Brazil Emmett T. Cunningham, Jr., M.D., Ph.D., M.P.H. United States Christine Curcio, M.D. United States Amani Fawzi, M.D. Japan Michael Larsen, M.D.

Transcription

1 COURSE DIRECTORS K. Bailey Freund, M.D. David Sarraf, M.D. CO-DIRECTORS SriniVas Sadda, M.D. Richard F. Spaide, M.D. Lawrence A. Yannuzzi, M.D. FACULTY Anita Agarwal, M.D. Francesco Bandello, M.D. Italy Gaetano R. Barile, M.D. Alexander J. Brucker, M.D. Joseph Carroll, Ph.D. Antonio Ciardella, M.D. Italy Rogerio A. Costa, M.D., Ph.D. Brazil Emmett T. Cunningham, Jr., M.D., Ph.D., M.P.H. Christine Curcio, M.D. Jay Duker, M.D. Justis P. Ehlers, M.D. Michael Engelbert, M.D., Ph.D. Amani Fawzi, M.D. Jasmine Francis, M.D. K. Bailey Freund, M.D. James G. Fujimoto, Ph.D. Alain Gaudric, M.D. France Tomohira Iida, M.D., Ph.D. Japan Lee Jampol, M.D. Szilard Kiss, M.D. Hideki Koizumi, M.D., Ph.D. Japan Michael Larsen, M.D. Denmark Brandon J. Lujan, M.D. H. Richard McDonald, M.D. Edoardo Midena, M.D., Ph.D., FARVO, FEBO Italy William Mieler, M.D. Kyoko Ohno-Matsui, M.D. Japan Jose Pulido, M.D. Giuseppe Querques, M.D., Ph.D. France Richard Rosen, M.D. Philip Rosenfeld, M.D., Ph.D. SriniVas Sadda, M.D. David Sarraf, M.D. Ursula Schmidt-Erfurth, M.D. Austria Carol Shields, M.D. Jerry Shields, M.D. Lawrence J. Singerman, M.D. Jason S. Slakter, M.D. R. Theodore Smith, M.D., Ph.D. Richard F. Spaide, M.D. Giovanni Staurenghi, M.D. Italy Stephen Tsang, M.D., Ph.D. Lawrence A. Yannuzzi, M.D. CLINICAL CONTENT REVIEWERS Kavita V. Bhavsar, M.D. David Sarraf, M.D.

2 Saturday June 21, :00 7:30 REGISTRATION AND CONTINENTAL BREAKFAST 7:30 7:40 INTRODUCTION K. Bailey Freund,M.D. OCT TECHNOLOGY MODERATOR: David Sarraf, M.D. 7:40 7:50 Ultrahigh speed OCT for structural and functional imaging James G. Fujimoto, Ph.D. 7:52 8:02 OCT Innovations for vitreous evaluation: Enhanced Vitreal Imaging (EVI) Jay Duker, M.D. 8:04 8:14 SS-OCT and EDI-OCT imaging in macular diseases Tomohira Iida, M.D., Ph.D. ADVANCED IMAGING SYSTEMS MODERATOR: Gaetano R. Barile, M.D. 8:16 8:26 Clinical feasibility and utility of ultra widefield ICG angiography Szilard Kiss, M.D. 8:28 8:38 Macular capillary pattern and flow imaged by a motion contrast camera (Retinal Function Imager) Michael Larsen, M.D. 8:40 8:50 Hyperspectral retinal imaging R. Theodore Smith, M.D. 8:52 9:02 Adaptive Optics Scanning Laser Ophthalmoscope Fluorescein Angiography and Motion Contrast Imaging of the Retinal Circulation Richard Rosen, M.D. ANATOMY MODERATOR: Alexander J. Brucker, M.D. 9:04 9:14 Directional OCT intensity modeling of outer photoreceptor bands overlying retinal pathology Brandon J. Lujan, M.D. 9:16 9:26 Sub-cellular sources of OCT reflectivity: pathology & experimental studies Christine Curcio, M.D.

