Canonical Pathway E-value Ratio mediated Signaling 4.90E BB Signaling in T Lymphocytes 2.57E Actin Cytoskeleton Signaling
|
|
|
- Ethan French
- 5 years ago
- Views:
Transcription
1 Canonical Pathway E-value Ratio mediated Signaling 4.90E BB Signaling in T Lymphocytes 2.57E Actin Cytoskeleton Signaling 1.78E Actin Nucleation by ARP-WASP Complex 1.29E Activation of IRF by Cytosolic Pattern Recognition Receptors 8.13E Acute Myeloid Leukemia Signaling 9.33E Acute Phase Response Signaling 7.94E Agrin Interactions at Neuromuscular Junction 2.88E Airway Inflammation in Asthma Airway Pathology in Chronic Obstructive Pulmonary Disease 5.62E Alanine and Aspartate Metabolism 9.55E Aldosterone Signaling in Epithelial Cells 8.91E Allograft Rejection Signaling Altered T Cell and B Cell Signaling in Rheumatoid Arthritis Aminoacyl-tRNA Biosynthesis 2.40E Aminophosphonate Metabolism 5.25E Aminosugars Metabolism 1.48E AMPK Signaling 9.33E Amyloid Processing 1.10E Amyotrophic Lateral Sclerosis Signaling 1.55E Androgen and Estrogen Metabolism 4.48E Androgen Signaling 1.62E Angiopoietin Signaling 3.47E Antigen Presentation Pathway 2.10E Antiproliferative Role of Somatostatin Receptor E Antiproliferative Role of TOB in T Cell Signaling 6.17E Apoptosis Signaling 4.68E April Mediated Signaling 2.14E Arginine and Proline Metabolism 1.41E Aryl Hydrocarbon Receptor Signaling 7.76E Ascorbate and Aldarate Metabolism 2.40E Assembly of RNA Polymerase I Complex 1.16E Assembly of RNA Polymerase II Complex 1.23E Assembly of RNA Polymerase III Complex 6.46E Atherosclerosis Signaling 5.24E ATM Signaling 2.34E Autoimmune Thyroid Disease Signaling Axonal Guidance Signaling 6.61E B Cell Activating Factor Signaling 9.55E B Cell Receptor Signaling 3.31E Basal Cell Carcinoma Signaling Bile Acid Biosynthesis 1.91E Biosynthesis of Steroids 6.17E Bladder Cancer Signaling 4.27E BMP signaling pathway 9.77E Breast Cancer Regulation by Stathmin1 1.26E Butanoate Metabolism 1.78E C21-Steroid Hormone Metabolism Calcium Signaling 8.71E
2 Calcium-induced T Lymphocyte Apoptosis 6.17E camp-mediated signaling 3.44E Cardiac Hypertrophy Signaling 5.13E Cardiac β-adrenergic Signaling 3.63E Cardiomyocyte Differentiation via BMP Receptors Caveolar-mediated Endocytosis Signaling 5.62E CCR3 Signaling in Eosinophils 3.47E CCR5 Signaling in Macrophages 1.12E CD27 Signaling in Lymphocytes 3.47E CD28 Signaling in T Helper Cells 1.86E CD40 Signaling 1.20E Cdc42 Signaling 2.75E CDK5 Signaling 5.37E Cell Cycle Control of Chromosomal Replication 4.47E Cell Cycle Regulation by BTG Family Proteins 6.76E Cell Cycle: G1/S Checkpoint Regulation 4.27E Cell Cycle: G2/M DNA Damage Checkpoint Regulation 1.78E Cellular Effects of Sildenafil (Viagra) 3.09E Ceramide Signaling 2.00E Chemokine Signaling 5.13E Cholecystokinin/Gastrin-mediated Signaling 5.62E Chondroitin Sulfate Biosynthesis Chronic Myeloid Leukemia Signaling 4.68E Circadian Rhythm Signaling 6.17E Citrate Cycle 1.38E Clathrin-mediated Endocytosis Signaling 5.37E Cleavage and Polyadenylation of Pre-mRNA 5.13E CNTF Signaling 1.05E Coagulation System 2.29E Colorectal Cancer Metastasis Signaling 1.58E Complement System 1.74E Corticotropin Releasing Hormone Signaling 3.63E CREB Signaling in Neurons 4.90E Crosstalk between Dendritic Cells and Natural Killer Cells CTLA4 Signaling in Cytotoxic T Lymphocytes 1.82E CXCR4 Signaling 5.01E Cyanoamino Acid Metabolism 1.37E Cyclins and Cell Cycle Regulation 3.98E Cysteine Metabolism 4.21E Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells D-arginine and D-ornithine Metabolism 5.24E Death Receptor Signaling 3.39E Dendritic Cell Maturation 2.28E D-glutamine and D-glutamate Metabolism DNA Double-Strand Break Repair by Homologous Recombination 1.05E DNA Double-Strand Break Repair by Non-Homologous End Joining 4.27E DNA Methylation and Transcriptional Repression Signaling 1.05E Docosahexaenoic Acid (DHA) Signaling 1.41E Dopamine Receptor Signaling 1.55E Dopamine-DARPP32 Feedback in camp Signaling 2.69E
