Your single-source laboratory solution. Antibody Library

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1 Your single-source laboratory solution. Antibody Library

2 A-ACT Alpha-1 antichymotrypsin; histiocytes; pancreatic pseudopapillary tumor A-AT Alpha-1-antitrypsin; inherited AAT deficiency ACTH Adrenocorticotropic hormone; anterior pituitary Actin - Muscle Specific Actin - Smooth Muscle (SMA) Skeletal, smooth, and cardiac muscle; myofibroblastic differentiation Myofibroblasts; myoepithelial cells Adenovirus Adenovirus Adipophilin Identification of sebaceous neoplasms AE1 Cytokeratin AE1; epithelial marker AE1/AE3 Screening cytokeratin cocktail; epithelial marker AE3 Cytokeratin AE3; high molecular weight cytokeratin; epithelial marker AFP Alpha fetoprotein; hepatocellular carcinoma; hepatoid carcinoma; yolk sac tumor AKT Phosphate AKT (protein kinase B) ALK (D5F3) FDA-approved CDx; identifies NSCLC patients eligible for crizotinib ALK-1 Anaplastic lymphoma kinase-1; anaplastic large-cell lymphoma; inflammatory myofibroblastic tumor; adenocarcinoma of lung subset Alpha Beta Flow T-cell receptor Amyloid A Amyloid A protein Androgen Receptor Prostate carcinoma; associated with prognosis and treatment outcome Annexin A1 Hairy cell leukemia; myeloid cells Arginase-1 Benign and hepatocellular carcinoma (HCC) B72.3 Simple epithelium; adenocarcinoma; excludes mesothelioma BCA-225 Breast carcinoma-associated glycoprotein; breast carcinoma and other adenocarcinoma BCL-1 (Cyclin D1) Mantle cell lymphoma; multiple myeloma subset BCL-1/CD20 Double stain; useful for the diagnosis of mantle cell lymphoma 1

3 BCL-2 /Flow Follicular lymphoma; other B- and T-cell lymphoma; soft tissue tumor BCL-2/BCL-6 Double stain; useful for the diagnosis of follicular center cell lymphoma, diffuse large-cell type BCL-6 Follicular center B-cells; follicular lymphoma; DLBCL subset Ber-EP4 /Flow Epithelial antigen; carcinoma; differentiate carcinoma from mesothelioma Beta Amyloid Alzheimer s disease; senile plaques; neurofibrillary tangles; cerebrovascular deposits Beta-Catenin Soft tissue lesion; fibromatosis; synovial sarcoma BG8 (Lewis Y) Adenocarcinoma; exclude mesothelioma BOB-1 B-cells CA 19.9 Pancreas, GI, ovary, lung, and transitional cell carcinoma CA 125 (OC125) Female genital tract; breast carcinoma; other adenocarcinoma including lung and pancreatobiliary CAIX Carbonic anhydrase IX; renal cell carcinoma (RCC); distinguish clear cell renal cell carcinoma from other RCC subset Calcitonin Thyroid C-cells; medullary carcinoma Caldesmon Smooth muscle and myoepithelial cells Calponin Myoepithelial, myofibroblastic, and smooth muscle cells Calretinin Mesothelial cells; sex cord stromal tumor; adrenal cortical tumor CAM 5.2 Low molecular weight cytokeratin 8; epithelial neoplasm CAM 5.2/AE1 Screening cytokeratin cocktail; epithelial tumor CD1a /Flow Cortical thymocytes; Langerhans cell histiocytosis; T-ALL subset CD2 /Flow Pan, thymic, and peripheral T-cells; NK cells; neoplastic mast cells CD3 /Flow Pan T-cells CD3/CD20 Double stain; useful to distinguish B-cells (CD20+) and T-cells (CD3+) CD4 /Flow Helper/inducer T-cells; thymocyte and monocyte subsets CD5 /Flow Pan T-cells; B-cell lymphoma subset (B-CLL/SLL and MCL); thymic carcinoma 2

