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1 oi:1.138/nture1138 Supplementl Figure 1 Inflmmtory Monoytes Host ells CCR2 CCL2 Disseminting Tumor Cells Metstsis Assoite Mrophges VEGF Extrvstion & Metstti Seeing Supplementl Figure 1 The t from this stuy support the moel tht isseminting tumor ells n host orgn-erive hemokine CCL2 reruit inflmmtory monoytes, whih filittes effiient tumor ell metstsis seeing n growth in the istnt metstti sites of lung. 1
2 oi:1.138/nture1138 Supplementl Figure 2 CCL2 Expression in Fink Brest Groupe y Cner Type CCL2 Expression in Frmer Brest Groupe y Cner Type Supplementl Figure 2 Onomine 27 serh results inite tht CCL2 is overexpresse in oth tumor n tumor strom of invsive rest rinom whih is orrelte with metstti isese n poor prognosis, CCL2 is over-expresse in tumor strom of invsive rest rinom ompre to norml strom. P=3.58E-16, fol hnge Mirorry t soure GSE , CCL2 is over-expresse in the sl-like sutype of invsive rest rinom ompre to porine rest rinom n luminl-like sutype of invsive rest rinom. P=8.23E-6. Mirorry t soure GSE
3 oi:1.138/nture1138 Supplementl Figure <PE-Cy7-A> 1 4 CD CD115 Gr Csf-1r-GFP Ly6C Ly6G <APC-A> CD62L 8 1 MHCII 8 IL4R e % of Mx % of Mx <PE-A> Ly-6C- Ly-6C+ Csf-1r-GFP DAPI Supplementl Figure 3, Flow igrm of CD45+ one mrrow ells lele with CD11 (Y xis) n CD115 (X xis)., Monoytes seprte into Gr1 + IM n Gr1 - RM popultions y FACS n hve the sme level of Csf1r-GFP expression., Virtully ll CD115 + monoytes in the one mrrow re Ly6G - (X xis) n seprte into Ly6C+ n Ly6C (Y xis) popultions whih orrespon to the Gr1 + n Gr1 popultions., Representtive flow histogrm showing tht IMs (re) hs elevte CD62L ell surfe expression (Left pnel)ompre with RMs (Blue). Both popultions express miniml level of ell surfe MHCII n IL4R (mile n right pnels). e, Representtive flow igrm of reovere GFP + onor ells (oxe) from peripherl loo of reipient mie. 3
4 oi:1.138/nture1138 Ly6 Supplementl Figure CD115 Norml Lung Mets Lung (PyMT) Norml Lung Mets Lung e Rtio of reruite IM Vs RM per 1^6 CD45+ ells Donor ells per 1^6 CD45+ ells Donor IM per 1^6 CD45+ ells Norml Lung RM PyMT Pre-mets Lung 1 ** IM Gr CD f Perentge of CD11+ Gr1- in CD45+ ells PBS Ctrl A * Bes nti-ccl2 A Supplementl Figure 4, Representtive flow igrm showing expression of Ly6C (Y xis) n CD115 (X xis) of enogenous monoytes (CD115+CD11+F4/8+) reruite in norml lung (left) n lungs ering spontneous metstsis (right) of lte stge PyMT tumor, n=5., Rtio of lung-reruite IMs vs RMs fter overnight optive trnsfer into 7 week-ol PyMT mie with no etetle lung metstsis n their norml litter mtes. n=3, NS., Numer of RM n IM reruite into estlishe pulmonry metstsis of i.v. injete Met-1 ells. n=4, p=.19., Representtive flow igrm showing the leling of GFP + IMs reovere from norml lung n metstsis-ering lung with Gr1 (Y xis) n CD11 (X xis) 2 ys fter optive trnsfer. Numers shown re perentge of CD11 + Gr1 - ells reltive to totl GFP + ells, n=4. e, Reltive numer of lung reruite IMs fter overnight optive trnsfer into nue mie with PBS or ltex es i.v. injetion. n=3, NS. All r represents men + s.e.m.. f, CD11 + Gr1 - MAMs in lungs hllenge with i.v. injete Met-1 ells for 36 hours with ontrol n nti-mouse CCL2 ntioy tretment. Dt show men + s.e.m., n=3, p=
