Supplementary information table of content

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1 Supplementary information table of content 13 supplementary tables Supplementary Table S1. List of the 4356 genes and corresponding antibodies used in the study. Separate excel file available. Supplementary Table S2. Description of the cell lines used in the study. Supplementary Table S3. List of all top 100 genes resulting from each two-group comparison. Separate excel file available. Supplementary Table S4. Gene Ontology (GO)-based enrichment analysis of the top 100 genes resulting from twogroup comparisons of hematological cell lines compared to cell lines established from solid tumors. Supplementary Table S5. GO-based enrichment analysis of the top 100 genes resulting from two-group comparisons of cell lines established from solid tumors compared to hematological cell lines. Supplementary Table S6. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of lymphoma/leukemia cell lines compared to multiple myeloma cell lines. Supplementary Table S7. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of lymphoma/leukemia cell lines compared to myeloid cell lines. Supplementary Table S8. GO-based enrichment analysis of the 97 most significant genes from two-group comparisons of multiple myeloma/myeloid cell lines compared to lymphoma/leukemia cell lines. Supplementary Table S9. GO-based enrichment analysis of the 97 most significant genes from two-group comparisons of multiple myeloma cell lines compared to lymphoma/leukemia cell lines. Supplementary Table S10. GO-based enrichment analysis of the top 100 genes resulting from two-group comparisons of myeloid cell lines compared to lymphoma/leukemia cell lines. Supplementary Table S11. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of myeloid cell lines compared to lymphoid cell lines. Supplementary Table S12. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of lymphoid cell lines compared to myeloid cell lines.

2 Supplementary Table S2. Description of the cell lines used in the study. Cell line Description of cell line Original reference Source Myeloid HEL Erythroleukemia cell line Martin et al., Science 216: 1233 (1982) HL-60 Acute promyelocytic leukemia (APL) cell line Collins et al., Nature 270: (1977) HMC-1 Mastcell leukaemia cell line Butterfield et al., Leukemia Res. 12: (1988) KN 1 K-562 Chronic myeloid leukemia (CML) cell line Lozzio et al., J Natl Cancer Inst 50: 535 (1973) NB-4 Acute promyelocytic leukaemia (APL) cell line Lanotte et al., Blood 77: 1080 (1991) THP-1 Acute monocytic leukemia (AML) cell line Tsuchiya et al., Int J Cancer 26: 171 (1980) U-937 Myelomonocytic histiocytic lymphoma cell line Lymphoid Sundström C, Nilsson K., Int J Cancer 17: (1976) KN 1 Daudi Human Burkitt lymphoma cell line Klein et al., Cancer Res 28: 1300 (1968) HDLM-2 Hodgkin lymphoma cell line Drexler et al., Leuk Res 10: 487 (1986) Karpas-707 Multiple myeloma cell line Karpas et al., Lancet Apr 24;1(8278):931-3 (1982) KN 1 KM3 B-cell leukaemia cell line (ALL, second relapse) Schneider et al., Int J Cancer 19: (1977) * LP-1 Multiple myeloma cell line Pegoraro et al., Blood 73: 1020 (1989) MOLT-4 Acute lymphoblastic leukemia (T-ALL) cell line Minowada et al., J Natl Cancer Inst 49: 891 (1972) RPMI-8226 Multiple myeloma cell line Matsuoka et al., Proc Soc Exp Biol Med 125: 1246 (1967) U-266/70 Multiple myeloma cell line (1970, IL-6- Nilsson et al Clin Exp Immunol 7: dependent) (1970) KN 1 U-266/84 Multiple myeloma cell line (1984 (in vitro Hellman et al., Eur J Immunol 18: differentiated) (1988) KN 1 U-698 B-cell lymphoma cell line Nilsson et al., Int J Cancer 13: (1974) Brain D341 Med Medulloblastoma cell line Friedman HS., et al. Am. J. Pathol. 130: 472 (1988) LGC/ATCC SH-SY5Y Metastatic neuroblastoma Biedler et al., Cancer Res 33: 2643 (1973) U-138MG Glioblastoma cell line Ponten et al., Acta Pathol Microbiol Scand 74: 465 (1968) U-251MG Glioblastoma cell line Westermark B., Int J Cancer12: 438 (1973) BW 2 U87 Lung Glioblastoma; astrocytoma cell line Ponten J., Macintyre EH., Acta Pathol. Microbiol. Scand. 74: (1968) LGC/ATCC A-549 Lung carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) SCLC-21H Abdominal Small cell lung carcinoma cell line Bepler et al., J Cancer Res Clin Oncol 113: 31 (1987) CACO-2 Colon adenocarcinoma cell line Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977) CAPAN-2 Pancreas adenocarcinoma cell line Kyriazis et al., Cancer Res 46: 5810 (1986)

