DEAR COLLEAGUE, 9 th. September 19-20, 2008 Miami, Florida InterContinental Miami

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2 9 th September 19-20, 2008 Miami, Florida DEAR COLLEAGUE, It is with great pleasure and enthusiasm that we invite you to attend the 9 th Annual Perspectives in Colorectal Cancer. We are certain you will value the unique approach of this meeting in its coverage of a broad range of topics dealing with colorectal cancer. From genetics to the management of advanced disease, from screening to surgery and supportive care, from the optimal use of standard therapies to expert perspectives on emerging agents, the full spectrum of clinical management will be addressed. Our ultimate goal is to provide you with the information needed to optimize care of your colorectal cancer patients and to direct your attention to those trends and evolutions that may affect your practice in the future. Again this year we will be examining and discussing challenging cases submitted by clinical oncology fellows. We received many positive comments last year about the fresh approach and valuable information these presentations provide to attendees. We encourage fellows to submit their cases for consideration by the July 11 th deadline. We are sure you will find this meeting to be informative and enjoyable. We look forward to welcoming you in Miami again this September! Sincerely, Richard M. Goldberg, MD Mace L. Rothenberg, MD

3 9 th September 19-20, 2008 Miami, Florida CONFIRMED FACULTY Timothy J. Akhurst, MD Memorial Sloan-Kettering Cancer Center New York, New York Nancy N. Baxter, MD, PhD, FRCSC University of Toronto St. Michael s Hospital Toronto, Ontario, Canada Francis M. Giardiello, MD Johns Hopkins University Baltimore, Maryland Richard M. Goldberg, MD The University of North Carolina at Chapel Hill Chapel Hill, North Carolina Catherine Handy, PhD, RN, AOCN St. Vincent s Comprehensive Cancer Center New York, New York Mario Lacouture, MD Northwestern University Chicago, Illinois Omaha, Nebraska Timothy Maughan, MD University of Wales Cardiff, United Kingdom Timothy Pawlik, MD, MPH Johns Hopkins University School of Medicine Baltimore, Maryland Karen A. Roesser, RN, MS, AOCN Thomas Johns Cancer Center Richmond, Virginia Mace L. Rothenberg, MD Vanderbilt University Nashville, Tennessee David P. Ryan, MD Harvard Medical School Massachusetts General Hospital Boston, Massachusetts Katherine S. Virgo, PhD Saint Louis University Saint Louis, Missouri Henry T. Lynch, MD Creighton University School of Medicine *Visit regularly to see the most updated faculty list and conference agenda IMPORTANT DATES Discounted Registration Deadline...July 24, 2008 Regular Registration Deadline...September 11, 2008 Presentation Dates...September 19-20, 2008

4 SCIENTIFIC AGENDA FRIDAY, SEPTEMBER 19, :00 am Welcome and introduction Session I: Biology and pathogenesis 8:10 am Cell signaling in colorectal cancer 8:30 am Topic to be determined 8:50 am Genetics of colorectal cancer: Hereditary aspects 9:10 am Panel discussion Session II: Screening and prevention 9:30 am Optimal strategies for surveillance after initial treatment 9:50 am Applying translational research to the clinic: Concepts in colorectal cancer prevention 10:10 am Coffee break 10:30 am Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening? 10:50 am Molecular markers for colorectal cancer screening and validation 11:10 am Panel discussion 11:30 am Fellows clinical case studies and expert discussion: Determining screening recommendations based on family history 12:00 pm Lunch break Session IIIa: Colorectal surgery and staging 1:15 pm PET scan vs. whole-body CT scan in the preoperative staging of colorectal cancer 1:35 pm Advances in colorectal surgery 1:55 pm Staging of rectal cancer: MRI versus ultrasound 2:15 pm Altering outcomes: Interventions for hepatic metastases 2:35 pm Panel discussion 2:55 pm Break Session IIIb: Symptom management and supportive care 1:15 pm Diarrhea: Identifying who s at increased risk and offering the appropriate management 1:35 pm Optimizing the treatment strategies for chemotherapyinduced neurotoxicity 1:55 pm Caring for the patient with advanced colorectal cancer 2:15 pm Mechanisms and management of EGFR inhibitor associated dermatologic toxicities 2:35 pm Panel discussion 2:55 pm Coffee break Session IV: Adjuvant treatment for rectal cancer 3:15 pm Optimizing standards in the surgical management of rectal cancer 3:35 pm Perioperative adjuvant chemotherapy for locally advanced rectal cancer 3:55 pm Adjuvant radiation therapy for rectal cancers: Evidence from randomized trials and applications to practice 4:15 pm Panel discussion 4:35 pm Closing remarks 4:40 pm Adjourn