5 oi:1.138/nture1138 Supplementl Figure 5 CD DAPI CD4.53% CD Perentge of CD3+CD4+ ells in totl CD45+ ells Ctrl A.23% Ctrl Mets 36hr Ctrl % Anti-CCL A 5.2% % CD4 1 1 Mets 36hr CD % Foxp3 CCR2 Supplementl Figure 5, Representtive flow igrm showing the gting of CD3 + CD4 + T ells in CD45 + hemtopoieti ells isolte from mouse lung., Reruitment of CD3 + CD4 + T ells in totl CD45 + hemtopoieti ells in ontrol lungs n lungs hllenge with i.v. injete tumor ells for 36 hours, n=4, NS., Representtive flow igrm showing the gting of CD3 + CD4 + Foxp3 + regultory T ells in ontrol lungs n lungs hllenge with i.v. injete tumor ells for 36 hours. Perentge shown is reltive to totl CD45 + hemtopoieti ells, n=4, NS., Representtive flow igrm showing the gting of CD3 + CD4 + T ells lele with CD25 (Y xis) n CCR2 (X xis) in lungs ering estlishe metstses of i.v. injete Met-1 tumor ells with ontrol A or nti-mouse CCL2 A tretment. Perentge shown is reltive to totl CD45 + hemtopoieti ells, n=4. 5
6 oi:1.138/nture1138 Supplementl Figure 6 Primry Tumor Lung Mets 2 n A only Anti-CCL2 A e 4 ** f 5 CCR2 mrna level (Fol Vs GAPDH) Donor IM per 1^6 CD45+ ells RM IM Control Lung Mets Lung Supplementl Figure 6, Representtive mirogrph of CCL2 expression etermine y immunohistohemistry using seonry ntioy lone (,) or nti-ccl2 ntioy (,) in primry PyMT tumors (,) n their spontneous lung metstses (,). Brown olor inites positive signls. Br equls 2 um. e, Reltive CCR2 mrna expression in resient n inflmmtory monoytes etermine y quntittive reltime PCR, normlize ginst housekeeping gene, GAPDH, r represents men + s.e.m., n=3, p=.53. f, Numer of reruite CCR2 knokout IMs into norml lung n lung ering experimentlly-inue metstsis with Met-1 ells in nue mie fter overnight optive trnsfer, n=3 NS. 6
7 oi:1.138/nture1138 Supplementl Figure 7 Hu CD Hu CD e Humn CD45+ ells per 1^6 totl CD45+ ells 1 4 * CD14 lo CD16+ w/o Hu CSF-1 Isotype ontrol CD14 lo CD16+ CD14+CD16- CD14+CD w/ Hu CSF HuCD45 % of Mx CCR2 5K 1K 15K 2K 25K FSC f Donor IM per 1^6 CD45+ ells Hu CD Hu CD Ctrl A ** nti-hu CCL2 A 7
8 oi:1.138/nture1138 Supplementl Figure 7, Humn peripherl CD14 + ells were sorte y FACS into CD14 + CD16 - n CD14 lo CD16 + popultions., Flow igrm showing the reovery of humn ells (re ox) fter overnight optive trnsfer into nue mie supplemente with humn CSF-1., Representtive flow histogrm showing CCR2 expression of the ifferent humn monoyte popultions s shown ompre to n isotype ontrol, n=3., Numer of optively trnsferre humn monoytes reruite into lungs ering metstses from 4173 tumors, n=6, p=.239. e, Representtive flow histogrm showing reovery of humn monoytes fter overnight optive trnsfer into mie with s.. injetion of humn CSF-1 (ottom) or ontrol injetion (top), n=3. f, Numer of mouse IM reruite fter overnight optive trnsfer into mie with estlishe pulmonry metstsis from i.v. injete 4173 ells with nti-humn CCL2 A or ontrol A tretment, r represents men + s.e.m., n=5, **p=
9 oi:1.138/nture1138 Supplementl Figure 8.25 Mets Inex Ctrl A Anti-CCL12 A Supplementl Figure 8 Stereologil quntifition of normlize Mets uren of i.v. injete Met-1 ells with tretment of ontrol A or nti-mouse CCL12 A, r represents men + s.e.m., n=9, NS. 9
