Case 26 Male 37. Right jawline 5mm nodule?keloid. The best diagnosis is:
|
|
- Patrick Fox
- 5 years ago
- Views:
Transcription
1 Case 26 Male 37. Right jawline 5mm nodule?keloid. The best diagnosis is: A. Desmoplastic Spitz naevus B. Atypical Spitz Tumour C. Spitzoid melanoma D. Deep penetrating naevus E. Spitz naevus
2 Case 26: M 37. Right jawline 5mm nodule?keloid
3 Case 26: M 37. Right jawline 5mm nodule?keloid
4 S100 useful for architecture
5
6
7
8
9
10 Ill-defined deep border, some lack of maturation
11
12
13 mitoses and nuclear pleomorphism
14
15 Case 26: M 37 Diagnosis? p16 variable expression Ki67 low (5%)
16 Atypical Spitz tumour:? slightly favouring benign
17 Case 26: atypical Spitz tumour Differential diagnosis: desmoplastic Spitz naevus Similar but more sclerotic stroma, less atypia
18 Case 26: atypical Spitz tumour Differential diagnosis: Spitzoid melanoma Similar but more atypia, asymmetry, mitoses etc.
19 Differential diagnosis: Spitzoid melanoma Similar but more atypia, asymmetry, mitoses etc. Slides courtesy of melanocytepathology.com Free access site by Prof Wolter Mooi, 2013 BSD guest speaker
20
21 Differential diagnosis: deep penetrating naevus wedge-shaped, less atypia
22 Case 26: atypical Spitz tumour Differential diagnosis: deep penetrating naevus wedge-shaped, less atypia,
23 Differential diagnosis: Spitz naevus more symmetry, clefts surrounding nests, Kamino bodies, less atypia
24 Case 26: atypical Spitz tumour Differential diagnosis: Spitz naevus more symmetry, less atypia,
25 FISH results Vysis Melanoma FISH Probe Kit Total Value Parameters +/- (Gerami et al.am J Surg Pathol 2008;33: ) % of nuclei with > 2 CCND1 signals % Cut-off >/ % - % of nuclei with > 2 RREB1 signals % Cut-off >/ % - % of nuclei with gain of RREB1 relative to CEP % Cut-off >/ % - % of nuclei with loss of MYB (6q23) relative to CEP % Cut-off >/ % + Abbott Average CCND1 signals per nucleus Cut-off >/ % of atypical nuclei (signals/nucleus >or<2) for RREB % Cut-off >/ % - Average MYB signals per nucleus Cut-off >/ % of nuclei with loss of MYB (6q23) 8 relative to CEP % Cut-off >/ % + FISH positive for 6q23 loss with both probe kits FISH courtesy of JE Calonje
26 Case 26: M 37. Final diagnosis? Atypical Spitz tumour with 6q23 deletion
27 Atypical spitz tumors with 6q23 deletions: a clinical, histological, and molecular study. Shen L, Cooper C, Bajaj S, Liu P, Pestova E, Guitart J, Gerami P. Am J Dermatopathol Dec;35(8): retrospective case-controlled study probes targeting 6p25, 6q23, Cep6, 11q13, 9p21, and Cep9. 24 cases of atypical Spitz tumours (ASTs) with isolated copy number deletions in 6q23 6 of 11 patients had a positive sentinel node biopsy, BUT none of the patients developed tumor in a non-sentinel node, palpable adenopathy, in transit metastasis, or distant metastasis BUT mean follow up only 22 months (2 of 3 cases with at least 5 yrs had positive sentinel node)
28 Atypical spitz tumors with 6q23 deletions: a clinical, histological, and molecular study. Shen L, Cooper C, Bajaj S, Liu P, Pestova E, Guitart J, Gerami P. Am J Dermatopathol Dec;35(8): Can we predict the deletion histologically? NO! minimal pagetoid spread (P = 0.004) expansile nodular growth (P = 0.08) focal ulceration (P = 0.19)
29 Atypical Spitz tumours with possible good prognosis: 3p21 and 6q23 loss 3p21 (BAPoma / BAP1 associated Spitz tumour) 6q23 but is it really a good prognosis? as 6 of 11 patients had a positive sentinel node biopsy! Both can show much cytological atypia
30 Atypical Spitz tumours with possible poor prognosis: HOMOZYGOUS 9p21 loss, 6p25gain, 11q13 gain Risk assessment for atypical spitzoid melanocytic neoplasms using FISH to identify chromosomal copy number aberrations. Gerami P, Scolyer RA, Xu X, Elder DE, Abraham RM, Fullen D, Prieto VG, Leboit PE, Barnhill RL, Cooper C, Yazdan P, Guitart J, Liu P, Pestova E, Busam K. Am J Surg Pathol May;37(5): FISH detecting a limited number of chromosomal copy number aberrations can provide clinically useful and statistically significant risk assessment for atypical Spitz tumors. In multivariate analysis, homozygous 9p21 deletion was highly associated with clinically aggressive behavior (P<0.0001) and death due to disease (P=0.003). Cases with 6p25 or 11q13 gains also have higher risk for aggressive clinical behavior than FISH-negative atypical Spitz tumors or cases with 6q23 deletions.
