Iris S. and Bert L. Wolstein Research Building Case Western Reserve University Cleveland, Ohio

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2 Participate on-site or via the internet: 8 th Annual Cleveland Neurocritical Care and Stroke Thursday and Friday, October 7 & 8, rd Annual CWRU Critical Care Bioinformatics Workshop Saturday, October 9, 2010 Offered live only: 2 nd Annual CWRU Transcranial Doppler Ultrasound Workshop Saturday, October 9, st Annual Center for Music and Medicine Conference Saturday, October 9, 2010 Iris S. and Bert L. Wolstein Research Building Case Western Reserve University Cleveland, Ohio Presented by Neurological Institute University Hospitals Case Medical Center and Case Western Reserve University School of Medicine

3 A Global Conference of Neurocritical Care and Music Introduction Neurocritical care has evolved over the past twenty years in parallel with the growth of critical care medicine and the stunning developments in the fields of neurology and neurosurgery. Advances in imaging and a better understanding of pathophysiology of neuronal injury have revolutionized the management of an acute stroke patient in the last decade. Today the Neurological Intensive Care Unit is the epicenter for acute stroke intervention and the care of complex, critically ill patients with neurological disease. The multidisciplinary approach of the NICU brings experts in all specialties shoulder to shoulder at the bedside and it is no different in the educational setting. For the Neurocritical Care and Stroke Conference and the Bioinformatics Workshop you have the option of participating on-site or via the internet.

4 8 th Annual Cleveland Neurocritical Care & Stroke Conference Objectives After attending this program participants will be able to: Apply the new definition of stroke that incorporates brain imaging in order to best plan for treatment. Utilize CT angiograph / CT perfusion, Diffusion Weighted MR Imaging and Perfusion Weighted MR Imaging. Recognize how Diffusion / Perfusion MRI Imaging can be used to treat patients in whom the exact onset of stroke is not clear. Identify the spectrum of hypercoaguability syndromes, when to order the work up and when not to and how to interpret the results. Identify the risks and benefits of each carotid endarectomy and carotid stenting and how to select the best procedure for a specific patient. Understand the natural history of patients with malignant MCA territory stroke, how to optimally manage patients medically, and which patients and when to perform decompressive craniectomy. Review the natural history of patients with intracerebral hemorrhage, how to optimally manage patients medically, and which patients and when to perform surgical evacuation. Recognize the benefits of hypothermia, how to initiate this approach and the pitfalls to avoid. Approach patients with severe strokes and know what factors determine prognosis. Identify ramifications of DNR orders and the interactions between physician perceptions of outcome and outcome. Continuing Education The Case Western Reserve University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education to physicians. Neurocritical Care and Stroke Conference: The Case Western Reserve University School of Medicine designates this educational activity for a maximum of 14.0 AMA PRA Category 1 Credits TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. Bioinformatics; Transcranial Doppler; Music & Medicine: The Case Western Reserve University School of Medicine designates each educational activity for a maximum of 4 AMA PRA Category 1 Credits TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. W h o S h o u l d Attend This symposium is designed for neurointensivists, neurologists, neurosurgeons, critical care physicians, internists, anethesiologists and emergency medicine physicians. Nurses and other allied health professionals may also find this education of value.

5 8 th Annual Cleveland Neurocritical Care & Stroke Conference Faculty Course Director: Michael De Georgia, MD Anthony Furlan, MD Warren Selman, MD Special Guest Speakers: Robert White, MD University Hospitals Case Medical Center/Case Western Reserve University Mary Alice Annecharico, MS John Holmes, PhD Larry Raber John Bartholomew, MD Alan Hoffer, MD Cathy Sila, MD James Bates, MD Daniel Hsu, MD Joel Smirnoff Kristine Blackham, MD David Huron, PhD Sophia Sundararajan, MD, PhD Per Aage Brandt, PhD Frank Jacono, MD Robert Tarr, MD Teresa Carmen, MD Deforia Lane, PhD, MT-BC Curtis Tatsouka, PhD Jack Conomy, MD, JD Ken Loparo, PhD Peter Whitehouse, MD, PhD Annie Cox, PhD Cliff Megerian, MD Chris Wilson, PhD Mary Davis, PhD Jonathan Miller, MD Max Wiznitzer, MD Vikram Dhawan, MD Dick Moberg Bob Elson, MD, MS Svetlana Pundik, MD Guest Faculty Gary Bernardini, MD, PhD, Albany Medical Center Timothy Buchman,MD, PhD, Washington University Seemant Chaturvedi, MD, Wayne State University William Coplin, MD, Wayne State University David Crippen, MD, University of Pittsburgh Donna Lee Davis, CNRN, Cardinal Health Jeffrey Frank, MD, University of Chicago Julian Goldman, MD, Massachusetts General Hospital J. Claude Hemphill, MD, University of Southern California Stephan Mayer, MD, Columbia University Lewis Morgenstern, MD, University of Michigan Soojin Park, MD, University of Pennsylvania Kees Polderman, MD, PhD, VU University Medical Center, Amsterdam Lawrence Wechsler, MD, University of Pittsburgh Eelco Wijdicks, MD, Mayo Clinic The policy of the Case Western Reserve University School of Medicine CME Program (CWRU) requires that the Activity Director, planning committee members and all activity faculty (that is, anyone in a position to control the content of the education activity) disclose to the activity participants all relevant financial relationships with commercial interests. Disclosure will be made to activity participants prior to the commencement of the activity. CWRU also requires that faculty make clinical recommendations based on the best available scientific evidence and that faculty identify any discussion of off-label or investigational use of pharmaceutical products or medical devices.