4 CD7 /Flow Pan T-cells; NK cells, thymocytes; rare AML CD8 /Flow Suppressor/cytotoxic T-cells; thymocyte and T-/NK cell subsets; T-LGL leukemia CD10 /Flow CALLA; B- and T-cell lymphoma subsets; endometrial stromal cells; renal cell carcinoma subset CD11a Flow Leukocytes; utilized in the assessment for leukocyte adhesion deficiency (LAD) CD11b Flow Granulocytes; monocytes CD11c Flow Monocytes/macrophages; hairy cell leukemia; AML subset CD13 Flow Monocytes/macrophages; myeloid cells CD14 /Flow Mature monocytes; some granulocytes; macrophages CD15 /Flow Epithelial, myeloid, and Reed-Sternberg cells; Hodgkin lymphoma CD16 Flow NK cells; granulocytes; neutrophils; monocytes CD18 Flow Leukocytes; utilized in the assessment for leukocyte adhesion deficiency (LAD) CD19 Flow Pan B-cell marker CD20 /Flow Pan B-cells CD21 Follicular dendritic cells; B-cell subset CD22 /Flow Pan B-cells CD23 /Flow Follicular dendritic cells; B-cell subset; B-CLL CD24 Flow Variety of leukocytes; GPI-linked; utilized in the assessment for PNH CD25 /Flow Activated T- and B-cells; HCL; ATLL CD26 Flow Evaluation of mycosis fungoides and Sezary syndrome CD30 /Flow Reed-Sternberg cells; anaplastic large-cell lymphoma; DLBCL subset; Hodgkin lymphoma; embryonal carcinoma CD31 Endothelium; vascular neoplasm; plasma cells CD33 /Flow Monocytes; myeloid cells; AML; ALL subset CD34 /Flow Blasts; stem cells; endothelium; GIST; soft tissue tumor subset CD35 Follicular dendritic cells CD38 Flow Plasma cells; activated T-, B-, and myeloid cells; epithelial tumor subset CD41a Flow Platelets; megakaryocytes 3

5 CD42a Flow Megakaryocytes; platelets CD43 /Flow T-cells; B-cell lymphoma subset (B-CLL/SLL, MCL, Burkitt); plasma and myeloid cells; histiocytes CD45 (LCA) /Flow Leukocyte common antigen CD45RA B-cells CD45RO Activated/memory T-cells; B-cell subset CD52 Flow Thymocytes; lymphocytes; monocytes; macrophages CD55 Flow Leukocytes; erythrocytes CD56 /Flow Neural and neuroendocrine tumor; soft tissue tumor subset; NK cells; plasma and T-cell subsets; LGL leukemia CD57 /Flow Neural and neuroendocrine tumor; thymoma; NK cells; T-LGL leukemia; T-cell subset CD59 Flow Leukocytes; erythrocytes; PNH CD61 /Flow Megakaryocytes; platelets CD62 Flow Activated platelets CD64 Flow Monocytes; macrophages CD68 Histiocytes; macrophages CD71 /Flow Erythroid precursors and large-cell lymphoma; transferrin receptor; activated T- and B-cells; macrophages CD74 B-cells CD79a /Flow Pan B-cells CD79b Flow A component of the CLL MRD panel CD81 Flow Expressed by many tissue types, including hematopoietic cells; a component of the CLL MRD panel CD99 PNET/Ewing sarcoma; soft tissue tumor subset; sex cord stromal tumor CD103 Flow Hairy cell leukemia; enteropathy type T-cell lymphoma CD117 (c-kit) /Flow GIST; subset of carcinoma including adenoid cystic carcinoma; germ cell neoplasm; hematolymphoid neoplasm CD123 Dendritic cell precursors; type 2 (DC2) cells; blastic plasmacytoid dendritic cell neoplasm (BPDCN) CD138 /Flow Plasma cells; subset of epithelial cells CD158a Flow Subsets of NK cells and T-cells; utilized in the assessment of NK cell proliferations 4