3 Hep-G2 Hepatocellular carcinoma cell line Aden et al., Nature 282: 615 (1979) Breast, female reproductive AN3-CA Metastatic endometrial adenocarcinoma cell line Dawe et al., J Natl Cancer Inst 33: 441 (1964) EFO-21 Metastatic ovarian serous cystadenocarcinoma cell line Simon et al., J Natl Cancer Inst 70: 839 (1983) HeLa Cervical epithelial adenocarcinoma cell line Scherer et al., J Exp Med 97: 695 (1953) MCF-7 Metastatic breast adenocarcinoma cell line Soule et al., J Natl Cancer Inst 51: 1409 (1973) SK-BR-3 SiHa Urinary, male reproductive NTERA-2 PC-3 RT-4 Metastatic breast adenocarcinoma cell line Cervical squamous cell carcinoma cell line Metastatic embryonal carcinoma cell line Metastatic poorly differentiated prostate adenocarcinoma cell line Urinary bladder transitional cell carcinoma cell line Fogh J, editor. Human tumor cells in vitro. New York: Plenum Press (1975) Friedl F. et al., Proc. Soc. Exp. Biol. Med. 135: (1970) Fogh & Trempe, Human Tumor Cells in Vitro: 115 (1975) Kaighn et al., Invest Urol 17: (1979) Rigby et al., Br J Cancer 24: 746 (1970) LGC/ATCC LGC/ATCC Skin A431 Epidermoid carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) HaCaT SK-MEL-30 WM-115 Sarcoma Keratinocyte cell line Metastatic malignant melanoma cell line Malignant melanoma cell line Boukamp et al, J Cell Biol Mar; 106(3):761, (1988) Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976) Westermark B. et al, Proc Natl Acad Sci U S A. Oct; 83(19):7197 (1986) RH-30 Metastatic rhabdomyosarcoma cell line Douglass et al., Cytogenet Cell Genet 45: (1987) U- 2 OS Osteosarcoma cell line Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967) LGC/ATCC U-2197 Malignant fibrous histiocytoma cell line Genberg et al., Am J Pathol 135: 1185 (1989) Miscellaneous NEF 3 BEWO Metastatic choriocarcinoma cell line Pattillo et al., Cancer Res 28: (1968) HEK 293 Embryonal kidney cell line Graham et al., J Gen Virol 36: 59 (1977) HTh 83 Anaplastic thyroid carcinoma cell line Dahlman et al., J. Pathol. 191: , 2000 NEH 4 BW 2 TIME Telomerase-immortalized human microvascular endothelial cells (pooled) Venetsanakos et el., Exp Cell Res., Feb 1;273(1):21-33 (2002) McM 5 *Due to misidentification, KM3 has been deleted from the catalogue and is now listed as "false leukemia cell line", Drexler et al., False leukemia-lymphoma cell lines: An update on over 500 cell lines. Leukemia 17: (2003) Source information 1 Prof. Kenneth Nilsson, Uppsala University, Uppsala, Sweden 2 Prof. Bengt Westermark, Uppsala University, Uppsala, Sweden 3 Prof. Norbert E Fusenig, DKFZ, Heidelberg, Germany 4 Assoc. Prof. Nis-Erik Heldin, Uppsala University, Uppsala, Sweden 5 Prof. Martin McMahon, UCSF Comprehensive Cancer Center, San Fransisco, USA

