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1 CISH EBV (EBER1 RNA) EBVISH CISH Kappa by ISH or CISH Lambda by ISH or Cytogenetics Chromosomal Analysis Cytogenetics 88237, 88264, 88280, (may include or additional units of 88280; used in lieu of for solid tumor) 11q22.3 (ATM) CLL/SLL Panel test q23 MLL (Breakapart) MLL (11q23) t(11q23) MLL Acute Lymphocytic Leukemia Panel test q14.3_D13S319 CLL/SLL Panel test Myeloma Panel test Myeloproliferative Disorder (MPD) Panel test p13.1_P53 CLL/SLL Panel test; Myeloma Panel test p36/19q13 â Oligodendroglioma Oligodendroglioma Panel test (1p36/1q25 and 19q13/19p13) 88374x2 1q21+1p21 Myeloma Panel Test q12 MDS Panel test; Myeloproliferative Disorder (MPD) Panel test or q31 / del 7q 7q31/CEP7 MDS Panel test Acute Myelogenous Leukemia Panel test ALK (2P23) translocations EML4-ALK ALL (Acute Lymphocytic Leukemia) Panel This is a send out panel. Probes vary by vendor, and Client may be billed for the testing. Contact PhenoPath Client Services for details. Call to confirm AML (Acute Myelogenous Leukemia) Panel t(8;21) RUNX1/RUNX1T1 t(15;17) PML/RARA CBFB 88374x6, inv16 breakapart 7/del 7q 11q23 CEP8 (trisomy) EGR1 (5q31/5p15.5) * Panel makeup subject to change APL (Acute Promyelocytic Leukemia) Panel t(15;17) PML/RARA RARA (17q21) brreakapart 88374x2 (reference only; * Panel makeup subject to change BCL6 (3q27) n Hodgkin Lymphoma (Agressive B- BCL6 translocations NHL) Panel test n Hodgkin Lymphoma (Indolent B- NHL) Panel test CBFB inv(16) Breakapart CBFB inv16 Acute Myelogenous Leukemia Panel test CEP-X/Y CEP12 CEP12 (12p11.1) CLL/SLL Panel test or CEP17-Hydatidiform Mole Hydatidiform Mole Panel test or CEP8 (Trisomy) Trisomy 8 MDS Panel test Acute Myelogenous Leukemia Panel test Myeloproliferative Disorder (MPD) Panel test or CLL/SLL Panel 11q22.3_ATM 13q14_D13S319 13q34_LAMP 17p13.1_P53 CEP12 (trisoomy) IGH breakapart t(11;14) CCND1/IGH * Panel makeup subject to change 88374x5, CML Panel t(9;22) BCR/ABL (reference only; Copy Control 9 (CC9) CEP9 (9p11-q11.1) Myeloma Panel test Myeloproliferative Disorder (MPD) Panel test or EGFR/CEP EGR1 (5q31/5p15.5) 5q31/5p15.5 MDS Panel test AML Panel test EWSR1 Breakapart FUS Breakapart HER2/CEP17 (PathVysion) ; 88360; 88367; Hydatidiform Mole Evaluation (Molar p57 and Ki-67 (MIB-1) by CEP17 by * Panel (reference only; Pregnancy) makeup subject to change Hyperdiploidy probes CC3, CEP5, CEP7, CEP11, CC15 IGH Breakapart IGH (14q32) CLL/SLL Panel test MYC Panel test n Hodgkin Lymphoma (Agressive B-NHL) Panel test n Hodgkin Lymphoma (Indolent B-NHL) Panel test MALT Panel MALT1 (18q21) (reference only; MALT1 Breakapart n Hodgkin Lymphoma (Indolent B-NHL) Panel test MALT Panel test MALT1 Breakapart (18q21) positive, reflex t(11;18) MALT1/API2 t(14;18) IGH/MALT1 * Panel 88374x2 (reference only; panel makeup subject to change MDM-2/SE12 MDM MDS (Myelodysplastic Syndrome) Panel 88374x2, 88367; EGR1 (5q31/5p15.5) 7/del 7q CEP8 Deletion 20q * Panel makeup subject to change 1 of 7

