety of cancers. The structure is a prodrug which is converted in the body to the active compound. What is the initial step in this activation process? a. Ring opening of the aziridine ring. b. Hydrolysis of the urethane group. c. Alkylation of the primary amino group. d. Reduction of the quinone ring system.
12 28) The following agent is called mitomycin C and is used as an anticancer drug against a variety of cancers: Which of the following statements is true regarding the above drug? a. It is one of the safest anticancer agents used in clinical practice. b. It promotes intrastrand cross linking in DNA. c. Adenine units are alkylated by the agent. d. It is possible that the drug may be more effective against tumours in oxygen starved environments. 29) The following structure is calicheamicin 1 and is an anti tumour agent derived from a bacterium. Which of the following functional groups is not involved in the mechanism of action? a. Thioamide. b. Trisulfide. c. -unsaturated ketone. d. Enediyne system.
13 30) The following structure is calicheamicin 1 and it is an anti tumour agent derived from a bacterium: What effect does the agent have? a. It alkylates DNA. b. It is an antimetabolite. c. It inhibits topoisomerases. d. It cleaves the DNA chain by the production of radicals. 31) Match the following agents (aciclovir, calicheamicin 1 chlormethine, doxorubicin) to their mechanism of action (alkylating agent, chain cutting agent, chain terminator, intercalating agent) a. Doxorubicin b. Chlormethine c. Calicheamicin 1 d. Aciclovir 32) Which of the following structures is not an intercalating agent? a. Structure A. b. Structure B. c. Structure C. d. Structure D.
14 33) Cisplatin is used for the treatment of testicular and ovarian cancers. Which of the following statements is untrue? a. The amino groups are displaced before the drug becomes active. b. Intrastrand cross linking of DNA results from the action of the agent. c. Base pairing between cytosine and guanine is disrupted by the agent. d. Ondansetron is often administered with the agent to reduce nausea. 34) Identify the following structures: a. Procarbazine b. Calicheamicin 1 c. Dacarbazine d. Mitomycin C 35) What is the active form of aciclovir? a. The compound itself. b. The monophosphate. c. The diphosphate. d. The triphosphate.
15 36) Aciclovir is a prodrug which is phosphorylated in virally infected cells to the active antiviral agent. Which of the following structures is the active agent? a. Structure A. b. Structure B. c. Structure C. d. Structure D.
Patrick: An Introduction to Medicinal Chemistry 5e Chapter 06
01) Match the following structures to their names. a. b. c. d. 02) ame the following structures (i) (iv) i) H ii) 2 iii) iv) H 2 CH 3 H H H H H H a. Deoxyadenosine = b. Deoxyguanosine = c. Deoxythymidine
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