3 9:28 9:38 Outer Retinal Tubulation in Age-related Macular Degeneration: SD OCT Correlates with Histology K. Bailey Freund, M.D. 9:40 9:50 Interpretation of adaptive optics images of the photoreceptor mosaic Joseph Carroll, Ph.D. 9:52 10:02 Ischemia of the superficial and deep capillary plexi as identified by SD OCT David Sarraf, M.D. 10:04 10:34 BREAK (Refreshments) SURGERY MODERATOR: Richard F. Spaide, M.D. 10:34 10:44 Swept-Source OCT imaging of the vitreous Michael Engelbert, M.D. Ph.D. 10:46 10:56 Clinical applications of intraoperative OCT and perioperative OCT: New insights and approaches Justis P. Ehlers, M.D. 10:58 11:08 Long term effects of ILM peeling on RNFL thickness change Antonio Ciardella, M.D. TUMORS MODERATOR: Jerry Shields, M.D. 11:10 11:20 A few new observations in imaging ocular tumors Jose Pulido, M.D. 11:22 11:32 OCT EDI of the choroid post radioactive plaque therapy for choroidal melanoma William Mieler, M.D. 11:34 11:44 Autofluorescence of intraocular tumors: tips that can shed light on the diagnosis Carol Shields, M.D. 11:46 11:56 Swept Source OCT Findings in Choroidal Nevi, Suspicious Melanocytic Lesions and Small Melanomas Jasmine Francis, M.D

4 RETINAL DYSTROPHIES MODERATOR: Stephen Tsang, M.D., Ph.D. 11:58 12:08 Imaging Macular Dystrophies (Pattern, North Carolina, Fundus flavimaculatus, MIDD, etc) Anita Agarwal, M.D. 12:10 12:20 Contribution of Fundus Autofluorescence to the Clinical Characterization of Stargardt Disease Francesco Bandello, M.D. 12:22 12:32 Next generation imaging in retinal dystrophies Stephen Tsang, M.D., Ph.D. 12:32 1:32 LUNCH DIABETES MODERATOR: Lawrence J. Singerman, M.D. 1:32 1:42 In Vivo Imaging Biomarkers of Glial Activation in Human Diabetes Edoardo Midena, M.D., Ph.D., FARVO, FEBO 1:44 1:54 New Algorithmic Approach to Grading Diabetic Retinopathy in Clinical Trials Jason S. Slakter, M.D. MASQUERADE & WHITE DOT SYNDROMES MODERATOR: Lawrence A. Yannuzzi, M.D. 1:56 2:06 Imaging intraocular and uveal lymphoma (Summary of findings and approach to diagnosis) Emmett T. Cunningham, Jr., M.D., Ph.D., M.P.H. 2:08 2:18 Multimodal imaging I: MEWDS and the related white dot syndromes Lawrence Yannuzzi, M.D. 2:20 2:30 Multimodal imaging II: Multifocal choroiditis/punctate inner choroidopathy Lee Jampol, M.D. 2:32 2:42 Diagnostic OCT Signs H. Richard McDonald, M.D.

5 MYOPIA MODERATOR: Kyoko Ohno-Matsui, M.D. 2:44 2:54 Proposal for new classification of posterior staphyloma by using a combination of Optos and 3D MRI Kyoko Ohno-Matsui, M.D. 2:56 3:06 New data on the morphology of dome shaped macula Alain Gaudric, M.D. 3:08 3:38 BREAK (Refreshments) NON-NEOVASCULAR AMD MODERATOR: Philip Rosenfeld, M.D., Ph.D. 3:38 3:48 Drusen to atrophy: What have we learned from OCT SriniVas Sadda, M.D. 3:50 4:00 En Face OCT imaging of Dry AMD Philip Rosenfeld, M.D. 4:02 4:12 Outer Retinal Atrophy: Imaging, Histology, and Clinical Significance in AMD Richard F. Spaide, M.D. 4:14 4:24 Multimodal imaging of regressing drusen Giuseppe Querques, M.D., Ph.D. NEOVASCULAR AMD MODERATOR: SriniVas Sadda M.D. 4:26 4:36 Multimodal images of choroidal neovascularization Giovanni Staurenghi, M.D. 4:38 4:48 Choroidal low-flow lesions: A distinct subtype of choroidal neovascularization? Rogerio A. Costa, M.D. 4:50 5:00 Function morphology correlation in neovascular AMD Ursula Schmidt-Erfurth, M.D. 5:02 5:12 Polypoidal choroidal vasculopathy New observations and therapeutic implications Hideki Koizumi, M.D. 5:12 MEETING ADJOURNMENT

