Application of 3D printed phantoms to preclinical radiotherapy and PET imaging studies. Dr. Christopher Cawthorne
|
|
- Rosanna Arnold
- 5 years ago
- Views:
Transcription
1 Application of 3D printed phantoms to preclinical radiotherapy and PET imaging studies Dr. Christopher Cawthorne
2 Preclinical Radiotherapy The aim of preclinical experimentation is to understand how to improve the effectiveness of radiotherapy in clinical practice Two major overall goals: Identify drug targets for combination therapy and understand MOA Develop tools for patient stratification for targeted therapy and the measurement of response
3 Preclinical Radiotherapy Day et al. Cell, 2015 Use of orthotopic/gemm cancer models to better mimic clinical situation
4 Preclinical Radiotherapy State of the art radiotherapy platforms can mimic clinical IMRT and IGRT delivery approaches University of Leeds Preclinical dosimetry is currently non-standardised (or completely lacking) Radiation response curves are typically steep, and dose uncertainty leads to high variation/large number of animals
5 Preclinical Radiotherapy Radiation response curves are typically steep, and dose uncertainty leads to high variation/large number of animals Need for physically accurate phantom to assess delivered dose.
6 Preclinical Dosimetry phantom Project outline: segment CT images of mouse into bone/lung/soft tissue Derive STL files for 3D printing skeleton and body for moulding
7 Preclinical Dosimetry phantom Skeleton embedded in vacuum-cast mould derived from print of whole mouse Mould filled with gelatin to re-create whole body Density of 3D printed material not high enough to mimic bone
8 Preclinical Dosimetry phantom A range of tissue-equivalent materials were evaluated for fabrication 3D printing of bone-density material combined with CNC milling of lung insert and moulding of body
9
10 Preclinical Dosimetry phantom Evaluation of morphology and density via CT
11 Preclinical Dosimetry phantom Evaluation of morphology and density via CT
12 Preclinical Dosimetry phantom Evaluation of morphology and density via CT
13 relative response Preclinical Dosimetry phantom Evaluation of passive detectors for dosimetry ongoing reading:1,2 Aug 2017 (Co-60) reading:3,4 Aug 2017 (Co-60) reading:8 Aug 2017 (Co-60) reading:15 Aug 2017 (Co-60) reading:17 Aug 2017 (Co-60) TLD #
14 Preclinical Imaging with PET Development of imaging biomarkers: Defined as "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". (Atkinson et al., 2001) Diagnostic/prognostic biomarkers predictive of patient outcome Predictive biomarkers predictive of patient outcome in response to a particular therapy, enabling patient stratification Response biomarkers early readouts of drug efficacy in clinical trials PET is has unlimited depth and is thus translatable
15 Preclinical Imaging with PET Imaging of mouse cancer models (similar to radiotherapy models) Quantitation in PET is dependent on many factors: size of ROI vs resolution of scanner, image reconstruction Positron ranges differ between isotopes, affecting resolution and % annihilation in different tissues Although scatter is negligible in a single mouse, this is not the case for multiple animal scanning Standard phantom (NEMA-NU4) suited to general figures of merit Need for physically accurate phantom to assess accuracy of image quantitation
16 Preclinical PET phantom Project outline: assess PSF in tissue equivalent material Incorporate voids for radioisotope addition to 3D-printed tissue equivalent phantom Tissue equivalent materials provided by Leeds Test objects: Lung inhale Lung exhale Water eq. Lung inhale (PU330) Lung exhale (PU450) Water equivalent (WT1) Trabecular bone (HA50) Cortical bone (SB5) Trabecular bone Cortical bone
17 Preclinical PET phantom 0.4 mm syringe 0.2 mm capillary 10 mm Mean Positron range for: 18 F = 0.56 mm 68 G = 2.57 mm 0.2 mm external diameter silica capillary with 0.1 mm internal diameter to minimize positron annihilation
18 Preclinical PET phantom 18 F 9.00 radial profile distribution (mm) FWHM FWTM FWThM Lung inhale Lung exhale Water equivalent Trabecular bone Cortical Bone
19 Preclinical PET phantom 68 Ga radial profile distribution (mm) FWHM FWTM FWThM Lung inhale Lung exhale Water equivalent Trabecular bone Cortical Bone
20 FWHM (MM) Preclinical PET phantom 68 Ga: FBP vs OSEM 3.50 Full width at Half Maximum (mm) Lung inhale Lung exhale Water equivalent Trabecular bone Cortical Bone FBP OSEM
21 FWHM (MM) FWHM (MM) Preclinical PET phantom 68 Ga: FBP vs OSEM Full width at Tenth Maximum (mm) Full width at Twentieth Maximum (mm) Lung inhale Lung exhale Water equivalent Trabecular bone Cortical Bone FBP Lung inhale Lung exhale Water equivalent Trabecular bone Cortical Bone FBP OSEM OSEM
