Faculty of Medicine, University of Novi Sad Department of Pathology school year 2018/2019 INFORMATIONS OF THE COURSE GENERAL AND ORAL PATHOLOGY

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1 Faculty of Medicine, University of Novi Sad Department of Pathology school year 2018/2019 INFORMATIONS OF THE COURSE GENERAL AND ORAL PATHOLOGY The information is intended for regular second-year students of the Faculty of Medicine in Novi Sad - integrated studies of dentistry. This guide contains basic information about the course, information of the total hours number, the organization of theoretical and practical teaching, the curriculum, the list of histological slides, informations of taking exams, exam questions and a list of basic and supplementary textbooks. We believe that this type of information will help students to master knowledge successfully related to this course and studies in general. Authors Prof. dr Slavica Knežević Ušaj, Head of the Department Assoc. Prof dr. Milana Panjković, Deputy Head of the Department

2 I. GENERAL INFORMATION General and oral pathology is held during winter semester of second year of study with a total number of 60 hours of theoretical and 30 hours of practical training. Theoretical teaching is held in the amphitheaters of Faculty of Medicine by the schedual that is going to be published at the beginning of the semester by the student service. Practical classes are held at : 1. Department of Pathology and Histology, Faculty of Medicine in Novi Sad. Theoretical and practical lectures of the course lead: 1. Two full professors 2. One associate professor 3. Three assistant professors 4. Two teaching assistants II. PROGRAM of theoretical lectures A. GENERAL PATHOLOGY 32 hours * Introduction 1 hour * Environmental diseases 2 hours * Cell demage and death 3 hours * Degeneration 4 hours * Circulatory disorders 4 hours * Inflammations 4 hours * Repair and regeneration 4 hours * Developmental and genetic diseases 2 hours * General pathology of neoplasia 8 hours B. ORAL PATHOLOGY 28 hours * Pathology of the mouth 4 hours * Pathology of salivary glands 4 hours

3 * Pathology of teeth and jaws 6 hours * Changes in the mouth related with the diseases of endocrine system 2 hours * Changes in the mouth related with hematological diseases 4 hours * Changes in the mouth related with dermatological diseases 4 hours * Changes in the mouth related with nutritional disorders 4 hours III. PROGRAM of practical training - 2 hours per week in the winter semester Histological diagnostics During the semester, students attend the exercises of the histological diagnosis two hours per week according to the schedule that is going to be published under the general schedule classes for students of the Medicine Faculty. These exercises are held at the Department of Pathology and Histology in the hall for microscopy on the first floor of the School of Medicine. Students are required to wear white laboratory coats during practical teaching. From academic year 2015/2016, the teaching of histopathological diagnosis is performed on computers with scanned histological slides, which will allow interactive teaching and easier way to master the subject matter of this type of diagnosis. Department believes that the introduction of digital microscopic diagnosis is of great importance to the improvement and modernization of the teaching of pathological anatomy. This type of instruction will allow students to review and practice all slides throughout the year so there is no need for performing the pre-examination exercises. List of preparations for the practical part of the course: Excercise Slides Number of slide in handbook 1 Atrophia fusca myocardii (Myocardial atrophy with lipofuscin deposition) 23 Atrophia musculorum neurogenes (Neurogenic muscular atrophy) 24 Degeneratio parenchymatosa renis (Parenchymatous degeneration of the kidney) 37 Steatosis hepatis (Hepatic steatosis) 69 2 Calcificationes dystrophicae cutis (Dystrophic skin calcification) 25 Carcinoma medullare glandulae thyreoideae cum amyloidosis stromae 28 (Medullar carcinoma of the thyroid gland with amyloid in stroma) Haemosiderosis pulmonis (Hemosiderosis of the lung) 44