4 Supplementary Table S4. Gene Ontology (GO)-based enrichment analysis of the top 100 genes resulting from two-group comparisons of hematological cell lines compared to cell lines established from solid tumors. The neuroid cell lines were left out of the analysis. All 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process immune response E-5 2.8E-2 Biological Process immune system process E-5 3.3E-2 Biological Process cell surface receptor linked signal transduction E-4 1.5E-1 Biological Process mast cell activation 4 4.4E-4 1.6E-1 Biological Process defense response E-4 1.4E-1 Biological Process cell activation E-4 1.3E-1 Biological Process regulation of immune system process E-4 1.3E-1 Biological Process leukocyte activation E-4 1.2E-1 Biological Process positive regulation of immune system process E-4 1.3E-1 Biological Process integrin-mediated signaling pathway 6 9.9E-4 1.5E-1 Biological Process regulation of homeostatic process 8 1.2E-3 1.6E-1 Biological Process positive regulation of cell proliferation E-3 3.3E-1 Biological Process positive regulation of biological process E-3 3.7E-1 Biological Process lymphocyte activation 9 4.0E-3 3.7E-1 Biological Process positive regulation of T cell activation 6 4.5E-3 3.8E-1 Biological Process regulation of immunoglobulin production 4 4.9E-3 3.9E-1 Biological Process regulation of T cell activation 7 5.0E-3 3.8E-1 Biological Process regulation of response to stimulus E-3 4.1E-1 Biological Process cell-cell adhesion 9 6.5E-3 4.2E-1 Biological Process positive regulation of multicellular organismal process 9 6.5E-3 4.2E-1 Biological Process positive regulation of mononuclear cell proliferation 5 6.7E-3 4.2E-1 Biological Process positive regulation of lymphocyte proliferation 5 6.7E-3 4.2E-1 Biological Process positive regulation of leukocyte proliferation 5 6.7E-3 4.2E-1 Biological Process T cell activation 7 7.1E-3 4.2E-1 Biological Process regulation of immune response 9 7.2E-3 4.1E-1 Biological Process leukocyte degranulation 3 8.0E-3 4.3E-1 Biological Process positive regulation of growth 5 8.3E-3 4.3E-1 Biological Process positive regulation of T cell differentiation 4 9.8E-3 4.7E-1 Biological Process regulation of lymphocyte activation 7 1.1E-2 5.0E-1 Biological Process neutrophil chemotaxis 3 1.1E-2 4.9E-1

