AAV Apolipoprotein D APOD Lipid transport AAA Complement C3 C3 Inflammatory response/complement
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1 Supplementry Tble 1. Smple 1 A25T + CSF. AAA Immunoglobulin mu chin Inflmmtory response/complement AAV Apolipoprotein D APOD Lipid trnsport AAA Complement C3 C3 Inflmmtory response/complement AAK Fibulin-1 FBLN1 Host-virus interction NP_ EGF-contining fibulin-like extrcellulr EFEMP1 peptidyl-tyrosine phosphoryltion H7I_A Apolipoprotein E APOE Lipid trnsport NP_ Kininogen-1 KNG1 Blood cogultion/inflmmtory response AAA Complement C4-A C4A Inflmmtory response/complement AAA Fibrinogen bet chin FGB Blood cogultion CAA Complement fctor H CFH Inflmmtory response/complement EAW HCG , isoform CRA_b PLG Blood cogultion (Plsminogen) BAA Complement C1s subcomponent C1S Inflmmtory response/complement B45874 Ig lph-1 chin C region IGHA1 Inflmmtory response CAA Ig gmm-3 chin C region IGHG3 Inflmmtory response P01857 Ig gmm-1 chin C region IGHG1 Inflmmtory response AAA52282 Angiotensinogen AGT regultion of ntriuresis NP_ Prostglndin-H2 D-isomerse PTGDS Ftty cid biosynthesis AAA Complement component C7 C7 Inflmmtory response/complement AAA Ectonucleotide pyrophosphtse/phosphodiesterse fmily member 2 Complement C1q subcomponent subunit B ENPP2 Chemotxis/Lipid degrdtion P02746 C1QB Inflmmtory response/complement NP_ Gelsolin GSN Cilium biogenesis/degrdtion BAA Ceruloplsmin CP oxidtion-reduction process AAA Complement component C9 C9 Inflmmtory response/complement CAA Prothrombin F2 Acute phse/blood cogultion NP_ Complement component C8 lph chin C8A Inflmmtory response/complement CAA Monocyte differentition ntigen CD14 CD14 Inflmmtory response CAA Actin, cytoplsmic 1 ACTB dherens junction orgniztion AAA Clusterin CLU Apoptosis/Inflmmtory
2 response/complement ª Fibrinogen lph chin FGA Blood cogultion ATH_A Antithrombin-III SERPINC1 Blood cogultion CAA Complement component C8 bet chin C8B Inflmmtory response/complement EAW Fc frgment of IgG binding protein Inflmmtory response/complement AAA Vitmin K-dependent protein S PROS1 Blood cogultion CAA Fibronectin FN1 Cell dhesion AAA Complement C5 C5 Inflmmtory response/complement Significnt threshold p<0.05 (Mscot score >45). b Exponentilly Modified Protein Abundnce Index (empai)
3 Supplementry Tble 1. Smple 2 A25T + CSF. P01619 Ig kpp chin V-III region B6 Inflmmtory response/complement CAA Ig gmm-3 chin C region IGHG3 Inflmmtory response P01857 Ig gmm-1 chin C region IGHG1 Inflmmtory response P01764 Ig hevy chin V-III Inflmmtory response/complement P01834 Ig kpp chin C region IGKC Inflmmtory response/complement P02746 Complement C1q subcomponent subunit C1QB Inflmmtory response/complement B P0CG05 Ig lmbd-2 chin C regions IGLC2 Inflmmtory response/complement AAA Fibrinogen bet chin FGB Blood cogultion NP_ EGF-contining fibulin-like extrcellulr EFEMP1 peptidyl-tyrosine phosphoryltion AAA Complement C3 C3 Inflmmtory response/complement P01034 Cysttin-C CST3 defense response B45874 Ig lph-1 chin C region IGHA1 Inflmmtory response H7I_A Apolipoprotein E APOE Lipid trnsport BAA Complement C1s subcomponent C1S Inflmmtory response/complement AAV Apolipoprotein D APOD Lipid trnsport AAK Fibulin-1 