3 EGF Signaling 3.98E Eicosanoid Signaling 2.06E EIF2 Signaling 3.98E Endometrial Cancer Signaling 1.05E Endoplasmic Reticulum Stress Pathway 1.51E Endothelin-1 Signaling 1.91E Ephrin Receptor Signaling 7.76E ERK/MAPK Signaling 3.72E ERK5 Signaling 3.63E Erythropoietin Signaling 8.32E Estrogen Receptor Signaling 3.16E Estrogen-Dependent Breast Cancer Signaling 9.12E Extrinsic Prothrombin Activation Pathway 5.75E Factors Promoting Cardiogenesis in Vertebrates 6.76E FAK Signaling 1.66E Fatty Acid Biosynthesis 1.58E Fatty Acid Elongation in Mitochondria 4.07E Fatty Acid Metabolism 5.01E Fc Epsilon RI Signaling 9.55E Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes 1.58E FcγRIIB Signaling in B Lymphocytes 9.33E FGF Signaling 1.02E FLT3 Signaling in Hematopoietic Progenitor Cells 1.55E fmlp Signaling in Neutrophils 1.23E Folate Biosynthesis Fructose and Mannose Metabolism 1.82E FXR/RXR Activation 8.91E G Beta Gamma Signaling 2.51E G Protein Signaling Mediated by Tubby 3.47E Galactose Metabolism 8.91E Gap Junction Signaling 3.09E Germ Cell-Sertoli Cell Junction Signaling 6.17E Glioblastoma Multiforme Signaling 2.57E Glioma Invasiveness Signaling 9.77E Glioma Signaling 7.24E Glucocorticoid Receptor Signaling 2.51E Glutamate Metabolism 2.14E Glutamate Receptor Signaling Glutathione Metabolism 4.45E Glycerolipid Metabolism 7.94E Glycerophospholipid Metabolism 7.76E Glycine, Serine and Threonine Metabolism 8.71E Glycolysis/Gluconeogenesis 8.91E Glycosaminoglycan Degradation 6.03E Glycosphingolipid Biosynthesis - Ganglioseries 1.29E Glycosphingolipid Biosynthesis - Globoseries 5.13E Glycosphingolipid Biosynthesis - Lactoseries Glycosphingolipid Biosynthesis - Neolactoseries 5.13E Glyoxylate and Dicarboxylate Metabolism 6.17E GM-CSF Signaling 3.47E
4 GNRH Signaling 1.78E G-Protein Coupled Receptor Signaling 4.72E Graft-versus-Host Disease Signaling Granzyme A Signaling 4.03E Granzyme B Signaling 5.01E Growth Hormone Signaling 5.13E Gα 12/13 Signaling Gα12/13 Signaling 4.90E Hepatic Cholestasis 3.31E Hepatic Fibrosis / Hepatic Stellate Cell Activation 4.79E HER-2 Signaling in Breast Cancer 2.88E Hereditary Breast Cancer Signaling 3.31E HGF Signaling 1.48E HIF1α Signaling 2.14E Histidine Metabolism 4.66E HMGB1 Signaling 3.02E Human Embryonic Stem Cell Pluripotency Huntington's Disease Signaling 5.01E Hypoxia Signaling in the Cardiovascular System 1.00E icos-icosl Signaling in T Helper Cells 3.98E IGF-1 Signaling 4.68E IL-1 Signaling 6.76E IL-10 Signaling 1.48E IL-12 Signaling and Production in Macrophages 4.27E IL-15 Production 3.24E IL-15 Signaling 1.15E IL-17 Signaling 4.57E IL-17A Signaling in Airway Cells 2.19E IL-17A Signaling in Fibroblasts 6.76E IL-17A Signaling in Gastric Cells 1.68E IL-2 Signaling 1.17E IL-22 Signaling 1.62E IL-3 Signaling 3.39E IL-4 Signaling 3.63E IL-6 Signaling 3.16E IL-8 Signaling 1.02E IL-9 Signaling 5.89E ILK Signaling 6.76E Induction of Apoptosis by HIV1 1.05E Inhibition of Angiogenesis by TSP1 9.77E Inositol Metabolism 1.33E Inositol Phosphate Metabolism 2.51E Insulin Receptor Signaling 3.98E Integrin Signaling 6.31E Intrinsic Prothrombin Activation Pathway 8.13E JAK/Stat Signaling 6.31E Keratan Sulfate Biosynthesis 4.27E Leptin Signaling in Obesity 4.47E Leukocyte Extravasation Signaling 3.16E Lipid Antigen Presentation by CD
5 LPS/IL-1 Mediated Inhibition of RXR Function 2.24E LPS-stimulated MAPK Signaling 3.89E LXR/RXR Activation 7.41E Lymphotoxin β Receptor Signaling 7.08E Lysine Biosynthesis 5.64E Lysine Degradation 1.91E Macropinocytosis Signaling 3.63E Maturity Onset Diabetes of Young (MODY) Signaling Mechanisms of Viral Exit from Host Cells 9.55E Melanocyte Development and Pigmentation Signaling 1.29E Melanoma Signaling 5.62E Melatonin Signaling 5.01E Methane Metabolism 3.80E Methionine Metabolism 1.38E MIF Regulation of Innate Immunity 4.98E MIF-mediated Glucocorticoid Regulation Mismatch Repair in Eukaryotes 3.16E Mitochondrial Dysfunction 1.00E Mitotic Roles of Polo-Like Kinase 8.51E Molecular Mechanisms of Cancer 6.31E MSP-RON Signaling Pathway 9.55E mtor Signaling 2.51E Myc Mediated Apoptosis Signaling 1.26E Natural Killer Cell Signaling 2.34E Neuregulin Signaling 3.72E Neuropathic Pain Signaling In Dorsal Horn Neurons 3.72E Neuroprotective Role of THOP1 in Alzheimer's Disease 4.33E Neurotrophin/TRK Signaling 2.75E NF-κB Activation by Viruses 4.57E NF-κB Signaling 1.55E NGF Signaling 7.94E N-Glycan Biosynthesis 6.31E N-Glycan Degradation 4.47E Nicotinate and Nicotinamide Metabolism 6.46E Nitric Oxide Signaling in the Cardiovascular System 5.37E Nitrogen Metabolism 4.16E Non-Small Cell Lung Cancer Signaling 3.47E Notch Signaling 3.03E NRF2-mediated Oxidative Stress Response 8.51E Nucleotide Excision Repair Pathway 6.03E Nucleotide Sugars Metabolism 4.68E Nur77 Signaling in T Lymphocytes 5.35E O-Glycan Biosynthesis 2.08E Oncostatin M Signaling 1.02E One Carbon Pool by Folate 6.17E Ovarian Cancer Signaling 5.01E OX40 Signaling Pathway Oxidative Phosphorylation 6.31E P2Y Purigenic Receptor Signaling Pathway 2.24E p38 MAPK Signaling 1.22E