10 oi:1.138/nture1138 Supplementl Figure 9 CCR2 CCL2 GAPDH Tumor ell Met-1 Enothelil monolyer Monoyte/ ECM BMM BMM Enothelil Cells Cell numer per 2X fiel Trnsmigrte tumor ell per 2X fiel 6 p<.1 p= w/o BMM WT w/ BMM w/ BMM + nti-ccl2 A 6 p=.54 w/ BMM + ontrol A CCR2-/- Supplementl Figure 9 Mrophges promote tumor ell in vitro trns-enothelil migrtion., Shemti rwing of the ssy for in vitro tumor ell (re) trnsenothelil (lue) migrtion in Mtrigel (pink) ote invsion hmer with monoytes or one mrrow erive mrophges (BMM, green) loe to the sl-lterl sie of the hmer., Presene of primry BMMs (w/bmm) signifintly promote tumor ell in vitro trns-enothelil migrtion s ompre with the sene of mrophges (w/o BMM). This effet is ompletely inhiite y nti-mouse CCL2 neutrlizing ntioy ut not y isotype mthe ontrol ntioy. Br represents men + s.e.m. of 3 experiments with uplites., RT-PCR shows tht tumor ells (Met-1), mrophges (BMM) n enothelil ells ll express CCL2, ut only mrophges express CCR2 reeptor., Averge numer of trnsmigrte Met-1 ells in the presene of mrophges from WT or CCR2-/- mie. Br represents men + s.e.m. of 3 experiments with uplites, p
11 oi:1.138/nture1138 Supplementl Figure 1 Reltive expression.25 p= Cell Numer 6 Control RNAi CCL2 RNAi 4 2 Mets Inex ***. ontrol RNAi Control RNAi CCL2 RNAi hr 24hr CCL2 RNAi 36hr 48hr. Ctrl RNAi CCL2 RNAi e Reltive expression Control ** CCL2 KD f Normlize Rine Control *** CCL2 KD Supplementl Figure 1, Reltive CCL2 expression in Met-1 ells infete with retrovirl ontrol (srmle) RNAi n CCL2 RNAi. Dt show men ± s.e.m. n=3., In vitro prolifertion of Met-1 ells infete with retrovirl ontrol RNAi n CCL2 RNAi. Dt show men ± s.e.m. n=3, NS., Representtive mirogrph showing H&E stine trnsverse setions of Met-1 lung metstsis following ontrol or CCL2 sirna tretment. Br equls 1 mm., Mets uren of Met-1 ells with ontrol or CCL2 RNAi. n=6, p=.4. e, Reltive CCL2 expression etermine y quntittive reltime RT-PCR in 4173 ells infete with retrovirl ontrol RNAi n CCL2 RNAi. Br represents men + s.e.m. n=5. **p=.89. f, Normlize ioluminesene (BLI) signl of lung tumor uren of mie inoulte with 4173 ells tht h een trnsfete with luiferse onstrut. The signl intensities were normlize to y, whih ws set ritrrily s 1. n=8, *** p=.1. n, unpire t test with Welh's orretion. 11
12 oi:1.138/nture1138 Supplementl Figure 11 Reltive mrna expression RM VEGFA IM ** Mets Numer Inex flox VEGF ** flox VEGF ;Csf1r-Cre Donor Ly6+ monoytes per 1^6 CD45+ ells IM flox VEGF VEGF KO IM Supplementl Figure 11, Reltive mrna expression of VEGF y mouse RM n IM y reltime PCR normlize to GAPDH expression. Dt show men + s.e.m., n=5, ** p=.28., Stereologil quntifition of normlize Mets numer (numer of Mets noules per mm^2 of lung re in ross setions) in VEGF flox/flox mie with or without Csf1r-Mer-iCre-Mer trnsgene trete with sme ose of s.. injetion of tmoxifen. n=6, **p=.95., Numer of IMs or VEGF knokout IMs reruite into estlishe pulmonry metstsis of i.v. injete Met-1 ells fter overnight optive trnsfer. n 4, NS. All t shown re men+s.e.m. 12
