OIE Reference Laboratory Reports Activities

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1 OIE Reference Laboratory Report Activitie Activitie in 2017 Thi report ha been ubmitted : :59:41 Name of dieae (or topic) for which you are a deignated OIE Reference Laboratory: Foot mouth dieae Addre of laboratory: 177, Hyeokin 8-ro Gimcheon-i Gyeongangbukdo, KOREA (REP. OF) Tel.: Fax: addre: parkjhvet@korea.kr Webite: Name (including Title) of Head of Laboratory (Reponible Official): Sung-Hwan Wee (Director of Foot--Mouth Dieae Divion) Name (including Title Poition) of OIE Reference Expert: Jong-Hyeon Park (Senior Veterinary Reearcher) Which of the following define your laboratory? Check all that apply: Governmental OIE Reference Laboratory Report Activitie,

2 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) ToR 1: To ue, promote dieminate diagnotic method validated according to OIE Stard 1. Did your laboratory perform diagnotic tet for the pecified dieae/topic for purpoe uch a dieae diagnoi, creening of animal for export, urveillance, etc.? (t for quality control, proficiency teting or taff training) Diagnotic Tet Indicated in OIE Manual (/) Total number of tet performed lat year Indirect diagnotic tet Nationally Internationally FMD Ab tet(sp) 3,327 0 FMD Ab tet(nsp) 1,706 0 Direct diagnotic tet Nationally Internationally (Realtime) RT-PCR 3,180 0 Viru Iolation 9 0 ELISA 9 0 VP1 gene equencing 9 0 ToR 2: To develop reference material in accordance with OIE requirement, implement promote the application of OIE Stard. To tore ditribute to national laboratorie biological reference product any other reagent ued in the diagnoi control of the deignated pathogen or dieae. 2. Did your laboratory produce or upply imported tard reference reagent officially recognied by the OIE? 3. Did your laboratory upply tard reference reagent (non OIE-approved) /or other diagnotic reagent to OIE Member Countrie? 2 OIE Reference Laboratory Report Activitie, 2017

3 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) Type of reagent available Related diagnotic tet Produced/ provide Amount upplied nationally (ml, mg) Amount upplied internationally (ml, mg). of recipient OIE Member Countrie Region of recipient Rapid kit for Pan, erotype O or A Trial verion Tet Monglia Aia Eat Rapid kit for Pan, erotype O, A or Aia1 Trial verion Tet Sri Lanka Aia Eat Antibody kit NSP ELISA Tet Sri Lanka Aia Eat Antibody kit SP(O) ELISA Tet Sri Lanka Aia Eat Rapid kit for Pan, erotype O, A or Aia1 Trial verion Tet Vietnam Aia Eat OIE Reference Laboratory Report Activitie,

4 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) Rapid diagnotic kit for Pan, erotype O A or Aia1 Trial verion Tet Myanmar Aia Eat Antibody kit NSP ELISA Tet Myanmar Aia Eat Rapid kit for Pan, erotype O, A or Aia1 Trial verion Tet LAO PDR Aia Eat Antibody kit NSP ELISA Tet LAO PDR Aia Eat antibody kit SP(O) ELISA Tet LAO PDR Aia Eat Rapid kit for Pan, erotype O, A oraia1 Trial verion Tet Cambodia Aia Eat 4 OIE Reference Laboratory Report Activitie, 2017

5 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) Antibody kit NSP ELISA Tet Cambodia Aia Eat Antibody kit SP(O) ELISA Tet Cambodia Aia Eat Rapid kit for Pan, erotype O, A or Aia1 Trial verion Tet UK(Pirbright) Aia Eat Rapid kit for erotype differentiation Trial verion Tet FAO((For Nepa, Kenya) Aia Eat 4. Did your laboratory produce vaccine? 5. Did your laboratory upply vaccine to OIE Member Countrie? ToR 3: To develop, tardie validate, according to OIE Stard, new procedure for diagnoi control of the deignated pathogen or dieae 6. Did your laboratory develop new diagnotic method validated according to OIE Stard for the deignated pathogen or dieae? OIE Reference Laboratory Report Activitie,