6 p53 Signaling 5.25E p70s6k Signaling 1.00E PAK Signaling 1.91E Pancreatic Adenocarcinoma Signaling 8.13E Pantothenate and CoA Biosynthesis 2.24E Parkinson's Signaling 4.89E Paxillin Signaling 2.09E PDGF Signaling 9.33E Pentose and Glucuronate Interconversions 3.80E Pentose Phosphate Pathway 7.94E Phenylalanine Metabolism 3.03E Phenylalanine, Tyrosine and Tryptophan Biosynthesis 3.80E Phospholipase C Signaling 1.78E Phospholipid Degradation 6.46E Phototransduction Pathway PI3K Signaling in B Lymphocytes 4.57E PI3K/AKT Signaling 1.10E PKCθ Signaling in T Lymphocytes 5.75E Polyamine Regulation in Colon Cancer 4.27E PPAR Signaling 7.94E PPARα/RXRα Activation 1.12E Primary Immunodeficiency Signaling 2.26E Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 3.72E Prolactin Signaling 1.45E Propanoate Metabolism 9.77E Prostate Cancer Signaling 6.03E Protein Kinase A Signaling 8.51E Protein Ubiquitination Pathway 7.94E PTEN Signaling 4.07E Purine Metabolism 7.94E PXR/RXR Activation 6.17E Pyrimidine Metabolism 7.94E Pyruvate Metabolism 1.38E Rac Signaling 5.37E RAN Signaling 3.16E RANK Signaling in Osteoclasts 1.82E RAR Activation 1.38E Reelin Signaling in Neurons 1.02E Regulation of Actin-based Motility by Rho 4.57E Regulation of eif4 and p70s6k Signaling 1.58E Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.35E Relaxin Signaling 6.46E Renal Cell Carcinoma Signaling 5.13E Renin-Angiotensin Signaling 7.94E Retinoic acid Mediated Apoptosis Signaling Retinol Metabolism 2.45E RhoA Signaling 3.89E RhoGDI Signaling 9.12E Riboflavin Metabolism 3.25E Role of BRCA1 in DNA Damage Response 3.24E
7 Role of CHK Proteins in Cell Cycle Checkpoint Control 1.74E Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza Role of IL-17A in Arthritis 2.29E Role of IL-17A in Psoriasis Role of IL-17F in Allergic Inflammatory Airway Diseases 6.31E Role of JAK family kinases in IL-6-type Cytokine Signaling 1.91E Role of JAK1 and JAK3 in γc Cytokine Signaling 7.59E Role of JAK1, JAK2 and TYK2 in Interferon Signaling 1.15E Role of JAK2 in Hormone-like Cytokine Signaling 7.76E Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 1.38E Role of MAPK Signaling in the Pathogenesis of Influenza 4.90E Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 1.99E Role of NFAT in Cardiac Hypertrophy 1.29E Role of NFAT in Regulation of the Immune Response 3.72E Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency 1.91E Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 4.07E Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 1.82E Role of PI3K/AKT Signaling in the Pathogenesis of Influenza 2.72E Role of PKR in Interferon Induction and Antiviral Response 1.51E Role of RIG1-like Receptors in Antiviral Innate Immunity 2.30E Role of Tissue Factor in Cancer 2.29E Role of Wnt/GSK-3? Signaling in the Pathogenesis of Influenza SAPK/JNK Signaling 2.34E Selenoamino Acid Metabolism 3.89E Semaphorin Signaling in Neurons 1.00E Serotonin Receptor Signaling Sertoli Cell-Sertoli Cell Junction Signaling 4.47E Signaling by Rho Family GTPases 1.58E Small Cell Lung Cancer Signaling 2.40E Sonic Hedgehog Signaling 1.08E Sphingolipid Metabolism 1.32E Sphingosine-1-phosphate Signaling 1.66E Spliceosomal Cycle Starch and Sucrose Metabolism 3.47E Stilbene, Coumarine and Lignin Biosynthesis 1.62E Sulfur Metabolism 4.98E Synaptic Long Term Depression 3.72E Synaptic Long Term Potentiation 3.72E Synthesis and Degradation of Ketone Bodies 9.77E Systemic Lupus Erythematosus Signaling 4.37E T Cell Receptor Signaling 3.31E T Helper Cell Differentiation Taurine and Hypotaurine Metabolism 4.78E Telomerase Signaling 2.69E Telomere Extension by Telomerase 3.72E TGF-β Signaling 1.32E Thrombin Signaling 1.58E Thrombopoietin Signaling 1.17E Thyroid Cancer Signaling 3.31E
8 Tight Junction Signaling 1.86E TNFR1 Signaling 3.02E TNFR2 Signaling 8.32E Toll-like Receptor Signaling 2.04E TR/RXR Activation 3.98E TREM1 Signaling 1.05E Tryptophan Metabolism 8.32E Tumoricidal Function of Hepatic Natural Killer Cells 3.24E TWEAK Signaling 9.77E Type I Diabetes Mellitus Signaling 7.08E Type II Diabetes Mellitus Signaling 3.98E Tyrosine Metabolism 2.62E Ubiquinone Biosynthesis 9.12E Urea Cycle and Metabolism of Amino Groups 6.76E Valine, Leucine and Isoleucine Biosynthesis 8.91E Valine, Leucine and Isoleucine Degradation 5.75E VDR/RXR Activation 5.33E VEGF Signaling 5.62E Virus Entry via Endocytic Pathways 4.57E Wnt/ß-catenin Signaling Xenobiotic Metabolism Signaling 7.76E α-adrenergic Signaling 3.72E β-alanine Metabolism 2.14E
Supplementary Table 1. Complete Diseases and Disorders results from IPA simulations.