13 oi:1.138/nture1138 Supplementl Movie 1 Representtive 3D reonstrute onfol imges of tumor ells (CFP, lue) n mrophges (GFP, green) 24 hours fter tumor ell til vein injetion in mie trete with ontrol A. Bloo vessels were stine with Alex Fluor 647 onjugte nti-mouse CD31 ntioy (re). Tumor ell ws in the extrvsulr spe with mrophge intertions. Overlpping re of oth re n lue olor ws use y refletion of lser light from the lveolr spe. Supplementl Movie 2 Representtive 3D reonstrute onfol imges of tumor ells (CFP, lue) n mrophges (GFP, green) 24 hours fter tumor ell til vein injetion in mie trete with nti-mouse CCL2 A. Bloo vessels were stine with Alex Fluor 647 onjugte nti-mouse CD31 ntioy (re). Tumor ell stye intrvsulr without mrophge intertion. Overlpping re of oth re n lue olor ws use y refletion of lser light from the lveolr spe. Referenes: 27 Rhoes, D. R. et l. ONCOMINE: ner mirorry tse n integrte t-mining pltform. Neoplsi 6, 1-6 (24). 28 Fink, G. et l. Stroml gene expression preits linil outome in rest ner. Nture meiine 14, (28). 29 Frmer, P. et l. Ientifition of moleulr porine rest tumours y mirorry nlysis. Onogene 24, (25). 13
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DOI: 1.138/n358 TLR2 nd MyD88 expression in murine mmmry epithelil supopultions. CD24 min plus MRU Myo-epithelil Luminl progenitor (CD61 pos ) Mture luminl (CD61 neg ) CD49f CD61 Reltive expression Krt5
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{ OI: 1.138/n31 Srifie n nlyze APs on week 1 s of iet 1 4 6 High-ft iet BrU High-ft iet BrU 4 High-ft iet BrU 6 High-ft iet BrU Lin - Lin - : C34 + : C9 + 1 1 3 1 4 1 5 C45 1 C34 1 1 1 1 3 1 4 1 5 S-1
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doi: 1.138/nture862 humn hr. 21q MRPL39 murine Chr.16 Mrpl39 Dyrk1A Runx1 murine Chr. 17 ZNF295 Ets2 Znf295 murine Chr. 1 COL18A1 -/- lot: nti-dscr1 IgG hevy hin DSCR1 DSCR1 expression reltive to hevy
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DOI: 1.138/n2977 Numer of ells per field 6 4 2 P =.1 Orthotopi eum Normlized ventrl photon flux 1E7 1E6 1E5 1E4 1E3 1E2 n=8 n=9 1 2 3 4 5 6 Dys Dy54 1.5E5 2.4E7 d Mie with lymph node metstsis (%) 1 8 6
Alimonti_Supplementary Figure 1. Pten +/- Pten + Pten. Pten hy. β-actin. Pten - wt hy/+ +/- wt hy/+ +/- Pten. Pten. Relative Protein level (% )
Alimonti_Supplementry Figure 1 hy 3 4 5 3 Neo 4 5 5 Proe 5 Proe hy/ hy/ /- - 3 6 Neo β-tin d Reltive Protein level (% ) 15 1 5 hy/ /- Reltive Gene Expr. (% ) 15 1 5 hy/ /- Supplementry Figure 1 Chrteriztion
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SUPPLEMENTARY INFORMATION CD169 + MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES Ptrii Brrl, Polo Polzell, Andres Brukuer, Nio vn Rooijen, Gurdyl S.
(% of adherent cells) *** PBL firm adhesion. Frequency (% ) 4 1 L 2 CXCR3 DP-2
Chemotxis (% of dded ells) PBL totl dhesion (N ells/mm 2 /1.1 6 PBL) Frequeny (% ) PBL firm dhesion Supplementry Figure 1 4 4 3 3 2 2 1.1-4 1-3 1.1.2. 1 1 8 6 4 2 Adiponetin ( g/ml) - + Adiponetin ( g/ml)
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SUPPLEMENTARY INFORMATION doi:.8/nture89 4 4 Ilr -/- Ilr -/- Ilr -/- Cspse- -/- As -/- Nlrp -/- Il8 -/- Ilr -/- Supplementl figure. Inresed severity of NASH in inflmmsome-defiient mie, ut not in Ilr-defiient
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% ells with ili (mrke y A-Tu) Reltive Luiferse % ells with ili (mrke y Arl13) % ells with ili DOI: 1.138/n2259 A-Tuulin Hoehst % Cilite Non-ilite -Serum 9% 8% 7% 1 6% % 4% +Serum 1 3% 2% 1% % Serum: -
Cos7 (3TP) (K): TGFβ1(h): (K)
IP#2: IP#1: Totl Lystes luiferse tivity (K): 6-4 - (K): luiferse tivity luiferse tivity (K): 2 1 RL-: - + + + + + Sm4-3F: + - + + + + MYC-Sm3: - - - - + + TβRI-HA(T204D): - - - + - + α-ha Luiferse Ativity
Supplementary Figure S1
