Symbol Name Con Simva Atorva ANOVA Simvastatin - Downregulated Simvastatin - Upregulated

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1 Symbol Name Con Simva Atorva ANOVA Simvastatin - Downregulated Asb13 ankyrin repeat and SOCS box-containing protein / / / Ascc3 activating signal cointegrator 1 complex subunit / / / Cav2 caveolin / / / Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide / / / Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide / / / Dr1 down-regulator of transcription / / / Eaf1 ELL associated factor / / / Gmppa GDP-mannose pyrophosphorylase A 308 +/ / / Grm5 glutamate receptor, metabotropic / / / Mcart1 mitochondrial carrier triple repeat / / / Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily / / / Phyhip phytanoyl-coa hydroxylase interacting protein / / / Rbbp4 retinoblastoma binding protein / / / Slc35f4 solute carrier family 35, member F / / / Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) / / / Suv39h2 suppressor of variegation 3-9 homolog 2 (Drosophila) 178 +/ / / Topbp1 topoisomerase (DNA) II binding protein / / / Tpo1 developmentally regulated protein TPO / / / Ugt8a UDP galactosyltransferase 8A / / / Uhrf1 ubiquitin-like, containing PHD and RING finger domains, / / / Zmym4 zinc finger, MYM-type / / / Simvastatin - Upregulated Acss2 acyl-coa synthetase short-chain family member / / / Capn7 calpain / / / Ccdc72 coiled-coil domain containing / / /

2 Cck cholecystokinin / / / Clca3 chloride channel calcium activated / / / Cnpy3 canopy 3 homolog (zebrafish) 229 +/ / / Cyp51 cytochrome P450, subfamily / / / Egfl7 EGF-like domain / / / Enoph1 enolase-phosphatase / / / Gpkow G patch domain and KOW motifs 148 +/ / / Hadha hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzy / / / Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase / / / Klhl22 kelch-like 22 (Drosophila) 364 +/ / / Mboat5 membrane bound O-acyltransferase domain containing / / / Mvd mevalonate (diphospho) decarboxylase 290 +/ / / Nppa natriuretic peptide precursor type A 233 +/ / / E-06 Psmc5 protease (prosome, macropain) 26S subunit, ATPase / / / PVR poliovirus receptor 58 +/ / / Qsox1 quiescin Q6 sulfhydryl oxidase / / / Rps6ka1 ribosomal protein S6 kinase polypeptide / / / Rrm2 ribonucleotide reductase M2 11 +/ / / Sc4mol sterol-c4-methyl oxidase-like / / / Thoc1 THO complex / / / Thrsp thyroid hormone responsive 636 +/ / / Tm7sf2 transmembrane 7 superfamily member / / / Tmem49 transmembrane protein / / / Tox4 TOX high mobility group box family member / / / Twf1 twinfilin, actin-binding protein, homolog 1 (Drosophila) / / / Wbp1 WW domain binding protein / / / Wbscr28 Williams-Beuren syndrome chromosome region 28 (human) 120 +/ / / Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 888 +/ / / Atorvastatin - Upregulated

3 Abca8b ATP-binding cassette, sub-family A (ABC1), member 8b 319 +/ / / Actg2 actin, gamma 2, smooth muscle, enteric 13 +/ / / Atp13a2 ATPase type 13A / / / Bre brain and reproductive organ-expressed protein 662 +/ / / Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subun 542 +/ / / Ccdc125 coiled-coil domain containing / / / Cpsf3l cleavage and polyadenylation specific factor 3-like 348 +/ / / Fance Fanconi anemia, complementation group E 75 +/ / / Hnrnpr heterogeneous nuclear ribonucleoprotein R / / / Lhpp phospholysine phosphohistidine inorganic pyrophosphate p 861 +/ / / Mboat2 membrane bound O-acyltransferase domain containing / / / Mrpl38 mitochondrial ribosomal protein L / / / Nhlrc3 NHL repeat containing / / / Nle1 notchless homolog 1 (Drosophila) 182 +/ / / Pop5 processing of precursor 5, ribonuclease P/MRP family (S. cer 482 +/ / / Prokr2 prokineticin receptor / / / Rp2h retinitis pigmentosa 2 homolog (human) 197 +/ / / Scamp4 secretory carrier membrane protein / / / Sfrs14 splicing factor, arginine/serine-rich / / / Shq1 SHQ1 homolog (S. cerevisiae) 67 +/ / / Srebf1 sterol regulatory element binding transcription factor / / / E-05 St6galnac3 ST6 (alpha-n-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-n-a 468 +/ / / Tbl1xr1 transducin (beta)-like 1X-linked receptor / / / Tyms thymidylate synthase 103 +/ / / Wdr36 WD repeat domain / / / Atorvastatin - Downregulated Adcy2 adenylate cyclase / / / Adnp2 ADNP homeobox / / / Ahcyl1 S-adenosylhomocysteine hydrolase-like / / /

