ADVANCED STAINING PRODUCT CATALOG. In Situ Hybridization Probes Immunohistochemistry Antibodies Detection Systems Ancillary Reagents

Transcription

1 2017 ADVANCED STAINING PRODUCT CATALOG In Situ Hybridization Probes Immunohistochemistry Antibodies Detection Systems Ancillary Reagents

2 A History of Delivering Superior Products Genemed a wholly-owned subsidiary of Sakura Finetek U.S.A., Inc. was founded in 1987 and is located in the center of the South San Francisco Biotechnology community. For over 25 years, Genemed has been providing outstanding contract development and manufacturing services for well-established pharmaceutical and diagnostic companies. At Genemed we incorporate quality from the inside out, from our dedicated employees and efficient operations to our finished products. We are FDA registered and ISO-13485:2003 certified. Every part of our facility, systems, and processes are continuously monitored to ensure that we meet the highest standards of quality and customer satisfaction. Mission Statement Genemed provides cancer and infectious disease advanced staining diagnostic reagents. We create smarter and user-friendly diagnostic tools and solutions by applying our expertise in product design and manufacturing processes. Genemed strives to go above and beyond to meet every customer need with our personalized service. We are passionate at applying innovative technology and breakthrough scientific discoveries to improve product quality and reliability which ensure accurate diagnoses and enhanced patient care. We pride ourselves in conducting business in a fair and ethical manner. Genemed values our employees by promoting a learning environment with professional growth.

3 TABLE OF CONTENTS In Situ Hybridization New Product 2 Probes 3 Detection Kit 7 Ancillary Reagents 7 Immunohistochemistry Primary Antibodies 8 Detection Kits 24 Ancillary Reagents 26 International Distributors Index Product List by Name 28 Ordering Information

4 ISH - New Product HER2 Chromogenic In Situ Hybridization (CISH) Kit Genemed HER2 CISH Kit is intended to detect HER2 gene amplification in formalin-fixed, paraffin-embedded (FFPE) tissue sections using Chromogenic In Situ Hybridization. The human gene HER2, or c-erbb-2, and the rat equivalent gene, neu, have been identified as proto-oncogenes sharing homology with the closely related v-erbb oncogene. The HER2 gene is located on chromosome 17 (17q12-21) and encodes a 185 kda membrane receptor-like protein. HER2 has tyrosine kinase activity and shares homology with, but is distinct from, the epidermal growth factor receptor (known as EGFr, HER1, or c-erbb-1). Genemed HER2 Probe (Reagent C) is a double-stranded DNA probe that has been labeled with digoxigenin. It is supplied in a liquid format in hybridization buffer. It has been demonstrated to contain the HER2 gene by PCR, and to bind specifically to the HER2 gene locus on chromosome 17q12-21 by metaphase FISH in normal lymphocytes. No. of Tests: 20 (20 µl probe per test) : Intended Use: USA RUO, CE IVD CISH Advantages: a. Bright-field microscopy b. Morphology observable c. Quantitative interpretation d. Archivable results 2 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

5 ISH - Probes In Situ Hybridization Probes Genemed CISH and FISH probes provide a practical method to detect gene aberration, including gene amplification, deletion, chromosome/gene copy number change, chromosome translocation, gene expression at RNA level, and viral/bacterial detection. With CISH, tissue and cell morphology can be evaluated simultaneously with the gene status by using bright-field microscopy and standard immunohistochemistry techniques (conventional peroxidase or alkaline phosphatase reactions). Genemed multiplex FISH allows for simultaneous detection of multiple targets using dual-colored probes. Chromosome 3 Centromere Digoxigenin Labeled CISH Probe CISH µl Chromosome 7 Centromere Digoxigenin Labeled CISH Probe CISH µl Chromosome 17 Centromere Digoxigenin Labeled CISH Probe CISH µl Chromosome X Centromere CISH Probe CISH µl Chromosome Y Region Yq12 CISH Probe CISH µl 3

6 ISH - Probes EBER Digoxigenin Labeled CISH Probe CISH µl HER2 Digoxigenin Labeled CISH Probe CISH µl ABL Break Apart FISH Probe FISH µl Chromosome 3 Centromere Green FISH Probe FISH µl Chromosome 7 Centromere Green FISH Probe FISH µl Chromosome 17 Centromere Green FISH Probe FISH µl 4 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

