The third EUPON Meeting Update on Optic Nerve Degeneration A European Network

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1 The third EUPON Meeting Update on Optic Nerve Degeneration A European Network 14 15th April 2018, Düsseldorf, Germany copyright: Copyright Creativity & Illustration.

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3 FOREWORD Welcome to The EUPON Meeting 2018 Update on Optic Nerve Degeneration: a European Network The third annual EUPON meeting will be held on Apr 14 15th 2018 in Düsseldorf. EUPON is a unique interdisciplinary scientific meeting focusing on diseases of the optic nerve and retina from both an ophthalmologic and a neurologic perspective. This year s meeting covers nine main topics which will be covered from the preclinical, diagnostic and therapeutic point of view: Optic neuritis and multiple sclerosis, neuromyelitis spectrum disorders, preclinical retinal imaging of mice and rats, hereditary optic neuropathies, glaucoma, retinal diseases affecting the optic nerve, standardization of retinal imaging (quality control criteria and reporting guidelines), anterior ischemic optic neuropathy, and pseudotumor cerebri syndrome. We have tried to put a special focus on including not only cutting edge lectures on the clinical state of the art but also integrating the relevant translational aspects of basic science research in the field. We hope to see you in Düsseldorf for EUPON 2018 and are looking forward to exciting scientific talks and interdisciplinary discussions with you. Kind regards, Philipp Albrecht, Wolf Lagrèze, Rainer Guthoff and Orhan Aktas

4 PROGRAM 14 th APRIL :30 8:50 Registration / Coffee Optic Neuritis / MS Chairs: Wolf Lagrèze, Friedemann Paul 8:50 9:00 Welcome Hans-Peter Hartung, Düsseldorf 9:00 9:20 Pathophysiology of ganglion cell loss in EAE Ricarda Diem, Heidelberg 9:20 9:40 Diagnostic approaches assessing the visual system in MS Friedemann Paul, Berlin 9:40 10:00 The value of VEP and mfvep in MS Letizia Leocani, Milan 10:00 10:20 MRI imaging of the visual system in MS Inigo Gabilondo, Bilbao 10:20 10:40 Coffee break 10:40 11:00 The thickness of the inner nuclear layer (INL) and disease activity in MS Benjamin Knier, München 11:00 11:20 Reexamining the INL in MS: Findings and relevance of INL thickness in a multicenter study Lisanne Balk, Amsterdam 11:20 11:40 The prognostic value of (mf)vep and OCT in ON and MS Jette Frederiksen Lautrup Battistini, Kopenhagen 11:40 12:00 Therapeutic approaches to Optic Neuritis Wolf Lagrèze, Freiburg 12:00 13:00 Lunch AION and IIH Chairs: Christian van Oterendorp, Ullrich Wüllner 13:00 13:20 Animal models for AION and their application to translational research Chantal Dysli, Bern

5 13:20 13:40 An update on the diagnostic approaches for AION Helmut Wilhelm, Tübingen 13:40 14:00 The therapeutic approaches for AION Christian van Oterendorp, Göttingen 14:00 14:20 Current opinion and data on the pathopyhsiology and therapeutic options of pseudotumor cerebri syndrome Ullrich Wüllner, Bonn 14:20 14:40 Diagnostic approaches to pseudotumor cerebri syndrome Wolf Lagrèze, Freiburg 14:40 15:10 Coffee break NMOSD Chairs: Orhan Aktas, Hans-Peter Hartung 15:10 15:30 Retinal imaging as diagnostic parameter for NMOSD Joachim Havla, München 15:30 15:50 Visual evoked potentials in NMOSD Marius Ringelstein, Düsseldorf 15:50 16:10 Established and emerging therapeutic strategies for NMOSD Orhan Aktas, Düsseldorf The interface: Retinal diseases affecting brain/optic nerve and vice versa Chairs: Rainer Guthoff, Elmar Pinkhardt 16:10 16:30 Systemic diseases affecting retina and visual system Neurodegeneration in Diabetic Retinopathy Rainer Guthoff, Düsseldorf 16:30 16:50 etinal findings in Parkinson s disease and other R neurodegenerative diseases Elmar Pinkhardt, Ulm 16:50 17:10 Cerebrovascular disease and the retina posterior cerebral artery infarction John-Ih Lee, Düsseldorf