31 Atypical Spitz tumours with possible poor prognosis: HOMOZYGOUS 9p21 loss, 6p25gain, 11q13 gain HOMOZYGOUS 9p21 loss Severe cytologic atypia predominance of epithelioid cytomorphology increased dermal mitotic activity p16-100% of cases had areas with complete loss of staining
32 Case 26 Male 37. Right jawline 5mm nodule?keloid. The best diagnosis is: A. Desmoplastic Spitz naevus B. Atypical Spitz Tumour C. Spitzoid melanoma D. Deep penetrating naevus E. Spitz naevus
Melanocytic Lesions: Use of Immunohistochemistry and Special Studies Napa Valley 2018
Melanocytic Lesions: Use of Immunohistochemistry and Special Studies Napa Valley 2018 Victor G. Prieto, MD, PhD Professor Depts. of Pathology and Dermatology University of Texas - MD Anderson Cancer Center
More informationUpdate on Spitzoid and Blue nevus-like melanocytic lesions Emphasis on molecular studies informing diagnosis, prognosis and therapy
Update on Spitzoid and Blue nevus-like melanocytic lesions Emphasis on molecular studies informing diagnosis, prognosis and therapy Michael T. Tetzlaff MD, PhD Associate Professor Department of Pathology,
More informationFemale 18. Deeply pigmented lesion on trunk.?warty naevus?seborrhoeic keratosis?malignant melanoma. The best diagnosis is:
Female 18. Deeply pigmented lesion on trunk.?warty naevus?seborrhoeic keratosis?malignant melanoma. The best diagnosis is: A. deep penetrating naevus B. naevoid malignant melanoma C. pigment synthesising
More informationMichael T. Tetzlaff MD, PhD
Molecular alterations informing the diagnosis of melanocytic tumors Michael T. Tetzlaff MD, PhD Associate Professor Department of Pathology, Section of Dermatopathology Department of Translational and
More informationMelanoma and the genes: Molecular alterations informing the diagnosis of melanocytic tumors
Melanoma and the genes: Molecular alterations informing the diagnosis of melanocytic tumors Michael T. Tetzlaff MD, PhD Associate Professor Department of Pathology, Section of Dermatopathology Department
More information6/22/2015. Original Paradigm. Correlating Histology and Molecular Findings in Melanocytic Neoplasms
6 Correlating Histology and Molecular Findings in Melanocytic Neoplasms Pedram Gerami MD, Associate Professor of Dermatology and Pediatrics at Northwestern University Disclosures: I have been a consultant
More informationThe Enigmatic Spitz Lesion
The Enigmatic Spitz Lesion The Dawn of Spitz S Spitz Sophie Spitz Melanomas of Childhood ; Am J Pathol 1948 1910-1956 13 children (18 mo - 12 yrs) 12/13 had a benign clinical course Sophie Spitz Born 1910
More informationMelanocytic proliferations in sundamaged
Atypical Spitzoid Tumor: What Does It Mean And How Should It Be Managed? Melanocytic proliferations in sundamaged skin Jane L. Messina, Jane L. Messina MD International Melanoma Pathology Working Group
More informationConflict of Interest 9/2/2014. Pathogenesis and Comparison of Atypical Spitz Nevi vs Benign Spitz, and Childhood Melanoma
Pathogenesis and Comparison of Atypical Spitz Nevi vs Benign Spitz, and Childhood Melanoma Martin C. Mihm Jr., M.D., F.A.C.P. Harvard Medical School Brigham and Women s Hospital Dana Farber Cancer Center
More informationMelanocytic Tumours. Molecular Biology 02/06/2015. Cutaneous Melanocytic Tumours Introduction. Thomas Brenn. Intermediate Malignancy
Cutaneous Melanocytic Tumours Introduction Melanocytic Tumours: Update on Epidemiology and Molecular Biology Thomas Brenn Wide clinical and morphological spectrum Ranging from benign naevi to melanoma
More informationCase 231: F7. Exophytic naevus over left trapezious. Grown over a few weeks. Iniitally flat.?spitz naevus,?malignant