22 Preclinical PET phantom Density also affects quantitation!
23 Preclinical PET phantom Phantom design to assess quantitative effects of reconstruction Plastic phantom recapitulated 3 areas of uptake seen in animals, regions filled independently with typical activity levels
24 Preclinical PET phantom
25 Acknowledgements Giuseppe Schettino Anna Subiel Sanjiv Mooneram Georgios Soultanidis Nikos Efthymiou John Greenman Vicky Green Craig Moore Time Wood Andy Beavis Amanda Tulk Adrian Walker Funding:
Application of 3D Printing to Molecular Radiotherapy Phantoms. Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester
Application of 3D Printing to Molecular Radiotherapy Phantoms Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester Molecular Radiotherapy Radionuclide administered to patient
More informationBiases affecting tumor uptake measurements in FDG-PET
Biases affecting tumor uptake measurements in FDG-PET M. Soret, C. Riddell, S. Hapdey, and I. Buvat Abstract-- The influence of tumor diameter, tumor-tobackground activity ratio, attenuation, spatial resolution,
More informationCT NUMBER ACCURACY ANALYSIS FOR RADIOTHERAPY TREATMENT PLANNING IMAGING
CT NUMBER ACCURACY ANALYSIS FOR RADIOTHERAPY TREATMENT PLANNING IMAGING Julian Liu a, Keisha Robinson a, DhanaJayan Kothandan a and Joshua Luis b (a) Cancer Centre London (b) University College London
More informationUnrivaled, End-to-End
PHANTOMS Unrivaled, End-to-End Stereotactic QA Industry-leading 0.1mm accuracy minimizes errors at each link in the stereotactic quality assurance chain. Stereotactic radiosurgery (SRS) is governed by
More informationM. J. Maryanski, Three Dimensional BANG Polymer Gel Dosimeters AAPM'99, CE Course
Three Dimensional BANG Polymer Gel Dosimeters Marek J. Maryanski MGS Research, Inc. Guilford, CT Educational objectives: Describe the need for high-resolution 3D dosimetry in 3D CRT. Explain the physics
More informationUse of molecular and functional imaging for treatment planning The Good, The Bad and The Ugly
Use of molecular and functional imaging for treatment planning The Good, The Bad and The Ugly Robert Jeraj, PhD Associate Professor of Medical Physics, Human Oncology, Radiology and Biomedical Engineering
More informationProduction and dosimetry of simultaneous therapeutic photons and electrons beam by linear accelerator: a monte carlo study
Production and dosimetry of simultaneous therapeutic photons and electrons beam by linear accelerator: a monte carlo study Navid Khledi 1, Azim Arbabi 2, Dariush Sardari 1, Mohammad Mohammadi 3, Ahmad
More informationPOSITRON EMISSION TOMOGRAPHY PHANTOM STUDIES FOR RADIATION THERAPY TARGET DELINEATION MICHAEL VINTSON LAWRENCE
POSITRON EMISSION TOMOGRAPHY PHANTOM STUDIES FOR RADIATION THERAPY TARGET DELINEATION BY MICHAEL VINTSON LAWRENCE A Dissertation Submitted to the Graduate Faculty of WAKE FOREST UNIVERSITY GRADUATE SCHOOL
More informationA. DeWerd. Michael Kissick. Larry. Editors. The Phantoms of Medical. and Health Physics. Devices for Research and Development.
Larry Editors A. DeWerd Michael Kissick The Phantoms of Medical and Health Physics Devices for Research and Development ^ Springer Contents 1 Introduction to Phantoms of Medical and Health Physics 1 1.1
More informationFuture upcoming technologies and what audit needs to address
Future upcoming technologies and what audit needs to address Dr R.I MacKay History of audit Absolute dose - Simple phantom standard dose measurement Point doses in beams - Phantoms of relatively simple
More informationDigital film dosimetry in radiotherapy and the development of analytical applications software
University of Wollongong Research Online University of Wollongong Thesis Collection 1954-2016 University of Wollongong Thesis Collections 2005 Digital film dosimetry in radiotherapy and the development
More informationOut-of-field doses of CyberKnife in stereotactic radiotherapy of prostate cancer patients
EURAMED,MELODI and EURADOS Workshop, Helsinki 19.-20.4.2017 Out-of-field doses of CyberKnife in stereotactic radiotherapy of prostate cancer patients Jan Seppälä, Chief Physicist Tuomas Virén, Medical
More informationProtons Monte Carlo water-equivalence study of two PRESAGE formulations for proton beam dosimetry J. Phys.: Conf. Ser.
