2013 Descriptive Vet Path Course. Gross Exam #1 KEY

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1 2013 Descriptive Vet Path Course Gross Exam #1 KEY

2 2013 DESCRIPTIVE VETERINARY PATHOLOGY COURSE GROSS EXAM #1 1. Tissue from a horse. Morphologic Diagnosis: Diffuse macronodular hepatocellular regeneration, fibrosis, and cholestasis Name two possible causes: Aflatoxin, pyrollizzidine alkaloids (or name of any plants that produce them) 2. Tissue from a mouse. Name the condition: Ringtail Cause: Low humidity, high temperature 3. Tissue from a horse. Morphologic Diagnosis: Maxillary squamous cell carcinoma 4. Tissue from a dog. Morphologic Diagnosis: Multifocal atrioventricular valve endocardiosis Name another possible lesion in this animal: Chronic passive hepatic congestion 5. Tissue from a guinea pig. Morphologic Diagnosis: Ossification of the ciliary body 6. Tissue from a dog. Morphologic Diagnosis: Diffuse pancreatic atrophy Name two associated clinicopathologic abnormalities: Decrease serum trypsinlike immunoreactivity, decreased cobalamin, and increased folate. 7. Tissue from a caiman. Morphologic Diagnosis: Fat necrosis of the tail 8. Tissue from a horse. Morphologic Diagnosis: Subuxation of cervical vertebrae with stenosis of the spinal canal and hypertrophy of the ligamentum flavum Name the Condition: Cervical stenotic myelopathy 9. Tissue from an opossum. Etiologic Diagnosis: Lingual besnoitiasis Cause: Besnoitia darlingi 10. Tissue from a pig. Morphologic Diagnosis: Diffuse fibrinonecrotic ileitis Cause: Lawsonia intracellulare

3 11. Tissue from a puppy. Morphologic Diagnosis: Multifocal to coalescing necrohemorrhagic nephritis Name two possible causes: Canine herpesvirus-1, canine adenovirus Tissue from a horse. Morphologic Diagnosis: Pituitary adenoma of the pars intermedia Name an associated clinicopathologic findings: Hyperglycemia, glycosuria, hypercortisolemia, increased ACTH, elevated alpha MSH 13. Tissue from a gibbon. Give two morphologic diagnoses: 1) Multifocal to coalescing necrotizing splenitis, 2) Multifocal to coalescing necrotizing lymphadenitis, 3) Suppurative embolic hepatitis Cause: Yersinia pseudotuberculosis or enterocolitica (Francisella tularensis OK) 14. Tissue from a turkey. Morphologic Diagnosis: Multifocal to coalescing hepatic necrosis Cause: Histomonas meleagridis 15. Tissue from an ox. Name the condition: Hemorrhagic bowel syndrome Cause: Clostridium perfringens type A 16. Tissue from a cat Give two morphologic diagnoses: Diffuse fibrinous peritonitis, diffuse hepatic lipidosis Cause: Mutated feline coronavirus (FIP virus) 17. Tissue from a dog: Morphologic Diagnosis: Urate urolithiasis Name a likely breed: Dalmatian or Bulldog 18. Tissue from a horse. Morphologic Diagnosis: Unilateral suppurative eustachitis (guttural pouch empyema) 19. Tissue from an ox. Morphologic Diagnosis: Diffuse proliferative abomasitis Cause: Ostertagia ostertagi 20. Tissue from an ox Morphologic Diagnosis: Focally extensive fibrinosuppurative valvulitis Name three possible causes: E. coli, Truperella pyogenes, Staphylococcus aureus, Streptococcus bovis, Bartonella bovis