2 MET (7q31.2) / CC7 CMET, c-met, hepatocyte growth factor receptor, HGFR MYC Breakapart c-myc n Hodgkin Lymphoma (Agressive B-NHL) Panel test MYC Panel test ALL Panel test: MYC (8q24) rearrangements Myeloma Panel 1q21+1p21 13q14.3_D13S319 13q34_LAMP 88374x6, 88367; 88373x5 17p13.1_P53 t(11;14) CCND1/IGH t(14;16) IGH/MAF (reference only; panel run t(4;14) FGFR3/IGH Copy Control 3 (CC3) CEP5 as algorithm; CPTs may CEP7 Copy Control 9 (CC9) CEP11 Copy Control 15 (CC15) * Panel makeup subject to change Myeloproliferative Neoplasm (MPN) Panel n Hodgkin Lymphoma (Aggressive B- NHL) Panel n Hodgkin Lymphoma (Indolent B-NHL) Panel - Paraffin n Hodgkin Lymphoma (Indolent B-NHL) Panel - Wet Alternate name: MPD Panel 13q14.3_D13S319 Deletion 20q CEP8 (trisomy) Copy Control 9 (CC9) (hyperdiploidy) * Panel makeup subject to change MYC (8q24) breakapart IGH breakapart t(14;18) IGH/BCL2 BCL6 breakapart * Panel makeup subject to change IgH breakapart t(14;18) IGH/BCL2 BCL6 breakapart t(11;14) CCND1/IGH MALT1 breakapart * Panel makeup subject to change IgH breakapart t(14;18) IGH/BCL2 BCL6 breakapart t(11;14) CCND1/IGH * Panel makeup subject to change 88374, 88367; 88373x x4 (reference only; 88374x5 (reference only; 88374x4 (reference only; P16 (CDKN2A)/CC9 CDKN2A/CC RARA Breakapart RARA (17q12) RET Breakapart Chromosome 10q ROS-1 Breakapart SS18-SYT-synovial sarcoma-x18 SS18 (SYT-18q11.2) t(11;14)(q13;q32) (IGH/CCND1) Myeloma Panel test t(11;14) CCND1/IGH CLL/SLL Panel test n Hodgkin Lymphoma (Indolent B-NHL) Panel test t(11;18) MALT1/API2 (& MALT1/BIRC3) t(11;18)(q21;q21) (API2/MALT1) t(11;18)(q21;q21) (BIRC3/MALT1) MALT1 (18q21) positive Reflex Panel test t(14;16) IGH/MAF t(14;16)(q32;q23) (IGH/MAF) t(14;18) IGH/BCL2 t(14;18)(q32;q21) (IGH/BCL2) n Hodgkin Lymphoma (Indolent B-NHL) Panel test n Hodgkin Lymphoma (Aggressive B-NHL) Panel test t(14;18) IGH/MALT t(14;18)(q32;q21) MALT1 MALT1 (18q21) positive Reflex Panel test t(15;17) PML/RARA t(15;17)(q22;q21.1) (PML/RARA) Acute Promyelocytic Leukemia Panel test Acute Myelogenous Leukemia Panel test t(4;14) FGFR3/IGH t(4;14)(p16;q32) (IGH/FGFR3) Myeloma Panel test t(8;14)(igh/myc) NHL (Aggressive B-NHL) Panel test t(8;21) (RUNX1/RUNX1T1) t(8;21) Acute Myelogenous Leukemia Panel test t(9;22) BCR/ABL t(9;22)(q34;q11.2) (BCR/ABL) Acute Lymphocytic Leukemia Panel test CML Panel test TFE3(Xp11) TOP2A/CEP17 TOP2A B-ALL add-on tube CD11b, CD19, CD22, CD33, CD34, CD45, CD56, 88185x10 (reference only; CD79b, HLA-DR, TdT B-ALL minimal residual disease panel x 1, x 8, CD5, CD10, CD19, CD20, CD34, CD38, CD45, x 