Protons Monte Carlo water-equivalence study of two PRESAGE formulations for proton beam dosimetry T Gorjiara, Z Kuncic, J Adamovics and C Baldock 2013 J. Phys.: Conf. Ser. 444 012090 PRESAGE is a radiochromic
More informationPublishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy
Publishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy Overview The overall aim of this project is to provide the metrology for the clinical
More informationCalculation of Effective Doses for Radiotherapy Cone-Beam CT and Nuclear Medicine Hawkeye CT Laura Sawyer
Calculation of Effective Doses for Radiotherapy Cone-Beam CT and Nuclear Medicine Hawkeye CT Laura Sawyer Department of Medical Physics and Bioengineering, Royal United Hospital, Bath Overview Varian Acuity
More informationTraceability and absorbed dose standards for small fields, IMRT and helical tomotherapy
Traceability and absorbed dose standards for small fields, IMRT and helical tomotherapy Simon Duane, Hugo Palmans, Peter Sharpe NPL, UK Stefaan Vynckier UCL, Brussels, Belgium LNE-LNHB / BIPM workshop,
More informationMAX-HD SRS PHANTOM THE COMPREHENSIVE END-TO-END SRS PHANTOM SCAN PLAN LOCALIZE TREAT. distributed by:
SRS PHANTOM SCAN PLAN LOCALIZE TREAT THE COMPREHENSIVE END-TO-END SRS PHANTOM distributed by: Tel: +33 (0) 42 88 68 41 info@orion-france.com www.orion-france.com 2, Avenue du General Balfourier 75016 Paris,
More informationEffective and efficient radiotherapy dosimetry audit: Where to next?
Effective and efficient radiotherapy dosimetry audit: Where to next? Catharine Clark, Eduard Gershkevitsh, Milan Tomsej and Nuria Jornet National Physical Laboratory Royal Surrey County Hospital Radiotherapy
More informationGATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT
GATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT R Aamir, C Lowe, J Damet, P Carbonez, A P H Butler, N Schleich, N G Anderson MARFO, Emmanuel Geant4 User Workshop 2017, Wollongong Overview MARS
More informationApplication(s) of Alanine
Application(s) of Alanine Simon Duane Radiotherapy Standards User Group, 5 June 2007 Outline Alanine/EPR dosimetry characteristics, usage (dis)advantages for reference dosimetry Traceable dosimetry for
More informationPET in Radiation Therapy. Outline. Tumor Segmentation in PET and in Multimodality Images for Radiation Therapy. 1. Tumor segmentation in PET
Tumor Segmentation in PET and in Multimodality Images for Radiation Therapy Wei Lu, Ph.D. Department of Radiation Oncology Mallinckrodt Institute of Radiology Washington University in St. Louis Outline
More informationVerification of treatment planning system parameters in tomotherapy using EBT Radiochromic Film
Verification of treatment planning system parameters in tomotherapy using EBT Radiochromic Film E.B.Rajmohan¹, Pratik Kumar¹, Bhudatt Paliwal,² David Westerly², N.Gopishankar³, R.K.Bisht³, D.Tewatia²,
More informationCredentialing for Clinical Trials -IGRT. Evidence Based Radiation Oncology. Levels of Clinical Evidence. Why Credentialing?
