PSYCHOPHARMACOLOGY CLINICAL DIALOGUE: UPDATE ON NEW YORK, NEW YORK. APRIL 30 MAY 1, 2010 Sheraton New York Hotel and Towers FIRST ANNOUNCEMENT

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1 2010 CLINICAL DIALOGUE: UPDATE ON PSYCHOPHARMACOLOGY NEW YORK, NEW YORK APRIL 30 MAY 1, 2010 Sheraton New York Hotel and Towers CHAIRS Jeffrey A. Lieberman, MD University of Texas Southwestern Medical School Dallas, Texas FIRST ANNOUNCEMENT Jointly sponsored by The College of Physicians and Surgeons of Columbia University and Imedex, LLC W W W. I M E D E X. C O M

2 LETTER FROM THE CHAIRS Dear Colleague: It is with great pleasure that we invite you back to New York for the 2010 Clinical Dialogue: Update on Psychopharmacology. This educational conference will provide you with the opportunity to interact with expert faculty and enhance your knowledge on new and upcoming management techniques and treatments of patients with psychotic and mood disorders. Agenda topics include an expert look at the 2009 APA unipolar and bipolar treatment guidelines, the latest update on clinically meaningful differences between first and second generation antipsychotics, discussion on the management of psychotic symptoms in patients with dementia and a look at new developments in brain stimulation modalities. We received great feedback on the level of audience participation at last year s meeting, so we will continue to offer expert panel and clinical case discussions attendees described the meeting as excellent with relevant and useful material. We look forward to sharing essential clinical information with you at this important educational forum. Space is limited so we encourage you to register early to guarantee your seat! Sincerely, Jeffrey A. Lieberman, MD FACULTY Kiki Chang, MD Stanford University School of Medicine Stanford, California Donald C. Goff, MD Massachusetts General Hospital Harvard Medical School Boston, Massachusetts L. Fredrik Jarskog, MD Jeffrey A. Leiberman, MD, Sarah H. Lisanby, MD Setphen R. Marder, MD UCLA Neuropsychiatric Institute Los Angeles, California Joseph P. McEvoy Duke University Medical Center Durham, North Carolina Maria A. Oquendo, MD T. Scott Stroup, MD Madhukar H. Trivedi, MD University of Texas Southwestern Medical School Dallas, Texas CONFERENCE ORGANIZER 4325 Alexander Drive Alpharetta, Georgia USA Tel.: +1 (770) Fax: +1 (770) meetings@imedex.com

3 CLINICAL DIALOGUE: UPDATE ON 2010 PSYCHOPHARMACOLOGY NEW YORK, NEW YORK I APRIL 30 MAY 1, 2010 CONTINUING MEDICAL EDUCATION This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The College of Physicians and Surgeons of and Imedex, LLC. The College of Physicians and Surgeons of is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The College of Physicians and Surgeons of designates this educational activity for a maximum of 12.0 of AMA PRA Category 1 Credit(s) TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. WHO SHOULD ATTEND This educational activity is specifically designed for psychiatrists, psychologists and other physicians, clinicians, physiciansin-training, and healthcare professionals (psychiatry nurses, pharmacists, physician assistants) involved and/or interested in the therapeutic management of patients with psychotic and mood disorders. OBJECTIVES After successful completion of this educational activity, attendees should be able to: Review the efficacy and safety of antipsychotic agents in the treatment of schizophrenia Discuss the side effects associated with first and second generation antipsychotics Comment on the role of polypharmacy in schizophrenia Outline a therapeutic strategy to overcome refractory psychosis Discuss diagnostic and treatment strategies for major depression with psychotic features Summarize available and emerging treatment options for dementia with psychotic features Discuss the nonpharmacological options for patients (such as exercise and neuromodulation) with depressive disorders Expand the therapeutic armamentarium for comorbid depression and anxiety Describe the therapeutic strategies available to treat bipolar depression in adults and in children Summarize the effective management of patients who experience mixed episodes Discuss pathophysiology of fibromyalgia and the mechanisms of agents used to treat patients with this disorder CORPORATE SUPPORT Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) , or by at cme@imedex.com.

4 SCIENTIFIC AGENDA FRIDAY, APRIL 30, 2010 PSYCHOSIS 8:30 am Opening remarks Jeffrey Lieberman, MD SESSION I 8:35 am New developments in the pharmacologic treatment of schizophrenia Steven Marder, MD 9:20 am First CATIE, now CUtLASS and EUFEST: Are there any meaningful clinical differences between first and second generation antipsychotics? 10:05 am Coffee break 10:30 am DEBATE: Motor versus metabolic side effect risk with antipsychotic treatments Joseph McEvoy, MD Steven Marder, MD 11:15 am Roundtable case discussion: Polypharmacy rational or irrational? Moderated by Donald Goff, MD Steven Marder, MD Joseph McEvoy, MD 12:00 pm Lunch break SESSION II 1:00 pm Avoiding missing psychotic features in major depression 1:45 pm Considerations in the management of psychotic symptoms in patients with dementia 2:30 pm Coffee break 2:55 pm Preventing weight gain with atypical antipsychotics: Pharmacologic and nonpharmacologic approaches L. Fredrik Jarskog, MD SATURDAY, MAY 1, 2010 MOOD DISORDERS 8:30 am Opening remarks SESSION III 8:35 am First look at the APA Unipolar & Bipolar Treatment Guideline :20 am Treatment for anxiety comorbid with major depressive disorder 10:05 am Coffee break 10:30 am Pediatric bipolar disorder: Controversies and clarifications around diagnosis and treatment Kiki Chang, MD 11:15 am Roundtable case discussion: Recognition and treatment of mixed episodes in bipolar disorder Moderated by Maria A. Oquendo, MD Kiki Chang, MD 12:00 pm Lunch break SESSION IV 1:00 pm New developments in brain stimulation Sarah H. Lisanby, MD 1:45 pm Beyond the fibromyalgia debate: Understanding the pathophysiology and differing mechanisms of action for medications approved for fibromyalgia 2:30 pm Coffee break 2:55 pm Update on the use of atypical antipsychotics in major depression 3:40 pm Exercise for the treatment of depression 4:05 pm Ask the expert: Panel discussion Moderated by Sarah H. Lisanby, MD 3:40 pm Ask the expert: Panel discussion Moderated by Jeffrey Lieberman, MD 4:30 pm Adjourn * Please visit L. Fredrik Jarskog, MD for the most up-to-date agenda and to register. 4:30 pm Adjourn