1 (reference only; kappa, lambda CD5-positive B cell therapy add-on tube CD5, CD19, CD22, CD45, CD52, CD79b, CD49d 88185x7 (reference only; CLL / SLL / mantle cell lymphoma (MCL) addon tube Cytoplasmic lineage add-on tubes Follicular lymphoma (FL)/Burkitt lymphoma (BL) add-on tubes Full bone marrow screening panel Hairy cell leukemia/marginal zone lymphoma add-on tube CD5, CD19, CD22, CD23, CD43, CD45, CD200, FMC7 CD3, CD19, CD34, CD38, CD45, CD79a, CD117, myeloperoxidase bcl-2, CD5, CD10, CD11c, CD19, CD20, CD38, CD45 CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD13, CD14, CD15, CD16, CD19, CD20, CD33, CD34, CD36, CD38, CD45, CD56, CD64, CD71, CD117, CD123, HLA-DR, kappa, lambda CD5, CD11c, CD19, CD22, CD25, CD38, CD45, CD103 Large T cell therapy add-on tube CD3, CD25, CD30, CD45, CD52, HLA-DR Myeloid 4 add-on tube Myeloid 5 add-on tube CD9, CD19, CD34, CD38, CD45, CD90, CD117, CD133, HLA-DR CD11c, CD34, CD41, CD45, CD61, CD117, CD235a (glycophorin A) 88185x10 (reference only; 88185x8 (reference only; 88185x8 (reference only; x 1, x 26, x 1 (reference only; 88185x8 (reference only; 88185x6 (reference only; 88185x9 (reference only; 88185x7 (reference only; 2 of 7

3 88184 x 1, x 9, Paroxysmal nocturnal hemoglobinuria (PNH) CD10, CD14, CD16, CD24, CD33, CD45, CD59, x 1 (reference only; panel CD235a/glycophorin A, FLAER, HLA-DR Rule out lymphoma panel Rule out mastocytosis panel Rule out plasma cell dyscrasia panel T cell receptor add-on tube T cell therapy add-on tube T-ALL add-on tube CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD19, CD20, CD34, CD38, CD45, CD56, kappa, lambda CD2, CD4, CD25, CD33, CD34, CD38, CD45, CD117, HLA-DR CD5, CD19, CD20, CD45, CD38, CD56, kappa, lambda, surface antibodies x 1, x 14, x 1 (reference only; x 1, x 8, x 1 (reference only; x 1, x # of antibodies, x 1 CD3, CD4, CD5, CD8, CD45, CD56, TCR-alpha-beta, 88185x8 (reference only; TCR-gamma-delta CD3, CD4, CD5, CD8, CD279, CD25, CD45, CD52, 88185x8 (reference only; CD16 CD1a, CD3, CD33, CD34, CD45, CD99, HLA-DR, 88185x8 (reference only; TdT x 1, x 8, x 1 (reference only; T-ALL minimal residual disease panel CD1a, CD2, CD3, CD4, CD5, CD8, CD34, CD45, CD56 ACTH or Adenovirus or ALK protein (p80) or Alpha-1-antitrypsin or Alpha-fetoprotein AFP or AMACR (p504s) Alpha-methylacyl-CoA racemase; p504s or Amyloid A AA or Amyloid Beta or Amyloid P or Amyloid A Amyloid P Component Kappa Light Chains Amyloid Type Analysis Lambda Light Chains Transthyretin Congo Red * 88342; 88341x4; Panel makeup subject to change Androgen Receptor or Arginase-1 Arginase or ATRX Alpha Thalassemia/Mental Retardation Syndrome X- Linked or BAP1 BRCA-associated protein or bcl-10 BCL or bcl-2 (Clone 124) BCL2 clone or bcl-2 (Clone C2) BCL2 (Clone C2) or