TAVR: Echo Measurements Pre, Post And Intra Procedure
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1 2017 ASE Florida, Orlando, FL October 10, :00 8:25 AM 25 min TAVR: Echo Measurements Pre, Post And Intra Procedure Muhamed Sarić MD, PhD, MPA Director of Noninvasive Cardiology Echo Lab Associate Professor of Medicine Disclosures Speakers Bureau (Philips, Medtronic) Advisory Board (Siemens) 1
2 PRIMARY INDICATIONS FOR SURGICAL OR PERCUTANEOUS TREATMENT OF AORTIC STENOSIS SEVERE Aortic Stenosis SYMPTOMS Dyspnea, angina, syncope LV FUNCTION Diminished LVEF Severe symptomatic AS irrespective of LVEF Severe AS with diminished LVEF irrespective of symptoms TAVR Indications Based on STS Risk Score LOW RISK (< 4 %) INTERMEDIATE (4 8 %) HIGH RISK (> 8 %) TAVR vs. surgical AVR trials in progress TAVR is a safe and effective alternative to surgical AVR 2
3 TAVR Prostheses Used in United States Edwards Sapien Valves Balloon-expandable bovine pericardial aortic valve prosthesis Medtronic CoreValves Self-expandable porcine pericardial aortic valve prosthesis TAVR Prostheses Used in United States Edwards Sapien Valve Balloon Expandable Medtronic CoreValve Self Expanding 3
4 Sapien Valve Implantation CoreValve Implantation 4
5 IMAGING IN PATIENTS UNDERGOING TAVR Role of various imaging modalities before, during and after TAVR procedure Role of echocardiography relative to other imaging modalities in TAVR cases Echo CT Fluoroscopy IMAGING IN PATIENTS UNDERGOING TAVR BEFORE TAVR Procedure DURING TAVR Procedure AFTER TAVR Procedure ECHOCARDIOGRAPHY : Primary means of establishing diagnosis, severity and subtype of aortic stenosis : Secondary means of TAVR valve sizing ECHOCARDIOGRAPHY : Primary means of assessing for paravalvular leak, overall valve function and possible complications. ECHOCARDIOGRAPHY : Primary means of assessing for prosthetic and overall cardiac function. CHEST CT : Primary means of TAVR valve sizing FLUOROSCOPY / CINE : Primary means of AVR valve implantation guidance Saric M, Williams MR. Transthoracic echocardiography guidance for TAVR. J Am CollCardiol Img. 2015;8(3):
6 Echocardiography Prior to TAVR ROLE OF ECHO PRIOR TO TAVR Establish whether indications for TAVR are present Severity of aortic stenosis Subtype of aortic stenosis (high vs. low-gradient) Asses LV ejection fraction Assist in TAVR valve sizing 6
7 Types of Aortic Stenosis Classic High-Gradient AS 65-85% Low-Gradient AS with Preserved EF 10-25% Low-Gradient AS with Diminished EF 5-10% Severe Aortic Stenosis TTE Apical 3-Chamber 7
8 Severe Aortic Stenosis TTE Apical 3-Chamber Severe Aortic Stenosis TTE Apical 4-Chamber 8
9 Severe Aortic Stenosis TTE Apical 5-Chamber SEVERE AORTIC STENOSIS Continuous Wave (CW) Doppler Pulsed Wave (PW) Doppler AORTIC VALVE VTI = 134 cm Vmax = 4.3 m/sec Peak/Mean Gradient 74/43 mm Hg LVOT VTI = 24 cm Vmax = 0.8 m/sec Area 3.14 cm 2 Dimensionless Index = 24 / 134 = 0.18 Aortic Valve Area = 0.6 cm 2 9
10 SEVERE SENILE CALCIFIC AORTIC STENOSIS OF A TRILEAFLET AORTIC VALVE Severe Aortic Stenosis Peak velocity (V max ) > 4 m/sec Mean gradient (ΔP mean ) > 40 mm Hg Dimensionless Index < 0.25 Aortic valve area (AVA) < 1.0 cm 2 AVA Index < 0.6 cm 2 /m 2 Our Patient 4.3 m/sec 43 mm Hg cm cm 2 /m 2 ASE/EAE Guidelines on Valvular Stenosis J Am Soc Echocardiogr May;22(5):442. TTE STUDY CONCLUSIONS Severe senile calcific high-gradient aortic stenosis of a trileaflet native aortic valve with preserved LVEF If symptoms attributable to aortic stenosis are: Present >>> Refer for TAVR evaluation Absent >>> Consider stress testing 10