5 Supplementary Table S5. GO-based enrichment analysis of the top 100 genes resulting from two-group comparisons of cell lines established from solid tumors compared to hematological cell lines. The neuroid cell lines were left out of the analysis. All 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process cell adhesion E-8 2.5E-5 Biological Process biological adhesion E-8 1.3E-5 Biological Process cell-substrate adhesion 7 4.7E-4 1.8E-1 Biological Process locomotion E-4 1.8E-1 Biological Process cell migration E-4 1.7E-1 Biological Process cell motion E-4 1.6E-1 Biological Process cell motility E-4 1.5E-1 Biological Process localization of cell E-4 1.5E-1 Biological Process cellular response to extracellular stimulus 6 1.1E-3 1.6E-1 Biological Process response to endogenous stimulus E-3 2.0E-1 Biological Process response to hormone stimulus E-3 2.4E-1 Biological Process anatomical structure morphogenesis E-3 2.4E-1 Biological Process response to oxidative stress 8 2.5E-3 2.3E-1 Biological Process response to inorganic substance 9 3.4E-3 2.9E-1 Biological Process response to mechanical stimulus 5 3.8E-3 2.9E-1 Biological Process response to reactive oxygen species 6 3.9E-3 2.8E-1 Biological Process cell junction organization 5 4.2E-3 2.9E-1 Biological Process cellular component organization E-3 3.1E-1 Biological Process integrin-mediated signaling pathway 5 5.3E-3 3.1E-1 Biological Process positive regulation of anti-apoptosis 4 5.5E-3 3.1E-1 Molecular Function structural molecule activity E-3 8.5E-1 Molecular Function cytoskeletal protein binding E-3 6.7E-1 Biological Process response to hydrogen peroxide 5 7.3E-3 3.7E-1 Biological Process regulation of anti-apoptosis 4 7.6E-3 3.7E-1 Biological Process response to steroid hormone stimulus 8 7.8E-3 3.6E-1 Molecular Function phosphatase binding 4 8.5E-3 5.9E-1 Molecular Function extracellular matrix structural constituent 5 9.3E-3 5.2E-1 Biological Process regulation of endothelial cell proliferation 4 1.0E-2 4.3E-1 Molecular Function calcium ion binding E-2 5.3E-1 Biological Process positive regulation of cell proliferation E-2 4.7E-1

6 Supplementary Table S6. GO-based enrichment analysis of the top 100 genes resulting from a two-group comparison of lymphoma/leukemia cell lines compared to multiple myeloma cell lines. All 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process positive regulation of immune system process E-5 5.0E-2 Biological Process regulation of immune system process E-4 1.1E-1 Biological Process positive regulation of leukocyte activation 8 5.0E-4 2.1E-1 Biological Process regulation of lymphocyte activation 9 5.2E-4 1.7E-1 Biological Process regulation of T cell differentiation 6 5.4E-4 1.4E-1 Biological Process B cell receptor signaling pathway 4 6.9E-4 1.5E-1 Biological Process positive regulation of cell activation 8 7.4E-4 1.4E-1 Biological Process regulation of leukocyte activation 9 7.9E-4 1.3E-1 Biological Process positive regulation of T cell differentiation 5 9.1E-4 1.3E-1 Biological Process regulation of T cell activation 8 9.8E-4 1.3E-1 Biological Process regulation of lymphocyte differentiation 6 9.9E-4 1.2E-1 Biological Process positive regulation of lymphocyte differentiation 5 1.1E-3 1.2E-1 Biological Process regulation of cell differentiation E-3 1.4E-1 Biological Process regulation of cell activation 9 1.4E-3 1.4E-1 Biological Process positive regulation of lymphocyte activation 7 2.2E-3 1.9E-1 Biological Process leukocyte activation E-3 2.1E-1 Biological Process positive regulation of antigen receptor-mediated 3 3.3E-3 2.4E-1 i li th Biological Process lymphocyte activation 9 4.0E-3 2.7E-1 Biological Process positive regulation of T cell activation 6 4.5E-3 2.8E-1 Biological Process positive regulation of alpha-beta T cell activation 4 4.9E-3 2.9E-1 Biological Process regulation of cellular component biogenesis 7 6.6E-3 3.6E-1 Biological Process positive regulation of mononuclear cell proliferation 5 6.7E-3 3.5E-1 Biological Process positive regulation of lymphocyte proliferation 5 6.7E-3 3.5E-1 Biological Process positive regulation of leukocyte proliferation 5 6.7E-3 3.5E-1 Biological Process cell activation E-3 3.4E-1 Biological Process regulation of developmental process E-3 3.9E-1 Biological Process regulation of alpha-beta T cell activation 4 9.8E-3 4.3E-1 Molecular Function molecular transducer activity E-3 9.6E-1 Molecular Function signal transducer activity E-3 9.6E-1 Biological Process positive regulation of cell differentiation 9 1.1E-2 4.6E-1

