L I V E W E L L, W O R K W E L L

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1 I N S I D E T H I S I S S U E E X E R C I S E P R O T E C T S T H E B R A I N H E A L T H Y R E C I P E M A I L O R D E R R X 1 2 First came endorphins, those home-grown opioids or painkillers that produce a runner s high. Then came the endocannabinoids, the pleasure-inducing molecules released during hard workouts that turn exercise nuts into gym rats. Now, decades after scientists first speculated on the effects of physical activity on the brain, Swedish researchers have discovered a new reason for lacing up those sneakers: Wellness Committee Rose Ray Jami Rogers Samuel Brady Amanda Cook C A L E N D A R 3 E V E N T 4 S C H E D U L E W A L K W I T H A 5 D O C S C H E D U L E F L I E R S 6 F L I E R S 7 Exercise not only feels good, it may also protect the brain from depression. In house studies at the Karolinska Institute in Stockholm, neuroscientists showed that exercise helped rid the body of kynurenine, a stress-induced amino acid associated with mental illness. Our initial research hypothesis was that trained muscle would produce a substance with beneficial effects on the brain, Jorge Ruas, principal investigator at Karolinska s Department of Physiology and Pharmacology, said last week. We actually found the opposite: Well-trained muscle produces an enzyme that purges the body of harmful substances. So in this context, the muscle s function is reminiscent of that of the kidney or liver. Well-trained muscles produce increased levels of a protein known as PGC-1(alpha)1. The Swedish scientists developed a genetically modified mouse strain with high levels of the protein in their muscles and exposed those mice (as well as normal mice) to a highly stressful environment of noises and flashing lights. After five weeks, the normal mice showed evidence of depressed behavior, including lethargy and indifference to food, but the genetically modified mice did not. The reason, the scientists believe, is that the modified mice had above-normal levels of KAT, an enzyme that, under stress, converts kynurenine into kynurenic acid, which cannot cross the blood-brain barrier. In effect, KAT in these muscled-up mice detoxed their brains of stress-related neurochemicals. Tiffany Dunkley Cendy Espinoza Michelle Fettes Veronica Gentry Susan Gottschalk Katie Howell Marty Lawrence Mary McFarland Jennifer Palmer Tracy Pethick John Ragland Claudia Rodriguez Ashley Taylor Natalie Valle It s possible that this work opens up a new pharmacological principle in the treatment of depression, where attempts could be made to influence skeletal muscle function instead of targeting the brain directly, Ruas said. Skeletal muscle [when activated] can protect the brain from insults and related mental illness.

2 P A G E 2 Getting Started It s easy to register and order your first prescription. Online: Register at Walgreens.com/MailService. From the registration confirmation page, follow the instructions to submit your new prescription. By mail: Complete the registration form included with your enrollment packet. Mail the form along with your original prescription. By phone: Call our Customer Care Center and have your insurance information handy. Additional ordering options after registration. Ask your prescriber to fax or e-prescribe your new prescription.* Fax: Use the enclosed fax form or log in to your online account to print a prescriber fax form. Give the form to your prescriber to complete and fax to the number listed on the form. E-prescribe: If your prescriber has the technology to submit prescriptions electronically, request that he or she do so. If you need your medication right away. Request two prescriptions from your prescriber: one for an initial short-term supply (e.g., 30- day supply or the amount allowed by your plan) that your local pharmacy can fill immediately and one for a 90-day supply with three refills (or the maximum amount allowed by your plan) for your doctor to submit to Walgreens. Free standard shipping. Please allow 10 business days from the time you place your order until you receive it at the address you specified. Convenient Auto Refills For an added convenience, you can choose to have your refills processed automatically. All you need to do is check the Automatic Refill option on your order form. We will process your order and bill the credit card you placed on file with us. Please note: By law, medications cannot be returned once they are dispensed from our pharmacy. If you need to cancel or modify your next Automatic Refill, notify us three weeks prior to your next refill date. Doing so may allow you to avoid unnecessary charges. Flexible Payment Options Payment in full by credit card or check is required with every prescription order. We accept all major credit cards. For your convenience, we can keep your credit card on file for future orders by adding it to your secure online account. Simply complete the fields on your registration form or call our Customer Care Center. For more information, visit: Walgreens.com/MailService Ingredients: 1 onion, chopped 1 (15 oz) can ranch-style beans 1/4 teaspoon ground cumin 3 cloves garlic, minced 2 1/2 cups chopped cabbage 1 green bell pepper, choped Cabbage Patch Stew 1 (14.5 oz) can stewed tomatoes, with liquid 2 stalks celery, chopped 1/4 cup picante sauce 1 cup water salt to taste pepper to taste Instructions: In skillet over medium heat, brown the ground beef with the onion. Drain off fat. Combine ranch-style beans cumin, garlic, cabbage and green pepper in crock pot. Stir in stewed tomatoes, celery, picante sauce, water, and beef mixture. Salt and pepper to taste. Cover and cook for 6 to 8 hours in your crock pot.

3 P A G E 3

4 PAGE 4 Fit To A "T" Event Schedule 8 a.m. noon City U CPR Training 12/15/15 8 a.m. noon City U CPR Training 12/26/15 Tyler Parks and Recreation On-Going Classes and Programs: American Karate Classes: Glass Recreation Center, Tues. 6:30 to 7:30 p.m. (beginner) Clogging Classes: Tyler Senior Center, Tues. 11:30 a.m. to 12:30 p.m. 50 Plus Pickle Ball: Glass Recreation Center, Tues. and Thurs., 9 a.m. to 1 p.m. Line Dance Classes: Tyler Senior Center, Tues. and Thurs., 12:30 to 2:30 p.m. Open Co-ed Adult Volleyball: Glass Recreation Center, Fri., 7 to 10 p.m. Over 30 Basketball: Glass Recreation Center, Wed., 7 to 10 p.m. Step Aerobics: Glass Recreation Center, Mon. and Thurs. 6:30 to 7:30 p.m. Zumba Classes: Glass Recreation Center, Mon. 7:30 to 8:30 p.m., Wed. 6:30 to 7:30 p.m.and Sat. 9:00 to 10:00 a.m. For other classes and fun activities, please visit the City of Tyler s website:

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