6 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) 7. Did your laboratory develop new vaccine according to OIE Stard for the deignated pathogen or dieae? Name of the new tet or diagnotic method or vaccine developed Decription Reference (Publication, webite, etc.) for erotype differentiation(o, A, Aia1) On going (Relative comparion with ly available lateral flow device(lfd, Svanodip) for antigen ) ToR 4: To provide diagnotic teting facilitie,, where appropriate, cientific technical advice on dieae control meaure to OIE Member Countrie 8. Did your laboratory carry out diagnotic teting for other OIE Member Countrie? 9. Did your laboratory provide expert advice in technical conultancie on the requet of an OIE Member Country? Name of the OIE Member Country receiving a technical conultancy Purpoe How the advice wa provided CAMBODIA Training on FMD diagnoi vaccine technology 5th Workhop on diagnoi of animal dieae(5-13 Sep, 2017) LAOS Training on FMD diagnoi vaccine technology 5th Workhop on diagnoi of animal dieae (5-13 Sep,2017) MYANMAR Training on FMD diagnoi vaccine technology 5th Workhop on diagnoi of animal dieae (5-13 Sep,2017) SRI LANKA Training on FMD diagnoi vaccine technology 5th Workhop on diagnoi of animal dieae (5-13 Sep,2017) VIETNAM Training on FMD diagnoi vaccine technology 5th Workhop on diagnoi of animal dieae (5-13 Sep,2017) ToR 5: To carry out /or coordinate cientific technical tudie in collaboration with other laboratorie, centre or organiation 10. Did your laboratory participate in international cientific tudie in collaboration with OIE Member Countrie other than the own? 6 OIE Reference Laboratory Report Activitie, 2017

7 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) Title of the tudy Duration Purpoe of the tudy Partner (Intitution) OIE Member Countrie involved other than your country Comparative tudie for avian influenza viru FMD viru between Vietnam 9 year ( ) Comparative tudie of Avian Influenza viru between Vietnam) NCVD (National Center for Veterinary Diagnoi), DAH, Vietnam VIETNAM Comparative tudie for avian influenza viru FMD viru between Cambodia 5 year ( ) Contraction of MOU Join reearch project NAHPRI (National Animal Health Production Reearch Intitute),GDAHP, Cambodia CAMBODIA Comparative tudie for avian influenza viru FMD viru between LAO PDR 5 year ( ) Contraction of MOU Join reearch project NAHL (National Animla Health Laboratory), DLFMAF, LAO PDR LAOS Collaborative work in evaluation of developing rapid kit for 2016.DEC.~ 2017.AUG. Evaluation of developing rapid kit for by APQA Regional Reference laboratory for FMD in SEA, Pakchong (RRLFMD),Thail THAILAND Collaborative work in evaluation of developing rapid kt for ~ Evaluation of developing rapid kit for by APQA Livetock Breeding Veterinary Department, Minitry of Agriculture, Livetock Irrigation, Myanmar MYANMAR Annual cientific eminar on contagiou animal dieae including FMD Annually Preparedne for FMD outbreak Animal Health Laboratory, New Zealnad NEW ZEALAND To differentiate the erotype a the third OIE reference laboratory 2017 Jan To differentiate the erotype a the third OIE reference laboratory Regional Reference laboratory for FMD in SEA, Pakchong (RRLFMD), Thail THAILAND ToR 6: To collect, proce, analye, publih dieminate epizootiological data OIE Reference Laboratory Report Activitie,