11 SEVERE SENILE CALCIFIC AORTIC STENOSIS OF A TRILEAFLET AORTIC VALVE Severe Aortic Stenosis Peak velocity (V max ) > 4 m/sec Mean gradient (ΔP mean ) > 40 mm Hg Dimensionless Index < 0.25 Aortic valve area (AVA) < 1.0 cm 2 AVA Index < 0.6 cm 2 /m 2 Our Patient m/sec mm Hg cm cm 2 /m 2 ASE/EAE Guidelines on Valvular Stenosis J Am Soc Echocardiogr May;22(5):442. AORTIC STENOSIS 2014 ACC/AHA Valvular Heart Disease Guidelines Low Gradient AS Low LVEF Normal LVEF 11
12 AORTIC STENOSIS 2014 ACC/AHA Valvular Heart Disease Guidelines Low Gradient AS DOBUTAMINE STRESS ECHO (LV Contractile Reserve) EXERCISE STRESS TESTING (Symptoms) Low LVEF Normal LVEF Echocardiography During TAVR Procedure 12
13 Question Echo Type Should I use transesophageal echo (TEE) or transthoracic echo (TTE) during TAVR procedures? These recommendations support the use of TEE for TAVR. 13
14 J Am Coll Cardiol Img. 2015;8(3): Evolution of Anesthesia & Echo Imaging for TAVR INITIAL TAVR EXPERIENCE General anesthesia SUBSEQUNT TAVR EXPERIENCE Moderate sedation Endotracheal intubation No endotracheal intubation TEE guidance TTE guidance 14
15 Semin Cardiothorac Vasc Anesth. 2016;20(2): NYU TAVR Program TEE vs. TTE Sep 1, 2011 Nov 30,
16 What to Look For During TAVR on Echo? TAVR Valve Function Paravalvular Leak Complications TAVR Intraprocedural Echo Evaluation When.. Proper preprocedural TAVR valve sizing is done, and When newer generation TAVR valves are used, By a an experienced TAVR team TAVR procedure is typically uneventful Complications are relatively rare 16
17 TAVR Valve Function TAVR: Markers of Good Implantation Valve Shape & Location Short axis: Circular rather than ovoid Long axis: Proximal end just a few millimeters in the LVOT Valve Gradient Vmax typically < 2.0 m/sec Valve Regurgitation No significant paravalvular or transvalvular aortic regurgitation If one or more suboptimal, consider: Repositioning TAVR valve (for self-expanding valves) Post-dilatation of TAVR valve with a balloon Implantation of another TAVR valve (valve-in-valve procedure) 17
18 TAVR Valve Shape TAVR Valve Shape OPTIMAL SHAPE Circular 18
19 TAVR Valve Shape SUBOPTIMAL SHAPE Ovoid TAVR Valve Location OPTIMAL LOCATION No excessive protrusion into LVOT 19
20 TAVR Valve Location SUBOPTIMAL LOCATION Too deep into LVOT Most Common TAVR Valves at Present BALLOON EXPANDABLE Sapien 3 SELF-EXPANDING CoreValve Evolut R SELF-EXPANDING CoreValve Evolut Pro 20
21 TAVR Valve Gradients Aortic Valve Gradients Pre & Post TAVR Before TAVR (Severe native valve stenosis) Vmax = 4.3 m/sec Peak/Mean Gradient 74/43 mm Hg Time to peak gradient 140 msec (late peaking) After TAVR (Minimal aortic valve gradients) Vmax = 1.4 m/sec Peak/Mean Gradient 9/3 mm Hg Time to peak gradient 95 msec (early peaking) 21
22 TAVR Valve Gradients OPTIMAL GRADIENT Vmax < 2.0 m/sec SUBOPTIMAL GRADIENT Vmax > 2.0 m/sec Vmax = 1.4 m/sec Peak/Mean Gradient 9/3 mm Hg Time to peak gradient 95 msec (early peaking) Vmax = 2.6 m/sec Peak/Mean Gradient 27/17 mm Hg Time to peak gradient > 100 msec (late peaking) Paravalvular Leak Evaluation 22