4 3 4 5 Hyperaemia passiva hepatis (Passive hyperemia of the liver) 45 Infarctus anaemicus renis (Anemic infyarction of the kidney) 46 Infarctus anaemicus recens myocardii (Anemic myocardial 47 infarction) Infarctus haemorrhagicus pulmonis (Hemorrhagic infarction of lung) Mucocoela 45 Granulationes nonspecificae (Nonspecific granulation tissue) 25 Granuloma corporis alieni (Foreign body granuloma) 24 Keratosis solaris (Solar keratosis) 34 Leptomeningitis purulenta acuta (Acute purulent leptomeningitis) 52 Appendicitis phlegmonoso-purulenta acuta (Suppurative (phlegmonous) appendicitis) 22 Cholecystitis gangraenosa acuta (Gangrenous cholecystitis) 32 Osteomyelitis purulenta acuta (Acute purulent osteomyelitis) Lymphadenitis reactiva (Reactive lymphadenitis) 55 Sialoadenitis chronica fibrosa obstructiva (Chronic obstructive fibrous sialoadenitis) 68 Tonsillitis chronica (Chronic tonsillitis) 70 Lymphadenitis tuberculosa caseosa (Caseous tuberculous lymphadenitis) Pemphigus vulgaris (Pemphigus vulgaris) 67 Leukoplakia (Leukoplakia) 37 Melanoma malignum (Malignant melanoma) 42 Fibroma cutis (Fibroma of the skin) 39 Epulis gigantocellularis (Giant cell epulis) 38 Haemangioma capillare cutis (Cappilary hemangioma of the skin) 42 Haemangioma cavernosum textus adiposi subcutanei (Cavernous hemangioma of the subcutaneous adipose tissue) Cysta lateralis colli (Branchial or lymphoepithelial cyst) 33 Cysta follicularis (Follicular or dentigerous cyst) 34 Cysta mediana colli (Thyroglossal tract cyst) 35 Cysta radicularis (Radicular cyst) Ameloblastoma (Ameloblastoma) 21 Adenoma monomorphum glandulae salivalis (Monomorphic adenoma of the salivary gland) 19

5 Adenoma pleomorphum glandulae salivalis (Pleomorphic adenoma of the salivary gland) Adenolymphoma glandulae salivalis (Adenolymphoma of the salivary gland) Adenocarcinoma metastaticum lymphonodi (Metastatic adenocarcinoma of the lymph node) Papilloma squamosum (Squamous papilloma) 66 Laesio lymphoepithelialis glandulae salivalis (Lymphoepithelial lesion of the salivary gland) 51 Lymphoma non-hodgkin diffusum (B-cell type) (Diffuse large B-cell lymphoma) Morbus Hodgkin typus sclerosis nodularis (Hodgkin lymphoma, nodular sclerosis type) Carcinoma adenocysticum glandulae salivalis 26 (Adenoid cystic carcinoma (cylindroma) Carcinoma baseocellulare cutis (Basal cell carcinoma of the skin) 27 Carcinoma planocellulare labii oris (Squamous cell carcinoma of the lip) 30 Carcinoma mucoepidermoides glandulae salivalis (Mucoepidermoid carcinoma of the salivary gland) 29 Carcinoma planocellulare metastaticum lymphonodi (Metastasis of the squamous cell carcinoma in the lymph node) 31 IV. EXAM Examination of General and Oral Pathology consists of two parts: 1. Pre-exam activities 2. Final - oral part of the exam 1. Pre-exam activities include: - Regular attendance to the lectures, - Regular attendance and active participation in exercises with checking and evaluating knowledge on each exercise, - Passing the colloquium for practical training - Passing the eliminatory test of theoretical knowledge 1. Exercises At the last exercise of the semester students take the practical exam (description of the 3 slides in front of the teacher who has the right to ask theoretical questions related to the preparations). Recognition and proper description of 2 slides are required for a student to pass the practical exam. A student who does not pass practical exam can take the exam during the regular exam period.