7 ISH - Probes Chromosome X Centromere Green FISH Probe FISH µl Chromosome Y Region Yq12 Red FISH Probe FISH µl Chromosome Y Region Yq12 Red and Chromosome X Centromere Green FISH Probe Cocktail FISH µl EGFR Green and Chromosome 7 Centromere Red FISH Probe Cocktail FISH µl HER2 Green and Chromosome 17 Centromere Red FISH Probe Cocktail FISH µl HER2 Red and Chromosome 17 Centromere Green FISH Probe Cocktail FISH µl 5

8 ISH - Probes MALT Break Apart Fish Probe FISH µl TERC Red FISH Probe FISH µl TERC Red and Chromosome 3 Centromere Green Probe FISH Cocktail FISH µl TOPOIIa Green and Chromosome 7 Red Fish Probe Cocktail FISH µl 6 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

9 ISH - Detection Kits & Ancillary Reagents In Situ Hybridization Detection Kit Genemed offers highly-sensitive polymer HRP detection systems for CISH applications. Genemed s sensitive and easy-to-use detection systems enable strong staining signals with lowest possible background. CISH HRP Detection Kit for DIG Labeled Probes Kit Includes HRP Conjugate for + AP for Intended Use tests (200µL per test) RUO Description This kit is a non-biotin system and utilizes a HRP (horseradish peroxidase) and AP (alkaline phoshatase) conjugates to locate where the mouse or rabbit primary antibody is bound to the target antigens. The complexes formed between HRP conjugate with mouse primary antibody and AP conjugate with rabbit primary antibody are observed through the use of two substrate-chromogen solutions, which when added sequentially, result in two colored precipitates at the antigen locations. The staining location and pattern is easily observable by light microscopy. In Situ Hybridization Ancillary Reagents Description Intended Use SSC Buffer (20X) ml RUO CISH Tissue Pretreatment Kit mL/1000mL RUO 7

10 Immunohistochemistry Primary Antibodies Genemed offers primary antibodies with high affinity and specificity for in vitro diagnostic and research use. Our primary antibodies are optimized and titrated for immunohistochemistry (IHC) testing using human formalin-fixed, paraffin-embedded (FFPE) tissue sections along with Genemed IHC Detection Systems and Ancillary reagents. Actin (Muscle) HHF , , / Cytoplasm Positive Control Tissue Gastric Intestinal Tract Actin (Smooth Muscle) 1A , , / IgG2a Cytoplasm Positive Control Tissue Gastrointestinal Tract AFP / Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Hepatocellular Carcinoma AMACR 13H , , / Cytoplasm Positive Control Tissue Prostate Cancer Bcl-2 Bcl , , / Cytoplasm 8 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

11 CA19-9 (Sialyl Lewis) SPan-1 IgM , , / Positive Control Tissue Membrane and Cytoplasm Pancreas Calponin CALP / Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Appendix, breast, leiomyoma, uterus Calretinin , , / Cytoplasm and Nucleus Positive Control Tissue Mesothelioma CD , , / Membrane and Cytoplasm CD5 GR , , / Membrane and Cytoplasm CD8 C8/144B / Concentrate 0.2 ml / RTU 7 ml Membrane, Spleen, Thymus 9

12 CD10 GM , , / IgG2b Membrane Positive Control Tissue Follicular lymphoma, diffuse large B-cell lymphoma CD19 GR014 Rabbi , , / Membrane CD20 B Cell L , , / IgG2a Membrane CD23 GR , , / Positive Control Tissue Membrane Tonsil CD30 Ber-H , , / Membrane and Cytoplasm Positive Control Tissue Hodgkin Disease CD , , / Membrane and Cytoplasm Positive Control Tissue ALCL or Hodgkin s Lymphoma 10 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

13 CD31 (PECAM-1) GM , , / Membrane CD34 QBend , , / Membrane Positive Control Tissue GIST CD45 (LCA) GR , , / Membrane Positive Control Tissue Tonsil CD45RO UCHL-1 IgG2a , , / Membrane CD56 (SCLC) 123C , , / Cytoplasm and Membrane Positive Control Tissue Small cell lung carcinoma CD68 GR , , / Cytoplasm 11

14 CD79a GR , , / Membrane and Cytoplasm CDX2 GR , , / Nucleus Positive Control Tissue Colon Cancer CEA COL , , / IgG2a Cytoplasm and Membrane Positive Control Tissue Colon Cancer Chromogranin A , , / Cytoplasm granular Positive Control Tissue Neuroendocrine Tumor c-kit (CD117) , , / Membrane and Cytoplasm Positive Control Tissue Gastrointestinal Stromal Tumor Cyclin D1 AM29 IgG2a , , / Nucleus Positive Control Tissue Mantle Cell Lymphoma or Breast Cancer 12 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