Acknowledgements Credentialing for Clinical Trials -IGRT Invitation from Organizers RTOG Headquarter QA Team ATC Collaborators Evidence Based Radiation Oncology Clinical Trials From Collaborative Groups
More informationDollars and Sense: Are We Overshielding Imaging Facilities? Part 2
Disclosure Dollars and Sense: Are We Overshielding Imaging Facilities? Part 2 Bryon M. Murray, M.S., DABR Paid consultant to NELCO Worldwide Owner, CEO ZapIT! Medical Objectives Understand methods for
More informationph fax
This product is available through: JRT Associates www.standardimaging.com 800-261-4446. ph 608-831-0025. fax 608-831-2202 5 Nepperhan Avenue, Suite 2B 3120 Deming Way Middleton WIElmsford, 53562-1461 NY
More informationAdvanced film dosimetry for a UK brachytherapy audit
Advanced film dosimetry for a UK brachytherapy audit Tony Palmer Lead Scientist Medical Physics, Portsmouth Hospitals NHS Trust, UK University of Surrey, UK Institute of Physics and Engineering in Medicine
More information5th ADAMAS Workshop at GSI December 15-16, 2016, Darmstadt, Germany
Evaluation of 3D diamond detectors for application in medical radiation dosimetry K. Kanxheri (1,2), L. Servoli (2), C. Zucchetti (5), A. C. Dipilato (5), M. Iacco (5), S. Lagomarsino (3,4), A. Morozzi
More informationLearning objectives. What kind of motions? 3D Dosimetry in the Clinic: Motion Interplay Effects in Dynamic Radiotherapy
3D Dosimetry in the Clinic: Motion Interplay Effects in Dynamic Radiotherapy Sofie Ceberg, PhD Medical Physicist and Lund University Lund, Sweden Learning objectives 1: 3D Dosimetry in the Clinic: Background
More informationXstrahl designs and delivers effective clinical and research solutions to advance radiation oncology
Xstrahl designs and delivers effective clinical and research solutions to advance radiation oncology Xstrahl is a leading designer and manufacturer of superficial orthovoltage medical X-ray systems used
More informationQuality assurance and credentialing requirements for sites using inverse planned IMRT Techniques
TROG 08.03 RAVES Quality assurance and credentialing requirements for sites using inverse planned IMRT Techniques Introduction Commissioning and quality assurance of planning systems and treatment delivery
More informationMeasurement of Dose to Implanted Cardiac Devices in Radiotherapy Patients
Measurement of Dose to Implanted Cardiac Devices in Radiotherapy Patients Moyed Miften, PhD Professor and Chief Physicist University of Colorado Chester Reft, PhD Associate Professor University of Chicago
More informationOut-of-field dosimetry in radiotherapy for input to epidemiological studies. Roger Harrison
MELODI 7th Workshop, 9 11 November 2015 Helmholtz Zentrum München Next Generation Radiation Protection Research Out-of-field dosimetry in radiotherapy for input to epidemiological studies Roger Harrison
More informationCalculation methods in Hermes Medical Solutions dosimetry software
Calculation methods in Hermes Medical Solutions dosimetry software Helena McMeekin MSc. Clinical Applications Scientist, Hermes Medical Solutions MRTDosimetry Scientific Workshop The Principals and Clinical
More informationNon-target dose from radiotherapy: Magnitude, Evaluation, and Impact. Stephen F. Kry, Ph.D., D.ABR.
Non-target dose from radiotherapy: Magnitude, Evaluation, and Impact Stephen F. Kry, Ph.D., D.ABR. Goals Compare out-of-field doses from various techniques Methods to reduce out-of-field doses Impact of
More informationEORTC Member Facility Questionnaire
Page 1 of 9 EORTC Member Facility Questionnaire I. Administrative Data Name of person submitting this questionnaire Email address Function Phone Institution Address City Post code Country EORTC No Enter
More informationEstimating Iodine Concentration from CT Number Enhancement
Estimating Iodine Concentration from CT Number Enhancement Rosemary Eaton, Andrew Shah, Jane Shekhdar Medical Physics, Mount Vernon Hospital CT Users Group 4 th October 212, Edinburgh Summary Background
More information45 Hr PET Registry Review Course
45 HR PET/CT REGISTRY REVIEW COURSE Course Control Document Timothy K. Marshel, MBA, R.T. (R), (N)(CT)(MR)(NCT)(PET)(CNMT) The PET/CT Training Institute, Inc. SNMMI-TS 028600-028632 45hr CEH s Voice Credits
More informationTitle Radiotherapy Treatment Planning in Nasopharyngeal Carcinoma.
A New Brain Positron Emission Tomog Title Semiconductor Detectors for Target Radiotherapy Treatment Planning in Nasopharyngeal Carcinoma. Katoh, Norio; Yasuda, Koichi; Shiga Author(s) Masakazu; Onimaru,
More informationSimulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy. Using GATE
GATE Simulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy Using GATE Quick tour & Highlights! GATE Training, INSTN-Saclay, October 2015 Albertine
More informationKEYWORDS: nuclear medicine; gamma camera; radiopharmaceutical activities.