23 Older TAVR Designs Newer TAVR Designs JACC Cardiovasc Imaging Mar;8(3):
24 TAVR PROCEDURE TRANSTHORACIC ECHO Annulus CoreValve inserted too deep into LVOT 24
25 TAVR PROCEDURE TRANSTHORACIC ECHO Significant Paravalvular Aortic Regurgitation TAVR PROCEDURE TRANSTHORACIC ECHO Significant Paravalvular Aortic Regurgitation 25
26 TAVR PROCEDURE TRANSTHORACIC ECHO Significant Paravalvular Aortic Regurgitation POST TAVR TRANSESOPHAGEAL ECHO Significant Paravalvular Aortic Regurgitation 10/10/2017 NYU LEON H. CHARNEY DIVISION OF CARDIOLOGY 52 26
27 PARAVALVULAR AORTIC REGURGITATION POST TAVR No easy way to grade it VARC II Criteria An expert consensus without empiric validation POST TAVR TRANSESOPHAGEAL ECHO AR occupies > 30% of prosthetic circumference Consistent with severe aortic regurgitation 27
28 TAVR PROCEDURE TRANSTHORACIC ECHO Pressure Half-time = 63 msec Consistent with acute aortic regurgitation POST TAVR TRANSESOPHAGEAL ECHO Holodiastolic Flow Reversal in Descending Aorta Consistent with severe aortic regurgitation 28
29 Echocardiography Post TAVR Procedure What to Look For Post TAVR on Echo? Assess for TAVR complications Pericardial effusion LV rupture [LV wire related] RV rupture [Pacing wire related] Annular rupture 29
30 Thank you! New York University Langone Medical Center Case #1 Pericardial Effusion Post LV Wire Removal 30
31 Prior to CoreValve Insertion 6:49:59 PM No pericardial effusion Post CoreValve Insertion But Wire Still in LV 7:23:03 PM First TEE image of CoreValve 7:26:036 PM Still no effusion 31
32 Post TAVR Insertion, LV Wire Removed 7:31:06 PM First appearance of effusion 7:39:01 PM Massive effusion Case #2 Pericardial Effusion Post RV Wire Removal 32
33 Day 0 Uneventfully implantation of a TAVR valve No pericardial effusion Day 1 Hypotension minutes post removal of temporary RV pacing wire New hemorrhagic pericardial effusion 33
34 Day 1 Hypotension minutes post removal of temporary RV pacing wire Mitral Inflow Marked respiratory variations indicative of tamponade Day 1 Post Pericardiocentesis Resolution of pericardial effusion 34
35 Case #3 Annular Rupture After CoreValve Post Dilation CASE 2017;1(2):
36 ANNULAR RUPTURE POST TAVR Balloon Expandable TAVR Self-expanding TAVR Several Weeks Post CoreValve Severe new-onset heart failure with normal LVEF Bilateral pleural effusions 36
37 Several Weeks Post CoreValve Severe new-onset heart failure with normal LVEF Abnormal color Doppler jet at caudal end of CoreValve 37
38 Several Weeks Post CoreValve Severe new-onset heart failure with normal LVEF Abnormal color Doppler jet from CoreValve region to RVOT Several Weeks Post CoreValve Severe new-onset heart failure with normal LVEF Systolic AND diastolic flow 38
39 TTE Study Conclusions Peri-annular rupture with ascending aorta to RVOT communication CONTRAST CT CONFIRMS ANNULAR RUPTURE 39
40 CONTRAST CT CONFIRMS ANNULAR RUPTURE 40
41 TEE & Fluoroscopy Guided Closure Aorta-to-RV communication closed using an 8-mm Amplatzer Vascular Plug (AVP) 41
42 42
43 NYU TAVR TEAM Thank You! New York University Langone Medical Center 43
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