7 Supplementary Table S7. GO-based enrichment analysis of the top 100 genes resulting from a two-group comparison of lymphoma/leukemia cell lines compared to myeloid cell lines. 97 of 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Molecular Function protein binding E-2 1.0E0 Molecular Function transcription cofactor activity 7 6.8E-2 1.0E0 Biological Process biological regulation E-2 1.0E0 Molecular Function transmembrane receptor protein tyrosine kinase adaptor protein activity 2 7.9E-2 1.0E0 Molecular Function transcription coactivator activity 5 8.8E-2 1.0E0

8 Supplementary Table S8. GO-based enrichment analysis of the 97 most significant genes from two-group comparisons of multiple myeloma/myeloid cell lines compared to lymphoma/leukemia cell lines. 95 of the 97 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process protein folding 7 1.5E-3 7.4E-1 Molecular Function unfolded protein binding 5 2.7E-2 1.0E0 Biological Process regulation of ossification 4 4.6E-2 1.0E0 Biological Process vasculogenesis 3 5.3E-2 1.0E0 Biological Process regulation of osteoblast differentiation 3 7.5E-2 1.0E0 Molecular Function monosaccharide binding 3 7.8E-2 1.0E0 Biological Process receptor clustering 2 8.1E-2 1.0E0

9 Supplementary Table S9. GO-based enrichment analysis of the top 100 genes resulting from two-group comparisons of multiple myeloma cell lines compared to lymphoma/leukemia cell lines. 97 of the 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process regulation of muscle contraction 5 7.3E-3 1.0E0 Biological Process regulation of transport E-2 1.0E0 Biological Process peptidyl-amino acid modification 6 3.9E-2 1.0E0 Biological Process regulation of localization E-2 1.0E0 Biological Process transport E-2 1.0E0 Biological Process vasculogenesis 3 5.8E-2 1.0E0 Biological Process establishment of localization E-2 1.0E0 Molecular Function sugar binding 5 6.8E-2 1.0E0 Biological Process membrane depolarization 3 7.0E-2 1.0E0 Biological Process vesicle organization 3 7.0E-2 1.0E0 Biological Process multicellular organismal process E-2 1.0E0 Molecular Function monosaccharide binding 3 8.0E-2 1.0E0 Biological Process macromolecule localization E-2 1.0E0 Biological Process cellular localization E-2 1.0E0 Molecular Function lipid binding 7 8.9E-2 1.0E0 Molecular Function protein binding E-2 1.0E0

10 Supplementary Table S10. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of myeloid cell lines compared to lymphoma/leukemia cell lines. All 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Molecular Function protein dimerization activity E-3 8.5E-1 Biological Process phospholipid biosynthetic process 4 1.6E-2 1.0E0 Molecular Function protein homodimerization activity 9 1.6E-2 9.1E-1 Biological Process regulation of localization E-2 1.0E0 Molecular Function identical protein binding E-2 9.1E-1 Biological Process negative regulation of multicellular organismal process 6 3.2E-2 1.0E0 Biological Process negative regulation of catabolic process 3 4.0E-2 1.0E0 Biological Process carbohydrate biosynthetic process 4 4.4E-2 1.0E0 Biological Process regulation of ossification 4 5.1E-2 1.0E0 Biological Process lipid biosynthetic process 6 5.5E-2 1.0E0 Biological Process Golgi vesicle transport 4 5.7E-2 1.0E0 Biological Process vesicle-mediated transport 9 6.3E-2 1.0E0 Biological Process positive regulation of transport 6 6.6E-2 1.0E0 Biological Process positive regulation of calcium ion transport 3 6.8E-2 1.0E0 Biological Process regulation of transport 9 7.2E-2 1.0E0 Molecular Function glycoprotein binding 3 7.3E-2 1.0E0 Biological Process transport E-2 1.0E0 Biological Process regulation of osteoblast differentiation 3 8.0E-2 1.0E0 Biological Process receptor clustering 2 8.4E-2 1.0E0 Molecular Function monosaccharide binding 3 8.6E-2 1.0E0 Biological Process cell adhesion E-2 1.0E0 Biological Process regulation of binding 5 9.0E-2 1.0E0 Biological Process establishment of localization E-2 1.0E0 Biological Process biological adhesion E-2 1.0E0