Radiopharmaceutical Activities Administered for Diagnostic Procedures in Nuclear Medicine in the First Six Months of the Gamma Camera Use in the Clinical Center of Montenegro - Podgorica Nevenka Antovic
More informationComparison of microlion liquid filled ionisation chamber with Semiflex and Pinpoint air filled chambers
Comparison of microlion liquid filled ionisation chamber with Semiflex and Pinpoint air filled chambers Rhys Carrington, Ysbyty Glan Clwyd, Bodelwyddan. MSc Medical Radiation Physics. Small field dosimetry
More informationAssessing Heterogeneity Correction Algorithms Using the Radiological Physics Center Anthropomorphic Thorax Phantom
Assessing Heterogeneity Correction Algorithms Using the Radiological Physics Center Anthropomorphic Thorax Phantom David Followill, Ph.D. Associate Director Radiological Physics Center RPC History Lesson
More informationPHYSICS 2: HSC COURSE 2 nd edition (Andriessen et al) CHAPTER 20 Radioactivity as a diagnostic tool (pages 394-5)
PHYSICS 2: HSC COURSE 2 nd edition (Andriessen et al) CHAPTER 20 Radioactivity as a diagnostic tool (pages 394-5) 1. (a) A radioisotope is an isotope that is unstable and will emit particles from the nucleus
More informationElectron Beam ET - Reloaded Therapy - Reloaded
8/4/216 Electron Beam ET - Reloaded Therapy - Reloaded Qiuwen Wu, Ph.D. Department of Radiation Oncology Duke University 1 Introduction: e vs. γ vs. p Electron Photon Proton Depth dose and lateral profiles
More informationMAESTRO: Methods and Advanced Equipment for Simulation and Treatment in Radiation Oncology
What is MAESTRO? Sixth Framework Program FP6 (2002-2006) European Commission Integrated Project Duration: 5 years MAESTRO: Methods and Advanced Equipment for Simulation and Treatment in Radiation Oncology
More informationFirst Clinical Experience with
First Clinical Experience with Discovery MI Digital PET/CT Martin Huellner Department of Nuclear Medicine University Hospital Zurich / University of Zurich Switzerland Agenda BelNuc GE Symposium 1. Digital
More informationVerification of micro-beam irradiation
Journal of Physics: Conference Series OPEN ACCESS Verification of micro-beam irradiation To cite this article: Qiongge Li et al 2015 J. Phys.: Conf. Ser. 573 012047 View the article online for updates
More informationRisk of a second cancer after radiotherapy
Risk of a second cancer after radiotherapy Francesco d Errico University of Pisa, Italy Yale University, USA Medical radiological procedures worldwide 2.5 billion diagnostic radiological examinations 78%
More informationImplementation of the 2012 ACR CT QC Manual in a Community Hospital Setting BRUCE E. HASSELQUIST, PH.D., DABR, DABSNM ASPIRUS WAUSAU HOSPITAL
Implementation of the 2012 ACR CT QC Manual in a Community Hospital Setting BRUCE E. HASSELQUIST, PH.D., DABR, DABSNM ASPIRUS WAUSAU HOSPITAL Conflict of Interest Disclaimer Employee of Aspirus Wausau
More informationReproducibility of Uptake Estimates in FDG PET: a Monte Carlo study
Reproducibility of Uptake Estimates in FDG PET: a Monte Carlo study Juliette Feuardent, Marine Soret, Irène Buvat 1 Abstract Tumor glucose metabolism measurements from Fluoro-deoxyglucose (FDG) Positron
More informationCompact Gamma Camera for Detection of Prostate Cancer
Compact Gamma Camera for Detection of Prostate Cancer Presented at: Human Interest Panel Federal Laboratory Consortium Annual Conference Nashville, Tennessee Brookhaven National Laboratory and Hybridyne
More informationImaging Rotation. University of Michigan Department of Radiation Oncology Division of Radiation Physics. Resident:
University of Michigan Department of Radiation Oncology Division of Radiation Physics Imaging Rotation Resident: Rotation staff mentor/ advisor: James Balter, supplemental mentors: Dale Litzenberg, Don
More informationAustin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF)
Austin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF) Overview Indication Sodium Fluoride F18 injection is a radioactive diagnostic agent for positron emission
More informationHOW TO USE PALTOP DIGITAL SERVICE?
HOW TO USE PALTOP DIGITAL SERVICE? **the service is currently available in Israel only** PALTOP Digital offers planning and production services according to your personal needs. Orders may be initiated
More informationQuantitative Imaging: A hospital physicist s perspective James Scuffham
Quantitative Imaging: A hospital physicist s perspective James Scuffham Clinical Scientist, Royal Surrey County Hospital NHS Foundation Trust Associate Tutor, University of Surrey Background The Royal
More informationTechnical Study. Institution University of Texas Health San Antonio. Location San Antonio, Texas. Medical Staff. Daniel Saenz. Niko Papanikolaou.