8 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) relevant to the deignated pathogen or dieae 11. Did your Laboratory collect epizootiological data relevant to international dieae control? 12. Did your laboratory dieminate epizootiological data that had been proceed analyed? 13. What method of diemination of information i mot often ued by your laboratory? (Indicate in the appropriate box the number by category) a) Article publihed in peer-reviewed journal: 7 1. Taeeong Kim, Soyoon Ryoo, Jin Ju Nah, Min Geun Sagong, Sumee Lee,Kwang-Nyeong Lee, Young-Joon Ko, Jong-Hyeon Park, Myoung-Heon Lee, Sung-Hwan Wee, Dongeob Tark, Bok Kyung Ku. Complete genome equence of a Foot--mouth dieae viru of erotype O iolated from Gochang, Republic of, in Genome Announc Mar 9;5(10) e Soyoon Ryoo, Taeeong Kim, Jin Ju Nah, Min Geun Sagong, Sumee Lee,Kwang-Nyeong Lee, Young-Joon Ko, Jong-Hyeon Park, Myoung-Heon Lee, Sung-Hwan Wee, Dongeob Tark, Bok Kyung Ku. Complete genome equence of a Foot--mouth dieae viru of erotype O iolated from Gimje, Republic of, in 2016.Genome Announc Mar 9;5(10) e Seo-Yong Lee, Yeo-Joo Lee, Rae-Hyung Kim,Jeong-Nam Park, Min-Eun Park, Mi-Kyeong Ko, Joo-Hyung Choi, Jia- Qi Chu, Kwang-Nyeong Lee, Su-Mi Kim, Dongeob Tark, Hyang-Sim Lee, Young-Joon Ko, Min-Goo Seo, Jung-Won Park, Byounghan Kim, Myoung-Heon Lee, Jong-Soo Lee, Jong-Hyeon Park. Rapid Engineering of Foot--Mouth Dieae Vaccine Challenge Virue, Journal of Virology, 91 (16), e Su-Hwa You, Taeeong Kim, Joo-Hyung Choi, Gundo Park, Kwang-Nyeong Lee, Byounghan Kim, Myoung-Heon Lee, Hyun-Soo Kim, Su-Mi Kim, Jong-Hyeon Park. Coinjection of a vaccine anti-viral agent can provide fatacting protection from foot--mouth dieae, Antiviral Reearch 143 (2017) 195e Park JH, Tark D, Lee KN, Chun JE, Lee HS, Ko YJ, Kye SJ, Kim YJ, Oem JK, Ryoo S, Lim SB, Lee SY, Choi JH, Ko MK, You SH, Lee MH, Kim B. Control of type O foot--mouth dieae by vaccination in South, J Vet Sci v 23(Epub ahead of Print) 6. Uharani J, Park SY, Cho EJ, Kim C, Ko YJ, Tark D, Kim SM, Park JH, Lee KN, Lee MH, Lee HS. Antiviral activity of ovine interferon tau 4 againt foot--mouth dieae viru. Antiviral Re Jul; 143 : Park ME, You SH, Lee SY, Lee KN, Ko MK, Choi JH, Kim B, Lee JS, Park JH. Immune repone in pig cattle vaccinated with half-volume foot--mouthe dieae viru vaccine. J Vet Sci Aug 31;18(S1) : b) International conference: Jin Ju Nah, Soyoon Ryoo, SangHyun PARK, Min Geun Sagong, Taeeong Kim, JinWoo LEE, HyunJi LEE, Sumee Lee, KiSik CHOUNG, SungHwan WEE, Bok Kyung KU. Genetic Characterization of Foot--Mouth Dieae viru Serotype O A in, 2017 (The 33th World Veterinarian Congre) 2. Soyoon RYOO, Taeeong KIM, MinGeun SAGONG1, JinJu NAH, HyunJi LEE, SangHyun PARK, JinWoo LEE, Sumee LEE, SungHwan WEE, ChungSu KIM, Bok Kyung KU. Comparion of clinical ymptom NSP antibody formation in experimentally infected pig. (The 33th World Veterinarian Congre) 3. Taeeong Kim, Soyoon Ryoo, Jin Ju Nah, Min Geun Sagong, Sumee Lee, JinWoo LEE, KiSik CHOUNG, SeMin JUNG, SungHwan WEE, Bok Kyung KU. Tiue ditribution of Foot--mouth Dieae viral antigen in experimentally infected pig (The 33th World Veterinarian Congre) 4. Bok Kyung KU, Jin Ju Nah, Soyoon Ryoo, Min Geun Sagong, Taeeong Kim, SangHyun PARK, JinWoo LEE, HyunJi LEE, SungHwan WEE. Development of rapid lateral flow trip kit for Foot- mouth dieae viru erotype O, A Aia1 (2017 GFRA cientific meeting) 8 OIE Reference Laboratory Report Activitie, 2017