6 PROGRAM 15 th APRIL 2018 Preclinical Session (Mice and Rats) Chairs: Philipp Albrecht, Mathias Seeliger 9:00 9:20 The role of microglia during experimental autoimmune encephalomyelitis/optic neuritis Marta Jordao, Freiburg 9:20 9:40 Retinal imaging in EAE for translational neuroprotection studies Philipp Albrecht, Düsseldorf 9:40 10:00 Diffusion tensor imaging of the visual system in EAE Sven Schippling, Zürich 10:00 10:20 Translation EAE to Optic Neuritis: Unsuspected effects of 4-Aminopyridine Michael Dietrich, Düsseldorf 10:20 10:50 Coffee break 10:50 11:10 Retinal imaging in neurodegenerative models Janos Groh, Würzburg 11:10 11:30 Preclinical models for retinopathies and their application in translational research Mathias Seeliger, Tübingen

7 Glaucoma Chairs: Ted Garway-Heath, Elmar Pinkhardt 11:30 11:50 Insights from preclinical models for glaucoma and retinal ganglion cell damage Dietmar Fischer, Düsseldorf 11:50 12:10 An overview on the diagnostic criteria and procedures as well as therapeutic options for glaucoma Ted Garway Heath, London 12:10 13:10 Lunch Hereditary optic neuropathies Chairs: Piero Barboni, Patrick Yu Wai Man 13:10 13:30 Preclinical models of hereditary optic neuropathies Bernd Wissinger, Tübingen 13:30 13:50 Diagnostic approaches to hereditary optic neuropathies Piero Barboni, Milan 13:50 14:20 Coffee break 14:30 14:50 Therapeutic options for hereditary optic neuropathies Patrick Yu Wai Man, Cambridge 14:50 15:10 The APOSTEL recommendations for reporting of OCT studies Philipp Albrecht, Düsseldorf

8 INVITED SPEAKERS Aktas, Orhan Düsseldorf Jordao, Marta Freiburg Albrecht, Philipp Düsseldorf Knier, Benjamin München Balk, Lisanne Amsterdam Lagrèze, Wolf Freiburg Barboni, Piero Milan Lee, John-Ih Düsseldorf Diem, Ricarda Heidelberg Leocani, Letizia Milan Dietrich, Michael Düsseldorf van Oterendorp, Christian Göttingen Dysli, Chantal Bern Paul, Friedemann Berlin Fischer, Dietmar Düsseldorf Pinkhardt, Elmar Ulm Frederiksen, Jette Lautrup Kopenhagen Ringelstein, Marius Düsseldorf Gabilondo, Inigo Bilbao Schippling, Sven Zürich Garway Heath, Ted London Seeliger, Mathias Tübingen Groh, Janos Würzburg Wilhelm, Helmut Tübingen Guthoff, Rainer Düsseldorf Wissinger, Bernd Tübingen Hartung, Hans-Peter Düsseldorf Wüllner, Ullrich Bonn Havla, Joachim München Yu Wai Man, Patrick Cambridge

9 GENERAL INFORMATION Mission EUPON inspires European multidisciplinary collaborations to further the knowledge in ophthalmological and neurological optic nerve pathologies. Vision To be a European reference and lead international efforts in diagnostic, therapeutic and research strategies involving optic nerve. Target audience Ophthalmologists, neurologists, engineers working in biomedicine, orthoptists, optometrists, nurses, medical technicians CME-Certification Application for CME-certification pending. Registration fees (VAT included) Regular Students, PHD candidates, technicians 200, Euro free of charge (student ID required) Registration fee includes conference documents and catering. Cancellation Terms Cancellation has to be submitted in written form to the company jottkaa GmbH. until 14th March = 50% from 15th March = no refund Substitute participants are accepted. Please register online under

10 ORGANIZED BY / VENUE Priv. Doz. Dr. Philipp Albrecht Consultant Neurologist University Hospital Düsseldorf / Dept. of Neurology phil.albrecht@gmail.com Tel.: +49 (0) 211 / Co-organizers: Wolf Lagrèze, Rainer Guthoff und Orhan Aktas Venue University Hospital Düsseldorf / Universitätsklinikum Düsseldorf MNR-Klinik Gebäude 13.55, Hörsaal 13 B Universitätsstraße Düsseldorf 13 B

11 WE THANK OUR SPONORS: Gold sponsor Novartis Pharma GmbH , Euro Roche Pharma AG , Euro Santhera (Germany) GmbH , Euro Silver sponsor Biogen GmbH 6.000, Euro Heidelberg Engineering GmbH 5.000, Euro Sanofi Genzyme 5.000, Euro Teva GmbH 7.000, Euro Sponsor Carl Zeiss Meditec GmbH 1.500, Euro Merck KGaA 2.000, Euro

12 Congress Office jottkaa Projekt.Konzept GmbH Inken Kienzle Tel.: +49 (0) 221 / copyright: Copyright Creativity & Illustration.

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