Technical Study Stereotactic Radiosurgery with Elekta Versa HD and Monaco Accuracy of a single isocenter, multiple brain metastases VMAT plan delivered to a pseudo-patient dosimetric gel phantom Institution
More informationAn anthropomorphic head phantom with a BANG polymer gel insert for dosimetric evaluation of IMRT treatment delivery
An anthropomorphic head phantom with a BANG polymer gel insert for dosimetric evaluation of IMRT treatment delivery G. Ibbott a, M. Beach a, M. Maryanski b a M.D. Anderson Cancer Center, Houston, Texas,
More informationMVCT Image. Robert Staton, PhD DABR. MD Anderson Cancer Center Orlando. ACMP Annual Meeting 2011
MVCT Image Guidance and QA Robert Staton, PhD DABR MD Anderson Cancer Center Orlando ACMP Annual Meeting 2011 Disclosures MDACCO has received grant funding from TomoTherapy, Inc. Overview TomoTherapy MVCT
More informationSBRT fundamentals. Outline 8/2/2012. Stereotactic Body Radiation Therapy Quality Assurance Educational Session
Stereotactic Body Radiation Therapy Quality Assurance Educational Session J Perks PhD, UC Davis Medical Center, Sacramento CA SBRT fundamentals Extra-cranial treatments Single or small number (2-5) of
More informationIROC Liver Phantom. Guidelines for Planning and Irradiating the IROC Liver Phantom. Revised July 2015
IROC Liver Phantom Guidelines for Planning and Irradiating the IROC Liver Phantom. Revised July 2015 The study groups are requests that each institution keep the phantom for no more than 2 weeks. During
More informationAmendment No. 2. Item No. 2 (Rfx/ Event number )
Amendment 2 Sub: Amendment to the Document 06.12.2018 Ref.: Notice Inviting Bid ref. HITES/PCD/NCI-AIIMS/36/18-19 dated 26.09.2018 read with its Amendment no. 1 dated 19.11.18 The following changes have
More informationBiases Affecting the Measurements of Tumor-to-Background Activity Ratio in PET
2112 IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 49, NO. 5, OCTOBER 2002 Biases Affecting the Measurements of Tumor-to-Background Activity Ratio in PET M. Soret, C. Riddell, S. Hapdey, and I. Buvat Abstract
More informationLung Spine Phantom. Guidelines for Planning and Irradiating the IROC Spine Phantom. MARCH 2014
Lung Spine Phantom Guidelines for Planning and Irradiating the IROC Spine Phantom. MARCH 2014 The study groups are requesting that each institution keep the phantom for no more than 2 week. During this
More informationRadiation treatment planning in lung cancer
Radiation treatment planning in lung cancer Georg Dietmar 1,2 1 Div. Medical Rad. Phys., Dept. of Radiation Oncology / Medical Univ. Vienna & AKH Wien 2 Christian Doppler Laboratory for Medical Radiation
More informationINNOVATING IN PERSONALISED SOLUTIONS
INNOVATING IN PERSONALISED SOLUTIONS At the forefront of custom medical technologies 4 EXPERIENCE BUILT ON SUCCESS Innovation and research, AVINENT s twin foundations AVINENT is at the forefront of custom
More informationDosimetric characterization with 62 MeV protons of a silicon segmented detector for 2D dose verifications in radiotherapy
Dosimetric characterization with 62 MeV protons of a silicon segmented detector for 2D dose verifications in radiotherapy C. Talamonti M. Bruzzi,M. Bucciolini, L. Marrazzo, D. Menichelli University of
More informationDependence of the thermoluminescent high-temperature ratio (HTR) of LiF:Mg,Ti detectors on proton energy and dose
Submitted to Radiation Measurements Dependence of the thermoluminescent high-temperature ratio (HTR) of LiF:Mg,Ti detectors on proton energy and dose P. Bilski 1, M. Sadel 1, J. Swakon 1, A. Weber 2 1
More informationADVANCES IN RADIATION TECHNOLOGIES IN THE TREATMENT OF CANCER
ADVANCES IN RADIATION TECHNOLOGIES IN THE TREATMENT OF CANCER Bro. Dr. Collie Miller IARC/WHO Based on trends in the incidence of cancer, the International Agency for Research on Cancer (IARC) and WHO
More informationThe need for standardization of dosimetry in experimental radiation biology
The need for standardization of dosimetry in experimental radiation biology Kurt Pedersen University of Wisconsin Medial Radiation Research Center Under the direction of Larry DeWerd, PhD. NCCAAPM Fall
More informationMolecular Imaging and Breast Cancer
Molecular Imaging and Breast Cancer Breast cancer forms in tissues of the breast usually in the ducts, tubes that carry milk to the nipple, and lobules, the glands that make milk. It occurs in both men
More informationIMAGE-GUIDED RADIATION THERAPY
IMAGE-GUIDED RADIATION THERAPY Your Single Source Oncology Solutions Provider Plan. Target. Treat. At Best NOMOS, we design products and solutions that help medical professionals treat a variety of cancers.