9 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) 5. Taeeong Kim, Soyoon Ryoo, Jin Ju Nah, Min Geun Sagong, Sumee Lee, SeMin JUNG, HyunJi LEE, JinWoo LEE, SangHyun PARK, SungHwan WEE, Bok Kyung KU. Field application of oral fluid collection uing cotton rope for FMD (2017 GFRA cientific meeting) 6. SangHyun PARK, Soyoon Ryoo, Jin Ju Nah, Sumee Lee, Kyung-Ju Yoon, SungHwan WEE, Bok Kyung KU. Detection of erotype O by real time RT-PCR aay uing peptide nucleic acid probe (2017 GFRA cientific meeting) 7.JinWoo LEE, Jin Ju Nah, Soyoon Ryoo, HyunJi LEE, SangHyun PARK, Min Geun Sagong, Taeeong Kim, SeMin JUNG, Kyung-Ju Yoon, SungHwan WEE, Bok Kyung KU. Detection of Serotype A by Real time RT-PCR uing Peptide Nucleic Acid (2017 GFRA cientific meeting) 8.Jin Ju Nah, Soyoon Ryoo, HyunJi LEE, Tho,N.D, SangHyun PARK, JinWoo LEE, Sumee Lee, SeMin JUNG, SungHwan WEE, Bok Kyung KU Comparative genetic analyi of Foot--mouth dieae viru of erotype A of in 2017 (2017 GFRA cientific meeting) 9.Soyoon Ryoo, Jin Ju Nah, HyunJi LEE, SangHyun PARK, Taeeong Kim, JinWoo LEE, Sumee Lee, SeMin JUNG, SungHwan WEE, Bok Kyung KU. Genetic characterization of the Foot--mouth dieae Viru erotype O in Republic of, 2017 (2017 GFRA cientific meeting) 10. HyunJi LEE, Jin Ju Nah, Soyoon Ryoo, Tho,N.D, Min Geun Sagong, SangHyun PARK, JinWoo LEE, KiSik CHOUNG, SungHwan WEE, Bok Kyung KU. Comparative genetic analyi of Foot--mouth dieae viru of erotype O iolated from Vietnam in 2014 (2017 GFRA cientific meeting) 11. Soyoon Ryoo, SangHyun PARK, Jin Ju Nah, Taeeong Kim, HyunJi LEE, JinWoo LEE, Min Geun Sagong, Kyung-Ju Yoon, SungHwan WEE, Bok Kyung KU. Development of peptide nucleic acid(pna)-baed real time RT-PCR for of Foot--mouth dieae(fmd) (10th an meeting on molecular diagnotic) 12.Taeyoung Lee, Hyejun Jo, Jida Choi, Jong-Hyeon Park, Jaejo Kim, Byounghan Kim. Laboratory moue model to evaluate efficacy of foot--mouth dieae vaccine. 33rd World Veterinary Congre) 13.Jaejo Kim, Hyejun Jo, Jida Choi, Taeyoung Lee, Young-Joon Ko, Kwang-Nyeung Lee, Jong-Hyeon Park, Yong-Joo Kim, Byounghan Kim. Foot--mouth dieae control meaure through nationwide vaccination in republic of (2017 Global foot--mouth dieae reearch alliance) 14.Jong-Hyeon Park, Kwang-Nyeong Lee, Young-Joon Ko, Jae-Jo Kim, Ah-Young Kim, Ji-Da Choi, Bok Kyung Ku, Soyoon Ryoo, Sung-Hwan Wee, Byounghan Kim, Bong-Kyun Park, FMD Outbreak Control Meaure in South (33rd world veterinary congre) 15. Park JH, Lee SY, Lee YJ, Kim RH, Park JN, Park ME, Ko MK, Choi JH, Chu JQ, Lee KN, Kim SM, Tark D, Lee HS, Ko YJ, Seo MG, Park JW, Lee MH, Lee JS, Kim B. Rapid Engineering of Foot--Mouth Dieae Vaccine Challenge Virue (2017 GFRA cientific meeting) 16. Su-Mi Kim, Su-Hwa You,Taeong Kim, Joo-Hyung Choi,Gundo Park, Kwang-Nyeong Lee, Byunghan Kim, Myoung-Heon Lee Jong-hyeon Park, Coinjection of a vaccine antivira-agent can provide fat-acting protection from foot--mouth dieae (2017 GFRA cientific meeting) 17. Kim Jaejo, Jo Hyejun, Choi Jida, Lee Tae Young, Ko Young-Joon, Lee Kwang-Nyeong, Park Jong-Hyeon, Kim Yong Joo, Kim Byounghan. Foot mouth dieae control meaure through nationwide vaccination in republic of korea (2017 GFRA cientific meeting) 18. Lee Kwang-Nyeong, Kim Min Yeong, Hwang Ji-Hyeon, Park Jong-Hyeon, Kim Byounghan. Intradermal delivery of oil-adjuvanted commercial fmd vaccine with needle device for pig (2017 GFRA cientific meeting) 19. Min Yeong KIM, Ji-Hyeon HWANG, Jeonghwan PARK, Kwang-Nyeong LEE, Jong-Hyeon PARK, Byounghan KIM, Quantification of 146S Particle of Foot--Mouth Dieae Viru by UV Spectrophotometer Photometry of Sucroe Denity Gradient (33rd world veterinary congre) 20.Su-Hwa YOU, Taeeong KIM, Joo-Hyung CHOI, Gundo PARK, Kwang-Nyeong LEE, Byounghan KIM, Myoung-Heon LEE, Hyun-Soo KIM, Su-Mi KIM, Jong-Hyeon PARK. Co-injection of a Vaccine Anti-viral Agent can Provide Fatacting Protection from Foot--mouth Dieae in Pig (33rd world veterinary congre) OIE Reference Laboratory Report Activitie,