6 Statement of Need: The last several years have seen rapid advances in the field of retinal imaging. We have witnessed widespread adoption of fundus autofluorescence and spectral domain OCT and, soon, swept source OCT devices as well. Additionally, adaptive optics is becoming a more common way to image the retinal microstructure. Several new ultra-widefield imaging systems are scheduled to be released in the upcoming year. Additional new technology such as hyperspectral imaging and tools to noninvasively evaluate the retinal microvasculature are soon to follow. It is critical that retinal specialists remain up-to-date on these emerging technologies in order to provide the best care for their patients. As these new devices are technically complex, and the subtleties of interpretation of the acquired images is challenging, it is important to have instructional courses such as the IRIS II meeting available to the clinicians who will be using this complex technology. Program Objectives: North Shore-LIJ Health System CME activities are intended to improve patient care, safety, and outcomes. Objective 1: Summarize new innovations of Optical Coherence Tomography (OCT) including swept source OCT so course participant may enhance skill in management of retinal /choroidal disorders such as choroidal tumors. Objective 2: Discuss the benefits of wide field angiography such as wide field indocyanine and fluorescein angiography which may improve course participant s understanding and management of various retinal/choroidal diseases such as central serous retinopathy and retinal vascular diseases. Objective 3: Summarize new advancements of OCT that allow a better understanding of retinal anatomy and structure and morphology which may improve insight and understanding of course participant of the various macular diseases such as age related macular degeneration and ischemic disorders of the retina and may also improve therapies. Objective 4: Discuss a multimodal imaging approach to the management of various retinal diseases such as neovascular age related macular degeneration which may improve treatment outcomes and decrease blindness.

7 Target Audience: Ophthalmologists: with an interest in the management of vitreous, retina and macular disease. CME Accreditation: North Shore-LIJ Health System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. Credit Designation: North Shore-LIJ Health System designates this live activity for a maximum of 7.5 AMA PRA Category 1 credits TM. Physicians should claim credit commensurate only to the extent of their participation in the activity. Verification Of Attendance: Will be provided to all professionals attending the conference. Faculty Disclosure Policy: North Shore-LIJ Health System adheres to the ACCME s New Standards for Commercial Support. Individuals in a position to control the content of a CME activity, including faculty, planners and managers are required to disclose all financial relationships with commercial interests. All identified potential conflicts of interest are thoroughly vetted by North Shore-LIJ for fair balance and scientific objectivity and to ensure appropriateness of patient care recommendations. Location: The Lighthouse Guild International 111 East 59th Street New York, N.Y (800) LightHouse.org

8 Americans with Disabilities Act: This conference is in compliance with provisions of the Americans with Disabilities Act (ADA) and is accessible for individuals with special needs. If you would like to attend this conference and require any special needs or accommodations, please contact Evaluation: Evaluation for this activity will be conducted through Survey Monkey. Please look for the that will have the link to the survey that will be sent to your on the next business day after conference conclusion. Your cooperation in completing the survey in a timely manner will be appreciated. Evaluations are not only a requirement they are helpful in planning future programs. Please be sure that you have provided the correct address for the survey. CME/Verification of Attendance Certificates: CME Transcripts can be downloaded right after the conference. Just visit our website at and click on the Download your CME Transcript link. (This link will also be included in the that contains the survey monkey link.) For those who would like a certificate, a PDF labeled, IRIS-II New York, will be included in the . Please fill out the form and return it to the Office of CME. A certificate will be sent to you via within 5 business days. The Office of CME is going GREEN!

9 DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS North Shore-LIJ Health System adheres to the ACCME s New Standards for Commercial Support. Any individuals in a position to control the content of a CME activity, including faculty, planners and managers are required to disclose all financial relationships with commercial interests. All identified potential conflicts of interest are thoroughly vetted by North Shore-LIJ for fair balance and scientific objectivity and to ensure appropriateness of patient care recommendations. FACULTY: COMMERCIAL FOR: INTEREST: Anita Agarwal, M.D. Francesco Bandello, M.D. Alcon, Inc. Alimera Sciences, Inc. Allergan, Inc. Bayer Bausch and Lomb Farmila-Thea Novartis Pharmaceuticals Corp. Pfizer, Inc. Schering Pharma Thrombogenics, Inc. Gaetano R. Barile, M.D. Kavita V. Bhavsar Alexander J. Brucker, M.D. Joseph Carroll, Ph.D. Carl Zeiss Meditec Equipment Antonio Ciardella, M.D. Rogerio A. Costa, M.D., Ph.D. Emmett T. Cunningham, Jr., M.D., Ph.D., M.P.H. Christine Curcio, M.D. Jay Duker, M.D. Carl Zeiss Meditec Research Support EMD Serono Consultant EyeNetraStock Holder Stock Holder Hemera Biosciences Stock Holder Novartis Pharmaceuticals Corp. Consultant Optos Consultant OptoVue Research Support Ophthotech Stock Holder Paloma Pharmaceuticals Stock Holder QLT Phototherapeutics, Inc. Consultant Thrombogenics, Inc. Consultant Justis P. Ehlers, M.D. Bioptigen Licensing Fee Thrombogenics, Inc. Michael Engelbert, M.D., Ph.D. Bristol-Myers Squibb Topcon

10 FACULTY (cont.): COMMERCIAL FOR: INTEREST: Amani Fawzi, M.D. Jasmine Francis, M.D. K. Bailey Freund, M.D. DigiSight Heidelberg Engineering Optos Valeant James G. Fujimoto, Ph.D. Carl Zeiss Meditec Royalty for IP Optovue Royalty for IP lain Gaudric, M.D. Bayer Congress Travel Reimb. Novartis Pharmaceuticals Corp. Novartis Pharmaceuticals Corp. Congress Travel Reimb. Thrombogenics, Inc. Congress Travel Reimb. Tomohira Iida, M.D., Ph.D. Lee Jampol, M.D. Szilard Kiss, M.D. Alcon, Inc. Alimera Sciences, Inc. Allergan, Inc. Optos Thrombogenics, Inc. Hideki Koizumi, M.D., Ph.D. Michael Larsen, M.D. Alcon, Inc. Compensation Allergan, Inc. Allergan, Inc. Compensation Bayer Bayer Compensation Bayer GlaxoSmithKline Compensation Novartis Pharmaceuticals Corp. Novartis Pharmaceuticals Corp. Compensation Novartis Pharmaceuticals Corp. Novo Nordisk Novo Nordisk Brandon J. Lujan, M.D. Avalanche Hoffmann-La Roche H. Richard McDonald, M.D. Edoardo Midena, M.D., Ph.D., FARVO, FEBO William Mieler, M.D. Acucela Kyoko Ohno-Matsui, M.D. Novartis Pharmaceuticals Corp. Research Fund.

11 FACULTY (cont.): COMMERCIAL FOR: INTEREST: Jose Pulido, M.D. Giuseppe Querques, M.D., Ph.D. Richard Rosen, M.D. Clarity OD-OS Lecture Fee Opticology, Inc. Intellectual Property OptoVue Lecture Fee Philip Rosenfeld, M.D., Ph.D. Carl Zeiss Meditec Research Grant/Lic. Fees SriniVas Sadda, M.D. Allergan, Inc. Research Grant Allergan, Inc. Carl Zeiss Meditec Research Grant Carl Zeiss Meditec Research Grant Optos Research Grant Optos David Sarraf, M.D. Ursula Schmidt-Erfurth, M.D. Carol Shields, M.D. Jerry Shields, M.D. Lawrence J. Singerman, M.D. NIH DRCRnet Grant Support Jason S. Slakter, M.D. Alimera Sciences, Inc. Allergan, Inc. Bayer GlaxoSmithKline Johnson & Johnson Lpath, Inc. Lpath, Inc. OHR Pharmaceutical OHR Pharmaceutical Oraya Therapeutics Oraya Therapeutics Sanofi SKS Ocular Ownership Interest R. Theodore Smith, M.D., Ph.D. Richard F. Spaide, M.D. Topcon Royalty for IP Giovanni Staurenghi, M.D. Heidelberg Engineering Giovanni Staurenghi, M.D. Carl Zeiss Meditec Optovue Grant Stephen Tsang, M.D., Ph.D. Lawrence A. Yannuzzi, M.D. Bayer Ophthotech Stock Options

12 ACKNOWLEDGEMENTS LuEsther T. Mertz Retinal Research Center North Shore-LIJ Health System / Manhattan Eye, Ear, and Throat Hospital The Macula Foundation, Inc. gratefully acknowledge financial support in the form of educational grants and exhibit fees from: EDUCATIONAL GRANTS Genentech ThromboGenics EXHIBITORS Alcon Annidis Genentech Heidelberg Engineering Nidek Notal Vision Ophthotech Optos Optovue Santen ThromboGenics Topcon Zeiss