6th International Workshop on the Treatment of Hepatic and Lung Metastases and Peritoneal Carcinomatosis of Colorectal Carcinoma

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2 6th International Workshop on the Treatment of Hepatic and Lung Metastases and Peritoneal Carcinomatosis of Colorectal Carcinoma November 16th and 17th, 2017 Venue: Hotel NH Barcelona Constanza Barcelona, Spain Organised by: Oncology and Hematology Service Unit of Hepato- Biliary and Pancreatic Surgery Thoracic Surgery Service Hospital Universitari MútuaTerrassa (Terrassa, Barcelona, Spain)

3 We welcome you to the SIXTH EDITION of the INTERNATIONAL WORKSHOP ON THE TREATMENT OF HEPATIC AND LUNG METASTASES AND PERITONEAL CARCINOMATOSIS OF COLORECTAL CARCINOMA that will take place in Barcelona (Spain) on the 16th and 17th November, 2017 For the first time we have included Peritoneal Carcinomatosis because of its clinical relevance and challenging management. The Workshop is focusing on the state-of-the art of the multimodal management of these three metastasic sites. We invite you to actively participate In the scientific programme. We look forward to an interesting and productive meeting and hope to see you in Barcelona! Lluis Cirera Workshop s Chairman Esteban Cugat and Ramón Rami-Porta Workshop s Vice-Chairmen

4 COMMITTEE Workshop coordinators Chairman: Lluis Cirera Vice-Chairmen: Esteban Cugat, Ramón Rami-Porta Organizing committee José Belda Carla Bellido Sergi Call Esther Casado Lluis Cirera Esteban Cugat Salvadora Delgado Julen Fernández Maribel García-Domingo José Manuel González Eric Herrero José Ángel de Marcos Marta Paraira Ramón Rami-Porta Montserrat Ysamat Scientific committee Rene Adam Sergi Call Lluis Cirera Esteban Cugat Jesús García-Foncillas Ramón Rami-Porta Paul van Schil Paul H. Sugarbaker

5 PROGRAMME

6 Thursday, November 16th, :00-10:45 11:00-11:30 11:30-14:00 14:00-15:15 14:15-20:00 15:15-16:40 Registration Welcome and introduction Rosa Asbert. Medical Director. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Lluis Cirera. Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud Barcelona Sponsored symposia Lunch Poster display INTERACTIVE SESSION 1: Clinical case with multidisciplinary team discussion. Patient with liver metastases and peritoneal carcinomatosis Moderators: Esteban Cugat. Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Lluis Cirera. Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona 15:15-15:45 15:45-16:00 16:00-16:15 16:15-16:30 16:30-16:40 Clinical case presentation Comments: Pedro Barrios. Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí Surgery of Liver Metastases: How far should we go? René Adam. Oncosurgical Unit. Hepatobiliary Center. University Paris Sud. Hôpital Paul-Brousse. Paris Radiological disappearance of hepatic metastases after systemic treatment: What can we do? Miguel Ángel Gómez Bravo. Surgery and Trasplantation Unit. Hospital Universitario Virgen del Rocio. Sevilla Minimal residual disease: a new paradigm Ramón Salazar. Medical Oncology. Institut Català de Oncologia. Barcelona Discussion

7 16:40-17:10 LECTURE Introduction: Eric Herrero. Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Fernando Pardo. Hepatobiliary Surgery Service. Clínica Universitaria de Navarra. Pamplona. Navarra 16:40-17:00 17:00-17:10 Staged hepatectomy: to rush with ALPPS or to wait with conventional two-stage? René Adam. Oncosurgical Unit. Hepatobiliary Center. University Paris Sud. Hôpital Paul-Brousse. Paris Questions 17:10-17:40 17:40-18:50 Coffee Break LIVER METASTASES Moderators: Maribel García Domingo. Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Miguel Ángel Gómez Bravo. Surgery and Trasplantation Unit. Hospital Universitario Virgen del Rocio. Sevilla 17:40-18:10 18:10-18:25 18:25-18:40 18:40-18:50 Benefits of laparoscopic liver resection Rubén Ciria. Surgery Service. University Hospital Reina Sofia. Córdoba Metastases resection after Aflibercept in second-line chemotherapy Andrés Muñoz. Oncology Service. Hospital Gregorio Marañón. Madrid Liver surgery before primary tumour resection Fernando Pardo. Hepatobiliary Surgery Service. Clínica Universitaria de Navarra. Pamplona. Navarra Discussion 18:50-19:30 LECTURE Introduction: Marta Paraira. Radiodiagnostic Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