Case 231: F7. Exophytic naevus over left trapezious. Grown over a few weeks. Iniitally flat.?spitz naevus,?malignant Dermoscopy: coarse vascular structures. c/o A, B, C RAC7750 Case 231: F7. Exophytic
More informationVernon K. Sondak. Department of Cutaneous Oncology Moffitt Cancer Center Tampa, Florida
Vernon K. Sondak Department of Cutaneous Oncology Moffitt Cancer Center Tampa, Florida Australasian Melanoma Conference 2016 Sydney, NSW, Australia October 29, 2016 Disclosures Dr. Sondak is a compensated
More informationDermatopathology. Dr. Rafael Botella Estrada. Hospital La Fe de Valencia
Dermatopathology Dr. Rafael Botella Estrada. Hospital La Fe de Valencia Melanoma and mimics Dr. Martin Mihm Malignant lesions result from the accumulation of mutations Class I lesions (benign) Class II
More informationMAPK Pathway. CGH Next Generation Sequencing. Molecular Tools in Care of Patients with Pigmented Lesions 7/20/2017
Molecular Tools in Care of Patients with Pigmented Lesions Tammie Ferringer, MD Geisinger Medical Center, Danville, PA tferringer@geisinger.edu DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Tammie Ferringer,
More informationDesmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC
R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o
More informationDavid B. Troxel, MD. Common Medicolegal Situations: Misdiagnosis of Melanoma
Common Medicolegal Situations: Misdiagnosis of Melanoma David B. Troxel, MD Medical Director, The Doctors Company, Napa, California Clinical Professor Emeritus, University of California at Berkeley Past
More informationCase RAC7783. M46. Ear. Mole. r/o MM.?Blue naevus RAC7783
Case RAC7783. M46. Ear. Mole. r/o MM.?Blue naevus RAC7783 Pie Chart Participants N=74 Benign: 48 N=74 Blue naevus: 38 Intradermal: 12 DPN: 10 Compound 3 Clonal: 3; Spitz 2; Special Site: 1; Congenital:
More informationThere is NO single Melanoma Stain. > 6000 Mutations in Melanoma. What else can be done to discriminate atypical nevi from melanoma?
Las Vegas Fall Clinical 2016: The Assessment and Diagnosis of Melanoma Whitney A. High, MD, JD, MEng Associate Professor, Dermatology & Pathology Director of Dermatopathology (Dermatology) University of
More informationA diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment
Modern Pathology (2016), 1 15 2016 USCAP, Inc All rights reserved 0893-3952/16 $32.00 1 A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment
More informationThe Pathology of Neoplasia Part II
The Pathology of Neoplasia Part II February 2018 PAUL BOGNER, MD A S S O C I A T E P R O F E S S O R O F O N C O L O G Y P A T H O L O G Y A N D D E R M A T O L O G Y Clinical goals of cancer pathology
More informationPage 1 of 3. We suggest the following changes:
Page 1 of 3 Loren E. Clarke, M.D. Myriad Genetic Laboratories, Inc. 320 Wakara Way, Salt Lake City, UT 84108 Phone: 801.883.3470 Email: lclarke@myriad.com Date of Request: June 2017 NCCN Guidelines Panel:
More informationConflicts of Interest
Challenging Melanocytic Lesions Carlos N. Prieto-Granada M.D. Assistant Professor University of Alabama at Birmingham (UAB) Department of Pathology 2017 AAD Annual Meeting 3/2/17 - Orlando, FL None Conflicts
More informationDiagnosis of melanocytic proliferations remains one of
Update on Fluorescence In Situ Hybridization in Melanoma State of the Art Pedram Gerami, MD; Artur Zembowicz, MD, PhD N Context. Recent advances in understanding the molecular basis of melanoma have resulted
More informationDIAGNOSTIC SLIDE SEMINAR: PART 1 RENAL TUMOUR BIOPSY CASES
DIAGNOSTIC SLIDE SEMINAR: PART 1 RENAL TUMOUR BIOPSY CASES Dr. Andrew J. Evans MD, PhD, FACP, FRCPC Consultant in Genitourinary Pathology University Health Network, Toronto, ON Case 1 43 year-old female,