6 CD158b Flow Subsets of NK cells and T-cells; utilized in the assessment of NK cell proliferations CD158e Flow Subsets of NK cells and T-cells; utilized in the assessment of NK cell proliferations CD163 Monocytes; macrophages; dendritic interstitial cells CDK4 Atypical lipomatous tumor and dedifferentiated liposarcoma CDX-2 Enteric differentiation; GI tumor; colorectal carcinoma; carcinoid tumor subset CDX-2/CK-7 Double stain; useful to distinguish stomach and colon carcinoma from breast, lung, and ovarian carcinoma CEA (M) Carcinoembryonic antigen (monoclonal); adenocarcinoma CEA (P) Carcinoembryonic antigen (polyclonal); epithelial marker; adenocarcinoma subset; negative in mesothelioma Chromogranin A Neuroendocrine neoplasm; paraganglioma Chymotrypsin Exocrine pancreas; acinar cell tumor CK-5 Tumor with squamous differentiation; squamous cell vs. adenocarcinoma of lung classification; myoepithelial cells; benign vs. malignant breast intraductal proliferation CK-5/6 Tumor with squamous differentiation; squamous cell vs. adenocarcinoma of lung classification; myoepithelial cells; benign vs. malignant breast intraductal proliferation CK-7 Various subtypes of carcinoma; frequently used in conjunction with CK-20 for tumor profiling CK-7/TTF-1 Double stain; useful for the diagnosis of lung adenocarcinoma CK-14 High molecular weight cytokeratin; tumor with squamous differentiation; myoepithelial cells; breast carcinoma with basal-like phenotype CK-17 High molecular weight cytokeratin; tumor with squamous differentiation; pancreatobiliary adenocarcinoma; breast carcinoma with basal-like phenotype CK-18 Low molecular weight cytokeratin CK-19 Epithelial tumor; papillary carcinoma of the thyroid vs. benign thyroid lesion CK-20 Subset of carcinoma; reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells 5

7 CK-HMW (34betaE12) CK-LMW (35betaH11) CK-903; broad-spectrum high molecular weight cytokeratin; squamous cell and subsets of adenocarcinoma and transitional cell carcinoma; prostate basal cells; prostate carcinoma vs. adenosis/pin CK8/CK18; epithelial neoplasm with simple epithelium cmet Non-small cell lung carcinoma CMV Cytomegalovirus cmyc Burkitt Lymphoma and some large B-cell lymphomas COLL-IV Collagen type IV; basement membrane material; soft tissue tumor subset COX-2 Cyclooxygenase-2; prognostic and predictive marker in a variety of tumors Cytokeratin FLOW CD45 non-hematopoietic cells D2-40 Evaluation of lymphatic endothelial differentiation for lymphatic invasion; subset of angiosarcoma; vascular tumor of lymphatic origin; mesothelioma DBA44 (HCL) Hairy cell leukemia Desmin Striated and smooth muscle; leiomyosarcoma; rhabdomyosarcoma; desmoplastic small round cell tumor DOG1 GIST, in particular CD117-negative lesion EBER - ISH ISH Epstein-Barr early RNA; Epstein-Barr virus identification EBV (LMP1) Epstein-Barr virus; latent membrane protein E-Cadherin Ductal vs. lobular lesion of breast; positive in ductal lesion and negative in lobular neoplasia EGFR Epidermal growth factor receptor; colon and lung carcinoma; basal-phenotype breast carcinoma EMA Epithelial membrane antigen; epithelial marker; subset of sarcoma, meningioma, and hematolymphoid neoplasm ER Estrogen receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset Factor VIII (vwf) Von Willebrand factor; endothelial marker; vascular neoplasm; blast cells in acute megakaryocytic leukemia Factor XIIIa Dermal dendrocytes and dendritic interstitial cells; used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans; fibrohistiocytic neoplasm 6