More informationTheragnostics for bone metastases. Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK
Theragnostics for bone metastases Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK NPL 2015 Ra-223 Biodistribution & dosimetry Ra-223: 11.4 days half-life, range of 100 µm Six
More informationTypical PET Image. Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located?
Typical PET Image Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located? PET/CT Oncology Imaging Anatometabolic fusion images are useful in the management
More informationDosimetry Optimization System and Integrated Software (DOSIS): a comparison against Fluka code results over a standard phantom
Dosimetry Optimization System and Integrated Software (DOSIS): a comparison against Fluka code results over a standard phantom Institute of Physics E. Gaviola - CONICET & LIIFAMIRX - Laboratorio de Investigación
More informationA comparison of dose distributions measured with two types of radiochromic film dosimeter MD55 and EBT for proton beam of energy 175 MeV
A comparison of dose distributions measured with two types of radiochromic film dosimeter MD55 and EBT for proton beam of energy 175 MeV M. Mumot, G. V. Mytsin, Y. I. Luchin and A. G. Molokanov Medico-Technical
More informationIntroduction. Measurement of Secondary Radiation for Electron and Proton Accelerators. Introduction - Photons. Introduction - Neutrons.
Measurement of Secondary Radiation for Electron and Proton Accelerators D. Followill, Ph.D. Radiological Physics Center U. T. M. D. Anderson Cancer Center Introduction Patients undergoing radiation therapy
More informationIMRT QUESTIONNAIRE. Address: Physicist: Research Associate: Dosimetrist: Responsible Radiation Oncologist(s)
IMRT QUESTIONNAIRE Institution: Date: / / Address: Physicist: e-mail: Telephone: Fax: Research Associate: email: Telephone: Fax: Dosimetrist: email: Telephone: Fax: Responsible Radiation Oncologist(s)
More informationUozu city/jp, Minatoku, Tokyo/JP Bones, Extremities, CT, Surgery, Physics, Artifacts, Image verification /ecr2014/C-0462
Metal Artifact Reduction Algorithm enablesreduce metal artifacts and improvement of diagnosis in the postoperative Pedicle screws implant for Spinal Fusion: A Phantom Study Poster No.: C-0462 Congress:
More informationIN VIVO IMAGING Proton Beam Range Verification With PET/CT
IN VIVO IMAGING Proton Beam Range Verification With PET/CT Antje-Christin Knopf 1/3 K Parodi 2, H Paganetti 1, T Bortfeld 1 Siemens Medical Solutions Supports This Project 1 Department of Radiation Oncology,
More informationSTEREOTACTIC DOSE VERIFICATION PHANTOM VERSATILE STEREOTACTIC QA PHANTOMS
PHANTOMS VERSATILE STEREOTACTIC QA For fast and accurate commissioning of Accuray CyberKnife treatment systems and patient specific dose verification plans STEREOTACTIC DOSE VERIFICATION PHANTOM Stereotactic
More information3D Dosimetry with Polymer Gel
3D Dosimetry with Polymer Gel Yoichi Watanabe, Ph.D. University of Minnesota Minneapolis, MN NCCAAPM Meeting, Minneapolis, MN NCCAAPM Meeting, Minneapolis, MN April 28, 2006 Outline I. Basics of polymer
More informationSecond Symposium on Precision Image-Guided Small Animal RadioTherapy, Vancouver, Canada, August
Second Symposium on Precision Image-Guided Small Animal RadioTherapy, Vancouver, Canada, August 11-13 2014 Program: Second Symposium on Precision Image-Guided Small Animal RadioTherapy, Aug 11-13, 2014
More information8/3/2016. The EPID Strikes Back! - EPID In-Vivo Dosimetry. EPID Research Number of Publications. Why EPID in-vivo? Detectable errors: patient
Number of Publications Number of publications 8/3/2016 The Strikes Back! - In-Vivo Dosimetry AAPM, Washington D.C, USA, 2016 Peter Greer 1,2 (1) University of Newcastle, Australia, (2) Calvary Mater Newcastle,
More informationThe IAEA BSS and development of an international dosimetry protocol
The BSS and development of an international dosimetry protocol MetroMRT 3 rd Workshop National Physical Laboratory, Teddington, UK 20-21 April 2015 Gian Luca POLI International Atomic Energy Agency Dosimetry
More informationDosisverifikation mit Delta 4 Discover während der Behandlung
Dosisverifikation mit Delta 4 Discover während der Behandlung Anders Adolfson, Regional Sales Manager at Scandidos AK IMRT 2015 in Erlangen, March 19 th 2015 Agenda Which problem does Delta 4 Discover
More informationMETROLOGY TO SUPPORT INNOVATION IN MOLECULAR RADIOTHERAPY. Glenn Flux