bcl-6 BCL or Ber-Ep4 (epithelial glycoprotein) BerEp4; epithelial glycoprotein or Beta-catenin Catenin-beta or Bg8 (blood group 8) Lewis Y Antigen or Blood Group A Bld Grp A or Blood Group B BLDGPB Blood Group Antigen B or Bob-1 Bob or Brachyury or Breast Multiplex (CK5/14 + P63 + CK7/18), BRG1 SMARCA or c-kit (CD117) CD117; Stem Cell Receptor; ckit or c-myc cmyc Calcitonin or Caldesmon Clone N5(22) or Calponin or Calretinin or Carbonic Anhydrase IX (CA-IX) CA-IX; CAIX or Cathepsin K or CD10 (CALLA) CALLA or CD103 & PAX and CD123 Alternative test to TRAP or CD or CD or CD or CD or CD or CD1a or CD or CD or CD or CD or of 7

4 CD or CD or CD25 (IL-2Rα) Alternative test to TRAP or CD or CD30 (K-1 antigen) or CD31 PECAM or CD or CD or CD or CD or CD or CD42b Platelet glycoprotein Ib or CD or CD or CD or CD56 (NCAM) NCAM or CD or CD or CD68 (KP-1) KP or CD or CD or CD79a or CD or CD or CDH17 Cadherin 17 LI-Cadherin Liver-Intestine Cadherin human peptide transporter 1 HPT or CDX2 Cdx2-D or CEA [monoclonal II-7] CD66e or CEA [polyclonal, to CEA family (CD66)] CEA polyclonal or Chromogranin A (PHE5) PHE or Clusterin or CXCL or Cyclin D1 Alternative test to TRAP or Cytokeratin 17 Cytokeratin 19 Cytokeratin 20 Cytokeratin 5 Cytokeratin 7 Cytokeratin 8, low molecular weight (35βH11) Cytokeratins (AE1/AE3) Cytokeratins (OSCAR) Cytokeratins, high molecular weight (34βE12) 34BE12 Cytomegalovirus Cocktail CMV cocktail or Desmin or DOG1 DOG or E-cadherin or EBV-LMP or EGFR EMA (Epithelial Membrane Antigen) Epithelial Membrane Antigen or ERG or Estrogen Receptor (clone SP1) or or Fascin or FOXP or FOXP or FSH (Follicle Stimulating Hormone) Follicle Stimulating Hormone or Galectin-3 GAL or Gastrin or GATA-3 GATA3, Clone L or GCDFP-15 (Brst2) Brst or GCET1 GCET-1 Germinal Center B-Cell-Expressed Transcript or GFAP (glial-fibrillary acidic protein) GFP8; glial-fibrillary acidic protein or Glucagon or Glycophorin A or Glypican-3 (GPC3) GPC or Granzyme B or Growth Hormone (GH) GH or H3K27me3 anti-tri-methyl-histone-h3 (Lys27) or Hairy Cell Leukemia (DBA.44) DBA or HBME-1 HBME or HCG (ßHCG) ßHCG or Helicobacter Pylori or of 7

5 Hemoglobin Hmgb or Hepatitis B core antigen Hep B Core or Hepatitis B surface antigen Hep B Surface or HepPar1 Antigen Hepatocyte; CSP1; Carbamoyl phosphate synthetase or HER2 4B5 4B HGAL GCET2, GCAT2, GCSAM or HHV8 (Herpes virus 8, human) Human Herpes Virus 8 KSHV HHV or HLA-DR (MHC class II) Class II histocompatibility antigen; HLADR or HMB-45 (gp100) gp100; Melanoma Specific Antigen; HMB or HSVI & HSVII (Herpes Simplex 1 and 2) Herpes Simplex 1 (HSV1); Herpes Simplex 2 (HSV2) or Human Placental Lactogen (HPL) HPL; Placental Lactogen or IDH1, human Human IDH1 R132H Point Mutation; IDH-1; Isocitrate or dehydrogenase 1 IgA or