8 Fascin Hodgkin and Reed-Sternberg cells FLAER Flow Binds to GPI anchor on leukocytes; utilized in the assessment for PNH FLI-1 Endothelial vascular cells/tumor; Ewing sarcoma/pnet; lymphoblastic lymphoma/leukemia FMC7 Flow B-cell neoplasm; mantle cell lymphoma FOXP1 Subclassification of large B-cell lymphomas FSH Follicular-stimulating hormone; anterior pituitary Galectin-3 Benign vs. malignant thyroid follicular neoplasm, in particular papillary carcinoma Gamma Delta Flow Gamma delta T-cell receptor; T-cell subset Gastrin Gastric carcinoid; pancreatic endocrine neoplasm subset GATA-3 Breast and urothelial carcinomas GCDFP-15 Gross cystic disease fluid protein-15; breast carcinoma; salivary and sweat gland neoplasm GFAP Glial fibrillary acidic protein; glioma; lesion with glial differentiation; salivary gland tumor; neural neoplasm subset Glucagon Pancreatic endocrine neoplasm Glycophorin A /Flow Erythroid cells Glypican-3 Hepatocellular carcinoma; germ cell tumor; yolk sac tumor Granzyme B Cytotoxic T-cell subset; NK cells Growth Hormone (GH) Growth hormone; anterior pituitary GST Distinguish Hodgkin disease and histiocytic malignancy from T-cell lymphoma HAM 56 Histiocytes HBME-1 Mesothelial cells; subset of adenocarcinoma, in particular lower female genital tract origin; papillary carcinoma of the thyroid HBP (H. pylori) Helicobacter pylori HCG Human chorionic gonadotropin (beta); germ cell tumor; trophoblastic disease Hemoglobin A Red cell precursors HEP B CORE (HBcAg) Hepatitis B core antigen; hepatitis B 7

9 HEP B SURF (HBsAg) Hepatitis B surface antigen; hepatitis B HepPar 1 Hepatocellular carcinoma; hepatoid tumor; germ cell tumor HER2 HER2 protein overexpression; FDA-approved test for detection of HER2/neu; prognostic and predictive indicator in breast carcinoma HER2 - ISH ISH HER2 gene amplification; FDA-approved test for detection of HER2 amplification; prognostic and predictive indicator in breast carcinoma Herpes I/II Double stain; Herpes simplex virus type I/II HGAL Subclassification of large B-cell lymphomas; diagnosis of follicular lymphoma HHV-8 Human herpesvirus 8; Kaposi s sarcoma; primary effusion lymphoma HLA-DR /Flow Human leukocyte antigen; MHC class II antigen; B-cells; monocytes; myeloid cells; AML; ALL HMB-45 Melanoma-associated marker; melanocytic lesion; pecoma HPL Human placental lactogen; intermediate trophoblasts; placental site trophoblastic lesion HPV (6/11) - ISH ISH Low-risk human papilloma virus subtypes HPV (16/18) - ISH ISH High-risk human papilloma virus subtypes HPV (31/33) - ISH ISH High-risk human papilloma virus subtypes IgA /Flow Immunoglobulin A heavy chain IgD /Flow Immunoglobulin D heavy chain IgG /Flow Immunoglobulin G heavy chain IgG4 IgG4-related sclerosing disease IgM /Flow Immunoglobulin M heavy chain Inhibin Sex cord stromal and adrenal cortical tumor; steroid lesion of the ovary Insulin Pancreatic endocrine neoplasm JC Virus - ISH ISH Progressive multifocal leukoencephalopathy virus Kappa /Flow Immunoglobulin light chain; B-cells and plasma cells Kappa - ISH ISH Immunoglobulin light chain; B-cells and plasma cells RNA KER, PAN Broad-spectrum cytokeratin cocktail 8