8 18:50-19:00 19:00-19:20 19:20-19:30 Liver imaging: MRI or CT? Judith Camps. Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Genomics and radiogenomics Luis Marti-Bonmati. Radiology Service. Hospital Universitario y Politécnico La Fe. Valencia Questions Friday, November 17th, :00-08:55 INTERACTIVE SESSION 2: Clinical case with multidisciplinary team discussion. Patient with lung and liver metastases Moderators: Mireia Serra. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Julen Fernández. Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona 08:00-08:30 08:30-08:45 08:45-08:55 Clinical case presentation Biomarkers for selection of chemotherapy David Paez. Medical Oncology Service. Hospital de la Santa Creu i Sant Pau. Barcelona Discussion 08:55-09:25 LECTURE Introduction: Ramón Rami-Porta. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Laureano Molins. Thoracic Surgery Service, Hospital Clínic, Hospital Universitari Sagrat Cor. Barcelona -Centro Médico Teknon. Grupo Quirónsalud. Barcelona 08:55-09:15 09:15-09:25 Surgery and ablative techniques for treatment of lung metastases of colorectal cancer: past, present and future Tom Treasure. Clinical Operational Research Unit. University College London. London Questions

9 09:25-09:45 09:45-10:55 Coffee Break LUNG METASTASES Moderators: Sergi Call. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Ramón Rami-Porta. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa 10:55-11:25 09:45-10:00 10:00-10:15 10:15-10:30 10:30-10:45 10:45-10:55 LECTURE Surgery for lung metastases of colorectal carcinoma. Do we believe in what we do? Results from the Survey of the Spanish Society of Thoracic Surgery Raúl Embún. Department of Thoracic Surgery. Hospital Universitario Miguel Servet. Zaragoza Role of major lung resections in the surgical treatment of lung metastases of colorectal carcinoma Jorge Hernández. Thoracic Surgery Unit. Hospital Universitari del Sagrat Cor. Barcelona Technical aspects of laser resection of lung metastases Sebastian Wiesemann. Department of Thoracic Surgery. University Medical Center Freiburg. Freiburg Isolated lung perfusion and related techniques for treatment of pulmonary metastasis. Is survival really improved? Paul Van Schil. Department of Thoracic and Vascular Surgery. University Hospital of Antwerp. Edegem Discussion Introduction: Pedro Barrios. Oncology surgery service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí 10:55-11:15 11:15-11:25 Management for peritoneal metastases: an update Paul H. Sugarbaker. Medical Director. Center for Gastrointestinal Malignancies Chief. Program in Peritoneal Surface Oncology. MedStar Washington Hospital Center. Washington Questions

10 11:25-13:05 INTERACTIVE SESSION 3: Clinical case with multidisciplinary team discussion. Patient with peritoneal carcinomatosis Moderators: Esther Casado. Oncology Service. Althaia. Xarxa Assistencial de Manresa. Manresa. Barcelona María Isabel Ramos. Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí 11:25-11:55 11:55-12:10 12:10-12:25 12:25-12:40 12:40-12:55 12:55-13:05 Clinical case presentation Pathophysiology of colorectal peritoneal carcinomatosis Paul H. Sugarbaker. Medical Director. Center for Gastrointestinal Malignancies Chief. Program in Peritoneal Surface Oncology. MedStar Washington Hospital Center. Washington Diagnostic imaging in peritoneal carcinomatosis Nadine Romera. Radiology Service. Hospital Quirónsalud. Barcelona -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Immune chekpoints and immunotherapy for mcrc Ferrán Losa. Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí Outcomes in the care of peritoneal carcinomatosis in the Catalonian public health system José María Borrás. University of Barcelona and Catalonian Cancer Strategy Discussion 13:05-13:35 LECTURE Introduction: Lluis Cirera. Oncology and Hematology. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona 13:05-13:25 13:25-13:35 Sidedness or molecular profile Jesús García-Foncillas. Oncology Department. Fundación Jiménez Díaz. Madrid Questions