10 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) 21. Taeyoung LEE, Hyejun JO, Jida CHOI, Jonghyeon PARK, Jaejo KIM, Byounghan KIM, Laboratory Moue Model to Evaluate Efficacy of Food--mouth Dieae Vaccine (33rd world veterinary congre) 22. Joo-Hyung CHOI, Mi-Kyeong KO, Su Hwa YOU, Kwang-Nyeong LEE, Su-Mi KIM, Byounghan KIM, Jong-Hyeon PARK, Early Protection againt Foot--Mouth Dieae in Mice Pig Treated with Ribavirin FMD Vaccine (33rd world veterinary congre) 23. Ji-Hyeon HWANG, Min Yeong KIM, Jeonghwan PARK, Kwang-Nyeong LEE, Jong-Hyeon PARK, Byounghan KIM. Comparion of Protective Spectrum of Serotype O n Iolate of Foot--mouth Dieae Viru a Vaccine Cidate in Guinea Pig (33rd world veterinary congre) c) National conference: 0 d) Other: (Provide webite addre or link to appropriate information) 0 ToR 7: To provide cientific technical training for peronnel from OIE Member Countrie To recommend the precribed alternative tet or vaccine a OIE Stard 14. Did your laboratory provide cientific technical training to laboratory peronnel from other OIE Member Countrie? a) Technical viit: 2 b) Seminar: 2 c) H-on training coure: 5 d) Internhip (>1 month): 0 Type of technical training provided (a, b, c or d) Country of origin of the expert() provided with training. participant from the correponding country a, b Brazil(PANAFTOSA) 1 a, b Netherl 1 c Vietnam 2 c Myanmar 2 c Sri Lanka 2 c LAOS 2 c Cambodia 2 10 OIE Reference Laboratory Report Activitie, 2017