6 Practical colloquium is graded (6 to 10) and the mark is signed at index. Practical exam is valid forever! 2. Theoretical exam 2.1. Theoretical test Before taking the final oral exam, students take an elimination test with 40 questions from the theory regarding general and oral pathology. The minimum number of points for passing is 60%, which is 24 correct answers. Passed theoretical test is valid forever! Elimination test is taken at regular examination periods starting from January-February's exam period of the current school year. The time and place of taking the test will be published on the website of Medical Faculty and at the bulletin board of the Department of Pathology and Histology. Students need to confirm taking practical exam, test and oral exam by leaving their signature at the Secretary of the Department (1st floor-medical School - Department of Pathology and Histology). The test results are published on the same day on official website of Medical faculty. It is possible to see the test after published results, at time and place that will be published with test results. After test students must sign on the list enrolled at the hall of Histology and Pathology Department, and select the desired date of examination. Department will try to meet the wishes of students (in the range of +/- 2 to 3 days) Oral exam Oral examination is conducted in the examination periods provided under the Statute of the School of Medicine Department of the Faculty of publication at the beginning of the school year and in line with the adopted Ordinance on examination at the Medical School. The theoretical part of the exam consists of four questions: two questions from oral pathology and two questions from general pathology. In case of constrained estimates examiners have discretion to set additional questions. For the oral exam, students 'electe teachers' by drawing cards with the names of predefined examiners randomly for each examination day. Department of Pathology has a common criterion that a candidate for a positive assessment must give a positive answer to each of the four questions. Time and place of the test and the theoretical exam stands out in a timely manner on the bulletin board of the Institute of Pathology and Histology, separately for each examination period because it is conditioned by the commitment auditoriums and gyms regular classes in Histology and Pathology. NOTE: The Department reserves the right to change the order in case of emergency. QUESTIONS FOR ORAL EXAM (applicable to all students of dentistry) 1. Mechanisms of cell injury 2. Necrosis 3. Atrophy 4. Hypertrophy, hyperplasia

7 5. Metaplasia, dysplasia 6. Principles of wound healing 7. Fatty infiltration and degeneration 8. Pigments 9. Amyloidosis 10. Concretions 11. Pathological calcification 12. Edema 13. Disorders of blood volume 14. Infarct 15.Thrombosis 16. Embolism 17. Bleeding 18.Shock 19. Principles of acute inflammations 20. Serous and fibrinous inflammation 21. Purulent and catarrhal inflammation 22. Haemorrhagic and gangrenous inflammation 23.Chronic inflammation 24. Tuberculosis 25. Syphilis 26. Sarcoidosis 27. Infectious diseases 28. Bacterial and viral infections 29. Fungal and parasitic infections 30. Definition, nomenclature and classification of tumors 31. Macroscopic tumor characteristics 32. Way of growth and local invasiveness 33. Histological grading and staging and tumor spread 34.Distinguishing between benign from malignant tumors 35. Metastasis 36. Pigmented tumors 37. Benign tumors of bone, cartilage and joints 38. Malignant tumors of bone, cartilage and joints 39. Morbus Hodgkin 40. Non Hodgkin malignant lymphomas 41. Tumors of squamocellulare epithelial origin 42. Tumors of cylindrical and glandular epithelium origin 43. Tumors of transitional epithelium origin 44. Tumors of fibrous tissue origin 45. Tumors of fat tissue origin 46. Tumors of smooth muscle origin 47. Tumors of striated muscle origin 48. Tumors of blood and lymphatic vessels origin 49. Teratomas 50. Developmental disorders of lips, palate and tongue 51. Disturbances in the number, size and shape of teeth 52. Disturbances in the structure of enamel 53. Disturbances in the structure of dentin and cementum 54. Dental plaque

8 55. Caries of dental enamel and dentin 56. Pulpitis 57. Gingival overgrowth 58. Acute gingivitis 59. Chronic gingivitis 60. Chronic periodontitis 61. Apical periodontitis 62. Juvenile, prepubertal and rapidly progressive periodontitis 63. Odontogenic and non-odontogenic cysts of maxillofacial region 64. Odontogenic tumors 65. Nonodontogenic tumors 66.Osteomyelitis 67. Stomatitis 68. Changes in the oral cavity as manifestations of general diseases 69. Changes in the oral cavity as part of endocrine diseases 70. Changes in the oral cavity as part of hematological diseases 71. Changes in the oral cavity within the eating disorders 72. Changes in the oral cavity as part of dermatological diseases 73. Changes in the oral cavity within immunodeficiency conditions 74. Leukoplakia and nicotine stomatitis 75. Pseudocarcinomatous changes in the oral cavity 76. Benign and malignant tumors of the oral cavity 77. Mucocele 78. Benign lymphoepithelial lesion 79. Sialolythiasis 80. Benign tumors of the salivary glands 81. Malignant tumors of the salivary glands 82.Lymphadenitis Each of the following groups (colors) is assigned as one question in the oral exam in random fashion for each student. BASIC BOOKS : * PATHOLOGY - Robins * A PRACTICAL HANDBOOK OF PATHOLOGICAL HISTOLOGY for dentistry students - Faculty of Medicine, Novi Sad * HISTOLOGICAL EXERCISES ON CD - Faculty of Medicine, Novi Sad