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7 8 th Annual Cleveland Neurocritical Care & Stroke Conference Thursday October 7 7:30 8:00 a.m. Registration and Continental Breakfast 8:00 8:10 Welcome Michael De Georgia, MD 8:10 9:00 Maxeen Stone and John A. Flower Lecture Michael De Georgia, MD Session 1 Advances in Stroke Diagnosis and Management Moderator: Cathy Sila, MD 9:00 9:20 Don t Let Me Be Misunderstood: New Definitions for Stroke and TIA Cathy Sila, MD 9:20 9:40 Kodachrome: Advances in Brain Imaging for Acute Stroke Kristine Blackham, MD 9:40 10:00 Rock Around the Clock: Wake-up Stroke and Mismatch Anthony Furlan, MD 10:00 10:20 Break Session 2 Anticoagulation Yes, No, Maybe Moderator: Svetlana Pundik, MD 10:20 10:40 Hot Blooded: Hypercoagulability and Stroke Teresa Carmen, MD 10:40 11:00 Do You Believe in Magic: Anticoagulation for Ischemic Stroke Gary Bernardini, MD, PhD 11:00 11:20 It Don t Come Easy: Heparin-Induced Thrombocytopenia John Bartholomew, MD 11:20 Noon Panel Discussion Session 3 Endovascular Intervention Moderator: Robert Tarr, MD 1:30 1:50 Bridge Over Troubled Water: Intervention for Acute Dissection Robert Tarr, MD 1:50 2:10 Brave New World: Opening Blocked Vessels in Acute Stroke Daniel Hsu, MD 2:10 2:30 The Times They Are a Changin : Stent v. CEA After CREST Seemant Chaturvedi, MD 2:30 2:50 Panel Discussion 2:50 3:10 Break Session 4 Tough Calls Moderator: Sophia Sundararajan, MD, PhD 3:10 3:30 Gold Only Knows: Thrombolysis and the 3:00 a.m. Phone Call Anthony Furlan, MD 3:30 3:50 Doctor My Eyes: Thrombolysis for Central Retinal Artery Occlusion James Bates, MD 3:50 4:10 Walk This Way: New Guidelines and Beyond Lawrence Wechsler, MD 4:10 4:30 We Can Work it Out: Medical-Legal Aspects of Thrombolysis Jack Conomy, MD, JD 4:30 5:00 Panel Discussion Noon 1:30 p.m. Lunch