11 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) ToR 8: To maintain a ytem of quality aurance, bioafety bioecurity relevant for the pathogen the dieae concerned 15. Doe your laboratory have a Quality Management Sytem certified according to an International Stard? Quality management ytem adopted ISO/IEC Certificate can (PDF, JPG, PNG format) KT372_KOLAS ISOIEC pdf 16. I your laboratory accredited by an international accreditation body? Tet for which your laboratory i accredited (Realtime RT-PCR, RT-PCR, ELISA) Antibody (SP ELISA, NSP ELISA) Accreditation body KOLAS(n Laboratory Accrediation Scheme) KOLAS(n Laboratory Accrediation Scheme) 17. Doe your laboratory maintain a biorik management ytem for the pathogen the dieae concerned? (See Manual of Diagnotic Tet Vaccine for Terretrial Animal, Chapter 1.1.4) ToR 9: To organie participate in cientific meeting on behalf of the OIE 18. Did your laboratory organie cientific meeting on behalf of the OIE? National/ International Title of event Co-organier Date (mm/yy) Location. Participant International Global Foot-- Mouth Dieae Reearch Alliance(GFRA) USDA The Pirbright Intitute 10/2017 Incheon, The Republic of Did your laboratory participate in cientific meeting on behalf of the OIE? OIE Reference Laboratory Report Activitie,

12 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) Title of event Date (mm/yy) Location Role (peaker, preenting poter, hort communication) Title of the work preented The 2017 Regional Animal Health Laboratory Technical Adviory Group (Lab-TAG) Meeting 11/17 Cambodia Speaker Panel dicuion SEACFMD 03/17 Cambodia Oberver Exchange the information on recent FMD outbreak The 12th OIE/FAO Reference Laboratory Network Annual Meeting 11/17 ARC-Ondertepoort Veterinary Intitute, Pretoria, South Speaker oberver Global overview; Pool 1 Eat Aia ToR 10: To etablih maintain a network with other OIE Reference Laboratorie deignated for the ame pathogen or dieae organie regular inter-laboratory proficiency teting to enure comparability of reult 20. Did your laboratory exchange information with other OIE Reference Laboratorie deignated for the ame pathogen or dieae? 21. Wa your laboratory involved in maintaining a network with OIE Reference Laboratorie deignated for the ame pathogen or dieae by organiing or participating in proficiency tet? 22. Did your laboratory collaborate with other OIE Reference Laboratorie for the ame dieae on cientific reearch project for the diagnoi or control of the pathogen of interet? ToR 11: To organie inter-laboratory proficiency teting with laboratorie other than OIE Reference Laboratorie for the ame pathogen dieae to enure equivalence of reult 23. Did your laboratory organie or participate in inter-laboratory proficiency tet with laboratorie other than OIE Reference Laboratorie for the ame dieae? 12 OIE Reference Laboratory Report Activitie, 2017

13 Foot mouth dieae - Jong-Hyeon Park - korea (rep. of) te: See Interlaboratory tet comparion in: Laboratory Proficiency Teting at: ee point 1.3 Purpoe for inter-laboratory tet comparion 1. participating laboratorie Region() of participating OIE Member Countrie National Proficiency tet for Diagnoi of FMD(Organier) 1t : 45 provincial Animal Health Laboratorie(pAHL), 2nd-46 pahl Aia Eat ToR 12: To place expert conultant at the dipoal of the OIE 24. Did your laboratory place expert conultant at the dipoal of the OIE? 25. Additional comment regarding your report: OIE Reference Laboratory Report Activitie,