5 REGISTRATION PROCEDURES To Register: You may register online by Thursday, April 22, 2010 at by calling Imedex at +1 (678) or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting. To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified. Group Discounts: Each one of multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees provided all registration forms and payments are received together. Only one discount will apply per physician. Payment: To pre-register, registration and payment must be received no later than Thursday, April 22, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received. Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the agenda. Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than Thursday, April 22, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after Thursday, April 22, 2010 Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice. REGISTRATION FEES Regular $199 If payment received by Thursday, April 22, 2010 Full/Onsite $249 If payment received after Thursday, April 22, 2010 Group discount (physicians only)* -$50 *cannot be combined with any other discounts HOTEL ACCOMMODATIONS Sheraton New York Hotel and Towers 811 Seventh Avenue Tel.: +1 (888) Fax: +1 (212) The Sheraton New York Hotel and Towers is located between Central Park and Times Square in the center of Manhattan s Midtown business and entertainment district. Move from your perfectly choreographed business event to preferred seating at a famous uptown eatery without missing a beat. Sheraton has a polished, contemporary flair that is enhanced throughout the hotel. All guest rooms feature the new ultra-comfortable pillow top Sheraton Sweet Sleeper(SM) Bed. Plus, the hotel is now 100% smoke-free for your added comfort. For the convenience of attendees, a limited number of rooms have been reserved until April 8, 2010 at a discounted rate of $179 single/double occupancy, plus tax, currently at 14.25% as well as $2.00 New York Occupancy Tax and a $1.50 Convention Center fee. This rate is not guaranteed outside the conference dates or after April 8, To reserve your room please contact the Sheraton New York Hotel and Towers reservations department at +1 (888) To receive the group rate, callers must identify themselves as being with the Clinical Dialogue: Update on Psychopharmacology group. Reservation requests received after April 8, 2010 may not be guaranteed the group rate.

6 A O Check if you require special facilities or assistance and attach a note with specific details and requirements Alexander Dr. Alpharetta, GA IMPORTANT DATES Regular Registration Deadline April 22, 2010 Conference Dates April 30 May 1, 2010 Past participants say: Thank you for this excellent conference in psychopharmacology Very good meeting and many new ideas The material presented was relevant and useful. Great conference and affordable for the part time community psychiatrist I will come back next year and bring my colleagues 3 WAYS TO LEARN: PRINT materials are produced by Imedex for your reference needs ONLINE products are produced by Imedex in 6 user-friendly formats LIVE meetings are produced by Imedex in 15 countries Visit to learn more. REGISTRANT INFORMATION DEGREE: O MD O PhD O PharmD O RN O Other SPECIALTY: O Psychiatry O Psychology O Family or General Medicine O Nursing O Other FIRST NAME MI LAST NAME INSTITUTE DEPARTMENT CITY STATE/PROVINCE ZIP/POSTAL CODE COUNTRY REGISTRATION FEES Regular (If payment received by Thursday, April 22, 2010 )...O $199 Full/Onsite (If payment received after Thursday, April 22, 2010 )...O $249 Group discount (physicians only)* (*cannot be combined with any other discounts)...o $ 50 NOTE: Registrants that pay with American Express will be charged in the USD equivalent which may incur additional charges. This is a policy of American Express. Foreign exchange rate information may be found at NOTE: After April 22, 2010, only credit card payments will be accepted for pre-registration. To pre-register, registration and payment must be received no later than April 22, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure that the meeting is being held as scheduled and to confirm that the meeting is not full. For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex. com no later than April 22, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after April 22, Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice. Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED. PAYMENT METHOD O American Express O MasterCard O Visa O Check in the amount of $ CARDHOLDER S NAME SIGNATURE CARD NUMBER EXP. DATE 4 EASY WAYS TO REGISTER: ONLINE... FAX US... You can fax your registration 24 hours a day. +1 (678) CALL US... The Registrar will take your registration over the phone. +1 (678) MAIL US... Imedex 4325 Alexander Drive Alpharetta, GA , USA In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual s own physician. Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society. Copyright 2008 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty. Imedex is committed to environmental excellence. This publication is printed on FSC-certified paper, which is acid-free and 25% elemental chlorine-free, and contains 50% recycled content including 25% post-consumer waste.