FOCUS ON NEUROENDOCRINE TUMORS 8 TH ANNUAL. Friday, March 8, am 2:30 pm. REGISTER ONLINE AT PennMedicine.org/Abramson/NETs

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1 8 TH ANNUAL FOCUS ON NEUROENDOCRINE TUMORS A PATIENT & CAREGIVER PROGRAM Friday, March 8, am 2:30 pm REGISTER ONLINE AT PennMedicine.org/Abramson/NETs Attend in Person or View Livestream OPEN TO THE PUBLIC Law Auditorium // Jordan Medical Education Center // Perelman Center for Advanced Medicine 3400 Civic Center Boulevard // Philadelphia, PA 19104

2 8 TH ANNUAL FOCUS ON NEUROENDOCRINE TUMORS A PATIENT & CAREGIVER PROGRAM DATE Friday, March 8, 2019 TIME 8 am 2:30 pm LOCATION Law Auditorium Jordan Medical Education Center Perelman Center for Advanced Medicine 3400 Civic Center Boulevard Philadelphia, PA FREE Parking, Breakfast & Lunch! FOLLOW US #PhillyNETS WHO SHOULD ATTEND: Newly diagnosed, currently in treatment or long-term survivor of: Gastrointestinal Tract NETs including: Pancreatic NETs (hereditary or sporadic) Zollinger-Ellison syndrome (gastrinomas) Insulinomas Alimentary tract NETs (foregut, midgut or hindgut) Functional (carcinoid syndrome) Non-functional Bronchial, Thymic and Carcinoid in other locations Pheochromocytomas and Paragangliomas including hereditary and sporadic forms Hereditary Syndromes associated with Neuroendocrine Tumors If you are a family member or caregiver REGISTRATION To register or for more information, call PENN (7366) or visit PennMedicine.org/Abramson/NETs. Parking will be validated Parking information can be found at PennMedicine.org. $25 suggested donation (non-tax deductible) to support the Focus On Neuroendocrine Tumors Conference.Credit cards accepted with on-line registration. Cash, check, money order or credit card accepted the day of the conference.

3 AGENDA 8:00 am Check-In Continental Breakfast, Visit Exhibits and Experts 8:40 am Welcome Opening Remarks Debbie L. Cohen, MD, Conference Co-Chair Joseph R. Carver, MD, Chief of Staff, Abramson Cancer Center 8:45 am News from the Abramson Cancer Center Andrew Bellet, Major Gifts Officer, Abramson Cancer Center MORNING SESSION 9:15 am Management of NETs Overview David C. Metz, MD, Gastroenterology Debbie L. Cohen, MD, Nephrology 9:35 am Penn NET Center Overview of Clinical & Basic Science Research Bryson W. Katona, MD, PhD, Gastroenterology Heather Wachtel MD, Endocrine & Oncologic Surgery 9:55 am Use of PRRT for NETS Daniel A. Pryma, MD, Radiology, Nuclear Medicine 10:15 am Genetics Update Anna C. Raper, MS, Genetics 10:35 am Break 10:45 am Systemic therapy for metastatic NETs Jennifer Eads, MD, Hematology Oncology 11:05 am KEYNOTE SPEAKER The role of Endocrinologist in the Management of NETs Lauren M. Fishbein, MD, PhD, MTR, Endocrinology, Metabolism, Diabetes 11:35 am Lunch CONFERENCE CO-CHAIRS David C. Metz, MD, Professor of Medicine, Gastroenterology, Co-Director, Neuroendocrine Tumor Center Debbie L. Cohen, MD, Associate Professor of Medicine, Director of Clinical Hypertension Programs, Co-director of Neuroendocrine Tumor Program

4 AFTERNOON SESSION 12:20 pm Multidisciplinary Team Approach for Managing NETs MODERATORS David C. Metz, MD & Debbie L. Cohen, MD PANEL MEMBERS Lauren M. Fishbein, MD, PhD, MTR, Endocrinology, Metabolism, Diabetes Maria L. Bonanni, NP, Genetics Diann E. Boyd, BSN, RN, OCN, Oncology Nurse Navigator Jason Brant, MD, Otorhinolaryngology Joseph R. Carver, MD, Cardiology Keith A. Cengel, MD, PhD, Radiation Oncology Nevena Damjanov, MD, Medical Oncology Jennifer Eads, MD, Hematology Oncology Anna Jung, PharmD, BCPS, GI Pharmacist Julia N. Kharlip, MD, Endocrinology John C. Kucharczuk, MD, Thoracic Surgery Daniel A. Pryma, MD, Radiology, Nuclear Medicine Robert E. Roses, MD, Endocrine & Oncologic Surgery Michael C. Soulen, MD, Interventional Radiology Ursina R. Teitelbaum, MD, Medical Oncology/Palliative Care Heather Wachtel, MD, Endocrine & Oncologic Surgery 1:50 pm Patient Power It Takes Guts MODERATORS Neal Niznan, MSW, LCSW & Bonnie J. Bennett, BSN, RN 2:30 pm Conference Closing EXHIBIT HALL Visit our experts in Survivorship and Integrative Therapies Integrative Therapies Surgery Nurse Coping with Emotions Giving Back Good Shepherd Penn Partners Penn Therapy and Fitness Optional Managing GI Symptoms Managing Symptoms Liver Directed Therapy Managing Symptoms Chemotherapy Nutrition Nurse Navigation Palliative Care

5 KEYNOTE SPEAKER Lauren M. Fishbein, MD, PhD, MTR Lauren M. Fishbein, MD, PhD, MTR is an Assistant Professor in Medicine at the University of Colorado School of Medicine in the Division of Endocrinology, Metabolism and Diabetes with a secondary appointment in the Division of Biomedical Informatics and Personalized Medicine. She received her bachelor s degree in Biochemistry from Vassar College and earned her MD, PhD degree from the University of Florida with a PhD in Molecular Genetics. She completed her Internal Medicine Residency at Harvard s Beth Israel Deaconess Medical Center in Boston and her Endocrinology Fellowship at the University of Pennsylvania where she also completed a Master s in Translational Research. Her research and clinical interests are in neuroendocrine tumor genetics with a special focus on pheochromocytomas and paragangliomas. Dr. Fishbein has a strong interest in personalized medicine including understanding the impacts and implications of germline predisposition genetics, as well as understanding tumor development and transformation to aggressive and metastatic disease. Among her contributions to the field, she, along with her collaborators, was the first to report the association between somatic ATRX mutations and aggressive pheochromocytoma, and she was the data coordinator for The Cancer Genome Atlas (TCGA) integrative genomics study on pheochromocytoma and paraganglioma. She has served and continues to serve on committees for the Endocrine Society, and she is currently a member of the Guidelines and Publications Committee for the North American Neuroendocrine Tumor Society. ABOUT Abramson Cancer Center PennMedicine.org/Abramson At the Abramson Cancer Center our mission is to reduce the burden of cancer throughout our region, the nation and the world through the development of an integrated program of laboratory, clinical and population based research. The Abramson Cancer Center has been continuously designated as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since The Abramson Cancer Center was rated EXCEPTIONAL by the NCI at our last competitive review the highest possible rating a Center can receive. The Focus on Neuroendocrine Tumors Conference is being held in collaboration with the Penn Medicine Development Office. Attendees will receive communication from the PENN Medicine Development Office regarding their research and programs. Participation in this conference is optional and patient privacy has been maintained. If you would prefer not to receive development materials, we will make reasonable efforts to honor such a request. Please send a written request with your name, and address to Tricia Bruning, Abramson Cancer Center Development Office, 3535 Market Street, Suite 750, Philadelphia, PA