Catalysts of Lipid Oxidation
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1 Catalysts of Lipid Oxidation
2 Iron The most important nonenzymic catalyst for initiation of lipid peroxidation The most abundant transitional metal in biological systems Possibility of various oxidation states (from II to +VI), the forms of Fe(II) and Fe(III) is dominated in biological systems
3 Role of iron and other metal ions in converting less reactive to more reactive species O H 2 O 2 + Fe ----->.OH (Iron-catalyzed Haber-Weiss reaction) Lipid peroxides (ROOH) -----> ROO., RO., cytotoxic aldehydes (4- hydroxyl-2,3-trans-nonenal, malondialdehyde) Thiols (RSH) + Fe/Cu + O > O 2-, H 2 O 2,.OH, thiyl (RS.) + O > thiyl peroxyl (RSO2.), RSO. (sulfenyl) NAD(P)H + Fe/Cu + O > NAD(P)., H 2 O 2, O 2-,.OH Ascorbic acid + Fe/Cu -----> semidehydroxy ascorbate radical, H 2 O 2,.OH Catecholamines, related autoxidazable molecules Fe/Cu + O > H 2 O 2, O 2-,.OH, semiquinones
4 Structural Iron Hb: 2/3 of total body iron Mb: muscle pigment. Most abundant heme pigment in meat Cytochrome c: electron transport chain Catalase: antioxidant enzyme
5 Heme Irons Ferrous heme pigment Ferric heme pigment Ferryl complexes Hematin Heating or addition of H 2 O 2 caused the release of heme iron due to oxidative cleavage of porphyrin ring of heme
6 Formation of reactive species by interaction of Hb with H 2 O 2 Hemoglobin (Ferryl?) access H 2 O 2 heme degradation Stimulation of lipid peroxidation iron ion release H 2 O 2.OH other tissue damage
7 Hematin Is released from myoglobin before the release of free ionic iron in the presence of H 2 O 2 Hematin can catalyze lipid peroxidation more efficiently than ionic iron because hematin is more reactive than hemeproteins and ferrous ion Is hydrophobicity allows it to permeate into membrane easily. Hematin monomer and hematin with hypervalent iron (FeIV=O) can initiate lipid oxidation.
8 Storage and Transport iron - Tightly bound iron - Ovotransferrin -Ferritin - Homosiderin
9 Loosely Bound Iron low molecular weight chelators 2.4~3.9% of total iron Depending on animal species and muscle types Concentration can be influenced by heating, the presence of ascorbic acid and H 2 O 2 and storage Organic phosphate esters (e.g. NAD(P)H, AMP, ADP, and ATP) Inorganic phosphates Amino acids Organic acids (e.g. citrate)
10 Free Ionic Iron Plays an important role in the catalysis of lipid peroxidation Fe(III) catalyzed lipid peroxidation only in the presence of ascorbic acid Hydrogen peroxide (H 2 O 2 ) and ascorbate can release free iron from heme pigments and ferritin Transferrin- and ferritin-bound irons nor heme pigments had any catalytic effect in raw muscle.
11 Biological iron complexes and their possible participation in oxygen radical reactions Decomposition of lipid Hydroxyl radical peroxides to form alkoxyl formation by Type of iron complexes and peroxyl radicals Fenton chemistry Loosely bound iron Iron ion attached to phosphate Yes Yes Esters (ATP etc.) Carbohydrates and organic acids Yes Yes (e.g., citrate, deoxiribose) DNA Probably yes Yes Membrane lipids Yes Yes Mineral ores (asbestos, silicates) Yes Yes Iron tightly bound to proteins Nonheme iron Ferritin (4500 mol Fe/mol protein) Yes Yes (when iron is released) Hemosiderin Weakly (when iron is released) Weakly (whe iron is released) Lactoferrin (2 mol Fe3+/mol protein) Transferrin (2 mol Fe2+/mol protein) No No No No Heme iron Hemoglobin Yes (when iron is released) Yes (when iron is released) Myoglobin Yes (when iron is released) Yes (when iron is released) Cytochrome c Yes (when iron is released) Yes (when iron is released) Catalase Weakly Not observed
12 Products of Lipid Oxidation
13 Products of Lipid Oxidation
14 Oxidation of diene lipids
15 Oxidation of triene lipids Autoxidation Photo-oxidation 9-OOH D10,12,15 (37%) 9-OOH D10,12,15 (23%) 10-OOH D8,12,15 (13%) 12-OOH D9,13,15 (8%) 12-OOH D9,13,15 (12%) 13-OOH D9,11,15 (10%) 13-OOH D9,11,15 (14%) 15-OOH D9,12,16 (13%) 16-OOH D9,12,14 (45%) 16-OOH D9,12,14 (25%)
16 Oxidation of triene lipids
17 Oxidation of highly unsaturated lipids
18 Oxidation of highly unsaturated lipids
19 Secondary Peroxidation Products from Fatty Acids
20 Hydrocarbons: Alkanes and Alkenes C8-OOH oleate Homolysis Homolytic beta-scission of a carbon bond on either side of the O-containing carbon atom Addition
21 Alkanes, Alkenes C8-hydroperoxide of oleic acid (8-OOH oleate): 1-decene C9-hydroperoxide of oleic acid (9-OOH oleate): 1-nonene C10-hydroperoxide of oleic acid (10-OOH oleate): 1-octene C13-hydroperoxide of linoleic and arachidonic acid: pentane produce pentane C13-hydroperoxide of linoleic acid produces ethane and ethylene