METROLOGY TO SUPPORT INNOVATION IN MOLECULAR RADIOTHERAPY Glenn Flux Head of Radioisotope Physics Royal Marsden Hospital & Institute of Cancer Research Sutton UK CGPM 2018 glenn.flux@icr.ac.uk Overview
More informationIROC Prostate Phantom. Guidelines for Planning and Treating the IROC IMRT Prostate Phantom. Revised March 2014
IROC Prostate Phantom Guidelines for Planning and Treating the IROC IMRT Prostate Phantom. Revised March 2014 The study groups are requesting that each institution keep the phantom for a period of time
More informationPhoton Attenuation Correction in Misregistered Cardiac PET/CT
Photon Attenuation Correction in Misregistered Cardiac PET/CT A. Martinez-Möller 1,2, N. Navab 2, M. Schwaiger 1, S. G. Nekolla 1 1 Nuklearmedizinische Klinik der TU München 2 Computer Assisted Medical
More informationRadiation Detection and Measurement
Radiation Detection and Measurement Range of charged particles (e.g.,!: µm; ": mm) Range of high energy photons (cm) Two main types of interactions of high energy photons Compton scatter Photoelectric
More informationDigital Autoradiography of 241 Am Spatial Distribution within Trabecular Bone Regions
USTUR Special Session 61 st Annual Meeting of the Health Physics Society Spokane, WA, July 19, 2016 Digital Autoradiography of 241 Am Spatial Distribution within Trabecular Bone Regions George Tabatadze,
More informationA dosimetric analysis of the Aeroform(tm) tissue expander in radiation therapy
A dosimetric analysis of the Aeroform(tm) tissue expander in radiation therapy Poster No.: R-0008 Congress: 2014 CSM Type: Scientific Exhibit Authors: T. Tran, W. Ding, L. Melvern, M. Chao, B. Subramanian;
More informationConsiderations when treating lung cancer with passive scatter or active scanning proton therapy
Mini-Review Considerations when treating lung cancer with passive scatter or active scanning proton therapy Sara St. James, Clemens Grassberger, Hsiao-Ming Lu Department of Radiation Oncology, Massachusetts
More informationDose differences between the three dose calculation algorithms in Leksell GammaPlan
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 15, NUMBER 5, 2014 Dose differences between the three dose calculation algorithms in Leksell GammaPlan Andy (Yuanguang) Xu, 1a Jagdish Bhatnagar 1, Greg
More informationCone Beam CT Protocol Optimisation for Prostate Imaging with the Varian Radiotherapy OBI imaging system. Dr Craig Moore & Dr Tim Wood
Cone Beam CT Protocol Optimisation for Prostate Imaging with the Varian Radiotherapy OBI imaging system Dr Craig Moore & Dr Tim Wood Background With the increasing use of CBCT imaging alongside complex
More informationPublishable JRP Summary Report for JRP HLT11 MetroMRT Metrology for Molecular Radiotherapy Background
Publishable JRP Summary Report for JRP HLT11 MetroMRT Metrology for Molecular Radiotherapy Background The medical treatment modality of molecular radiotherapy (MRT), or nuclear medicine therapy, has been
More informationAccuracy Requirements and Uncertainty Considerations in Radiation Therapy
Departments of Oncology and Medical Biophysics Accuracy Requirements and Uncertainty Considerations in Radiation Therapy Introduction and Overview 6 August 2013 Jacob (Jake) Van Dyk Conformality 18 16
More informationDual-Energy Imaging of Bone Marrow Edema on a Dedicated Multi-Source Cone-Beam CT System for the Extremities
Dual-Energy Imaging of Bone Edema on a Dedicated Multi-Source Cone-Beam CT System for the Extremities W Zbijewski, 1 A Sisniega, 1 JW Stayman, 1 N Packard, 2 J Yorkston, 2 G Thawait, 3 S Demehri, 3 J Fritz,
More informationOrigin, funding & collaboration
UK Brachytherapy Audit: Origin, funding & collaboration Tony Palmer OVERVIEW Purpose From idea to implementation Methodology, results & reflection Proposal for a Brachytherapy Audit Modern brachytherapy
More informationSmall field diode dosimetry
Small field diode dosimetry Parham Alaei, Ph.D. Department of Radiation Oncology University of Minnesota NCCAAPM Symposium-October 10, 2013 1 Diodes as beam data collection detectors Diodes as in vivo
More informationTopics covered 7/21/2014. Radiation Dosimetry for Proton Therapy
Radiation Dosimetry for Proton Therapy Narayan Sahoo Department of Radiation Physics University of Texas MD Anderson Cancer Center Proton Therapy Center Houston, USA Topics covered Detectors used for to
More information