15 Cyclin D1 GR , , / Nucleus Positive Control Tissue Mantle Cell Lymphoma or Breast Cancer Cytokeratin AE1/AE , , / Cytoplasm Positive Control Tissue Tissue with epithelial cells Cytokeratin AE , , / Cytoplasm Positive Control Tissue Tissue with epithelial cells Cytokeratin C , , / Positive Control Tissue Cytokeratin 5 GM , , / Cytoplasm Positive Control Tissue Mesothelioma, prostate Cytokeratin 5/6 D5/16B / Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Mesothelioma, prostate 13

16 Cytokeratin 7 OV-TL 12/ , , / Positive Control Tissue Cytoplasm Lung Adenocarcinoma Cytokeratin 18 DC , , / Cytoplasm Positive Control Tissue Gastric intestinal tract Cytokeratin 19 A53-B/A / IgG2a Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Tonsil, Salivary Gland, and GI Tract Cytokeratin 20 Ks , , / IgG2a Cytoplasm Positive Control Tissue Colon Cancer Cytokeratin HMW 34bE , , / Cytoplasm and Membrane Positive Control Tissue Prostate D2-40 D / Concentrate 0.2 ml / RTU 7 ml Cytoplasm and some membrane Positive Control Tissue Lymph Node 14 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

17 Desmin GM , , / Positive Control Tissue Cytoplasm Uterus E-Cadherin GM , , / Membrane and some cytoplasm Positive Control Tissue Esophagus, Endometrium EGFR GR , , / Positive Control Tissue EMA GM / IgG2a Concentrate 0.2 ml / RTU 7 ml Cytoplasm and Membrane Positive Control Tissue Breast Carcinoma Ep-Cam VU-1D , , / Membrane and Cytoplasm Positive Control Tissue Colon, Thyroid ER 1D , , / Intended Use USA ASR, CE IVD Positive Control Tissue 15

18 ER GR , , / Positive Control Tissue ER EP , , / Positive Control Tissue ER GM , , / Nucleus Positive Control Tissue Breast Carcinoma Galectin-3 9C4 IgG2aMo et hitatem licimoditi doluptam enis ut / Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Papillary or Follicular Carcinoma of Thyroid GFAP , , / Cytoplasm Positive Control Tissue Astrocytomas HER2 GR , , / Breast Cancer Intended Use USA ASR, CE IVD Positive Control Tissue 16 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

19 Human Chorionic Gonadotropin (hcg) , , / Positive Control Tissue Cytoplasm and Membrane Tonsil Human Kappa Light Chain HP , , / Cytoplasm and Membrane Human Kappa Light Chain , , / Cytoplasm and Membrane Human Lambda Light Chain HP , , / IgG2a Cytoplasm and Membrane Human Lambda Light Chain , , / Cytoplasm and Membrane Insulin 2D11-H , , / Cytoplasm Positive Control Tissue Pancreas 17

20 Ki-67 GM010 IgG2b , , / Nucleus Positive Control Tissue Tonsil Laminin RTU 7 ml USA IVD, CE IVDEctatum Lysozyme (Muramidase) , , / Cytoplasm or Lymph Node Melan-A A / Concentrate 0.2 ml / RTU 7 ml Cytoplasm Positive Control Tissue Melanoma Melanosome HMB , , / Cytoplasm Positive Control Tissue Melanoma Mesothelial Cell HBME / IgM Concentrate 0.2 ml / RTU 7 ml Membrane and cytoplasm Positive Control Tissue Mesothelioma or Salivary Gland or Spleen 18 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

21 MLH1 GM , , / Nucleus Positive Control Tissue Colon MSH6 GM , , / IgG2a Nucleus Positive Control Tissue Colon Cancer MUC5AC Nd , , / Cytoplasm and Perinuclear Positive Control Tissue Stomach MyoD1 5.8A / Concentrate 0.2 ml / RTU 7 ml Nucleus Positive Control Tissue Rhabdomyosarcoma Myogenin F5D / Concentrate 0.2 ml / RTU 7 ml Nucleus Positive Control Tissue Rhabdomyosarcoma N-Cadherin GM , , / Membrane and Cytoplasm Positive Control Tissue Gastrointestinal Tract 19