More informationI have no relevant conflicts of interest to disclose. John T. Seykora MD PhD Departments of Dermatology & Pathology and Laboratory Medicine
Molecular Characterization of Stage 1-3 Melanoma: Are we close to accurate prognostication and prediction? I have no relevant conflicts of interest to disclose. John T. Seykora MD PhD Departments of Dermatology
More information10/2/17. MELTUMP, SAMPUS, AST.An Algorithmic Approach to Challenging (Often Borderline) Melanocytic Tumors. An Introduction to SNP Arrays
MELTUMP, SAMPUS, AST.An Algorithmic Approach to Challenging (Often ) Melanocytic Tumors An Introduction to SNP Arrays Rajiv M. Patel, M.D. RCPA NZ ASM 2017 (11:45-12:30pm, Saturday, 23-09-17) Why do we
More information2/6/2018. Original Paradigm. Clonal Chromosomal A berrations. Only 20% of Spitz Nevi 95% 6p, 7q, 17q, 20q, 4q,8q, 1q, 11q. Isolated Gain in 11p
Molecular Diagnostics for Melanocytic Neoplasms: Moving towards a Revolution in the Management of Melanocytic Neoplasms Pedr am Gerami MD Associate Professor of Dermatology, Pathology and Pediatrics at
More information21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells
UPDATE IN CUTANEOUS VASCULAR S DERMATOPATHOLOGY SESSION BELFAST PATHOLOGY JUNE 21/2017 Dr E Calonje St John s Institute of Dermatology, London, United Kingdom THE FAMILY OF VASCULAR S WITH EPITHELIOID
More informationIntegrating Fluorescence in situ Hybridization and Genomic Array Results into the Diagnostic Workup of Melanoma
Integrating Fluorescence in situ Hybridization and Genomic Array Results into the Diagnostic Workup of Melanoma Association for Molecular Pathology United States and Canadian Academy of Pathology Companion
More informationMolecular Aspects of Melanocytic Neoplasia. Iwei Yeh MD, PhD University of California, San Francisco
Molecular Aspects of Melanocytic Neoplasia Iwei Yeh MD, PhD University of California, San Francisco Thanks to: Boris Bastian Timothy McCalmont Philip LeBoit Beth Ruben Jeff North Laura Pincus Thaddeus
More informationA PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL
A PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL OBJECTIVES Discuss current trends and changing concepts in our understanding of
More informationK Blessing, J J H Grant, D S A Sanders, M M Kennedy, A Husain, P Coburn
J Clin Pathol 2000;53:591 595 591 Papers Pathology, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, K Blessing Pathology, Birmingham University, Birmingham B15 2TT, D S A Sanders Pathology, Heartlands
More informationArtur Zembowicz, MD, PhD; Sung-Eun Yang, MD; Antonios Kafanas, MD; Stephen R. Lyle, MD, PhD
Correlation Between Histologic Assessment and Fluorescence In Situ Hybridization Using MelanoSITE in Evaluation of Histologically Ambiguous Melanocytic Lesions Artur Zembowicz, MD, PhD; Sung-Eun Yang,
More informationDermatologica Sinica
DERMATOLOGICA SINICA 30 (2012) 57e61 Contents lists available at SciVerse ScienceDirect Dermatologica Sinica journal homepage: http://www.derm-sinica.com CASE REPORT Pigmented epithelioid melanocytoma:
More informationS everal morphological features are frequently used in the
1194 ORIGINAL ARTICLE Interobserver reproducibility of histological features in cutaneous malignant melanoma C Urso, F Rongioletti, D Innocenzi, C Saieva, D Batolo, S Chimenti, R Filotico, R Gianotti,
More informationBlue Melanocytic Proliferations
Blue Melanocytic Proliferations Labib R. Zakka M.D., M.A. Research Fellow Melanoma Program Department of Dermatology Brigham and Women s Hospital Harvard Medical School Conflicts of Interest No conflicts
More informationPathological diagnosis of melanocytic tumours: clues and pitfalls # Richard A. Scolyer 1,2,3* and Stanley W. McCarthy 1,2,3
