A new subtype of progenitor cell in the mouse embryonic neocortex. Xiaoqun Wang, Jin-Wu Tsai, Bridget LaMonica & Arnold R.
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1 A new subtype of progenitor cell in the mouse embryonic neocortex Xiaoqun Wang, Jin-Wu Tsai, Bridget LaMonica & Arnold R. Kriegstein Supplementary Figures 1-6: Supplementary Movies 1-9:
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8 Supplementary Movie 1. This movie shows an example of mitotic somal translocation and org cell division. An org cell undergoes mitotic somal translocation and divides. The upper cell inherits the basal fiber whereas the lower cell rapidly extends a prominent process towards the ventricle. Images were acquired every 10m and the play rate is seven frames per second. Supplementary Movie 2. This movie shows interkinetic nuclear migration (INM) of RG cells in mouse neocortex. An RG cell undergoes INM and divides at the VZ surface. Images were acquired every 10m and the play rate is seven frames per second. Supplementary Movie 3. This movie shows an example of two IP cell divisions in situ. Two IP cells divide in situ without nuclear translocation. Images were acquired every 10m and the play rate is seven frames per second. Supplementary Movie 4. This movie shows an org cell that divides and generates a daughter neuron. An org cell undergoes mitotic somal translocation and divides. The apical daughter cell acquires neuronal morphology 40h after division, and extends a leading process toward the pia. After acquiring a short trailing process, the bipolar daughter cell migrates rapidly
9 to the cortical plate. Images were acquired every 30m and the play rate is seven frames per second. Supplementary Movie 5. This movie shows an example of an asymmetric org cell division that yields a daughter org cell and a daughter neuron. Cell fate was revealed by immunostaining with anti-pax6 (progenitor marker) and anti- NeuN (neuronal marker) after 12h further culture following time-lapse imaging. Supplementary Movie 6. This movie shows an example of org cells originating from RG cells. Two days after in-utero intra-ventricular retrovirus infection at E11.5, a GFP-labelled RG cell was monitored at 15m intervals. Asymmetric division of the RG cell generates a self-renewed RG cell, which undergoes a second division. Another daughter cell undergoes mitotic somal translocation before mitosis, a defining feature of org cell behaviour. Images were acquired every 15m and the play rate is seven frames per second. Supplementary Movie 7. This movie shows centrosome behaviour in mitotic org cells. The centrosome is revealed by DsRedex-Centrin1. Frames were acquired every 10m and the play rate is seven frames per second.
10 Supplementary Movie 8. This movie shows centrosome behaviour in mitotic RG cells. The centrosome is revealed by DsRedex-Centrin1. Frames were acquired every 10m and the play rate is seven frames per second. Supplementary Movie 9. This movie shows centrosome behaviour in mitotic IP cells. The centrosome is revealed by DsRedex-Centrin1. Frames were acquired every 10m and the play rate is seven frames per second.
11 Supplementary Movie 10. This movie shows interkinetic nuclear migration (INM) of group RG cells in mouse neocortex. Group of RG cell undergoes INM and divides at the VZ surface. Images were acquired every 10m and the play rate is seven frames per second. Supplementary Movie 11. This movie shows no org cells mitosis after purposefully severing the apical processes of radial glial cells. We used a scalpel to remove the apical surface of the VZ in order to severe the apical processes of radial glial cells. This process disrupted INM and division of RG cells at the VZ surface and does not produce org-like cell mitosis. Images were acquired every 10m and the play rate is seven frames per second.
Supplementary Figure 1
Supplementary Figure 1 Kif1a RNAi effect on basal progenitor differentiation Related to Figure 2. Representative confocal images of the VZ and SVZ of rat cortices transfected at E16 with scrambled or Kif1a
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