10 Ki-67 Cell proliferation marker Lambda /Flow Immunoglobulin light chain; B-cells and plasma cells Lambda - ISH ISH Immunoglobulin light chain; B-cells and plasma cells RNA LH Luteinizing hormone; anterior pituitary Lipase Exocrine pancreas; acinar cell tumor Lysozyme (MURA) Muramidase; AML; granulocytic sarcoma; histiocytic differentiation Mammaglobin Breast carcinoma; salivary gland lesion and sweat gland neoplasm MART-1 Melanoma-associated marker MBP Myelin basic protein; mucin; pancreatic carcinoma vs. chronic pancreatitis; colorectal carcinoma; endometrial carcinoma; Barrett s esophagus M-Cell Tryptase Mast cells MDM2 Atypical lipomatous tumor and dedifferentiated liposarcoma MEL-5 Melanoma-associated marker Melan-A Melanoma-associated marker; melanocytic lesion and adrenal cortical neoplasm; pecoma Melan-A/Ki-67 Double stain; useful to distinguish malignant melanoma from benign melanocytic proliferation Mesothelin Mesothelioma MiTF Malignant melanoma; melanocytic lesion MLH-1 DNA mismatch repair protein MOC-31 Epithelial differentiation; adenocarcinoma vs. mesothelioma MPO /Flow Myeloperoxidase; AML; granulocytic sarcoma MSH-2 DNA mismatch repair protein MSH-6 DNA mismatch repair protein MUC1 Pancreatobiliary and extra-pancreatobiliary non-mucinous adenocarcinoma MUC2 Colorectal adenocarcinoma and mucinous adenocarcinoma of various sites MUC4 Epithelial tumor (breast, lung, cervix); pancreatic carcinoma 9

11 MUC5AC MUC5AC glycoprotein; distinguish primary mucinous ovarian tumor from colonic carcinoma metastatic to the ovary MUM-1 Plasma cells; post-germinal B-cells; activated T-cells; Reed-Sternberg cells; DLBCL subset MYO DI Rhabdomyosarcoma Myogenin Rhabdomyosarcoma Myoglobin Rhabdomyosarcoma Myosin Heavy Chain (SMM-HC) Smooth-muscle myosin heavy chain; breast myoepithelial cells Napsin A Lung adenocarcinoma NB84a Neuroblastoma tumor cells (for bone marrow aspirate and stem cell products, fresh specimen only) NEU-N Neuronal differentiation NF Neurofilament; Merkel cells and neural tumor NKI-C3 Melanoma-associated marker; melanocytic lesion and neurothekeoma NPM Nucleophosmin; nucleophosmin mutations in AML NSE Neuron-specific enolase; present in neurons and neuroendocrine cells (central and peripheral) OCT-2 B-cell lymphocyte transcription factor; B-cells OCT-3/4 icular germ cell tumor, in particular seminoma and embryonal carcinoma OSCAR Broad-spectrum cytokeratin; epithelial lesion p16 HPV-associated dysplasia/carcinoma (CINtec p16ink4a) p21 Tumor suppressor gene p27/kip1 Cyclin-dependent kinase inhibitor p40 Squamous cell marker p53 Mutated tumor suppressor gene p57 Molar vs. non-molar gestation; distinguish complete hydatidiform mole (CHM) from partial hydatidiform mole (PHM) and hydropic villi p63 Prostatic basal cells; breast myoepithelial cells; squamous cell carcinoma p120 Ductal vs. lobular breast lesion; lobular breast carcinoma 10