Supplementary Data Supplementary Table 1. Complete Diseases and Disorders results from IPA simulations. Disease/Disorder Percentage of Simulations in which Disease/Disorder was Significantly Associated
Supplementary Figure 1. PCA separated RA and OA FLS isolated from (a) knees and (b) hips. by corresponding DMLs.
Supplementary Figure 1. PCA separated RA and OA FLS isolated from (a) knees and (b) hips by corresponding DMLs. Supplementary Table 1. Enriched biological pathways identified between 19 RA and 5 OA in
Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model
SUPPLEMENTARY INFORMATION FOR: Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model Camile Castilho Fontelles 1,2, Elissa Carney 1, Johan Clarke 1, Nguyen Nguyen
Systems biology approaches and pathway tools for investigating cardiovascular disease
Systems biology approaches and pathway tools for investigating cardiovascular disease Craig E. Wheelock 1,2*, Åsa M. Wheelock 2,3,4, Shuichi Kawashima 5, Diego Diez 2, Minoru Kanehisa 2,5, Marjan van Erk
Schizophrenia Interactome Pathways Pathway P-value Schizophrenia Genes Known Interactors Novel Interactors
Schizophrenia Interactome Pathways Pathway P-value Schizophrenia Genes Known Interactors Novel Interactors Molecular Mechanisms of Cancer 2.00E-41 TCF4,PAK6,AKT3,PRKD1,AKT 1 BCL2L1,AKT2,RBPJ,MAP3K7,ARH
Metabolomic Data Analysis with MetaboAnalystR
Metabolomic Data Analysis with MetaboAnalystR Name: guest623839008349489450 February 7, 2018 1 Background Understanding the functional importance of metabolites in untargeted metabolomics is limited due
Supplementary Figures
Supplementary Figures Figure S1. Urodynamic recording of BOO-induced LUTD patients. (A) DO group. BOO patients with increased detrusor pressure and reduced urine flow during pressure flow in combination
Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers
Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers ListHits ListTotal PopulationHits PopulationTotal Terms 3 72 10 1429 Glycolysis Pathway 3 72 11 1429 Regulation
Supplementary Figure S1. Unsupervised cluster analysis depicted as heat map showing relationship between (A) whole transcriptome and (B) mirnome with
A B Supplementary Figure S1. Unsupervised cluster analysis depicted as heat map showing relationship between (A) whole transcriptome and (B) mirnome with MM cell lines treated and untreated with bortezomib.
Pathways of changes in hypermethylation in F1 offspring exposed to intrauterine hyperglycemia
Supplementary Table 1. Pathways of changes in hypermethylation in F1 offspring exposed to intrauterine hyperglycemia Pathway Enrichment Score (-log10[p value]) p-value genes Glycosaminoglycan degradation
Supplementary Figure 1.
Supplementary Figure 1. Increased expression of cell cycle pathway genes in insulin + Glut2 low cells of STZ-induced diabetic islets. A) random blood glucose measuers of STZ and vehicle treated MIP-GFP
SUPPLEMENTARY DATA Supplementary Figure 1. Body weight and fat mass of AdicerKO mice.
SUPPLEMENTARY DATA Supplementary Figure 1. Body weight and fat mass of AdicerKO mice. Twelve week old mice were subjected to ad libitum (AL) or dietary restriction (DR) regimens for three months. (A) Body
K-means Clustering of a subset of five datasets that were identified as. TNBC by IHC. Since TNBCs are not identified by GE in the clinical setting, we
Supplemental Results K-means Clustering of a subset of five datasets that were identified as TNBC by IHC. Since TNBCs are not identified by GE in the clinical setting, we performed a similar GE analysis
SUPPLEMENTAL DIGITAL CONTENT (SDC)
SUPPLEMENTAL DIGITAL CONTENT (SDC) SDC, MATERIALS AND METHODS Animals This study used 9-12 week old male C57BL/6 mice (Jackson Laboratory, Bar Harbor, ME). This study conformed to the National Institutes
Signal transduction camp signaling pathway ko Signal transduction MAPK signaling pathway ko
Table S2 - Summary of the KEGG pathway annotation results for the P transcriptome. Pathway Hierarchy1 Pathway Hierarchy2 KEGG Pathway Pathway ID Gene Metabolism Amino acid metabolism Lysine degradation
Identification of Tissue-Specific Protein-Coding and Noncoding. Transcripts across 14 Human Tissues Using RNA-seq
Identification of Tissue-Specific Protein-Coding and Noncoding Transcripts across 14 Human Tissues Using RNA-seq Jinhang Zhu 1, Geng Chen 1, Sibo Zhu 1,2, Suqing Li 3, Zhuo Wen 3, Bin Li 1, Yuanting Zheng
Supplementary Figure 1: Func8onal Network Analysis of Kinases Significantly Modulated by MERS CoV Infec8on and Conserved Across All Time Points
A. B. 8 4 Supplementary Figure : Func8onal Network Analysis of Kinases Significantly Modulated by MERS CoV Infec8on and Conserved Across All Time Points Examined. A) Venn diagram analysis of kinases significantly
