SIMPLIFIED CHIRAL SEPARATIONS. FIVE Complementary Chiral Phases. for Greater Selectivity. Resolve 92 %

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1 SIMPLIFIED IRAL SEPARATIS FIVE omplementary hiral Phases for Greater Selectivity Resolve 9 % of all your Enantiomers using Screening Kits * FREE hiral Screening and Separation Services. *Based on screening 33 compounds on the 5 unique Lux phases.

2 EW Polysaccharide-Based hiral olumns! SIMPLIFIED IRAL SEPARATIS l ellulose-4 ovel hlorinated ellulose Phase cellulose tris(4-chloro-3-methylphenylcarbamate) ellulose-3 ellulose Ester hiral Selector cellulose tris(4-methylbenzoate) ellulose-3 and ellulose-4 phases are complementary to existing amylose and cellulose SPs (hiral Stationary Phases), and make an excellent addition to your chiral screen. igh efficiency and loading capacity Pressure stable up to 300 bar Stable in ormal Phase, Polar rganic, SF, and Reversed Phase onditions 3 µm and 5 µm packed columns and 0 µm bulk media for scale-up Meet the other members of the Lux Family! ellulose- cellulose tris(3,5-dimethylphenylcarbamate) ellulose- cellulose tris(3-chloro-4-methylphenylcarbamate) Amylose- amylose tris(5-chloro--methylphenylcarbamate) l l ellulose Backbone Guaranteed Replacement For *IRALEL D- ellulose Backbone hlorinated ellulose Phase Amylose Backbone hlorinated Amylose Phase *IRALEL and D- are registered trademarks of DAIEL hemical Industries, Ltd. Lux is a trademark of Phenomenex, Inc. 00 Phenomenex, Inc. All rights reserved.

3 SIMPLIFIED IRAL SEPARATIS Achieve ptimal Resolution by Screening all Five Unique Lux hiral olumns Utilizing differences in selectivity can help develop methods more efficiently by offering broad and contrasting chiral recognition abilities. chiral selectors provide a variety of complementary selectivities that give you the opportunity to screen for the most effective separation. Etozolin ellulose- a =.06 App ID 947 onditions for all columns: Dimensions: 50 x 4.6 mm Mobile Phase: Acetonitrile / 0. % Diethylamine in 0 mm 4 3 (60:40) Flow Rate: ml/min Detection: 0 nm Temperature: Ambient min ellulose-4 a =.35 App ID 95 S min Amylose- a =.45 App ID min ellulose- a =.48 App ID min ptimal Resolution ellulose-3 a =.70 App ID 95 Based on a five phase screen under Reversed Phase conditions, the optimal chiral stationary phase for resolving Etozolin is Lux ellulose min omparative separations may not be representative of all applications.

4 SIMPLIFIED IRAL SEPARATIS ellulose-4 cellulose tris(4-chloro-3-methylphenylcarbamate) Innovative new chiral selector will succeed where others fail. Tolperisone ellulose-4 a =.7 App ID 953 onditions for all columns: Dimensions: 50 x 4.6 mm Mobile Phase: 0. % Diethylamine in exane / 0. % Diethylamine in Isopropanol (90:0) Flow Rate: ml/min Detection: 0 nm Temperature: Ambient min *IRALEL D- a =.0 App ID min *IRALPAK AD - a =.00 App ID min ellulose-3 cellulose tris(4-methylbenzoate) Enhanced enantioselective properties provide higher resolution values and better performance for your separations. Disopyramide ellulose-3 a =.8 R s =.30 App ID 956 onditions for both columns: Dimensions: 50 x 4.6 mm Mobile Phase: 0. % Diethylamine in exane / 0. % Diethylamine in Ethanol (90:0) Flow Rate: ml/min Detection: 0 nm Temperature: Ambient min *IRALEL J- a =.7 R s =.03 App ID min omparative separations may not be representative of all applications. olumns used for comparison were manufactured by DAIEL hemical Industries, Ltd. *IRALEL, IRALPAK, AD, J- and D- are registered trademarks of DAIEL hemical Industries, Ltd. Lux is a trademark of Phenomenex, Inc.

5 Easy hiral Method Development SIMPLIFIED IRAL SEPARATIS With five unique and complementary polysaccharide phases for screening, chiral method development just got easier. The more phases you have available to screen, the greater the chance of achieving optimal chiral resolution. Build your own 3, 4, or 5 phase screening kits for in-house method development. To get you started, we have outlined a simple strategy for screening SPs under PL and SF conditions in our chiral method development solutions poster. all or go online today to create your own custom screening kit or to request a chiral method development solutions poster at FREE hiral Screening and Separation Services PL SF Preparative Training Screening multiple chiral columns and solvent strategies for new methods is often a time consuming process. Let us do the work for you hiral Phase Screening Method ptimization Method Re-Validation Scale-Up Services n-site Training For more information on these services or to begin a project, please contact your local Phenomenex representative or us at: phenologics@phenomenex.com You can also visit us on the web: Terms and onditions Subject to Phenomenex Standard Terms & onditions, which may be viewed at Trademarks IRALEL, IRALPAK, AD, J- and D- are registered trademarks of DAIEL hemical Industries, Ltd. Lux, Axia and SecurityGuard are trademarks of Phenomenex, Inc. Disclaimer omparative separations may not be representative of all applications. olumns used for comparison were manufactured by DAIEL hemical Industries, Ltd. 00 Phenomenex, Inc. All rights reserved.