IgD Immunoglobulin D heavy chain or IgG or IgG4 & Total IgG and and/or x number of additional antibodies performed IgM or IMP3 IMP or Inhibin-Alpha or INI-1 (SMARCB1) SMARCB1; BAF47; INI or INPP4B inositol polyphosphate 4-phosatase type II Insulin or Kappa Light Chains or Keratin 17 Cytokeratin 17 CK or Keratin 19 Cytokeratin 19; CK or Keratin 20 Cytokeratin 20; CK or Keratin 5 Cytokeratin 5; CK5-XM or Keratin 7 Cytokeratin 7; CK or Keratin 8, low molecular weight (35ßH11) Cytokeratin 8; low molecular weight (35ßH11); CK8; 35ßH11; 35BH or Keratins (AE1/AE3) Cytokeratins (AE1/AE3); AE1AE or Keratins (OSCAR) Cytokeratins (OSCAR) or Keratins, high molecular weight (34ßE12) Cytokeratins, high molecular weight (34ßE12); 34BE or Ki-67 Antigen (Clone SP6) Ki67; SP Ki-67 Antigen (MIB-1) Ki67; MIB Lambda Light Chains Lambda Light Chains or Langerin (CD207) CD or LEF1 LEF-1; Lymphoid enhancer-binding factor or LMO or Lutinizing Hormone (LH) or Lysozyme Muraminidase or Macrophage (HAM56) HAM or Mammaglobin A or MART-1 Antigen (Melan A) Melan A; MART or Merkel Cell Polyomavirus (MCPyV) MCPyV; MCPV or Mesothelin or Mitochondria or MLH or MMR (correlates with MSI), including: MLH1; MSH2; MSH6; PMS ; 88341x3 MNDA Myeloid cell Nuclear Differentiation Antigen or MOC-31 MOC31; Epithelial glycoprotein or MSH or MSH or MUM1 Interferon regulatory factor or Muscle actins (HHF35) Actin, muscle specific HHF or Myeloperoxidase or MyoD or Myogenin or Myoglobin Mouse Monoclonal, clone MG or NapsinA Naspin A or Nestin or Neu-N NeuN; A or Neurofilaments (2F11) 2F or NKX2.2 NKX or of 7

6 NKX3.1 NKX or NUT or OCT-2 OCT2.1; Octamer transcription factor or Oct3/4 Oct or p16-ink4a p16; E6H or p40 p63 isoform Î Np or p or p57-kip2 p or p or p75-ntr NGFR or Pancreatic Polypeptide (PP) PP or PAP (Prostatic Acid Phosphatase) Prostatic Acid Phosphatase or Parvovirus B or PAX-5 PAX or PAX-6 PAX or PAX-8 PAX or PD-1 (CD279) PD1; Programmed cell death protein 1; CD or PD-L1 (clone 22C3) pharmdx 22C3 PDL PD-L1 (clone 28-8) pharmdx 28-8 PDL PD-L1 (clone EIL3N) PDL1 Programmed Death-Ligand 1, CD PD-L1 (clone SP142) SP142 PDL PLAP (Placental Alkaline Phosphatase) or PMS or Pneumocystis or PNL2 Melanoma Associated Antigen or Podoplanin (D2-40) D or Polyomavirus (BK, JV & SV40 viruses) BK virus; JC virus (Jamestown Canyon); SV40 virus; SV or Progesterone Receptor (clone PgR 636) PR636-D or or Prolactin or Prostate Multiplex (CK5/14 + P63 + P504S), Multiplex PSA (Prostate Specific Antigen) Prostate Specific Antigen or PTEN Phosphatase and tensin homolog or PTH (Parathyroid Hormone) Parathormone; parathyroid hormone or PU.1 ROS1 ROS, MCF3, c-ros or S-100 S or SALL4 SALL or Serotonin or SF-1 SF or SMMHC (smooth muscle myosin heavy chain) Smooth muscle myosin heavy chain or Smooth