Pathological diagnosis of melanocytic tumours: clues and pitfalls # Richard A. Scolyer 1,2,3* and Stanley W. McCarthy 1,2,3 1 Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney,
More informationWays to get into trouble, ideas on avoiding trouble, and diagnostic approaches to keep trouble at bay
Pitfalls in the diagnosis of melanocytic tumors Timothy McCalmont, MD University of California, San Francisco Ways to get into trouble, ideas on avoiding trouble, and diagnostic approaches to keep trouble
More informationDifficulties in the diagnosis of spitzoid melanocytic lesions
For reprint orders, please contact reprints@expert-reviews.com Difficulties in the diagnosis of spitzoid melanocytic lesions Expert Rev. Dermatol. 5(5), 549 560 (2010) Stephen H Olsen 1, Rajiv M Patel
More informationManagement of pediatric melanocytic lesions
Open Journal of Clinical & Medical Case Reports Management of pediatric melanocytic lesions Volume 3 (2017) Issue 8 ISSN 2379-1039 Jin Kim, BS; Emmanuel Gabriel MD, PhD; Weiguo Liu MD, PhD; Lin Lin MD,
More informationACCME/Disclosures. Diagnosing Mesothelioma in Limited Tissue Samples. Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016
Diagnosing Mesothelioma in Limited Tissue Samples Papanicolaou Society of Cytopathology Companion Meeting March 12 th, 2016 Sanja Dacic, MD, PhD University of Pittsburgh ACCME/Disclosures GENERAL RULES
More informationSpitz nevi in the classic histopathological pattern - lamb in wolf`s clothing *
DERMATOPATHOLOGY 91 Spitz nevi in the classic histopathological pattern - lamb in wolf`s clothing * Gustavo Costa Verardino 1 Mayra Carrijo Rochael 1 DOI: http://dx.doi.org/10.1590/abd1806-4841.20153310
More informationSTUDY. Sensitivity of Fluorescence In Situ Hybridization for Melanoma Diagnosis Using RREB1, MYB, Cep6, and 11q13 Probes in Melanoma Subtypes
STUDY Sensitivity of Fluorescence In Situ Hybridization for Melanoma Diagnosis Using RREB1, MYB, Cep6, and 11q13 Probes in Melanoma Subtypes Pedram Gerami, MD; Mariam Mafee, BS; Teekay Lurtsbarapa, MD;
More informationTime to reconsider Spitzoid neoplasms?
DERMATOLOGY PRACTICAL & CONCEPTUAL www.derm101.com Time to reconsider Spitzoid neoplasms? Carmelo Urso 1 1 Department of Anatomic Pathology, Dermatopathology Section, SM Annunziata Hospital, AUSL Toscana
More informationRosette-like structures in the spectrum of spitzoid tumors
J Cutan Pathol 2013: 40: 788 795 doi: 10.1111/cup.12192 John Wiley & Sons. Printed in Singapore Rosette-like structures in the spectrum of spitzoid tumors 2013 John Wiley & Sons A/S. Published by John
More informationIntroduction. Cesinaro A M, Schirosi L, Bettelli S, Migaldi M & Maiorana A (2010) Histopathology 57,
Histopathology 2010, 57, 515 527. DOI: 10.1111/j.1365-2559.2010.03653.x Alterations of 9p21 analysed by FISH and MLPA distinguish atypical spitzoid melanocytic tumours from conventional Spitz s nevi but
More informationInstitute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
220 research article Sclerosing melanocytic lesions (sclerosing melanomas with nevoid features and sclerosing nevi with pseudomelanomatous features) an analysis of 90 lesions Biljana Grcar-Kuzmanov 1,
More information57th Annual HSCP Spring Symposium 4/16/2016
An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no
More informationMalignant tumors of melanocytes: Part 1. Deba P Sarma, MD., Omaha
Malignant tumors of melanocytes: Part 1 Deba P Sarma, MD., Omaha The melanocytic tumor is one of the most difficult and confusing areas in Dematopathology. It is true that most (95%) of such lesions are
More informationGuy Perrot (Ги Перро)
НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ (МАСТЕР-КЛАСС) «ПРАКТИЧЕСКИЕ АСПЕКТЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ МЕЛАНОМЫ КОЖИ» DIAGNOSTIC AND PITFALLS IN MELANOMA Guy Perrot (Ги Перро) MD PHD pathologist, University Hospital
More information> 6000 Mutations in Melanoma. Tests That Cay Be Employed. FISH for Additions/Deletions. Comparative Genomic Hybridization
Winter Clinical 2017: The Assessment and Diagnosis of Melanoma Whitney A. High, MD, JD, MEng Associate Professor, Dermatology & Pathology Director of Dermatopathology (Dermatology) University of Colorado
More informationTHE SPITZ NEVUS OFTEN POSES
OBSERVATION ONLINE FIRST Melanoma Mimic A Case of Multiple Pagetoid Spitz Nevi KaLynne Harris, MD; Scott R. Florell, MD; Jason Papenfuss, MD; Wendy Kohlmann, MS, CGC; Mona Jahromi, BS; Joshua D. Schiffman,
More informationSelf assessment case. Dr Saleem Taibjee Dorset County Hospital, Dorchester
Self assessment case Dr Saleem Taibjee saleemtaibjee@gmail.com Dorset County Hospital, Dorchester Clinical details 34-year-old man: Shave excision Skin tag / papilloma left thigh The best diagnosis is:
More informationGenetic Testing: When should it be ordered? Julie Schloemer, MD Dermatology
Genetic Testing: When should it be ordered? Julie Schloemer, MD Dermatology Outline Germline testing CDKN2A BRCA2 BAP1 Somatic testing Gene expression profiling (GEP) BRAF Germline vs Somatic testing
More informationSupplementary Figure 1. Spitzoid Melanoma with PPFIBP1-MET fusion. (a) Histopathology (4x) shows a domed papule with melanocytes extending into the
Supplementary Figure 1. Spitzoid Melanoma with PPFIBP1-MET fusion. (a) Histopathology (4x) shows a domed papule with melanocytes extending into the deep dermis. (b) The melanocytes demonstrate abundant
More informationApproximately 2% of the United States population
Differentiation of Malignant Melanoma From Benign Nevus Using a Novel Genomic Microarray With Low Specimen Requirements Wells M. Chandler, MD; Leslie R. Rowe, MS; Scott R. Florell, MD; Mona S. Jahromi,
More informationالمركب النموذج--- سبيتز وحمة = Type Spitz's Nevus, Compound SPITZ NEVUS 1 / 7
SPITZ NEVUS 1 / 7 Epidemiology An annual incidence rate of 1.4 cases of Spitz nevus per 100,000 individuals has been estimated in Australia, compared with 25.4 per 100,000 individuals for cutaneous melanoma
More informationMalignant tumors of melanocytes : Part 3. Deba P Sarma, MD., Omaha
Malignant tumors of melanocytes : Part 3 Deba P Sarma, MD., Omaha Let s go over one case of melanoma using the following worksheet. Of the various essential information that needs to be included in the
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationLess Common Variants of Cutaneous Melanoma
Less Common Variants of Cutaneous Melanoma Raymond L. Barnhill* 1, G. Peter Sarantopoulos 1, and Kapil Gupta 2 1 Department of Pathology and Laboratory Medicine, University of California, Los Angeles,
More informationF006 Imaging in Dermatology Melanocytic Neoplasia Clinical-Confocal-Pathological-Correlations
F006 Imaging in Dermatology Melanocytic Neoplasia Clinical-Confocal-Pathological-Correlations Melissa Gill, MD SkinMedical Research and Diagnostics Dobbs Ferry, NY, USA Department of Pathology SUNY Downstate
More informationCellular Neurothekeoma
Cellular Neurothekeoma Scott W Binder, MD Pritzker Professor of Pathology & Dermatology Sr. Vice Chair Director, Pathology Clinical Services Chief, Dermatopathology Geffen/UCLA School of Medicine Clinical
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationBAP-oma & BEYOND MICHAEL A NOWAK, MD
BAP-oma & BEYOND MICHAEL A NOWAK, MD CONFLICTS No conflicts with the content of this lecture BAP-oma Wiesner 2011: Families with multiple tan dome-shaped papules of head, neck, trunk, and extremities.