22 Neurofilaments (Pan) 2F , , / Concentrate (1:60) 1 ml, 0.5 ml, 0.2 ml / RTU 7 ml Positive Control Tissue Cytoplasm Paraganglioma Non-Immune Immunoglobulin RTU 7 ml No staining Positive Control Tissue Non-Immune Immunoglobulin RTU 7 ml No staining Positive Control Tissue p53 BP , , / IgG2a Concentrate 1 ml, 0.5 ml, 0.2 ml / RTU 7 ml Positive Control Tissue Nucleus Selective Squamous Cell Carcinoma p63 4B1E12 IgG2b RTU 7 ml Nucleus Positive Control Tissue Prostate For outside USA only PAX5 (B Cell Specific Activation Protein) GR , , / Nucleus 20 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

23 PCNA PC10 IgG2a , , / Nucleus Positive Control Tissue Tonsil PLAP GM , , / IgG2b Cytoplasm and membrane Positive Control Tissue Placenta, Seminoma PR Y , , / Intended Use USA ASR, CE IVD Positive Control Tissue PSA , , / Intended Use USA IVD, EU RUO Cytoplasm Positive Control Tissue Prostate PsAP PASE/4LJ , , / Cytoplasm Positive Control Tissue Prostate S , , / Cytoplasm Positive Control Tissue Melanoma 21

24 Synaptophysin GR , , / Positive Control Tissue Cytoplasm Neuroendocrine Tumor TdT / Concentrate 0.2 ml / RTU 7 ml IgG2aMo et hitatem licimoditi doluptam enis ut Nucleus Positive Control Tissue Thymus Thyroglobulin 2H11/6E , , / Cytoplasm and extracellular Positive Control Tissue Thyroid TTF-1 8G7G3/ , , / Nucleus Positive Control Tissue Thyroid Villin GR / Concentrate 0.2 ml / RTU 7 ml Membrane and/or Cytoplasm Positive Control Tissue Small Intestine or Colonic Mucosa Vimentin V , , / Cytoplasm Positive Control Tissue Any Tissue 22 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

25 Von Willebrand Factor (Factor VIII RA) , , / Cytoplasm WT1 6F-H / Concentrate 0.2 ml / RTU 7 ml Nucleus and cytoplasm Positive Control Tissue Wilms Tumor 23

26 IHC - Detection Kit Immunohistochemistry Detection Kits Genemed offers highly-sensitive polymer detection systems for immunohistochemistry applications. Genemed s sensitive and easy-touse detection systems enable strong staining signals with lowest possible background. We provide ready-to-use IHC detection reagents to meet variable needs, e.g. for mouse, or/and rabbit primary antibody; peroxidase (HRP) or alkaline phosphatase (AP) enzymes. Power-Stain 1.0 Kit HRP DAB for + Kit Includes HRP Conjugate for +, DAB Chromogen and Buffer Solutions , ml, 100 ml No. of Tests 150/1000 Description This kit is a non-biotin system and utilizes a HRP (horseradish peroxidase) conjugate to locate where the mouse or rabbit primary antibody is bound to the target antigen. The complex formed between HRP conjugate and the mouse or rabbit primary antibody is observed through the use of a substrate-chromogen solution, which when added, results in a colored precipitate at the antigen location. The staining location and pattern is easily observable by light microscopy. Power-Stain 1.0 Kit HRP AEC for + Kit Includes HRP Conjugate for +, AEC Substrate (Single Solution) , Description This kit is a non-biotin system and utilizes a HRP (horseradish peroxidase) conjugate to locate where the mouse or rabbit primary antibody is bound to the target antigen. The complex formed between HRP conjugate and the mouse or rabbit primary antibody is observed through the use of a substrate-chromogen solution, which when added, results in a colored precipitate at the antigen location. The staining location and pattern is easily observable by light microscopy. Power-Stain 2.0 HRP Kit for + Kit Includes HRP Conjugate for +, Linker for + Antibody Intended Use , ml, 100 ml USA IVD, CE IVD No. of Tests 150/1000 Description This kit is a non-biotin system and utilizes linker to locate where the mouse and/or rabbit primary antibody is bound to the target antigen. HRP (horseradish peroxidase) conjugate is then applied and binds to the linker. This complex is observed through the use of a substrate-chromogen solution, which when added, results in a colored precipitate at the antigen location. The staining location and pattern is easily observable by light microscopy. 24 IVD: In Vitro Diagnostic RUO: Research Use Only RTU: Ready-To-Use Concentrate Dilution: 1:100 unless indicated Application: Formalin-Fixed, Paraffin-Embedded