muscle actin (clone 1A4) 1A or Smoothelin or Somatostatin or SOX10 SRY-related HMG-Box gene or SOX11 MRQ-58, Sox-11, SOX or SSt2A SSt2A; Somatostatin receptor type 2A SSTR or STAT 6 STAT6 Signal Transducer and Activator of Transcription or Synaptophysin or TCL1 TCL1A; p14tcl1; TCL or TCR-ßF1 TCR beta F1; TCRßF1; TCRBF or TdT Terminal deoxynucleotidyltransferase or Thrombomodulin CD or Thymidylate Synthase (TS) TS Thyroglobulin or Thyroid Stimulating Hormone (TSH) TSH beta, TSH-B or TIA-1 TIA or Toxoplasma Gondii or Transthyretin (Pre Albumin) or Tryptase or TTF-1 (thyroid transcription factor 1) TTF1; Thyroid transcription factor or Type IV Collagen Collagen Type IV or Tyrosinase or Uroplakin or Varicella Zoster (VZV) VZV or Villin or Vimentin or VIP (vasoactive intestinal polypeptide) Vasoactive intestinal polypeptide or vwf (Factor VIII related antigen) von Willebrand Factor or WT-1 WT1; Wilms tumor gene product or of 7

7 ZAP-70 ZAP or ImmunofluoresceComplement C or ImmunofluoresceIgA or ImmunofluoresceIgG or ImmunofluoresceIgM or ImmunofluoresceSerum IF or BCR-ABL1, Major BCR-ABL p210, BCR-ABL Mbcr (reference only; BCR-ABL1, Minor BCR-ABL p190, BCR-ABL mbcr (reference only; 81210; may apply BRAF V600 BRAF V600 (in melanoma) (FDA-approved) V600E (melanoma) 81210; may apply Calreticulin Exon 9 CALR EGFR_Roche cobas EGFR Mutation Test (IVD) cobas EGFR IVD 81235; may apply EGFR_Roche cobas EGFR Plasma Mutation Test (IVD) cobas EGFR PLASMA Extended KRAS/NRAS Panel (KRAS exons 81311, (88381 may KRAS exons 3, 4 NRAS exons 2, 3, & 4 3 & 4, NRAS exons 2,3 & 4) apply) Ig-Kappa gene rearrangement B cell (Kappa) clonality 81264; may apply; IgH (B cell) gene rearrangement B cell (IgH) clonality 81261; may apply; JAK2 V617F Janus Kinase 2, JAK2 V617F 81270; may apply KRAS, cobas Mutation Test IVD KRAS, KRAS IVD, cobas KRAS, KRAS exon 2, KRAS codons 12 & (88381 may apply) 81301; may apply; MSI by Microsatellite Instability MSI MYD88 L265P Mutation RAS Panel (KRAS exon 3 & 4; NRAS exons 2,3 & 4) 81340; may apply; TCR-beta gene rearrangement TCR-gamma (T-cell) gene rearrangement T cell clonality 81342; may apply; Special Stains Acid Fast Bacteria AFB Special Stains Alcian Blue Special Stains B&B (Brown & Brenn) BBGRAM Special Stains Colloidal Iron Stain Special Stains Congo Red Special Stains Grocott Methenamine Silver GMS Special Stains Masson's Trichrome Trichrome Special Stains Mucin Special Stains Myeloperoxidase (MPO) MPO Special Stains Oil Red O Special Stains Periodic Acid Schiff (PAS) Special Stains Periodic Acid Schiff (PAS) with Diastase Special Stains Perl's Iron Stain Perls Special Stains PTAH Special Stains Reticulin, Gordon & Sweet's Gordon & Sweet's Special Stains Verhoeff Van Gieson (VVG) Special Stains Wright-Giemsa Wright's of 7