More informationDesmoplastic Melanoma: Clinical Behavior and Management Implications
Desmoplastic Melanoma: Clinical Behavior and Management Implications Collier S. Pace, MD, a Jyoti P. Kapil, MD, b Luke G. Wolfe, MS, c Brian J. Kaplan, MD, c and James P. Neifeld, MD c a Division of Plastic
More informationA 25 year old female with a palpable mass in the right lower quadrant of her abdomen
May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and
More informationSociety for Pediatric Pathology Spring Meeting Joint Symposium with American Society of Dermatopathology
Society for Pediatric Pathology 2013 Spring Meeting Joint Symposium with American Society of Dermatopathology Update on Cutaneous Melanocytic, Mesenchymal and Lymphoproliferative Lesions in Children Melanocytic
More information1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma
2016 MFMER slide-1 2016 MFMER slide-2 2016 MFMER slide-3 Soft Tissue Tumors Showing Melanocytic Differentiation Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester,
More informationSimulators of melanoma
Simulators of melanoma Philip E. LeBoit, M.D. Depts. of Pathology and Dermatology University of California, San Francisco Simulators of melanoma Simulators of melanoma in situ Melanocytic Non-melanocytic
More informationACCME/Disclosures. Cribriform Lesions of the Prostate. Case
Cribriform Lesions of the Prostate Ming Zhou, MD, PhD Departments of Pathology and Urology New York University Langone Medical Center New York, NY Ming.Zhou@NYUMC.ORG ACCME/Disclosures The USCAP requires
More informationMy approach to atypical melanocytic lesions. J Clin Pathol 2004;57: doi: /jcp
1121 REVIEW My approach to atypical melanocytic lesions K S Culpepper, S R Granter, P H McKee... Histological assessment of melanocytic naevi constitutes a substantial proportion of a dermatopathologist
More informationThe Dermal Melanocytoses. Conflicts of Interest 5/22/2018. The Nevi of Ota and Ito. Martin C. Mihm M.D.
The Dermal Melanocytoses Martin C. Mihm M.D. Director Mihm Cutaneous Pathology Consultative Service (MCPCS) Brigham and Women s Hospital Director Melanoma Program Brigham and Women s Hospital and Harvard
More informationNeoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath
Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand
More informationAGGRESSIVE VARIANTS OF PAPILLARY THYROID CARCINOMA DIAGNOSIS AND PROGNOSIS
AGGRESSIVE VARIANTS OF PAPILLARY THYROID CARCINOMA DIAGNOSIS AND PROGNOSIS PAPILLARY THYROID CARCINOMA Clinical Any age Microscopic to large Female: Male= 2-4:1 Radiation history Lymph nodes Prognosis
More informationMelanocytic lesions on Genital Skin Melanoma vs. Melanocytic Nevus, Revisited. Timothy H. McCalmont, MD University of California, San Francisco
Melanocytic lesions on Genital Skin Melanoma vs. Melanocytic Nevus, Revisited Timothy H. McCalmont, MD, San Francisco I. IS IT BENIGN OR IS IT MALIGNANT? One of the commonest determinations we make as
More informationCase 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is:
Case 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is: A. Angiosarcoma B. Haemangiopericytoma C.Myopericytoma D.Myofibroma E. Angioleiomyoma
More information5/21/2018. Disclosures. Consulting: Myriad Genetics SciBase. Superficial Atypical Melanocytic Proliferations. SSM, LMM and (some of) their Simulants
Disclosures Consulting: Myriad Genetics SciBase Superficial Atypical Melanocytic Proliferations SSM, LMM and (some of) their Simulants 1 Melanomas and Nevi. Nevi are important mainly in relation to melanoma
More informationSolid Tumour Section Review
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL INIST-CNRS Solid Tumour Section Review Skin: Spitz tumors Rajmohan Murali, Richard A Scolyer, Boris C Bastian Department
More informationHISTOPATHOLOGIC REPORTING OF MELANOCYTIC SKIN LESIONS. Problems, thoughts, proposals
HISTOPATHOLOGIC REPORTING OF MELANOCYTIC SKIN LESIONS Problems, thoughts, proposals Gerardo Ferrara Anatomic Pathology Unit Macerata General Hospital AV3 ASUR Marche Macerata, I Aims and scope STANDARDIZATION:
More informationInternational Society of Gynecological Pathologists Symposium 2007