27 IHC - Detection Kit Acu-Stain HRP Kit + Kit Includes Blocking Solution, Biotinylated Goat anti- + Secondary Antibody, Streptavidin-Peroxidase (HRP) , ml, 100 ml No. of Tests 150/1000 Description This kit utilizes a biotinlyated secondary antibody to locate where the mouse and/or rabbit primary antibody is bound to the target antigen. Streptavidin-HRP (horseradish peroxidase) is then applied and binds to the secondary antibody. This complex is observed through the use of a substratechromogen solution, which when added, results in a colored precipitate at the antigen location. The staining location and pattern is easily observable by light microscopy. Power-Stain 1.0 Double Stain Kit I ( HRP for + AP for ) Kit Includes HRP Conjugate for + AP for Intended Use ml USA IVD, CE IVD No. of Tests 150 Description This kit is a non-biotin system and utilizes a HRP (horseradish peroxidase) and AP (alkaline phosphatase) conjugates to locate where the mouse or rabbit primary antibody is bound to the target antigens. The complexes formed between HRP conjugate with mouse primary antibody and AP conjugate with rabbit primary antibody are observed through the use of two substrate-chromogen solutions, which when added sequentially, result in two colored precipitates at the antigen locations. The staining location and pattern is easily observable by light microscopy. Power-Stain 1.0 Kit AP for + Kit Includes AP Conjugate for +, AP Substrate-Chromogen Solution ml No. of Tests 150/1000 Description This kit is a non-biotin system and utilizes a AP (alkaline phosphatase) conjugate to locate where the mouse or rabbit primary antibody is bound to the target antigen. The complex formed between AP conjugate and the mouse or rabbit primary antibody is observed through the use of a substrate-chromogen solution, which when added, results in a colored precipitate at the antigen location. The staining location and pattern is easily observable by light microscopy. 25

28 IHC - Ancillary Reagents Immunohistochemistry Ancillary Reagents Description Intended Use Buffer PBS Powder (1L of 10X per pouch) Pouches USA IVD, CE IVD TBST (Tris Buffered Saline and 0.05% Tween 20), ph 7.4 (20X) ml USA IVD, CE IVD Chromogen AEC Substrate (Single Solution) , ml, 100 ml USA IVD, CE IVD BCIP/NBT Substrate Kit ml RUO Sensitive DAB Substrate Kit ml USA IVD, CE IVD Conjugate AP Streptavidin Conjugate ml RUO Biotin Goat anti- IgG+ IgM (H+L) ml RUO Biotin Goat anti- IgG (H+L) ml RUO HRP Streptavidin Conjugate ml RUO Diluent Antibody Diluent for Automated Stainers ml USA IVD, CE IVD Primary Antibody Diluent ml USA IVD, CE IVD Counterstain & Mounting CleanMount Aqueous Mounting Solution ml USA IVD, CE IVD GVA Aqueous Mounting Solution ml USA IVD, CE IVD Mayer's Hematoxylin ml USA IVD, CE IVD Mini PAP Pen Ea USA IVD, CE IVD Super PAP Pen Ea USA IVD, CE IVD Prestaining A/B Block (Avidin/Biotin Blocking Solution) ml USA IVD, CE IVD C-Block (Casein Blocking Solution) ml USA IVD, CE IVD Blocking Solution ml USA IVD, CE IVD Pretreatment Citrate Buffer, ph 6 (1X) ml USA IVD, CE IVD Citrate Buffer, ph 6 (20X) ml USA IVD, CE IVD Peroxidase Blocking Solution ml USA IVD, CE IVD Proteinase K ml USA IVD, CE IVD Tris EDTA Buffer, ph 9 (1X) ml USA IVD, CE IVD Tris EDTA Buffer, ph 9 (20X) ml USA IVD, CE IVD 26