REACTOME: Nonsense Mediated Decay (NMD) REACTOME:72764 Eukaryotic Translation Termination. REACTOME:72737 Cap dependent Translation Initiation
A REACTOME:975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACTOME:975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACTOME:927802
Supplementary data Table S3. GO terms, pathways and networks enriched among the significantly correlating genes using Tox-Profiler
Supplementary data Table S3. GO terms, pathways and networks enriched among the significantly correlating genes using Tox-Profiler DR CALUX Boys Girls Database Systemic lupus erythematosus 4.4 0.0021 6.7
Pathway Map Reference Guide
Pathway Map Reference Guide Focus Attention-grabber Your Pathway The most popular cell signaling pathways Sample & Assay Technologies Table of contents AKT Signaling 4 camp Signaling 5 Cellular Apoptosis
Additional file 2 List of pathway from PID
Additional file 2 List of pathway from PID Pathway ID Pathway name # components # enriched GO terms a4b1_paxdep_pathway Paxillin-dependent events mediated by a4b1 20 179 a4b1_paxindep_pathway Paxillin-independent
Genetics and Cancer Ch 20
Genetics and Cancer Ch 20 Cancer is genetic Hereditary cancers Predisposition genes Ex. some forms of colon cancer Sporadic cancers ~90% of cancers Descendants of cancerous cells all cancerous (clonal)
Animal Models to Understand Immunity
Animal Models to Understand Immunity Hussein El Saghire hesaghir@sckcen.be Innate Adaptive immunity Immunity MAPK and NF-kB TLR pathways receptors Fast Slow Non-specific Specific NOD-like receptors T-cell
Bachelor Nutrition Science Seminar Nutritional Biochemistry (Module BE2.3) Topics
Nutritional Biochemistry (Module BE2.3) Prof. Dr. Stefan Lorkowski 1 Bachelor Nutrition Science Seminar Nutritional Biochemistry (Module BE2.3) Topics Biosynthesis of amino acids 1. Amino acids: general
T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes:
Interactions between innate immunity & adaptive immunity What happens to T cells after they leave the thymus? Naïve T cells exit the thymus and enter the bloodstream. If they remain in the bloodstream,
T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes:
Interactions between innate immunity & adaptive immunity What happens to T cells after they leave the thymus? Naïve T cells exit the thymus and enter the bloodstream. If they remain in the bloodstream,
Published on Second Faculty of Medicine, Charles University (http://www.lf2.cuni.cz )
Published on Second Faculty of Medicine, Charles University (http://www.lf2.cuni.cz ) Biochemistry Submitted by Marie Havlová on 8. February 2012-0:00 Syllabus of Biochemistry Mechanisms of enzyme catalysis.
Principles of Genetics and Molecular Biology
Cell signaling Dr. Diala Abu-Hassan, DDS, PhD School of Medicine Dr.abuhassand@gmail.com Principles of Genetics and Molecular Biology www.cs.montana.edu Modes of cell signaling Direct interaction of a
AMINO ACIDS NON-ESSENTIAL ESSENTIAL
Edith Frederika Introduction A major component of food is PROTEIN The protein ingested as part of our diet are not the same protein required by the body Only 40 to 50 gr of protein is required by a normal
E.coli Core Model: Metabolic Core
1 E.coli Core Model: Metabolic Core 2 LEARNING OBJECTIVES Each student should be able to: Describe the glycolysis pathway in the core model. Describe the TCA cycle in the core model. Explain gluconeogenesis.
Intrinsic cellular defenses against virus infection
Intrinsic cellular defenses against virus infection Detection of virus infection Host cell response to virus infection Interferons: structure and synthesis Induction of antiviral activity Viral defenses
Formalin-fixed paraffin-embedded sections of liver from a recipient mouse sacrificed after two rounds
Supplementary figure legends Supplementary Figure 1 Fah + hepatocytes in a Fah -/- mouse transplanted with sorted cells. Formalin-fixed paraffin-embedded sections of liver from a recipient mouse sacrificed
Revision. camp pathway
االله الرحمن الرحيم بسم Revision camp pathway camp pathway Revision camp pathway Adenylate cyclase Adenylate Cyclase enzyme Adenylate cyclase catalyses the formation of camp from ATP. Stimulation or inhibition
Innate Immunity. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples Chapter 3. Antimicrobial peptide psoriasin
Know Differences and Provide Examples Chapter * Innate Immunity * kin and Epithelial Barriers * Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive
CYTOKINE RECEPTORS AND SIGNAL TRANSDUCTION
CYTOKINE RECEPTORS AND SIGNAL TRANSDUCTION What is Cytokine? Secreted popypeptide (protein) involved in cell-to-cell signaling. Acts in paracrine or autocrine fashion through specific cellular receptors.