12 P504S Prostatic carcinoma and high grade PIN; subset of renal cell carcinoma Pan Melanoma Cocktail Pan Melanoma Double Stain Cocktail (MART-1, tyrosinase, HMB45); for melanoma and melanocytic lesion; pecoma Double Stain (MART-1/Tyrosinase, S100); for melanoma and melanocytic lesion; pecoma PANC.POLY Pancreatic islet-cell tumor subset Parvovirus B19 Parvovirus PAX-2 Renal cell carcinoma PAX-5 B-cell transcription factor; B-cells; Reed-Sternberg cells; subset of carcinoma including small-cell carcinoma PAX-5/BCL2 Double stain; Follicular lymphoma and subsets of diffuse large cell B-cell lymphoma PAX-5/CD43 Double stain; useful for the identification of CD43-coexpressing B-cell lymphoma PAX-5/CD5 Double stain; useful for the identification of CD5-coexpressing B-cell lymphoma PAX-8 Renal cell carcinoma, GYN and follicular derived thyroid carcinoma PC (P. carinii) Pneumocystis carinii PD1 (heme) Angio immunoblastic T-cell lymphoma (AITL); germinal center T-cells PD-L1 (22C3) FDA-approved CDx in NSCLC patients for pembrolizumab. Global service only. PD-L1 (28-8) FDA-approved complementary Dx in non-squamous NSCLC and melanoma for nivolumab. Global service only. PD-L1 (SP142) FDA-approved complementary Dx in urothelium and NSCLC for atezolizumab. Global service only. Perforin Lymphomas of cytotoxic or NK derivation PGP 9.5 Protein gene product 9.5; neuroendocrine tumor PLAP Placental alkaline phosphatase; germ cell tumor; trophoblastic disease and subset of adenocarcinoma PMS-2 DNA mismatch repair protein PR Progesterone receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset 11

13 Prolactin Anterior pituitary hormone PSA Prostate-specific antigen; primary and metastatic prostatic neoplasm PSAP Prostatic acid phosphatase; primary and metastatic neoplasm; carcinoid tumor subset PSMA Prostate adenocarcinoma PTEN Cowden syndrome; carcinoma of the bladder, breast, endometrium, head and neck, kidney, lung, prostate, stomach, and thyroid; glioblastoma; melanoma PTH Parathyroid hormone; parathyroid neoplasm PTS Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs. prostate carcinoma RB Retinoblastoma gene protein; retinoblastoma RCC (PNRA) Renal cell carcinoma S100 Neural tumor; melanoma; chondrocytes; epithelial neoplasm subset SALL4 Seminoma, embryonal and yolk sac germ-cell tumors Serotonin Carcinoid; pancreatic endocrine neoplasm Somatostatin Somatostatin; islet cell tumor; carcinoid; pancreatic endocrine neoplasm SOX10 Melanoma and neural neoplasms SOX11 Mantle cell lymphomas; gliomas Surfactant (SP-A) Surfactant protein A; lung adenocarcinoma Synaptophysin Neural and neuroendocrine-derived tumor Synuclein Neurodegenerative diseases (synucleinopathies); Parkinson s disease TAU Neurofibrillary tangles; Lewy bodies TCL-1 Ewing sarcoma/pnet; blastic plasmacytoid dendritic cell neoplasm (BPDCN) TCR BETA /Flow Alpha-beta T-cells TdT /Flow Terminal deoxynucleotidyl transferase; cortical thymocytes; B-ALL; T-ALL Thrombomodulin Mesothelial cells; mesothelioma; lymphatic and vascular tumor Thyroglobulin Follicular and papillary carcinoma of the thyroid 12