29 Index Product List by Name A/B Block (Avidin/Biotin Blocking Solution) 26 ABL Break Apart Fish Probe 4 Actin (Muscle) 8 Actin (Smooth Muscle) 8 Acu-Stain HRP + AEC Substrate (Single Solution) AFP 8 AMACR 8 Antibody Diluent for Automated Stainers 26 AP Streptavidin Conjugate 26 BCIP/NBT Substrate Kit 26 Bcl-2 8 Biotin Goat anti- IgG+M (H+L) Biotin Goat anti- IgG (H+L) Blocking Solution (Nonimmune) C-Block (Casein Blocking Solution) CA19-9 (Sialyl Lewis) 9 Calponin 9 Calretinin 9 CD3 9 CD5 9 CD8 9 CD10 10 CD19 10 CD20 B Cell 10 CD23 10 CD30 10 CD31 (PECAM-1) 11 CD34 11 CD45 (LCA) 11 CD45RO 11 CD56 (SCLC) 11 CD68 11 CD79α 12 CDX2 12 Chromosome 7 Centromere Digoxigenin Labeled CISH Probe Chromosome 7 Centromere Green FISH Probe Chromosome 17 Centromere Digoxigenin Labeled CISH Probe Chromosome 17 Centromere Green FISH Probe Chromosome X Centromere CISH Probe Chromosome X Centromere Green FISH Probe Chromosome Y Region Yq12 CISH Probe Chromosome Y Region Yq12 Red FISH Probe Chromosome Y Yq12 Red & Chromosome X Centromere Green FISH Probe Cocktail CISH HRP Detection Kit for DIG Labeled Probes Citrate Buffer ph 6 (1X) 26 Citrate Buffer ph 6 (20X) 26 c-kit (CD117) 12 CleanMount Aqueous Mounting Solution Cyclin D1 12 Cyclin D1 13 Cytokeratin 13 Cytokeratin 5 13 Cytokeratin 5/6 13 Cytokeratin 7 14 Cytokeratin Cytokeratin Cytokeratin Cytokeratin HMW 14 D Desmin 15 E-cadherin 15 EBER Digoxigenin Labeled CISH Probe EGFR 15 EGFR Green and Chromosome 7 Centromere Red FISH Probe Cocktail 4 5 Galectin-3 16 GFAP 16 GVA Aqueos Mounting Solution 26 HER2 16 HER2 CISH Kit 2 HER2 Digoxigenin Labeled CISH Probe HER2 Green and Chromosome 17 Centromere Red FISH Probe Cocktail HER2 Red and Chromosome 17 Centromere Green FISH Probe Cocktail HRP Streptavidin Conjugate 26 Human Chorionic Gonadotropin (hcg) Human Kappa Light Chain 17 Human Lambda Light Chain 17 Insulin 17 ISH Tissue Pretreatment Kit 7 Ki Laminin 18 Lysozyme (Muramidase) 18 MALT Break Apart FISH Probe Mayer's Hematoxylin 26 Melan-A 18 Melanosome 18 Mesothelial Cell 18 Mini PAP Pen 26 MLH1 19 MSH6 19 MUC5AC 19 MyoD1 19 Myogenin 19 N-Cadherin 19 Neurofilaments (Pan) 20 Non-Immune Immunoglobulin Non-Immune Immunoglobulin p53 20 Peroxidase Blocking Solution 26 PLAP 21 Power-Stain 1.0 Double Stain Kit I ( HRP for + AP for ) Power-Stain 1.0 Kit AP for + Power-Stain 1.0 Kit HRP AEC for + Power-Stain 1.0 Kit HRP DAB for + Power-Stain 2.0 Kit HRP for PR 21 Primary Antibody Diluent 26 Proteinase K 26 PSA 21 PsAP 21 S Sensitive DAB Substrate Kit 26 SSC Buffer (20X) 7 Super PAP Pen 26 Synaptophysin 22 TBST (Tris Buffered Saline and 0.05% Tween 20), ph 7.4 (20X) 26 TdT 22 TERC Red FISH Probe 6 TERC Red and Chromosome 3 Centromere Green Probe FISH Cocktail Thyroglobulin 22 TOPOIIa Green and Chromosome 7 Red Fish Probe Tris EDTA Buffer ph 9 (1X) 26 Tris EDTA Buffer ph 9 (20X) 26 TTF1 22 Villin 22 Vimentin 22 Von Willebrand Factor (Factor VIII RA) WT1 23 CEA 12 EMA 15 p63 20 Chromogranin A 12 Chromosome 3 Centromere Digoxigenin Labeled CISH Probe Chromosome 3 Centromere Green FISH Probe 3 4 Ep-Cam 15 ER 15 ER 16 ER 16 ER 16 PAX5 (B cell Specific Activation Protein) 20 PBS Powder (10X) 26 PCNA 21 28

30 A wholly-owned subsidiary of Sakura Finetek U.S.A., Inc Genemed All Rights Reserved Deksan Laboratuar Sistemleri Ltd Sti Altaycesme Mahallesi, Cam Sokak no: 16/ Istanbul Turkey Tel: PN31371 Rev.03