Amino Acid Metabolism
Amino Acid Metabolism Last Week Most of the Animal Kingdom = Lazy - Most higher organisms in the animal kindom don t bother to make all of the amino acids. - Instead, we eat things that make the essential
Supplementary information
Supplementary information Unique polypharmacology nuclear receptor modulator blocks inflammatory signaling pathways Mi Ra Chang 1, Anthony Ciesla 1, Timothy S. Strutzenberg 1, Scott J. Novick 1, Yuanjun
Short polymer. Dehydration removes a water molecule, forming a new bond. Longer polymer (a) Dehydration reaction in the synthesis of a polymer
HO 1 2 3 H HO H Short polymer Dehydration removes a water molecule, forming a new bond Unlinked monomer H 2 O HO 1 2 3 4 H Longer polymer (a) Dehydration reaction in the synthesis of a polymer HO 1 2 3
Supplementary Methods
Supplementary Methods Analysis of time course gene expression data. The time course data of the expression level of a representative gene is shown in the below figure. The trajectory of longitudinal expression
Innate Immunity. Chapter 3. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples. Antimicrobial peptide psoriasin
Chapter Know Differences and Provide Examples Innate Immunity kin and Epithelial Barriers Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive Immunity
Objective: You will be able to explain how the subcomponents of
Objective: You will be able to explain how the subcomponents of nucleic acids determine the properties of that polymer. Do Now: Read the first two paragraphs from enduring understanding 4.A Essential knowledge:
Subject Index. Bcl-2, apoptosis regulation Bone marrow, polymorphonuclear neutrophil release 24, 26
Subject Index A1, apoptosis regulation 217, 218 Adaptive immunity, polymorphonuclear neutrophil role 31 33 Angiogenesis cancer 178 endometrium remodeling 172 HIV Tat induction mechanism 176 inflammatory
Sustainable Fish Diets for the 21st Century using Soybean Protein. Paul B. Brown, Purdue University, West Lafayette, Indiana, USA
Sustainable Fish Diets for the 21st Century using Soybean Protein Paul B. Brown, Purdue University, West Lafayette, Indiana, USA pb@purdue.edu *Introduction *If you want to grow an animal, you must provide
Overview of AMINO ACIDS
Overview of AMINO ACIDS Amino Acids are the chemical units or "building blocks" of the body that make up proteins. Protein substances make up the muscles, tendons, organs, glands, nails, and hair. Growth,
Allergy and Immunology Review Corner: Chapter 13 of Immunology IV: Clinical Applications in Health and Disease, by Joseph A. Bellanti, MD.
Allergy and Immunology Review Corner: Chapter 13 of Immunology IV: Clinical Applications in Health and Disease, by Joseph A. Bellanti, MD. Chapter 13: Mechanisms of Immunity to Viral Disease Prepared by
NBCE Mock Board Questions Biochemistry
1. Fluid mosaic describes. A. Tertiary structure of proteins B. Ribosomal subunits C. DNA structure D. Plasma membrane structure NBCE Mock Board Questions Biochemistry 2. Where in the cell does beta oxidation
RAS Genes. The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes.
۱ RAS Genes The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes. Oncogenic ras genes in human cells include H ras, N ras,
Cell signaling. How do cells receive and respond to signals from their surroundings?
Cell signaling How do cells receive and respond to signals from their surroundings? Prokaryotes and unicellular eukaryotes are largely independent and autonomous. In multicellular organisms there is a
renoprotection therapy goals 208, 209
Subject Index Aldosterone, plasminogen activator inhibitor-1 induction 163, 164, 168 Aminopeptidases angiotensin II processing 64 66, 214 diabetic expression 214, 215 Angiotensin I intrarenal compartmentalization
silent epidemic,. (WHO),
Tel: 02-740-8686; E-mail: hhbkim@snu.ac.kr silent epidemic,. (WHO),. 5 3, 1. 50 70. 50%, 25%, 20% (12~35%). 2.8% 0.7% 4. ( ). bone remodeling (osteoblast), (osteoclast),.. 3~4.. 70% (osteocyte) (bone lining
Mechanistic Toxicology
SECOND EDITION Mechanistic Toxicology The Molecular Basis of How Chemicals Disrupt Biological Targets URS A. BOELSTERLI CRC Press Tavlor & France Croup CRC Press is an imp^t o* :H Taylor H Francn C'r,,jpi
Interferon-gamma pathway is activated in a chronically HBV infected chimpanzee that controls HBV following ARC-520 RNAi treatment
Interferon-gamma pathway is activated in a chronically HBV infected chimpanzee that controls HBV following ARC-520 RNAi treatment Zhao Xu, Deborah Chavez, Jason E. Goetzmann, Robert E. Lanford and Christine
Cells. Variation and Function of Cells
Cells Variation and Function of Cells Plasma Membrane= the skin of a cell, it protects and nourishes the cell while communicating with other cells at the same time. Lipid means fat and they are hydrophobic
Four Classes of Biological Macromolecules. Biological Macromolecules. Lipids
Biological Macromolecules Much larger than other par4cles found in cells Made up of smaller subunits Found in all cells Great diversity of func4ons Four Classes of Biological Macromolecules Lipids Polysaccharides
Biological systems interact, and these systems and their interactions possess complex properties. STOP at enduring understanding 4A
Biological systems interact, and these systems and their interactions possess complex properties. STOP at enduring understanding 4A Homework Watch the Bozeman video called, Biological Molecules Objective:
NFκB What is it and What s the deal with radicals?
The Virtual Free Radical School NFκB What is it and What s the deal with radicals? Emily Ho, Ph.D Linus Pauling Institute Scientist Department of Nutrition and Food Management Oregon State University 117
Full Report (All Nutrients) 01174, Milk, reduced fat, fluid, 2% milkfat, without added vitamin A and vitamin D
National base for Standard Reference Release 28 slightly revised May, 206 Full Report (All s) 074, Milk, reduced fat, fluid, 2% milkfat, without added vitamin A and vitamin D Report Date: February 23,
Signal Transduction Cascades
Signal Transduction Cascades Contents of this page: Kinases & phosphatases Protein Kinase A (camp-dependent protein kinase) G-protein signal cascade Structure of G-proteins Small GTP-binding proteins,
ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS. Choompone Sakonwasun, MD (Hons), FRCPT
ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS Choompone Sakonwasun, MD (Hons), FRCPT Types of Adaptive Immunity Types of T Cell-mediated Immune Reactions CTLs = cytotoxic T lymphocytes
Late regulation of immune genes and micrornas in circulating leukocytes in a pig model of
1 Supplementary material for: 2 3 4 5 6 Late regulation of immune genes and micrornas in circulating leukocytes in a pig model of influenza A (H1N2) infection Louise Brogaard, Peter M. H. Heegaard, Lars
How Will New Therapies Affect HCC Development?