5 COMMENTS FROM PREVIOUS ATTENDEES: I believe this is one of the best conferences in colorectal cancer! Great review - covered many new points Fellow presentations were excellent SATURDAY SEPTEMBER 20, :00 am Welcome and introduction Session V: Adjuvant treatment for locally advanced colon cancer 8:10 am Currently available adjuvant treatment of stage II/III colon cancer 8:30 am Perspectives on the future of biologics in the adjuvant setting 8:50 am Clinical and molecular features guiding us in adjuvant therapy 9:10 am Panel discussion 9:30 am Fellows clinical case studies and expert discussion: Adjuvant therapy for locally advanced disease 10:00 am Coffee break Session VI: Metastatic colorectal cancer I 10:20 am Frontline chemotherapy erapy for metastatic colorectal cancer: Single agents versus combinations versus sequential therapy European perspective and American perspective 11:00 am Systematic continuum um of care: Second and third-line treatment for metastatic colorectal ct cancer cer 11:25 am Predicting survival in metastatic at colorectal cancer 11:50 am Panel discussion 12:10 pm Lunch break Session VII: Metastatic colorectal cancer II 1:15 pm Antiangiogenic therapy for colorectal cancer 1:40 pm Targeting EGFR: Implications in colorectal cancer management 2:05 pm Innovative and emerging agents for metastatic colorectal cancer 2:30 pm Fellows clinical case studies and expert discussion: Metastatic colorectal cancer 3:00 pm Break 3:20 pm Perspectives on key advances in colorectal cancer: Where we ve been and where we re going 3:45 pm Pharmacoeconomics of colorectal cancer management 4:10 pm Panel discussion 4:25 pm Closing remarks 4:30 pm Adjourn For the latest updates and to register, visit

6 9 th September 19-20, 2008 Miami, Florida CONTINUING MEDICAL EDUCATION Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Imedex, LLC designates this educational activity for a maximum 13.0 of AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. WHO SHOULD ATTEND This educational activity is specifically designed for medical and radiation oncologists, gastroenterologists, colorectal surgeons and other healthcare professionals (gastroenterology and oncology nurses) in active clinical practice who wish to review and update their knowledge and management of colorectal cancer. CORPORATE SUPPORT The following companies have provided unrestricted educational grant in support of this conference: GOLD SILVER EDUCATIONAL OBJECTIVES After successful completion of this continuing medical education activity, participants should be able to: Comment on the latest scientific developments in the understanding of colorectal tumor biology Identify contemporary methods related to screening, surveillance and prevention of colorectal cancer patients Discuss state-of-the-art surgical and staging procedures for colon and rectal cancer Select the most appropriate adjuvant regimens for patients with colon and rectal cancer Describe a systematic continuum of care for patients with advanced disease including selecting the most appropriate first and second line chemotherapy regimens Discuss symptom management and supportive care issues in the management of colorectal cancer patients Identify promising emerging agents in the treatment of colorectal cancer Describe clinical and molecular features that guide physicians during the identification and management of patients with colorectal cancer Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) , or by at cme@imedex.com. CONFERENCE ORGANIZER 4325 Alexander Drive Alpharetta, Georgia , USA Tel.: +1 (770) Fax: +1 (770) meetings@imedex.com WILL THIS CONFERENCE BE OF VALUE TO ME? From last year s evaluations Quality of scientific agenda (on a scale of 1-10) 9.04 Did you increase professional knowledge? 100% yes Will you share this information with colleagues? 100% yes

7 COMMENTS FROM PREVIOUS ATTENDEES: Amazing speakers and relevant experts. A good mix of oncologists, surgeons and gastrointestinal speakers. Case presentation were very good, brings reality to the conference, clinically HOTEL ACCOMMODATIONS 100 Chopin Plaza Miami, Florida Tel.: +1 (305) Fax: +1 (305) The offers richly appointed accommodations and state of the art conference facilities. Discover this enchanting downtown Miami hotel, in a magical setting and enjoy the following: Overlooking Biscayne Bay, in the heart of Miami Minutes from South Beach, the Port of Miami, Coconut Grove, and Coral Gables Only 7.5 miles from Miami International Airport (MIA) Just 25 miles from Fort Lauderdale International Airport (FLL) Modern fitness center Three stylish restaurants and cocktail lounges For the convenience of attendees, a limited number of rooms have been reserved until August 27, 2008 at a discounted rate of $165 single/double occupancy, plus tax, currently at 13%. This rate is not guaranteed outside the conference dates or after August 27, To reserve your room please contact the reservations department at (866) To receive the group rate, callers must identify themselves as being with the 9 th Annual Perspectives in Colorectal Cancer group. Reservation requests received after August 27, 2008 may not be guaranteed the group rate. CONFERENCE LOCATION AND REGISTRATION 100 Chopin Plaza Miami, Florida Tel.: +1 (305) Fax: +1 (305) The Registration and Information Desk will be staffed: Friday, September 19, :00 am 4:00 pm Saturday, September 20, :00 am 4:30 pm DISCOUNTED AIRFARES Contact conference travel agent, Williamsburg Travel, for assistance with your travel needs. Williamsburg Travel can also accommodate preand post-conference extensions. Tel.: +1 (888) or +1 (770) judit@willtrav.com Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/ or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED. In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual s own physician. Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society. Copyright 2008 Imedex, LLC. All rights reserved.