FBLN1 Host-virus interction CAA Actin, cytoplsmic 1 ACTB dherens junction orgniztion CAA Monocyte differentition ntigen CD14 CD14 Inflmmtory response AAA Clusterin CLU Apoptosis/Inflmmtory response/complement NP_ Kininogen-1 KNG1 Blood cogultion/inflmmtory response ATH_A Antithrombin-III SERPINC1 Blood cogultion AAA Complement C4-A C4A Inflmmtory response/complement BAA Ceruloplsmin CP oxidtion-reduction process P01023 Alph-2-mcroglobulin A2M blood cogultion Significnt threshold p<0.05 (Mscot score >45). b Exponentilly Modified Protein Abundnce Index (empai)
4 Supplementry Tble 1. CSF P02768 Serum lbumin ALB O14786 Neuropilin-1 NRP1 cell-cell signling P01034 Cysttin-C CST3 defense response A2NB43 Cold gglutinin FS-1 H-chin IGH@ P01834 Ig kpp chin C region IGKC Inflmmtory response/complement P02766 Trnsthyretin TTR trnsport NP_ Prostglndin-H2 D-isomerse PTGDS Ftty cid biosynthesis P02787 Serotrnsferrin TF cellulr iron ion homeostsis H7I_A Apolipoprotein E APOE Lipid trnsport P00738 hptoglobin HP cellulr iron ion homeostsis P0CG05 Ig lmbd-2 chin C regions IGLC2 Inflmmtory response/complement AAV Apolipoprotein D APOD Lipid trnsport P13987 CD59 glycoprotein CD59 blood cogultion humnized murine nti-veev ntibody Hy4-26C hevy chin BAB unnmed protein product unknown P68871 Hemoglobin subunit bet HBB blood cogultion P07998 Ribonuclese pncretic RNASE1 nucleic cid binding AAA Complement C3 C3 Inflmmtory response/complement P04217 Alph-1B-glycoprotein A1BG unknown P61916 Epididyml secretory protein E1 NPC2 cholesterol efflux P02765 Alph-2-HS-glycoprotein AHSG Minerl blnce Q9UBP4 Dickkopf-relted protein 3 DKK3 trnscription repressor ctivity P01011 Alph-1-ntichymotrypsin SERPINA3 cute-phse response AAA Clusterin CLU Apoptosis/Inflmmtory response/complement P02763 Alph-1-cid glycoprotein 1 ORM1 cute-phse response P05060 Secretogrnin-1 CHGB hormone ctivity P02790 Hemopexin HPX cellulr iron ion homeostsis Q92520 Protein FAM3C FAM3C multicellulr orgnisml development P02774 Vitmin D-binding protein GC hormone biosynthetic process P04156 Mjor prion protein PRNP xon guidnce NP_ Gelsolin GSN Cilium biogenesis/degrdtion Q16270 Insulin-like growth fctor-binding protein IGFBP7 cell dhesion P01764 Ig hevy chin V-III Inflmmtory response/complement P10451 Osteopontin SPP1 biominerl tissue development
5 AAA Complement C4-A C4A Inflmmtory response/complement P01861 Ig gmm-4 chin C region IGHG4 immune response P01023 Alph-2-mcroglobulin A2M blood cogultion P01009 Alph-1-ntitrypsin SERPINA1 cute-phse response NP_ Kininogen-1 KNG1 Blood cogultion/inflmmtory response NP_ EGF-contining fibulin-like extrcellulr EFEMP1 peptidyl-tyrosine phosphoryltion AAA52282 Angiotensinogen AGT regultion of ntriuresis P08697 Alph-2-ntiplsmin SERPINF2 cute-phse response P10645 Chromogrnin-A CHGA regultion of blood pressure P00751 Complement fctor B CFB Inflmmtory response/complement Q14515 SPARC-like protein 1 SPARCL1 signl trnsduction CAA Complement fctor H CFH Inflmmtory response/complement Q12860 Contctin-1 CNTN1 Notch signling CAA Fibronectin FN1 Cell dhesion Significnt threshold p<0.05 (Mscot score >45). b Exponentilly Modified Protein Abundnce Index (empai).
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