8 8 th Annual Cleveland Neurocritical Care & Stroke Conference Friday October 8 7:30 8:00 a.m. Registration and Continental Breakfast 8:00 8:10 Welcome Anthony Furlan, MD 8:10 9:00 In My Life Robert White, MD Session 1 State-of-the-Art management Moderator: Michael De Georgia, MD 9:00 9:20 Just What I Needed: Decompressive Craniectomy in Malignant MCA Territory Stroke Michael De Georgia, MD 9:20 9:40 Let It Bleed: Intraclot Thrombolysis and Endovascular Hemorrhage Evacuation Warren Selman, MD 9:40 10:00 Someone Saved My Life Tonight: Resuscitation After Cardiac Arrest Kees Polderman, MD, PhD 10:00 10:20 Break Session 2 Determining Prognosis Best Case Scenario Moderator: Jeffrey Frank, MD 10:20 10:40 Brain Damage: Determining Prognosis in Ischemic Stroke Jeffrey Frank, MD 10:40 11:00 Can t Get It Out of My Head: Determining Prognosis in Intracerebral Hemorrhage Lewis Morgenstern, MD 11:00 11:20 Superstition: Determining Prognosis in Cardiac Arrest Eelco Wijdicks, MD 11:20 Noon Noon 1:30pm Panel Discussion Lunch Session 3 The Ultimate Tough Call Withdrawal of Care Moderator: David Crippen, MD 1:30 1:50 End of the Line: When to Push Forward and When to Not Stephan Mayer, MD 1:50 2:10 The Grand Illusion: The Effect of DNR Orders on Outcome in the ICU J. Claude Hemphill, MD 2:10 2:50 Roundtable Discussion 2:50 3:10 Break Session 4 Critical Care Matters Moderator: Alan Hoffer, MD 3:10 3:30 Crazy On You: ICU Psychosis Vikram Dhawan, MD 3:30 3:50 Saturday Night Special: Advances in Trauma from the Motor City William Coplin, MD 3:50 4:10 You Ain t Seen Nothing Yet: Critical Care Informatics Timothy Buchman, MD 4:10 5:00 Guest Speaker 8:00 p.m. Concert featuring The Codes (Transportation from Glidden House provided)

9 8 th Annual Cleveland Neurocritical Care & Stroke Conference 3 rd Annual CWRU Critical Care Bioinformatics Workshop Saturday October 9 7:00 7:40 a.m. The Integrated Clinical Environment Julian Goldman, MD Session 1 Data Acquisition and the Critical Care Informatics Architecture 7:40 8:00 Data Acquisition in the Animal Lab Chris Wilson, PhD 8:00 8:20 Data Acquisition in the ICU Dick Moberg 8:20 8:40 An Information Architecture to Support Clinical Decision-Making Kenneth Loparo, PhD 8:40 9:00 Break Session 2 Knowledge-Based Clinical Decision Support 9:00 9:20 Information Systems and the Knowledge Engineering Project John Holmes, PhD 9:20 9:40 Visual Display and Wandering Data Soojin Park, MD Session 3 Physiology-Based Clinical Decision Support 9:40 10:00 Complex Systems Analysis in Mice and Men Frank Jacono, MD 10:00 10:20 Situation Awareness for the Intensivist Timothy Buchman, MD 10:20 10:40 Break Session 4 Moving Forward 10:40 11:00 Working with Industry Bob Elson, MD, MS 11:00 11:20 The Future of Health Information Technology Mary Alice Annecharico, MS 11:20 Noon Saturday October 9 7:00 7:40 Physiology Donna Lee Davis, CNRN 7:40 8:00 Subarachnoid Hemorrhage Cathy Sila, MD 8:00 8:20 Increased ICP and Brain Death Michael De Georgia, MD 8:20 8:40 PFOs and Right to Left Shunts (with Demonstration of Bubble Study) Svetlana Pundik, MD 8:40 9:00 Break 9:00 9:20 Intracranial Stenosis Cathy Sila, MD 9:20 9:40 Cerebrovascular Reactivity Cathy Sila, MD 9:40 10:00 Pediatric TCD Donna Lee Davis, CNRN 10:00 10:20 Emboli Monitoring: HITS Larry Raber 10:20 10:40 Break Wrap-up and Panel Discussion Michael De Georgia, MD 2 nd Annual CWRU Transcranial Doppler Ultrasound Workshop

10 8 th Annual Cleveland Neurocritical Care & Stroke Conference 10:40 11:00 CLOTBUST and Future of TCD Larry Raber 11:00 11:20 Documentation, Coding, Billing Donna Lee Davis, CNRN 11:20 Noon Panel Discussion and Hands-On Demonstration Center for Music and Medicine Conference Saturday October 9 1:15pm Introduction and Welcome Michael De Georgia, MD Session 3 Evolutionary Origins of Music Moderator: Mary Davis, PhD 3:30 3:50 Musical Experience and Imagery Arnie Cox, PhD 3:50 4:10 Rhythm and the Roots of Music Joel Smirnoff Session 4 Music and Healing Moderator: Deforia Lane, PhD, MT-BC 4:10 4:30 Music and Healing Deforia Lane, PhD, MT-BC 4:30 4:50 Music, Memory and Dementia Peter Whitehouse, MD, PhD 4:50 5:10 Panel Discussion 5:10 5:20 Break 5:20 6:00 TBD 7:00 TBD Special Guest Lecture Session 1 Neurological Foundations of Music Moderator: Jonathan Miller, MD 1:30 1:50 An Ear for Music: Turning Vibrations into Mozart Cliff Megerian, MD 1:50 2:10 Your Brain on Music: From Perception to Performance Jonathan Miller, MD Session 2 How and Why Music Affects Us Moderator: Per Aage Brandt, PhD 2:10 2:30 Music and Emotion Per Aage Brandt, PhD 2:30 2:50 Why Sad Songs Say so Much David Huron, PhD 2:50 3:10 Panel Discussion 3:10 3:30 Break