How Will New Therapies Affect HCC Development? July 6, 2018 Scott Friedman, M.D. Fishberg Professor of Medicine Dean for Therapeutic Discovery Chief, Division of Liver Diseases Icahn School of Medicine
Overview of the immune system
Overview of the immune system Immune system Innate (nonspecific) 1 st line of defense Adaptive (specific) 2 nd line of defense Cellular components Humoral components Cellular components Humoral components
BENEFITS OF COLLAGEN
ATHLETIC PERFORMANCE/TENDON/MUSCLE Alanine: Alanine is an important source of energy for muscle tissue. Helps to convert sugar into glucose for energy. Asparagine: Asparagine may increase endurance and
Table S4A- GOBP functional annotation of celecoxib-modulated genes common between CO
Table S4A- GOBP functional annotation of celecoxib-modulated genes common between CO Terms ListHits ListTotal PopulationHits cell proliferation 44 228 1156 cell cycle 34 228 806 DNA replication and chromosome
Nitrogen Metabolism. Overview
Nitrogen Metabolism Pratt and Cornely Chapter 18 Overview Nitrogen assimilation Amino acid biosynthesis Nonessential aa Essential aa Nucleotide biosynthesis Amino Acid Catabolism Urea Cycle Juicy Steak
Dental Students Biochemistry Exam V Questions ( Note: In all cases, the only correct answer is the best answer)
Dental Students Biochemistry Exam V Questions - 2006 ( Note: In all cases, the only correct answer is the best answer) 1. Essential fatty acids are: A. precursors of biotin B. precursors of tyrosine C.
Amino Acid Oxidation and the Urea Cycle
Amino Acid Oxidation and the Urea Cycle Amino Acids: Final class of biomolecules whose oxidation contributes significantly to the generation of energy Undergo oxidation in three metabolic circumstances
Medical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University
Medical Virology Immunology Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Human blood cells Phases of immune responses Microbe Naïve
# of transcr ipts FDR q- value transcripts PGF,CTNNB1,AKT2,FARP2,VEGFB,PDGFRA,DRD 2,CSF1,CDH1,ITGB1,SRC,KRAS,RASGRP3,MAP2. Pathway
Supplementary Table 9. Pathways and biological processes associated with transcripts specific to SEB in both the pre- and post- RASP leukocytes (transcripts included in the Reactome Function Interaction
Lynne A. Wolfe, MS, ACNP, PNP, BC Department of Genetics Yale School of Medicine
Lynne A. Wolfe, MS, ACNP, PNP, BC Department of Genetics Yale School of Medicine Harvey Levy, MD Mark Korson, MD Piero Rinaldo, MD, PhD Larry Sweetman, PhD K. Michael Gibson, PhD Charlie Roe, MD Jerry
Proteins consist in whole or large part of amino acids. Simple proteins consist only of amino acids.
Today we begin our discussion of the structure and properties of proteins. Proteins consist in whole or large part of amino acids. Simple proteins consist only of amino acids. Conjugated proteins contain
T. gondii. P. knowlesi
KEGG - Citrate cycle (TCA cycle) KEGG - Fatty acid biosynthesis KEGG - Glutathione metabolism KEGG - Fatty acid metabolism KEGG - Polyketide sugar unit biosynthesis KEGG - Folate biosynthesis KEGG - Urea
Biochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course Second Edition CHAPTER 30 Amino Acid Degradation and the Urea Cycle 2013 W. H. Freeman and Company Chapter 30 Outline Amino acids are obtained from the
Chapter 5: Structure and Function of Macromolecules AP Biology 2011
Chapter 5: Structure and Function of Macromolecules AP Biology 2011 1 Macromolecules Fig. 5.1 Carbohydrates Lipids Proteins Nucleic Acids Polymer - large molecule consisting of many similar building blocks
Deregulation of signal transduction and cell cycle in Cancer
Deregulation of signal transduction and cell cycle in Cancer Tuangporn Suthiphongchai, Ph.D. Department of Biochemistry Faculty of Science, Mahidol University Email: tuangporn.sut@mahidol.ac.th Room Pr324
Carbohydrates. Building a carbohydrate:
Carbohydrates Monomer: Monosaccharide (simple s) Example: glucose, fructose Disaccharide: 2 monosaccharides joined together Example: sucrose (glucose + fructose) olymer: olysaccharide (starch) Example:
Subject Index. hypothalamic-pituitary-adrenal axis 158. Atherosclerosis, ghrelin role AVP, see Arginine vasopressin.