11 13:35-14:10 POSTER SESSION 1 Increase in splenic volume predicts hepatic injury in patients with colorrectal liver metastases treated with chemotherapy Patricia Saez Carlin, Alejandra García Botella, Luis Díez Valladares, Ramiro Méndez Fernández, Luis Ortega Medina, Antonio Torres García Hospital Clínico San Carlos, Madrid. Spain 2 CD133 + cell infusion in patients with colorectal liver metastases going to be submitted to a major liver resection Alejandra García Botella, Patricia Sáez Carlin, Luis Ignacio Díez Valladares, Rocio Avellana, Luis Ortega Medina, Ramiro Méndez Fernández, Javier Armijo, Antonio Torres García Hospital Clínico San Carlos, Madrid. Spain 3 Oncological strategies in rectal cancer with liver metastases Lucas Casalduero García, Alberto Carabias Hernández, Carlos José Gamo Albero, Paloma Sanz Muñoz, Alvaro Sobrino Grande, Ana Serantes, Miguel Ángel Delgado, Jose María Jover Navalón Hospital Universitario de Getafe, España 4 Utility of 3D printing model reconstruction in complex hepatic surgery. Our experience Luque Molina, A 1 ; Alcalá, L2; López León, M3; López Martínez, C 1 ; Jodral, T 1 ; Luna Alcalá 2, A; López Cillero, P 3 1 Unidad de Cirugía HBP HSJDD Córdoba; 2 Servicio Radiología HSJDD Córdoba; 3 Facultad de Medicina Universidad de Córdoba 5 Oligometastasic colorectal cancer (CRC) lung metastases treated with stereotactic body radiotherapy (SBRT), experience of Hospital Universitario Donostia María Otaño 1, M.Aránzazu Bujedo 1, Ana Landa 1, M.Ángeles Díaz 1, Daniel Roura 2, M.Eguzki Iraolagoitia 2, Leyre González 2, Julian Minguez 2, Adelaida La Casta1 1 Medical Oncology, Hospital Universitario Donostia; 2 Radiotherapic Oncology, Hospital Universitario Donostia. San Sebastian, Spain 6 Wound recurrence: a rare event after colorectal hepatic metastases surgery A. Landa Magdalena; A. La Casta Muñoa; M. Otaño Ariño; MA. Diaz Gallego; M. Alkorta Zuloaga Hospital Universitario Donostia. San Sebastian. Spain

12 7 Location of colorectal cancer as a prognosis factor and a predictor in our area Jose Carlos Benítez1 MD, Julen Fernandez 1 MD, Carmen Ferrer 2 MD, José Ángel de Marcos 3 MD, Marta Paraira 3 MD, Luis Cirera1 MD 1 Department of Medical Oncology. Hospital Universitari Mutua Terrassa. Terrassa, University of Barcelona, Barcelona, Spain. 2 Department of Pathology. Hospital Universitari Mutua Terrassa. Terrassa, University of Barcelona, Barcelona, Spain. 3 Department of Radiology. Hospital Universitari Mutua Terrassa. Terrassa, University of Barcelona, Barcelona, Spain 14:10-14:15 14:15-14:20 14:20 BEST POSTER AWARD Closing LUNCH

13 SPEAKERS AND CHAIRPERSONS René Adam Oncosurgical Unit. Hepatobiliary Center. University Paris Sud. Hôpital Paul-Brousse. Paris Rosa Asbert Medical Director. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Pedro Barrios Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí José María Borrás University of Barcelona and Catalonian Cancer Strategy Sergi Call Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Judith Camps Surgery Service. Hospital MútuaTerrassa. Terrassa. Barcelona Esther Casado Oncology Service. Althaia. Xarxa Assistencial de Manresa. Manresa. Barcelona Lluis Cirera Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Rubén Ciria Surgery Service. University Hospital Reina Sofia. Córdoba Esteban Cugat Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Raúl Embún Department of Thoracic Surger. Hospital Universitario Miguel Servet. Zaragoza Julen Fernández Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Maribel García Domingo Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Jesús García-Foncillas Oncology Department. Fundación Jiménez Díaz. Madrid

14 Miguel Ángel Gomez Bravo Surgery and Trasplantation Unit. Hospital Universitario Virgen del Rocio. Sevilla Jorge Hernández Thoracic Surgery Unit. Hospital Universotari del Sagrat Cor. Barcelona Eric Herrero Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Ferrán Losa Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí Luis Marti-Bonmati Radiology Service. Hospital Universitario y Politécnico La Fe. Valencia Laureano Molins Thoracic Surgery Service. Hospital Clínic. Hospital Universitari Sagrat Cor. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Andrés Muñoz Oncology Service. Hospital Gregorio Marañón. Madrid David Paez Medical Oncology Service. Hospital de la Santa Creu i Sant Pau. Barcelona Marta Paraira Radiodiagnostic Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona Fernando Pardo Hepatobiliary Surgery Service. Clínica Universitaria de Navarra. Pamplona. Navarra Ramón Rami-Porta Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona María Isabel Ramos Oncology Surgery Service. Hospital Sant Joan Despí Moisès Broggi. Sant Joan Despí Nadine Romera Radiology Service. Hospital Quirónsalud. Terrassa -Centro Médico Teknon. Grupo Quirónsalud. Barcelona Ramón Salazar Medical Oncology. Institut Català de Oncologia. Barcelona Mireia Serra Thoracic Surgery Service. Hospital MútuaTerrassa. Terrassa. Barcelona

