September 5-6, 2008 Chicago, Illinois June 2008 Prague, Czech Republic. Chair. Barcelona, Spain

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1 26-28 June 2008 Prague, Czech Republic September 5-6, 2008 Chicago, Illinois Wyndham Chicago First Announcement Chairs: Robert Dreicer, MD, FACP Chair Joaquim Taussig Cancer Bellmunt, Institute MD Hospital Cleveland del Clinic Mar Cleveland, Ohio Barcelona, Spain Mark S. Soloway, MD Mark University S. Soloway, of Miami School MD of Medicine University Miami, Florida of Miami School of Medicine Miami, Florida W W W. I M E D E X. C O M

2 September 5-6, 2008 Chicago, Illinois Wyndham Chicago September 5-6, 2008 Chicago, Illinois Wyndham Chicago Letter from the Chairs It is with great pleasure that we invite you to attend the 2 nd Annual Perspectives in Urologic Oncology: A Case-Based Conference to Enhance Patient Management of Prostate, Renal and Bladder Cancer to be held September 5-6, 2008 in Chicago, Illinois. This conference will be a forum where urologists and medical/radiation oncologists can come together to learn and share their clinical experiences through both lecture presentations and interactive case discussions. Our panel of world-renowned experts will touch on the most significant aspects of prostate, renal, and bladder cancers. We will discuss the status of the latest treatment modalities as well as emerging approaches to therapy. The meeting will delve into the areas of controversy through vigorous discussion and debate using information from clinical trials as applicable. The speakers have all been selected because of their strong therapy area experience and ability to communicate effectively. Our ultimate goal is to provide you with the information needed to optimize patient care and to make you aware of pertinent current trends and evolutions. We hope you will join us in Chicago for what is sure to be an outstanding event with many lively discussions! Sincerely, Robert Dreicer, MD, FACP Mark S. Soloway, MD Confirmed Faculty Steven C. Campbell, MD, PhD Cleveland Clinic Cleveland, Ohio Carlos Cardon-Cardo, MD, PhD Herbert Irwing Comprehensive Cancer Center New York, New York Robert Dreicer, MD, FACP Taussig Cancer Institute Cleveland Clinic Cleveland, Ohio Laurence H. Klotz, MD University of Toronto Toronto, Ontario, Canada Drogo Montague, MD Cleveland Clinic Cleveland, Ohio William See, MD Medical College of Wisconsin Milwaukee, Wisconsin Mark S. Soloway, MD University of Miami School of Medicine Miami, Florida Gary D. Steinberg, MD, FACS University of Chicago Chicago, Illinois

3 Continuing Medical Education Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. This activity has been approved for A of AMA PRA Category 1 credits TM. Who Should Attend This meeting is intended for urologists, medical oncologists, radiation oncologists, surgeons and other healthcare providers involved or interested in management of renal, bladder and prostate cancer Corporate Support The following company has provided an unrestricted educational grant in support of this conference: Corporate Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) , or by at cme@imedex.com. Conference Organizer 4325 Alexander Drive Alpharetta, Georgia , USA Tel.: +1 (770) Fax: +1 (770) meetings@imedex.com Objectives After successful completion of this continuing medical education activity, participants should be able to: Comment on current trends to improve the diagnosis and prognosis of renal, bladder, and prostate cancers Implement state-of-the-art surgical advancements in renal, bladder and prostate cancers Improve adherence to the recently updated NCCN kidney cancer guidelines Improve patient stratification for front-line use of targeted therapies in stage IV or unresectable advanced renal cell carcinomas Debate the use of PSA screening for the detection of prostate cancer Compare and contrast systemic therapy regimens for hormonesensitive and hormone-refractory prostate cancer Employ the use of targeted therapies in prostate cancer Discuss therapeutic options to manage BCG toxicity and/or BCG failure in patients with bladder cancer Review the role of intravesical chemotherapy in bladder cancer and describe the optimal agent, timing, and dose of administration Integrate combination and sequencing strategies to improve upon current patient outcomes in renal, prostate and bladder cancers

4 Scientific Topics Friday, September 5, :00 am Welcome and introduction Saturday, September 6, :30 am Welcome and introduction Prostate cancer Session I: Locally Advanced Prostate Cancer 8:10 am Active surveillance: Best criteria, candidates, and triggers for active therapy 8:30 am Radiation as the primary treatment for localized disease 8:50 am Management of erectile dysfunction and other quality-of-life issues following local treatment of prostate cancer 9:10 am Questions 9:25 am Coffee break Session II: Case Discussions: Management of Locally Advanced Prostate Cancer: Selection an Integration of Multiple Treatment Regimens 9:45 am Panel discussion 11:45 am Lunch break Session III: Systemic Therapy for High-Risk Advanced Prostate Cancer 12:45 pm Issues in the management of biochemical failure 1:05 pm Patterns of toxicities with androgen-deprivation therapy 1:25 pm Questions 1:35 pm Coffee break Session IV: Case Discussions: Current Concepts in the Management of High-Risk Prostate Cancer 2:00 pm Panel discussion Session V: Translational Science: Integrating Advances on the Horizon in Urologic Oncology 3:30 pm How will molecular biology improve future care of patients with genitourinary tumors? 4:15 pm Questions 4:30 pm Adjourn Bladder cancer Session VI: Bladder Cancer 8:30 am Nuances of TURBT for Ta and T1 bladder cancers 8:50 am Decision processes on T1 bladder cancer: When bladder preservation should and should not be considered 9:10 am Questions Session VII: Case Discussions: Integrating Recent Advances for Bladder Cancer 9:20 am Panel discussion 10:15 am Coffee break Renal cancer Session VIII: Alternative Approaches for the Patient with (Small) Renal Masses 10:30 am Management of small renal masses 10:50 am Technical aspects and indications for partial nephrectomy: How do I choose between open and laproscopic approaches? 11:10 am Surgical approaches to patients with T3 RCC including vena cava involvement 11:30 am Questions 11:45 am Lunch break Session IX: Case Discussions: Controversies in Modern Management Approaches 12:45 pm Panel discussion 2:15 pm Coffee break Session X: Systemic Therapies for Metastatic Renal Cell Carcinomas 2:30 pm Optimal sequencing and combining of systemic therapies for metastatic disease 2:50 pm Questions Session XI: Case Discussions: Recent Advances for Metastatic and Advanced Renal Cell Carcinoma 3:00 pm Panel discussion 4:00 pm Adjourn *Please visit for the most up-to-date agenda and to register.