4 Akap13 A kinase (PRKA) anchor protein / / / E-05 Epm2aip1 EPM2A (laforin) interacting protein / / / Fgf10 fibroblast growth factor / / / Hdac4 histone deacetylase / / / Il13ra1 interleukin 13 receptor, alpha / / / Il6ra interleukin 6 receptor, alpha 279 +/ / / Lce1c late cornified envelope 1C 29 +/ / / Mgl1 macrophage galactose N-acetyl-galactosamine specific lectin 108 +/ / / Mrpl51 mitochondrial ribosomal protein L / / / Msi2 Musashi homolog 2 (Drosophila) 364 +/ / / Nek9 NIMA (never in mitosis gene a)- related kinase / / / Nudcd1 NudC domain containing / / / Phf7 PHD finger protein / / / Ptp4a2 protein tyrosine phosphatase 4a / / / Stat5b signal transducer and activator of transcription 5B 97 +/ / / Synpo2 synaptopodin / / / Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like / / / Zfp629 zinc finger protein / / / Simvastatin & Atorvastatin - Upregulated Acp1 acid phosphatase 1, soluble / / / Afg3l2 AFG3(ATPase family gene 3)-like 2 (yeast) 593 +/ / / Atg4b autophagy-related 4B (yeast) 586 +/ / / Ccdc91 coiled-coil domain containing / / / Cse1l chromosome segregation 1-like (S. cerevisiae) / / / Dhrs7b dehydrogenase/reductase (SDR family) member 7B 601 +/ / / Dusp14 dual specificity phosphatase / / / Fbxo16 F-box protein / / / Hells helicase, lymphoid specific 46 +/ / / Hrpap20 hormone-regulated proliferation associated protein / / /

5 Kcnip3 Kv channel interacting protein 3, calsenilin 168 +/ / / Ms4a2 membrane-spanning 4-domains, subfamily A, member / / / Ndufa7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B 532 +/ / / Nob1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 684 +/ / / Rassf7 Ras association (RalGDS/AF-6) domain family (N-terminal) m 124 +/ / / Rufy3 RUN and FYVE domain containing / / / Scfd1 sec1 family domain containing / / / Sdccag10 serologically defined colon cancer antigen / / / Slc25a46 solute carrier family 25, member / / / Tmem9 transmembrane protein / / / Uxs1 UDP-glucuronate decarboxylase / / / Zfp414 zinc finger protein / / / Zfp524 zinc finger protein / / / Simvastatin & Atorvastatin - Downregulated Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit / / / Cbl Casitas B-lineage lymphoma 370 +/ / / Cdk2ap2 CDK2-associated protein / / / Ift52 intraflagellar transport 52 homolog (Chlamydomonas) 774 +/ / / Ihpk1 inositol hexaphosphate kinase / / / Itsn1 intersectin 1 (SH3 domain protein 1A) 474 +/ / / Limk2 LIM motif-containing protein kinase / / / Map2k6 mitogen-activated protein kinase kinase / / / Med1 mediator complex subunit / / / E-05 Mpg N-methylpurine-DNA glycosylase 178 +/ / / Nfe2l1 nuclear factor, erythroid derived 2,-like / / / Phf5a PHD finger protein 5A 785 +/ / / Slc26a1 solute carrier family 26 (sulfate transporter), member / / / Syt7 synaptotagmin VII 168 +/ / / Trim41 tripartite motif-containing / / /

6 Wdr40b WD repeat domain 40B / / / Zfp219 zinc finger protein / / /

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