8 9 th September 19-20, 2008 Miami, Florida 4 EASY ways to register: ONLINE... CONFERENCE REGISTRATION FAX US (678) CALL US (678) MAIL US... Imedex 4325 Alexander Dr., Alpharetta, GA , USA A FIRST NAME LAST NAME DEGREE: MD PhD PharmD RN Other Degree \ SPECIALTY: Gastroenterology Medical Oncology Nursing Radiation Oncology Surgery Other ADDRESS TELEPHONE FAX INSTITUTE DEPARTMENT ADDRESS CITY STATE / PROVINCE ZIP / POSTAL CODE COUNTRY Check if you require special facilities or assistance and attach a note with specific details and requirements. REGISTRATION FEES $195 $295 $395 Discounted Physician If payment received by July 24, 2008 Regular Physician If payment received by September 11, 2008 Full/Onsite Physician If payment received after September 11, $50 $75 Group discount (physicians only)* *cannot be combined with any other discounts Nurses/Residents/Students* *proof of eligibility must accompany registration PAYMENT METHOD Credit card transactions will appear under the name Imedex Inc. on your next statement. American Express Discover MasterCard Visa Check in the amount of $ Card No. Exp. Date: / Cardholder s Name: Signature: To pre-register, registration and payment must be received no later than September 11, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure that the program is being held as scheduled and to confirm that the meeting is not full. For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 11, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 11, Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event program content is subject to change without notice.

9 REGISTRATION FEES Discounted Physician $195 If payment received by July 27, 2007 Regular Physician $295 If payment received by August 30, 2007 Group discount (physicians only)* -$50 *cannot be combined with any other discounts Nurses/Residents/Students* $75 *proof of eligibility must accompany registration Full/Onsite Physician $395 If payment received after August 30, 2007 REGISTRATION To Register: You may register online by September 11, 2008 at by calling Imedex at +1 (678) or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting. To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified. Group Discounts: Each one of multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Discounts are not available for Nurses/ Residents/Students rate. Payment: To pre-register, registration and payment must be received no later than September 11, Please register onsite after this date. Contact Imedex at +1 (678) or visit our website at to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Include the full name of the attendee and the name of the conference: A th Annual Perspectives in Colorectal Cancer. An attendee is not registered until full payment is received. Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the agenda. Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 11, The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 11, Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice. TRAVEL/EDUCATION GRANTS Applications are now available for a limited number of travel/education grants for fellows or residents to the 9th Annual Perspectives in Colorectal Cancer. The grant will provide each fellow or resident with complimentary conference registration, up to 2 nights (September 18-19, 2008) single or double occupancy at the Intercontinental Miami and round-trip travel to Miami, Florida (up to $400). Applicants are required to submit at least one clinical case for possible presentation at the meeting in one or more of the following areas: 1) determining screening recommendations based on family history 2) adjuvant therapy for locally advanced colon cancer 3) metastatic colorectal cancer Applications are available online at pdf or may be requested by to meetings@imedex.com. Grant applications must be received at Imedex by July 11, Notification of acceptance will be sent by July 25, WAYS TO LEARN: PRINT materials are produced by Imedex for your reference needs LIVE meetings are produced by Imedex in 15 countries ONLINE products are produced by Imedex in 6 user-friendly formats

10 4325 Alexander Drive Alpharetta, Georgia , USA 9 th September 19-20, 2008 Miami, Florida Comments from Previous Attendees: Excellent Conference - The best I have ever attended on Colo-Rectal Cancer I appreciated the clinical pointers greatly - terrific information, great ideas! I like the short, straight-forward lectures Excellent overall Excellent meeting. I am looking forward for the next one! 2008 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.