14 TIA-1 T-cell intracytoplasmic antigen; cytotoxic T-cell subset TLE1 Synovial sarcoma TOXO Toxoplasmosis TRAP Tartrate-resistant acid phosphatase; hairy cell leukemia TriView Breast Breast triple stain (CK5/p63/LMW); useful to differentiate DCIS from microinvasive breast carcinoma; differentiate radial scar from infiltrating carcinoma TriView Prostate Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs. prostate carcinoma Trypsin Exocrine pancreas; acinar cell tumor TS Thymidylate synthase; prognostic and predictive indicator for 5-FU-based chemotherapy in colorectal carcinoma TSH Thyroid stimulating hormone; anterior pituitary TTF-1 Thyroid transcription factor-1; lung and thyroid carcinoma; subset of small cell carcinoma Tyrosinase Malignant melanoma; melanocytic lesion Ubiquitin Neurofibrillary tangles; Lewy bodies Uroplakin Transmembrane protein expressed by urothelium VEGF Vascular endothelial growth factor; stimulates endothelial cell proliferation; induces microvessel permeability; prognostic indicator Villin Differentiate gastrointestinal adenocarcinoma, neuroendocrine carcinoma, and ovarian adenocarcinoma from other adenocarcinoma; label Merkel cells of the skin Vimentin (VIM) Mesenchymal neoplasms; malignant melanoma and subsets of carcinoma and lymphoma VIP Vasoactive intestinal polypeptide; pancreatic endocrine neoplasm VZV Varicella-Zoster virus WT1 (M) N-Terminus WT1 (P) C-Terminus Wilms tumor protein; mesothelial cells; malignant mesothelioma; ovarian adenocarcinoma; sex cord stromal tumor of the ovary; endometrioid stromal neoplasm Wilms tumor protein carboxyl terminal; desmoplastic small round cell tumor ZAP-70 /Flow T-cells; CLL/SLL prognosis 13

15 Marker Specimen Requirements Immunohistochemistry () Fixed Paraffin Block with corresponding H&E, if available Tissue should be well-fixed in formalin; if alternative fixative is used, it should be noted on the requisition 0.2 cm x 0.2 cm x 0.2 cm tissue Store specimen at room temperature Use cold pack for transport; be sure cold pack is not in direct contact with specimen during transport Unstained Slides Send all slides within 6 weeks of cutting Minimum of 2 slides per antibody Precut slides from paraffin blocks in 5 micron sections Mounted on Poly-L-Lysine coated or plus (+) slides Air dry; do not oven dry Store specimen at room temperature Use cold pack for transport; be sure cold pack is not in direct contact with specimen during transport Body Fluids Process fluids into formalin-fixed, paraffin-embedded cell blocks or cytospin preparation In Situ Hybridization (ISH) Fixed Paraffin Block with corresponding H&E, if available Tissue should be well-fixed in formalin. Please Note: Only formalin-fixed tissue will be accepted for ISH testing 0.2 cm x 0.2 cm x 0.2 cm tissue Store specimens at room temperature Use cold pack for transport. Be sure cold pack is not in direct contact with specimen during transport Unstained Slides Send all slides within 6 weeks of cutting slides should be sent for HPV testing and 6-8 slides for JC, Kappa, Lambda, and EBER testing Precut slides from paraffin block in 5 micron sections and mounted on Poly-L-Lysinecoated or plus (+) slides Air dry; Do not oven dry Body Fluids Process fluids into formalin-fixed, paraffin-embedded cell blocks Immunophenotyping by Flow Cytometry Fresh tissue Bone marrow Peripheral blood 14

16 Integrated Oncology your single-source laboratory solution. More than 490,000 tests performed on 225,000+ patients annually 1,600 contractual relationships with plans, payors, and other health care organizations across the US, some of which are on an exclusive basis Integrated with more than 700 electronic medical records (EMR) and practice management systems Menu of more than 450 genetic, pathology,, and FISH tests, including 15 oncology-specific pharmacogenetic tests Staff of more than 75 pathologists, PhDs, and genetic counselors dedicated to oncology and familial cancer testing More than 65 oncology- and pathology-specific publications and presentations since 2013 Lab Locations Arizona Integrated Oncology 5005 South 40th Street Phoenix, AZ Fax New York Integrated Oncology 521 West 57th Street, Sixth Floor New York, NY Fax North Carolina LabCorp Center for Molecular Biology and Pathology 1912 Alexander Drive Research Triangle Park, NC Fax Tennessee Integrated Oncology 201 Summit View Drive, Suite 100 Brentwood, TN Fax access answers actions CINtec is a registered trademark and service mark of ROCHE mtm laboratories AG Laboratory Corporation of America Holdings. All rights reserved. onc-011-v L

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