15 Paul H. Sugarbaker Medical Director. Center for Gastrointestinal Malignancies Chief. Program in Peritoneal Surface Oncology. MedStar Washington Hospital Center. Washington Tom Treasure Clinical Operational Research Unit. University College London. London Paul Van Schil Department of Thoracic and Vascular Surgery. University Hospital of Antwerp. Edegem Sebastian Wiesemann Department of Thoracic Surgery. University Medical Center Freiburg. Freiburg

16 SPONSORED SYMPOSIUMS 11:30-12:15 Treatment intensity modulation based on Bevacizumab in mcrc patients candidates to surgery Sponsored by Roche Management of potentially resectable colorectal cancer liver metastases Carles Pericay. Oncology Service. Hospital Parc Taulí. Sabadell Oncologist s point of view Vicente Alonso. Oncology Service. Hospital Miguel Servet. Zaragoza Surgeon s point of view Esteban Cugat. Surgey Service. Hospital Universitari MútuaTerrassa. Terrassa Discussion Carles Pericay. Oncology Service. Hospital Parc Taulí. Sabadell 12:20-13:05 Therapeutical Strategies in Metastatic Colorectal Cancer (mcrc): The Value of Panitumumab Sponsored by Amgen Moderator: Dr. Alfredo Carrato. Hospital Ramon y Cajal. Madrid Optimal sequencing in the treatment of mcrc: What s the role of Panitumumab? Dr. Javier Gallego. Hospital General Universitario de Elche. Alicante Does the sideness impact the treatment decision? New Panitumumab data Dra. Elena Elez. Hospital Vall d Hebron. Barcelona 13:10-13:55 Seeing is believing: livermetsurvey & ADCC Sponsored by Merck René Adam. Oncosurgical Unit. Hepatobiliary Center. University Paris Sud. Hôpital Paul-Brousse. Paris Jesús García-Foncillas. Oncology Department. Fundación Jiménez Díaz. Madrid

17 GENERAL INFORMATION

18 DATES November 16th and 17th, Barcelona, (Spain) VENUE Hotel NH Barcelona Constanza St/ Deu i Mata, Barcelona (Spain) TECHNICAL SECRETARIAT (REGISTRATION AND HOTEL RESERVATION) Acto Serveis C/ Bonaire, Mataró (Barcelona) Tel Fax info@oncology-bcn.com REGISTRATION Registration Fees Members of: ACROSS, AEC, GEMCAD, SEOM, TTD, ESSO Before September 15th After September 16th and on-site registration Others Residents *VAT (21% IVA) is included* ACOMMODATION Double Room Hotel NH Barcelona Constanza

19 CITY INFORMATION Barcelona overlooks the Mediterranean and is located in a heavily populated area which is a hub of economic activity. Barcelona enjoys a Mediterranean climate, with mild winters and warm summers. It is a coastal city and has over four kilometres of urban beaches and large areas of nearby forest. Although it is a large city, it is easy to get around on public transport and on foot. You can reach any point in the city by metro, bus and taxi. Barcelona is the capital of Catalonia. Its inhabitants are open and welcoming. The people of Barcelona speak Catalan, their own language, and Spanish. Many of them also understand a little English and French Visa Spain is part of the Schengen zone. This means that nationals from EU countries do not need a visa. Lenguage Most of Barcelona s inhabitants are bilingual and speak Catalan, their own language, and Spanish. Electricity The voltage in Spain is 220 volts, 50 Hz. The plug types are C and F. Climate The city has a typically Mediterranean climate and enjoys pleasant temperatures all the year round. Currency The euro ( ) is the official currency of the European Union and can be exchanged at savings banks and banks. Banks Business hours differ between banks. Most banks are open from Monday to Friday from 08:15 to 14:15. Customs In Barcelona mealtimes are usually a little later than the rest of Europe. The city s shops have long opening hours. Shopping in Barcelona Monday to Saturday, from 09:30 to 13:30 and from 16:30 to 20:00. Most of the department stores do not close at mid-day.

20 ACADEMIC SUPPORT EACCME CREDITS Each participant can only receive the number of credits he/she is entitled to according to his/her actual participation at the event once he/she has completed the feedback form. Cf. criteria 9 and 23 of UEMS In order to help you issue individual certificates to each participants, please find below the breakdown of ECMEC s per day: , ,00 The EACCME awards ECMEC s on the basis of 1 ECMEC for one hour of CME with a maximum of 8 ECMEC s per day. Cf. Chapter X of UEMS

21 SPONSORED BY SUPPORTED BY

22 TECHNICAL SECRETARIAT Acto Serveis C/ Bonaire, Mataró (Barcelona) Tel Fax