Supplementry Figure S1 - UTR m - 3HA - 2-1 hgh - 1 Uiquitin *! *! lk distl promoter m K3R/ K121R-3HA UTR hgh founder lines - HA - - founder lines TG- E1 L A2 B1 F9 G6 H4 H6 B C D2 G1 H3 J2 L - 7 IP: lk
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LHb VTA. VTA-projecting RMTg-projecting overlay. Supplemental Figure 2. Retrograde labeling of LHb neurons. a. VTA-projecting LHb
SUPPLEMENTARY INFORMATION Supplementl Figure 1 doi:10.1038/nture09742 Lterl 1.0 mm from midline mpfc BNST mpfc BNST Lterl 2.1 mm from midline LHA LHA Lterl 2.7 mm from midline SUPPLEMENTAL INFORMATION
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DOI: 1.13/n7 Reltive Pprg mrna 3 1 1 Time (weeks) Interspulr Inguinl Epididyml Reltive undne..1.5. - 5 5-51 51-1 1-7 7 - - 1 1-1 Lipid droplet size ( m ) 1-3 3 - - - 1 1-1 1-1 1-175 175-3 3-31 31-5 >5
Supplementary Information
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doi:1.138/nture1228 Totl Cell Numer (cells/μl of lood) 12 1 8 6 4 2 d Peripherl Blood 2 4 7 Time (d) fter nti-cd3 i.p. + TCRβ + IL17A + cells (%) 7 6 5 4 3 2 1 Totl Cell Numer (x1 3 ) 8 7 6 5 4 3 2 1 %
Supplementary figure 1
Supplementry figure 1 Dy 8 post LCMV infection Vsculr Assoc. Prenchym Dy 3 post LCMV infection 1 5 6.7.29 1 4 1 3 1 2 88.9 4.16 1 2 1 3 1 4 1 5 1 5 1.59 5.97 1 4 1 3 1 2 21.4 71 1 2 1 3 1 4 1 5 1 5.59.22
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2 weeks high holesterol diet 2 weeks high holesterol diet 2 weeks high holesterol diet 2 μm Mrophges Crystls Hoehst μm Mrophges Crystls Hoehst Hoehst Crystls Mrophges 2 μm 2 μm Supplementry Fig. 1: Erly
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SUPPLEMENTARY INFORMATION doi:1.18/nture129 ontrol-dna -DNA CD49 Blood Lung e.98 +/-.9.71 +/-.2.29+/-.1 2.9 +/-.6 Bsophils (x1 )/ml 4 Bsophils ( x1 ) d f 45. 22.5 15 75 ontrol-dna ontrol-dna -DNA -DNA
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DOI:.38/n83 k Mouse Ch8 lous 8 9 Stop CHD8L 75 CHD8L Chromoomins Helise/ATPse omin DNA ining omin 5 kd NIH 3T3 MEF 93T HeL HCT UOS SOS.. CHD8L IB: CHD8 8 5 L S Reltive mrna mount 3... Reltive mrna mount.8.
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nestin ironetin p75 s1 CNS SKPs Dermo-1 +ve SKPs CNS H2O SCGs Skin Di. SKPs TH SHOX2 GAPDH NCAM D H Figure S1, Immunoytohemil nlysis o SKP spheres ulture rom neontl mouse (nestin, ironetin, S-1) or rt
Supplementary Figure 1
doi: 1.138/nture6188 SUPPLEMENTARY INFORMATION Supplementry Figure 1 c CFU-F colonies per 1 5 stroml cells 14 12 1 8 6 4 2 Mtrigel plug Neg. MCF7/Rs MDA-MB-231 * * MCF7/Rs-Lung MDA-MB-231-Lung MCF7/Rs-Kidney
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DOI:.3/n95 Thymus Kiney (kd) TA T7 T TA T7 T Hert TA T7 T: +Dox Cylin B (kd) Thymus Kiney Hert TA T5 T TA T5 T TA T5 T: +Dox Cylin B Poneu S Poneu S CnB T7 CnB T Thymus (kd) + Liver Colon + + (kd) Thymus
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Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+
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SUPPEMENTARY INFORMATION DOI: 1.138/ncb956 Norml CIS Invsive crcinom 4 months months b Bldder #1 Bldder # Bldder #3 6 months (Invsive crcinom) Supplementry Figure 1 Mouse model of bldder cncer. () Schemtic
Supplementary Figure 1. Scheme of unilateral pyramidotomy used for detecting compensatory sprouting of intact CST axons.