Subject Index Acromegaly, somatostatin analog therapy dopamine agonist combination therapy 132 efficacy 132, 133 overview 130, 131 receptor subtype response 131, 132 SOM30 studies 131, 132 ACTH, see Adrenocorticotropic
Classification of amino acids: -
Page 1 of 8 P roteinogenic amino acids, also known as standard, normal or primary amino acids are 20 amino acids that are incorporated in proteins and that are coded in the standard genetic code (subunit
G-Protein-Coupled Receptors
Cellular Signalling Cells must be ready to respond to essential signals in their environment. These are often chemicals in the extracellular fluid (ECF) from distant locations in a multicellular organism
STANDARD FORMULATED SUPPLEMENTARY SPORTS FOODS
STANDARD 2.9.4 FORMULATED SUPPLEMENTARY SPORTS FOODS Purpose This Standard defines and regulates the composition and labelling of foods specially formulated to assist sports people in achieving specific
Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis
Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis Sweta Sharma 1, Paramita Mandal 1, Tamal Sadhukhan 1, Rahul Roy Chowdhury 2, Nidhu Ranjan Mondal
Cancer. Questions about cancer. What is cancer? What causes unregulated cell growth? What regulates cell growth? What causes DNA damage?
Questions about cancer What is cancer? Cancer Gil McVean, Department of Statistics, Oxford What causes unregulated cell growth? What regulates cell growth? What causes DNA damage? What are the steps in
Glycolysis. Cellular Respiration
Glucose is the preferred carbohydrate of cells. In solution, it can change from a linear chain to a ring. Energy is stored in the bonds of the carbohydrates. Breaking these bonds releases that energy.
Growth Factors. BIT 230 Walsh Chapter 7
Growth Factors BIT 230 Walsh Chapter 7 3 Definitions Autocrine: a mode of hormone action in which a hormone affects the function of the cell type that produced it. Paracrine: Relating to the release of
THE HALLMARKS OF CANCER
THE HALLMARKS OF CANCER ONCOGENES - Most of the oncogenes were first identified in retroviruses: EGFR (ErbB), Src, Ras, Myc, PI3K and others (slightly more than 30) - Mutated cellular genes incorporated
Enzyme-coupled Receptors. Cell-surface receptors 1. Ion-channel-coupled receptors 2. G-protein-coupled receptors 3. Enzyme-coupled receptors
Enzyme-coupled Receptors Cell-surface receptors 1. Ion-channel-coupled receptors 2. G-protein-coupled receptors 3. Enzyme-coupled receptors Cell-surface receptors allow a flow of ions across the plasma
Chapter 9. Cells Grow and Reproduce
Chapter 9 Cells Grow and Reproduce DNA Replication DNA polymerase Addition of a nucleotide to the 3 end of a growing strand Use dntps as substrate Release of pyrophosphate Initiation of Replication Replication
Amino acids. Dr. Mamoun Ahram Summer semester,
Amino acids Dr. Mamoun Ahram Summer semester, 2017-2018 Resources This lecture Campbell and Farrell s Biochemistry, Chapters 3 (pp.66-76) General structure (Chiral carbon) The amino acids that occur in
Carnelian uncovers hidden functional patterns across diverse study populations from whole metagenome sequencing reads
Carnelian uncovers hidden functional patterns across diverse study populations from whole metagenome sequencing reads Sumaiya Nazeen 1 and Bonnie Berger 1,2* 1 Computer Science and Artificial Intelligence
2 Which of these statements best explains the process of energy conversion that takes place in the mitochondria?
irst Semester Biology inal: 1. The technique known as chromosome painting is the result of scientific research. Scientists use chromosome painting to mark the locations of genes on human chromosomes with
Innate immunity. Abul K. Abbas University of California San Francisco. FOCiS
1 Innate immunity Abul K. Abbas University of California San Francisco FOCiS 2 Lecture outline Components of innate immunity Recognition of microbes and dead cells Toll Like Receptors NOD Like Receptors/Inflammasome
Amino acids. (Foundation Block) Dr. Essa Sabi
Amino acids (Foundation Block) Dr. Essa Sabi Learning outcomes What are the amino acids? General structure. Classification of amino acids. Optical properties. Amino acid configuration. Non-standard amino
Lecture 10 - Protein Turnover and Amino Acid Catabolism
Lecture 10 - Protein Turnover and Amino Acid Catabolism Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire 1 Introduction 2 Proteins are degraded into amino acids. Protein
Lecture 11 - Biosynthesis of Amino Acids
Lecture 11 - Biosynthesis of Amino Acids Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire 1 Introduction Biosynthetic pathways for amino acids, nucleotides and lipids
Age-related reference ranges
Authoriser: Peter Beresford Page 1 of 6 Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Both less than 14 days 90 273 Both 14 days
Table S7C- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 non-expressers
Table S7C- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 non-expressers Terms ListHits ListTotal PopulationHits PopulationTotal Hypoxia and p53 in the Cardiovascular system
CYTOKINES. Based on: Cellular and Molecular Immunology, 4 th ed.,abbas A.K., Lichtman A.H. and Pober J.S. Sounders company; Philadelphia, 2010.
CYTOKINES Based on: Cellular and Molecular Immunology, 4 th ed.,abbas A.K., Lichtman A.H. and Pober J.S. Sounders company; Philadelphia, 2010. 1 What are cytokines? Glycoproteins (15 25 kda): Interleukins
Proteins are sometimes only produced in one cell type or cell compartment (brain has 15,000 expressed proteins, gut has 2,000).
Lecture 2: Principles of Protein Structure: Amino Acids Why study proteins? Proteins underpin every aspect of biological activity and therefore are targets for drug design and medicinal therapy, and in
Cell Cell Communication
IBS 8102 Cell, Molecular, and Developmental Biology Cell Cell Communication January 29, 2008 Communicate What? Why do cells communicate? To govern or modify each other for the benefit of the organism differentiate
Immune system. Aims. Immune system. Lymphatic organs. Inflammation. Natural immune system. Adaptive immune system
Aims Immune system Lymphatic organs Inflammation Natural immune system Adaptive immune system Major histocompatibility complex (MHC) Disorders of the immune system 1 2 Immune system Lymphoid organs Immune