International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade
More informationEARLY ONLINE RELEASE
EARLY ONLINE RELEASE Note: This article was posted on the Archives Web site as an Early Online Release. Early Online Release articles have been peer reviewed, copyedited, and reviewed by the authors. Additional
More informationDisclosure. Relevant Financial Relationship(s) None. Off Label Usage None MFMER slide-1
Disclosure Relevant Financial Relationship(s) None Off Label Usage None 2013 MFMER slide-1 Case Presentation A 43 year old male, with partial nephrectomy for a right kidney mass 2013 MFMER slide-2 2013
More informationCase Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationPathology of the skin. 2nd Department of Pathology, Semmelweis University
Pathology of the skin 2nd Department of Pathology, Semmelweis University Histology of the skin Epidermis: Stratum corneum Stratum granulosum Stratum spinosum Stratum basale Dermis: papillary and reticular
More information5/21/2018. Prostate Adenocarcinoma vs. Urothelial Carcinoma. Common Differential Diagnoses in Urological Pathology. Jonathan I.
Common Differential Diagnoses in Urological Pathology Jonathan I. Epstein Prostate Adenocarcinoma vs. Urothelial Carcinoma 1 2 NKX3.1 NKX3.1 3 4 5 6 Proposed ISUP Recommendations Option to use PSA as a
More informationState of the Art, Nomenclature, and Points of Consensus and Controversy Concerning Benign Melanocytic Lesions: Outcome of an International Workshop
REVIEW ARTICLE State of the Art, Nomenclature, and Points of Consensus and Controversy Concerning Benign Melanocytic Lesions: Outcome of an International Workshop Raymond L. Barnhill, MD,* Lorenzo Cerroni,
More informationBasal cell carcinoma 5/28/2011
Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers
More informationDiagnostic problems in uterine smooth muscle tumors
Diagnostic problems in uterine smooth muscle tumors Marina Kos Ljudevit Jurak Clinical Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb Institute of Pathology, University of
More informationBRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance
DERMATOPATHOLOGY BJD British Journal of Dermatology BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance P.D. Da Forno, J.H. Pringle,* A. Fletcher, M. Bamford,
More informationHistopathology of Melanoma
THE YALE JOURNAL OF BIOLOGY AND MEDICINE 48, 409-416 (1975) Histopathology of Melanoma G. J. WALKER SMITH Department ofpathology, Yale University School ofmedicine, 333 Cedar Street, New Haven, Connecticut
More informationBSD 2015 Case 19. Female 21. Nodule on forehead. The best diagnosis is:
BSD 2015 Case 19 Female 21. Nodule on forehead. The best diagnosis is: A. mixed tumour of skin B. porocarcinoma C. nodular hidradenoma D. metastatic adenocarcinoma BSD 2015 Case 19 Female 21 Nodule on
More informationPaediatric Dermatology Column: Case Report. Paediatric melanoma: challenges in diagnosis and management
Hong Kong J. Dermatol. Venereol. (2014) 22, 30-34 Paediatric Dermatology Column: Case Report Paediatric melanoma: challenges in diagnosis and management M Liu, CJA Henderson, M Gupta Paediatric melanoma,
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationPrimary Cutaneous Melanoma Pathology Reporting Proforma DD MM YYYY. *Tumour site. *Specimen laterality. *Specimen type
Primary Cutaneous Melanoma Pathology Reporting Proforma Includes the International Collaboration on Cancer reporting dataset denoted by * Family name Given name(s) Date of birth DD MM YYYY Sex Male Female
More informationUntil recently, the prevailing paradigm in classification
Nevus/Melanocytoma/Melanoma An Emerging Paradigm for Classification of Melanocytic Neoplasms? Artur Zembowicz, MD, PhD; Richard A. Scolyer, MD, FRCPA, FRCPath N Context. Until recently, the prevailing
More informationBenign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more
Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more common on the trunk; but extremities, head and neck are
More informationPathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON
Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma
More information