() BDA 2 weeks fter Py () AAVs Cre or GFP t P1 BDA 2 weeks fter Py CSMN CST () Py t P7 or 2 months () Py t 2 months Supplementry Figure 1. Sheme of unilterl pyrmidotomy used for deteting ompenstory sprouting
RESEARCH ARTICLE. Supplemental Figure 5
11.5 2 2 11. RESEARCH ARTICLE RBC ( 1 12 /L) 1.5 1. 9.5 PLT ( 1 9 /L) 1 16 14 HGB (g/l) 19 1 17 16 9. 12 4 4 46 Cellulr & Moleulr Immunology dvne online pulition, PCV (%) 44 MCV (fl) 46 44 ; doi:1.13/mi.214.16
Supplemental Figures and Legends
Supplementl Figures n Legens Epigeneti trgeting of Hegehog trnsriptionl output through BET romoomin inhiition Yujie Tng 1,2, Shrreh Gholmin 2, Simone Shuert 1,2, Mine I. Willrson 3, Alex Lee 4, Prtiti
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doi: 10.1038/nture07679 Emryonic Stem (ES) cell Hemngiolst Flk1 + Blst Colony 3 to 3.5 Dys 3-4 Dys ES differentition Sort of Flk1 + cells Supplementry Figure 1. Chrcteristion of lst colony development.
a3 Chains of type V collagen regulate breast tumour growth via glypican-1
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unstimulte stimulte 11/7/11 Ientifiction of Unique Suset + (Denritic Cell-Specific Trnsmemrne Protein) T cells with Th17 Signture in Psoritic rthritis () Ptients Disclosures None Y.H. Chiu, E.M. Schwrz,
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DOI:./n BJ RAS:ER Herrnz et l Supplementry Figure HFFF RAS:ER.. mrna Expression..... ILα ILβ IL IL CCL INH VEGF mrna Expression..... ILα ILβ IL IL CCL INH VEGF + OHT Torin NVP-BEZ + OHT shmtor. shmtor.
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oi:1.138/nture1134 CS+ CS- MCH 3 OCT OCT 3 MCH CS- CS+ OCT MCH 3 MCH OCT 3 OCT vs MCH OCT vs MCH ppetitive memory (PI) A 1-1 Unpire onitioning DDC-GAL4/UAS-Trp UAS-Trp/+ -2 MCH OCT OCT MCH sugr OCT MCH
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Supplemental Information. Lymphocytes Negatively Regulate NK Cell Activity. via Qa-1b following Viral Infection
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Supplementry Figure S1_Cottini γ-h2a.x Krp OCIMy5 KMS11 Krps62 RPMI8226 INA6-1 µm Cleve C3 γ-h2a.x DAPI Merge OCIMy5 H929 JJN3 UTMC2 KMS11 KMS12PE KMS18 KMS2 RPMI8226 INA6 U266 KMS34 Krps62 1 2 3 4 5 6
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T- lymphocytes
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doi:1.138/nture1794 BR EPFs BRI1? ERECTA TMM BSKs YDA PP2A BSU1 BIN2 pbzr1/2 BZR1/2 MKK4/5/7/9 MPK3/6 SPCH Cell growth Stomtl production Supplementry Figure 1. The model of BR nd stomtl signling pthwys.
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doi:.8/nture98 : hr NEMO :5 hr IKK IKK NF-κB p65 p5 p65/-rel NF-κB p65 p5 p65/-rel Cytoplsm Cytoplsm p65/p5 Nuleus Nuleus NEMO IKK IKK d : hr > : hr p65/-rel NF- p65 p5 Cytoplsm Cytoplsm p65/p5 p65/-rel
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Icos-/ CD3 Icos Y181F OT-2 T cells doi:1.138/nture158 IgD Supplementry Figure 1. is required for folliculr locliztion of ctivted helper T cells. Icos nd Icos-/- OT-2 T cells were retrovirlly trnsduced
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. Norml Physiologicl Conditions. SIRT1 Loss-of-Function S1. Model for the role of SIRT1 in the regultion of memory nd plsticity. () Our findings suggest tht SIRT1 normlly functions in coopertion with YY1,
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Supplementry Figure 1 Ncor1 Expression 2. 1.5 1..5. Muscle Liver Lmi Ppropi Kindey Pncres Lung Testis Bone Mrrow Thymus Spleen Peripherl Lymph nods Smll Intestine Ncor1 Expression 1.5 1..5. DN DP SP CD8
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