5 Hotel Accommodations Wyndham Chicago 633 North St. Clair Street Chicago, Illinois Tel.: +1 (312) Fax: +1 (312) The Wyndham Chicago is an oasis of comfort and style in the heart of Chicago s Magnificent Mile. Just one block off Michigan Avenue in a neighborhood full of worldclass restaurants, shopping, museums and galleries. Lake Michigan, the Symphony Center and the Loop financial district are all nearby. Settle into a spacious room or suite with a dazzling view of downtown Chicago. Enjoy thoughtful touches like high-speed Internet access and a cordless multi-line phone. Dine at the chic Caliterra Bar & Grille or unwind in the fitness center and indoor pool. Relax with a walk through the vibrant neighborhood - or let the concierge plan a special outing. For the convenience of attendees, a limited number of rooms have been reserved until August 5, 2008 at a discounted rate of $229 single/double occupancy, plus tax, currently at 15.4%. This rate is not guaranteed outside the conference dates or after August 5, To reserve your room please contact the Wyndham Chicago reservations department at +1 (312) To receive the group rate, callers must identify themselves as being with the Perspectives in Urologic Oncology group. Reservation requests received after August 5, 2008 may not be guaranteed the group rate. Discounted Airfares Contact conference travel agent, Judi Tarpley with Williamsburg Travel, for assistance with your travel needs. Williamsburg Travel can also accommodate pre- and post-conference extensions. Tel.: +1 (888) or +1 (770) judit@willtrav.com Conference Location and Registration Wyndham Chicago 633 North St. Clair Street Chicago, Illinois Tel.: +1 (312) Fax: +1 (312) The Registration and Information Desk will be staffed: Friday, September 5, :00 am 4:30 pm Saturday, September 6, :30 am 4:00 pm Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/ or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED. In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual s own physician. Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.

6 September 5-6, 2008 Chicago, Illinois Wyndham Chicago 4 EASY ways to register: ONLINE FAX +1 (678) C O N F E R E N C E R E G I S T R AT I O N CALL +1 (678) MAIL Imedex,4325 Alexander Dr. Alpharetta, Georgia , USA A FIRST NAME LAST NAME DEGREE: qmd qphd qpharmd q RN q Other Degree SPECIALTY: q Medical Oncology q Pathology q Radiation Oncology qsurgery q Urology qother ADDRESS TELEPHONE FAX INSTITUTE DEPARTMENT ADDRESS CITY STATE / PROVINCE ZIP / POSTAL CODE COUNTRY q Check if you require special facilities or assistance and attach a note with specific details and requirements. Registration Fees q $245 Discounted If payment received by July 10, 2008 q $345 Regular If payment received by August 28, 2008 q $445 Full/Onsite: To register after August 28, 2008 q $99 nurses, Fellows, Resident *proof of eligibility must accompany registration q -$50 Group discount (physicians only)* *cannot be combined with any other discounts PAYMENT METHOD Credit card transactions will appear under the name Imedex Inc. on your next statement. qamerican Express qdiscover qmastercard qvisa qcheck in the amount of $ Card No. Exp. Date: / Cardholder s Name: Signature: To pre-register, registration and payment must be received no later than August 28, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure that the conference is being held as scheduled and to confirm that the meeting is not full. For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than August 28, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after August 28, Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this conference should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice.

7 Registration Fees Discounted...$245 If payment received by July 10, 2008 Regular...$345 If payment received after August 28, 2008 Full/Onsite...$445 To register after August 28, 2008 Nurses, Fellows, Resident...$99 *proof of eligibility must accompany registration Group discount (physicians only)*...-$50 *cannot be combined with any other discounts To Register You may register online by August 28, 2008 at by calling Imedex at +1 (678) or by returning the registration form in this announcement by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting. To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified Group Discounts Each one of multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Group discounts are not available for nurses, residentsm or students. Payment To pre-register, registration and payment must be received no later than August 28, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card, check, or wire transfer. Checks should be payable to Imedex. Include the full name of the attendee and the name of the conference: Perspectives in Urologic Oncology & A An attendee is not registered until full payment is received. Registration Fee Inclusions Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in this announcement Cancellation For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than August 28, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after August 28, Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice. 3 ways to learn: PRINT materials are produced by Imedex for your reference needs ONLINE products are produced by Imedex in 6 user-friendly formats LIVE meetings are produced by Imedex in 15 countries Visit to learn more

8 4325 Alexander Drive, Alpharetta, Georgia USA September 5-6, 2008 Chicago, Illinois Wyndham Chicago Important Dates Discounted Registration Deadline July 10, 2008 Regular Registration Deadline August 28, 2008 Conference Dates September 5-6, 2008 Comments from past participants Excellent meeting with good applicability to my practice I like the interactive way this conference was set up This was one of the best oncology conferences 2008 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.