11 8 th Annual Cleveland Neurocritical Care & Stroke Conference General Information Meeting Location and Parking Iris S. and Bert L. Wolstein Research Building Case Western Reserve University 2310 Cornell Road Cleveland, OH Parking is available in the Cornell/Mayfield Visitor Parking Garage, accessible only from Cornell or Mayfield Road. Exit the garage at ground level and proceed left on Cornell. You are responsible for your own parking charges. Accommodations A block of rooms has been reserved at the Glidden House Hotel, 1901 Ford Drive, at the rate of $???? single/double (plus tax) for the nights of Wednesday through Friday, October 6-8, Our room block is limited and expires???????????, Make your reservation by contacting the hotel at or Identify yourself as being with the Case Western Reserve University CME group. You can also make your reservation on-line at Enter reservation code??????????????. The hotel is approximately one-half mile from the Wolstein Research Building. Shuttle bus service will be provided in the morning and after the conference each day. For information on other lodging options call the CWRU CME Program at or visit case.edu/cme. Late Registration and Cancellation Policy After September 22, 2010, please register by calling the CME Program at (216) or (800) Neurocritical Care and Stroke Conference: Full refunds will be made for cancellations on or prior to September 22 only. Cancellations after September 22 but prior to September 30 require a $ administrative fee (onsite participants) or a $65.00 administrative fee (internet participants). No refunds will be made after September 30. Boards Review, Bioinformatics, Transcranial Doppler Ultrasound: Full refunds will be made for cancellations on or prior to September 24 only. Cancellations after September 24 but prior to October 1 require a $50.00 administrative fee (on-site participants) or a $25.00 administrative fee (internet participants). No refunds will be made after October 1. Acknowledgments This symposium will be supported by grants from industry. A complete listing of supporters will be provided in the syllabus materials distributed at the meeting. Acceptance of funding in support of this symposium does not constitute endorsement of any product or manufacturer. Registration Information On-site conference tuition includes all educational sessions, materials, continental breakfast, lunch and breaks daily, and a concert featuring The Codes on Friday night. Persons participating via the internet will be ed ed access instructions prior to the course. Persons with special needs that require additional assistance should call the CME Program at (216) or (800) not less than two weeks prior to the start of the symposium.

12 Registration Form Neurocritical Care 2010: Walk of Life (Please Print) First Name: Last Name: Degree(s): Last 4 Digits of Social Security No.: Business Phone: Street Address: City: State: Zip: Register Online or by Fax Register by Mail Complete this registration form with your check or credit card number and mail to: Registrar, CME Program Case Western Reserve University Euclid Avenue Cleveland, OH Register by Telephone or Fax Call (216) or (800) to register or complete this registration form with your credit card number and fax to (216) After??Month 00??, 2010, register by calling the Case Western Reserve University CME Program at (216) or (800) CID2355

13 Continuing Medical Education Program Euclid Avenue Cleveland, Ohio

14 October th Annual Cleveland Stroke Symposium Physician Fee $350 (Attend) or $125 (Internet) Nurse/Allied Health Fee $250 (Attend) or $100 (Internet) Resident/Fellow Fee $175 (Attend) or $75 (Internet) October 9 (Please select Review Course or only one Workshop) CWRU Critical Care Bioinformatics Workshop Physician Fee $125 (Attend) or $75 (Internet) Nurse/Allied Health Fee $100 (Attend) or $50 (Internet) Resident/Fellow Fee $125 (Attend) or $25 (Internet) CWRU Transcranial Doppler Ultrasound Workshop Physician Fee $125 (Attend) Nurse/Allied Health Fee $100 (Attend) Resident/Fellow Fee 1$75 (Attend) Center for Music and Medicine Conference Physician Fee $25 (Attend) Nurse/Allied Health Fee $25 (Attend) Resident/Fellow Fee $25 (Attend) TOTAL AMOUNT ENCLOSED OR TO BE CHARGED: $ Enclosed is my check payable to: Case Western Reserve University Charge my: Visa MasterCard Discover Credit Card No.: Expiration Date: Signature: Date: