Where Debate & Discussion Translate to Breakthroughs. Now Offering 2 Locations. Greatdebatesinhema.com

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1 Part of the Oncology Learning Network Now Offering 2 Locations March 22 23, 2019 Marina del Rey Marriott Marina del Rey, California April 5 6, 2019 Crowne Plaza Times Square Manhattan, New York Where Debate & Discussion Translate to Breakthroughs Greatdebatesinhema.com MARCH 22 23, 2019 MARINA DEL REY, CALIFORNIA APRIL 5 6, 2019 MANHATTAN, NEW YORK

2 2 Days of Unparalleled Education. Interactive Format. Practical Implications. Join us for a unique educational experience. In this 2-day debate-style series, nationally recognized thought leaders take opposing sides on clinical and sometimes controversial topics currently disrupting the practice of hematology and oncology. This one-of-a-kind hematology conference provides a substantial curriculum covering the broad continuum of: Multiple Myeloma Acute Leukemia Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Not So Benign Hematology Myelodysplastic Syndromes Myeloproliferative Neoplasms Lymphoproliferative Diseases Endorsements Exhibits Several options are available to companies who wish to exhibit at this meeting. For more information, please contact: Kathleen St. Jean, Director, Business Development at k.stjean@imedex.com. GREAT DEBATES & UPDATES IN HEMATOLOGIC MALIGNANCIES GREATDEBATESINHEMA.COM

3 Meet the Chairs John P. Leonard, MD Center for Lymphoma and Myeloma Weill Cornell Medicine Joseph Mikhael, MD, MEd, FRCPC City of Hope Cancer Center Translational Genomics Research Institute Phoenix, Arizona David P. Steensma, MD Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Meet the Faculty Rafael Bejar, MD, PhD UC San Diego Moores Cancer Center San Diego, California James Bussell, MD + Weill Cornell Medicine Naval Daver, MD MD Anderson Cancer Center University of Texas Houston, Texas Daniel J. DeAngelo, MD, PhD + Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Jonathan Friedberg, MD + University of Rochester Rochester, New York Richard R. Furman, MD + Weill Cornell Medicine Sarah A. Holstein, MD, PhD* University of Nebraska Medical Center Omaha, Nebraska Jonathon Kauffman, MD Emory University Atlanta, Georgia Brea C. Lipe, MD + University of Rochester Rochester, New York Jaroslaw P. Maciejewski, MD, PhD Cleveland Clinic Taussig Cancer Institute Cleveland, Ohio Ruben A. Mesa, MD + Mays Cancer Center UT Health San Antonio MD Anderson San Antonio, Texas Jerald P. Radich, MD Fred Hutchinson Cancer Research Center Seattle, Washington Noopur Raje, MD + Massachusetts General Hospital Boston, Massachusetts Gail J. Roboz, MD + Weill Cornell Medicine David Sallman, MD + H. Lee Moffitt Cancer Center Tampa, Florida Michael R. Savona, MD Vanderbilt-Ingram Cancer Center Nashville, Tennessee Saad Z. Usmani, MD, FACP + Levine Cancer Institute Charlotte, North Carolina Speaker Key: *: CA only; +: NY only MARCH MARCH 22 23, 22 23, 2019 MARINA 2019 MARINA DEL REY, DEL CALIFORNIA REY, CALIFORNIA APRIL 5 6, APRIL , MANHATTAN, 2019 MANHATTAN, NEW YORK NEW YORK

4 DAY I, 2019 Session I: Plasma Cell Disorders Session Chair: Joseph Mikhael, MD, MEd, FRCPC, FACP 08:00 AM Welcome and pre-activity audience survey 08:10 AM Novel Small Molecule Inhibitors in Multiple Myeloma 08:30 AM Emerging Immunotherapies in Multiple Myeloma 08:50 AM Update: Frontline Therapy 09:10 AM Update: Maintenance Therapy 09:30 AM Late-Breaking Lecture 09:50 AM Break 10:10 AM R/R Multiple Myeloma: Combination Therapy/Three Drugs/Four Drugs 10:30 AM Debate: MRD 11:00 AM Optimizing Dosing Regimen in MM 11:20 AM Final remarks and post-activity audience survey 11:30 AM Lunch Session II: Chronic Lymphocytic Leukemia Session Chair: John P. Leonard, MD 01:00 PM Introduction and pre-activity audience survey 01:10 PM Novel Treatment Options in CLL 01:30 PM Late-Breaking Lecture 01:50 PM Late-Breaking Lecture 02:10 PM Sequencing Monotherapy vs. Combination Therapy 02:30 PM Post-activity audience survey Session III: AML/ALL Session Chair: David P. Steensma, MD 02:40 PM Pre-activity audience survey 02:50 PM Update: New Drugs for ALL 03:10 PM Case: MRD+ ALL in Remission 03:30 PM Update: New Drugs for AML 03:50 PM Post-activity audience survey 04:00 PM Break Session IV: MPN/MDS Session Chair: David P. Steensma, MD 04:20 PM Pre-activity audience survey 04:30 PM Late-Breaking Lecture 04:50 PM Late-Breaking Lecture 05:10 PM Update: New Treatments for MPN/MDS 05:30 PM Final remarks and post-activity audience survey 05:40 PM Adjourn GREAT DEBATES & UPDATES IN HEMATOLOGIC MALIGNANCIES

5 Day II, 2019 Session V: Lymphoma I Session Chair: John P. Leonard, MD 8:15 AM Welcome and pre-activity audience survey 8:25 AM DLBCL 8:45 AM Debate: TBD 9:15 AM Update: Upfront and Maintenance Therapy in Follicular Lymphoma 9:35 AM Update: Relapsed/Refractory Follicular Lymphoma 9:55 AM CAR-T in Lymphoma 10:15 AM Post-activity audience survey 10:25 AM Break Session VI: Lymphoma II Session Chair: John P. Leonard, MD 10:45 AM Pre-activity audience survey 10:55 AM HL (Check Point Inhibitors in chl and PMBCL) 11:15 AM Late-Breaking Lecture 11:35 AM NHL 11:55 AM Debate: MCL 12:25 PM Late-Breaking Lecture 12:45 PM Post-activity audience survey 01:05 PM Lunch Session VII: CML Session Chair: David P. Steensma, MD 2:35 PM Pre-activity audience survey 2:40 PM Treatment Options for Ph+ CML 3:00 PM Debate: CML 3:30 PM Late-Breaking Lecture 3:50 PM Post-activity audience survey 3:55 PM Break Session VIII: Not-So-Benign Hematology Session Chair: David P. Steensma, MD 4:15 PM Pre-activity audience survey 4:20 PM Update: ITP Treatment 4:40 PM Aplastic Anemia 5:00 PM Late-Breaking Lecture 5:20 PM Final remarks and post-activity audience survey 5:30 PM Adjourn MARCH 22 23, 2019 MARINA DEL REY, CALIFORNIA APRIL 5 6, 2019 MANHATTAN, NEW YORK

6 Who Should Attend These live educational activities are designed to meet the educational needs of those who are involved and/or interested in the treatment of patients with multiple myeloma, lymphoma, chronic lymphocytic leukemia, and acute myeloid leukemia. Hematologists Medical Oncologists Physicians Physician Assistants Physicians-in- Training Oncology Nurses Pharmacists Continuing Education Imedex is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the ACCME, the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Group Discounts available for attendees from the same practice! Support Several options are available to companies interested in supporting this conference/symposium. For more information, please contact Dan Alba, Senior Director, Educational Strategy, Hematology & Oncology at or Shannon Stevenson, Director of Educational Strategy at Credit Statements These conferences will offer continuing education credit for physicians, pharmacists, nursing professionals, and physician assistants. ABIM MOC will also be available. Please visit hematologicmalignancies. oncnet.com/continuingeducation for the most up-to-date information. It is anticipated that this activity will award 13 credits/contact hours. GREAT DEBATES & UPDATES IN HEMATOLOGIC MALIGNANCIES GREATDEBATESINHEMA.COM

7 More Locations, Education, and Value Marina del Rey Marriott 4100 Admiralty Way Marina del Rey, CA Special Room Rate: $ per night, plus tax. Phone: (310) Crowne Plaza Times Square Manhattan 1605 Broadway New York, NY Special Room Rate: $ per night, plus tax. Phone: (212) Ways To Register Online: Greatdebatesinhema.com Phone: (800) International: (678) Rates Physicians PhD Pharmacists Nurse Practitioners Physician Assistants Nurses Residents Students Fellows Pharmaceutical Industry Early $279 $169 $89 $499 Regular $329 $199 $99 $499 For assistance, please contact To reserve the best rates, sign-up before: Marina del Rey: February 22, 2019 New York: March 5, 2019 Enroll in the Great Debates & Updates Value Package and save by signing up for multiple locations at once!

8 Where Debate & Discussion Translate to Breakthroughs March 22 23, 2019 Marina del Rey, California April 5 6, 2019 Reserve your seat today: Greatdebatesinhema.com Rainwater Drive, Suite 600, Alpharetta, GA