6 rdering Information SIMPLIFIED IRAL SEPARATIS 3 μm Analytical olumns (mm) SecurityGuard artridges (mm) 50 x.0 50 x.0 50 x x x x x.0* 4 x 3.0* Phases /0pk /0pk ellulose-4 00B-4490-B0 00F-4490-B0 00B-4490-E0 00D-4490-E0 00F-4490-E0 00G-4490-E0 AJ0-866 AJ0-867 ellulose-3 00B-449-B0 00F-449-B0 00B-449-E0 00D-449-E0 00F-449-E0 00G-449-E0 AJ0-86 AJ0-86 ellulose- 00B-4456-B0 00F-4456-B0 00B-4456-E0 00D-4456-E0 00F-4456-E0 00G-4456-E0 AJ AJ ellulose- 00B-4458-B0 00F-4458-B0 00B-4458-E0 00D-4458-E0 00F-4458-E0 00G-4458-E0 AJ0-840 AJ Amylose- 00B-447-B0 00F-447-B0 00B-447-E0 00D-447-E0 00F-447-E0 00G-447-E0 AJ0-847 AJ for ID: mm mm 5 μm Analytical olumns (mm) SecurityGuard artridges (mm) 50 x.0 50 x x x x x.0* 4 x 3.0* Phases /0pk /0pk ellulose-4 00B-449-B0 00B-449-E0 00D-449-E0 00F-449-E0 00G-449-E0 AJ0-866 AJ0-867 ellulose-3 00B-4493-B0 00B-4493-E0 00D-4493-E0 00F-4493-E0 00G-4493-E0 AJ0-86 AJ0-86 ellulose- 00B-4457-B0 00B-4457-E0 00D-4457-E0 00F-4457-E0 00G-4457-E0 AJ AJ ellulose- 00B-4459-B0 00B-4459-E0 00D-4459-E0 00F-4459-E0 00G-4459-E0 AJ0-840 AJ Amylose- 00B-447-B0 00B-447-E0 00D-447-E0 00F-447-E0 00G-447-E0 AJ0-847 AJ for ID: mm mm 5 µm Semi-Prep olumns (mm) SecurityGuard artridges (mm) 50 x x x 0.0 Phases /3pk ellulose-4 00F G AJ0-868 ellulose-3 00F G AJ0-863 ellulose- 00F G AJ ellulose- 00F G AJ Amylose- 00F G AJ0-847 for ID: 9-6 mm 0 µm Bulk Media 00 g kg Phases ellulose- 04G K-4473 ellulose- 04G K-4464 Amylose- Please inquire for 0 µm Lux Amylose-, ellulose-3 or ellulose-4 media. ustom 3, 4 or 5 Phase Screening Kits! all or go online today to create yours at a discounted price. 5 μm Axia Packed Preparative olumns (mm) SecurityGuard artridges (mm) 50 x. 50 x. 50 x x 50 5 x.** 5 x Phases /ea /ea ellulose-4 00F-449-P0-AX 00G-449-P0-AX 00G-449-U0-AX 00G-449-V0-AX AJ0-869 AJ ellulose-3 00F-4493-P0-AX 00G-4493-P0-AX 00G-4493-U0-AX 00G-4493-V0-AX AJ0-864 AJ0-865 ellulose- 00F-4457-P0-AX 00G-4457-P0-AX 00G-4457-U0-AX 00G-4457-V0-AX AJ AJ0-840 ellulose- 00F-4459-P0-AX 00G-4459-P0-AX 00G-4459-U0-AX 00G-4459-V0-AX AJ AJ Amylose- 00F-447-P0-AX 00G-447-P0-AX 00G-447-U0-AX 00G-447-V0-AX AJ AJ *SecurityGuard Analytical artridges require holder, Part o. : KJ0-48 SemiPrep SecurityGuard artridges require holder, Part o. : AJ0-70 **PREP SecurityGuard artridges require holder, Part o. : AJ PREP SecurityGuard artridges require holder, Part o. : AJ0-877 for ID: 8 9 mm mm If Lux analytical columns ( 4.6 mm ID) do not provide at least an equivalent or better separation as compared to a competing column of the same particle size, similar phase and dimensions, send in your comparative data within 45 days and keep the Lux column for FREE. BR _I