4 21. Tissue from a duck. Morphologic Diagnosis: Multiple intramuscular sarcocysts Cause: Sarcocystis rileyi 22. Tissue from a horse. Pathogenesis: Gram-negative sepsis =>endotoxinemia=>damage to endothelial cells in adrenal cortex => adrenal necrosis and hemorrhage Waterhouse-Freidrichsen-like syndrome 23. Tissue from an ox. Morphologic diagnosis: Focally extensive corneal ulcer Cause: Moraxella bovis 24. Tissue from a foal. Morphologic Diagnosis: Diffuse suppurative embolic nephritis Cause: Actinobacillus equuli 25. Tissue from a dog. Give two morphologic diagnoses: 1) Hepatic lipidosis 2) Hepatic hemangiosarcoma 26. Tissue from a sheep. Morphologic Diagnosis: Focally extensive facial dermatitis with photosensitization Cause: Sporodesmin toxicosis Name the condition: Facial eczema 27. Tissue from a pig. Morphologic diagnosis: Multifocal to coalescing proliferative and eosinophilic dermatitis Name the condition: Porcine juvenile pustular and psoriasiform dermatitis (pityriasis rosea) 28. Tissue from an ox. Morphologic Diagnosis: Diffuse necrohemorrhagic rhomboencephalitis Cause: Listeria monocytogenes 29. Tissue from a dog. Morphologic Diagnosis: Focally extensive granulomatous pneumonia Cause: Blastomyces dermatitis

5 30. Tissue from a rabbit. Name the condition: Shope fibroma Cause: Leporipoxvirus 31. Tissue from a sheep. Morphologic Diagnosis: Focal cerebral cysticercus Cause: Coenurus cerebralis 32. Tissue from a pig. Morphologic Diagnosis: Diffuse lymphocytic interstitial pneumonia Cause: Porcine circovirus-2 or porcine arterivirus 33. Tissue from an ox. Name the condition: Congenital porphyria Cause: Deficiency of uroporphyrinogen-3-cosynthetase Name an associated clinical condition: Hemolytic anemia, photosensitization 34. Tissue from a dog. Name the condition: Color dilution alopecia Give a characteristic histologic abnormality: Follicular dysplasia with abnormal clumping of melanin within follicular epithelium; fragmented anagen hair shafts, melanin-laden perifollicular macrophages 35. Tissue from a pig. Name two possible causes: Porcine parvovirus or porcine circovirus 36. Tissue from a dog. Morphologic Diagnosis: Segmental necrohemorrhagic enteritis Cause: Canine parvovirus Tissue from a cat. Morphologic Diagnosis: Multiple splenic myelolipomas (lymphoma half credit) 38. Tissue from a skunk Morphologic Diagnosis: Diffuse proliferative and hyperkeratotic pododermatitis Cause: Canine morbillivirus 39. Tissue from a dog. Morphologic Diagnosis: Splenic siderotic plaque 40. Tissue from an ox. Morphologic Diagnosis: Diffuse rumenal epithelial necrosis Name a likely sequela: Mycotic infections of forestomachs; hepatic or pulmonary abscessation

6 41. Tissue from a lamb. Morphologic Diagnosis: Multifocal to coalescing hepatic necrosis Cause: Fusobacterium necrophorum 42. Tissue from a snake. Morphologic Diagnosis: Focally extensive proliferative gastritis Cause: Cryptosporidium serpentis 43. Tissue from a cat Pathogenesis: Renal failure=>elevated blood urea nitrogen=>breakdown by urease-secreting bacteria in mouth=>production of ammonia=> lingual ulceration 44. Tissue from a calf. Morphologic Diagnosis: Hydranencephaly Give two possible causes: Bluetongue virus ser 8, Akabane, Cache Valley fever virus (bunyavirus) 45. Tissue from a chicken. Morphologic Diagnosis: Focally extensive granulomatous encephalitis Cause: Aspergillus flavus, Dactylaria gallopavo 46. Tissue from a foal. Name the condition: Osteopetrosis Describe the histologic lesion: Unremodeled primary spongiosa due to the lack of osteoclasts 47. Tissue from a dog Morphologic Diagnosis: Dorsal and ventral disk rupture with spinal cord compression and ventral spondylosis 48. Tissue from a pig. Morphologic Diagnosis: Focally extensive proliferative, hyperkeratotic and eosinophilic dermatitis Name the condition: Dermatosis vegetans Name an affected breed: Landrace 49. Tissue from a chicken Name the condition: Tibial dyschondroplasia Describe the histologic lesion: Retained unremodeled physeal cartilage with elongated hypertrophic zone 50. Tissue from a rat. Morphologic Diagnosis: Zymbal s gland tumor