11 Supplementary Table S11. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of myeloid cell lines compared to lymphoid cell lines. All 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process response to external stimulus E-5 4.1E-2 Biological Process response to stimulus E-5 5.1E-2 Molecular Function receptor activity E-4 3.5E-2 Molecular Function signal transducer activity E-4 1.9E-2 Molecular Function molecular transducer activity E-4 1.9E-2 Biological Process multi-organism process E-4 1.1E-1 Biological Process taxis 8 4.2E-4 1.3E-1 Biological Process chemotaxis 8 4.2E-4 1.3E-1 Biological Process response to stress E-4 1.6E-1 Biological Process defense response E-4 1.9E-1 Biological Process response to chemical stimulus E-3 2.1E-1 Biological Process immune system process E-3 2.0E-1 Biological Process cytokine production 5 1.4E-3 1.8E-1 Biological Process cell activation E-3 1.7E-1 Biological Process leukocyte activation E-3 2.0E-1 Molecular Function calcium ion binding E-3 2.1E-1 Biological Process locomotory behavior 9 2.8E-3 2.7E-1 Biological Process locomotion E-3 2.8E-1 Biological Process immune response E-3 3.2E-1 Biological Process female pregnancy 6 4.1E-3 3.0E-1 Biological Process cell adhesion E-3 3.5E-1 Biological Process biological adhesion E-3 3.4E-1 Biological Process response to bacterium 7 7.9E-3 4.4E-1 Biological Process neutrophil chemotaxis 3 1.0E-2 5.1E-1 Biological Process response to peptide hormone stimulus 7 1.1E-2 5.3E-1 Biological Process behavior E-2 5.3E-1 Biological Process response to wounding E-2 5.3E-1 Biological Process response to abiotic stimulus E-2 5.2E-1 Biological Process response to camp 4 1.5E-2 5.6E-1 Biological Process response to other organism 8 1.6E-2 5.8E-1

12 Supplementary Table S12. GO-based enrichment analysis of the top 100 genes resulting from two-group comparison of lymphoid cell lines compared to myeloid cell lines. 98 of the 100 genes were mapped to DAVID identifiers. The list contains biological process and molecular function categories and terms for the top hits sorted by enrichment p-value as well as the gene count and Benjamini-Hochberg multiple testing correction for each term. Biological Process immune response E-4 3.4E-1 Biological Process immune system process E-4 2.1E-1 Biological Process antigen processing and presentation 5 1.6E-3 4.3E-1 Biological Process humoral immune response 5 7.5E-3 8.7E-1 Biological Process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 3 9.9E-3 8.8E-1 Molecular Function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5 1.1E-2 9.5E-1 Biological Process regulation of T cell differentiation 4 2.7E-2 9.9E-1 Biological Process regulation of lymphocyte differentiation 4 3.8E-2 1.0E0 Biological Process defense response E-2 1.0E0 Molecular Function MHC class I receptor activity 2 4.4E-2 1.0E0 Molecular Function dihydropyrimidinase activity 2 4.4E-2 1.0E0 Biological Process anti-apoptosis 7 4.6E-2 1.0E0 Molecular Function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2 6.6E-2 1.0E0 Biological Process regulation of interleukin-2 production 3 6.8E-2 1.0E0 Biological Process response to stimulus E-2 1.0E0 Molecular Function MHC class II receptor activity 2 8.7E-2 1.0E0 Biological Process negative regulation of cell differentiation 6 9.1E-2 1.0E0 Biological Process lymphocyte activation 6 9.7E-2 1.0E0