22 Aldehydes A From C8-OOH oleate CH 3 (CH 2 ) 7 CH=CH-CH-(CH 2 ) 6 -COOH O.
23 Aldehydes from n-6 fatty acids Peroxidation of n-6 fatty acids (linoleic and arachidonic acid): 9-hydroperoxy linoleate: 2,4-decadienal, and 3-nonenal 13-hydroperoxy linoleate: hexanal and pentanal 10-hydroperoxy linoleate: 2-heptenal Other volatile aldehydes formed: 2-hexenal, 2-octenal, 2,4- nonadienal, 4,5-hydroxydecenal, 4-hydroxy-2,3-transnonenal
24 4-HNE formation Reduction 13-hydroperoxy linoleic acid (13-HPODE) H-abstraction isomerization oxidation cleavage
25 4-Hydroxy-2,3-trans nonenal (4HNE) Formed by linoleate, arachidonic acid oxidation Have high cytotoxicity at high concentrations Inhibits DNA and protein synthesis and generate oxidative stress Act in defense against fungi in plants At low concentrations, have chemotactic effect, stimulate guanylate cyclase and phospholipase C activities
26 Aldehydes from n-3 fatty acids Peroxidation of n-3 fatty acids (linolenic and EPA, DHA): Various compounds depending upon the location of hydroperoxy group 9-OOH linolenate: 2,4,7-decatrienal, 3,6-nonadienal 12-OOH linolenate: 2,4-heptadienal, 3-hexenal 13-OOH linolenate: 3-hexenal and 2-pentenal 16-OOH linolenate: propanal Other volatile aldehydes formed: butanal, 4,5-epoxy hepta- 2-enal, 4-hydroperoxy hexenal, 4,5-hydroxydecenal, 4- hydroxy-2,3-trans-hexenal
27 Malonaldehyde Formed by further degradation of hydroperoxy aldehydes The main precursor: monocyclic peroxides formed from fatty acids with 3 or more double bonds Introduces cross-links in proteins and induces profound alteration in their biochemical properties
28 Epoxides (or Oxirane oxygen) Linoleic epoxides
29 Epoxides Generated by the attack of any double bonds present in fatty acid chain by a lipid peroxyl radical (ROO.) Toxic Some of them (epoxyeicosatrienoic acid) affects blood flow, mitogenesis, platelate aggregation, anti-inflamatory, vasoregulation (relax renal arteries)
30 1-Pentene Pentane 1-Methoxy-2-methyl-1-propene 2-Methyl pentane 3-Methyl pentane 2,2-Dimethyl pentane 2,3-Dimethyl pentane 3,3-Dimethyl pentane 1-Hexene Hexane 2-Methyl hexane 3-Methyl hexane 3-Ethyl hexane 2,4-Dimethyl hexane 1-Octene Octane 2-Octene 3-Octene 3-Methyl octane 2,6-Dimethyl octane 1-Heptene Heptane 2,6-Dimethyl heptane 1,2,4-Trimethyl heptane Ethyl benzene 1,3-Dimethyl benzene 2,2,3-Trimethyl butane 3-Nonen-1-ol Undecanenitrile Octahydro-1H-indene 1,3-Cyclopentadiene 4-Methyl cyclopentene 3-Methyl cyclopentene Methyl cyclopentane 1,1,3-Trimethyl cyclopentane Cyclohexane Cyclohexene Methyl cyclohexane 1,3-Dimethyl cylohexane Ethyl cyclohexane 1,1,3-Trimethyl cyclohexane 1,2,4-Trimethyl cyclohexane 1,2,3,5-Tetramethyl cyclohexane 1-Ethyl-3-methyl cyclohexane Propyl cyclohexane 1-Ethyl-2,3-dimethyl cyclohexane Butyl cyclohexane 1,1,2,3-Tetramethyl cyclohexane 1-Methyl-4-(1-methylethyl)-cyclohexane 1,1,4-Trimethyl cyclohexane 1,2-Dimethyl cyclooctane Volatile compounds produced from arachidonic acid
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